Lumateperone (tosylate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.115113
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.106503
AKAP12 A kinase (PRKA) anchor protein 12 0.0947871
PDE4D phosphodiesterase 4D, cAMP-specific 0.0947103
BASP1 brain abundant, membrane attached signal protein 1 0.0670355
CMIP c-Maf inducing protein 0.0637613
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0605777
SAMD4A sterile alpha motif domain containing 4A 0.057247
THSD4 thrombospondin, type I, domain containing 4 0.0554013
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0553352
DOCK4 dedicator of cytokinesis 4 0.0540484
FMNL2 formin-like 2 0.0527135
WWOX WW domain containing oxidoreductase 0.0493059
FLNB filamin B, beta 0.0472926
TRIO trio Rho guanine nucleotide exchange factor 0.046012
ARHGAP26 Rho GTPase activating protein 26 0.0456055
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0449627
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0448855
FAM107B family with sequence similarity 107, member B 0.0444054
EXT1 exostosin glycosyltransferase 1 0.0440753
FNDC3B fibronectin type III domain containing 3B 0.0432802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0428615
SMOC1 SPARC related modular calcium binding 1 0.041807
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0415706
WAC WW domain containing adaptor with coiled-coil 0.0397639
ASPH aspartate beta-hydroxylase 0.0389908
PRRC2C proline-rich coiled-coil 2C 0.0383877
ELL2 elongation factor, RNA polymerase II, 2 0.037557
LOC102724023 ES1 protein homolog, mitochondrial 0.0374499
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0374385
IER3 immediate early response 3 0.0370694
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0368841
RBM39 RNA binding motif protein 39 0.0355609
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0355077
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0351314
ATXN1 ataxin 1 0.0350222
GOLGA4 golgin A4 0.0347801
CXCL8 chemokine (C-X-C motif) ligand 8 0.0342969
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0336791
MACF1 microtubule-actin crosslinking factor 1 0.0336638
RBM25 RNA binding motif protein 25 0.0332592
SNX14 sorting nexin 14 0.0331537
COPA coatomer protein complex, subunit alpha 0.0330752
STC1 stanniocalcin 1 0.0324671
NEBL nebulette 0.0319444
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0315301
LPP LIM domain containing preferred translocation partner in lipoma 0.031406
PTPRM protein tyrosine phosphatase, receptor type, M 0.0305011
MCL1 myeloid cell leukemia 1 0.0303754
EGFR epidermal growth factor receptor 0.0300783
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0299273
ACTN1 actinin, alpha 1 0.0293472
NDRG1 N-myc downstream regulated 1 0.029275
NHSL1 NHS-like 1 0.029253
RRM2 ribonucleotide reductase M2 0.0292448
KIF5B kinesin family member 5B 0.0290989
ERRFI1 ERBB receptor feedback inhibitor 1 0.0289243
KTN1 kinectin 1 (kinesin receptor) 0.0287887
LDHA lactate dehydrogenase A 0.0284708
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0283225
CAVIN1 caveolae associated protein 1 0.0282388
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0280464
IL6 interleukin 6 0.0279408
VCL vinculin 0.0277558
NAP1L1 nucleosome assembly protein 1-like 1 0.0277197
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0276279
EPAS1 endothelial PAS domain protein 1 0.0276025
PRELID2 PRELI domain containing 2 0.0273785
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0271984
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0268477
ZFAND3 zinc finger, AN1-type domain 3 0.0265098
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0264833
RAD51B RAD51 paralog B 0.0263595
EZR ezrin 0.0263181
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0261866
TRA2A transformer 2 alpha homolog (Drosophila) 0.0250713
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0246175
SQSTM1 sequestosome 1 0.0245895
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0245471
KMT2C lysine (K)-specific methyltransferase 2C 0.0236952
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0235788
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0235734
HELZ helicase with zinc finger 0.0234469
GLIS3 GLIS family zinc finger 3 0.023363
ACBD3 acyl-CoA binding domain containing 3 0.0233086
RAB7A RAB7A, member RAS oncogene family 0.0232618
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0231465
FHIT fragile histidine triad 0.0230388
SMYD3 SET and MYND domain containing 3 0.0227641
DST dystonin 0.0225091
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0222747
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0222381
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0219129
NBAS neuroblastoma amplified sequence 0.0218654
ITGA6 integrin, alpha 6 0.0218156
SLC35F3 solute carrier family 35, member F3 0.021753
EIF3A eukaryotic translation initiation factor 3, subunit A 0.021641
PRKCE protein kinase C, epsilon 0.0215739
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0214595
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0213492

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.477792
FTL ferritin, light polypeptide -0.232061
GRAMD1B GRAM domain containing 1B -0.159503
TMSB10 thymosin beta 10 -0.132814
FTH1 ferritin, heavy polypeptide 1 -0.120092
RPL19 ribosomal protein L19 -0.0783043
FGB fibrinogen beta chain -0.0761453
TXNRD1 thioredoxin reductase 1 -0.0757305
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0725623
IGF2 insulin-like growth factor 2 -0.0715034
EIF1 eukaryotic translation initiation factor 1 -0.0673462
RPS21 ribosomal protein S21 -0.0552679
RPL23 ribosomal protein L23 -0.0536413
RPLP1 ribosomal protein, large, P1 -0.0535438
RPL8 ribosomal protein L8 -0.0531385
PFN1 profilin 1 -0.0526384
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0511099
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0484085
S100A6 S100 calcium binding protein A6 -0.0482364
RPS19 ribosomal protein S19 -0.0444509
CFLAR CASP8 and FADD-like apoptosis regulator -0.0440863
NTN4 netrin 4 -0.0435724
RPS5 ribosomal protein S5 -0.0432394
HDAC9 histone deacetylase 9 -0.042871
RPS25 ribosomal protein S25 -0.0428422
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0423719
DENND4A DENN/MADD domain containing 4A -0.0407371
EEF2 eukaryotic translation elongation factor 2 -0.0372498
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.036373
UBC ubiquitin C -0.0361939
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0361068
RTN4 reticulon 4 -0.0359067
RPL4 ribosomal protein L4 -0.0352668
RPS8 ribosomal protein S8 -0.0351474
RHOA ras homolog family member A -0.0350949
PM20D1 peptidase M20 domain containing 1 -0.0340722
RPL34 ribosomal protein L34 -0.0340719
RPS23 ribosomal protein S23 -0.0339413
ASTN2 astrotactin 2 -0.0336164
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0333733
SVIL supervillin -0.0331238
ATP5F1B ATP synthase F1 subunit beta -0.0326092
RPS2 ribosomal protein S2 -0.032393
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0321584
RPS15 ribosomal protein S15 -0.0319801
PDIA6 protein disulfide isomerase family A, member 6 -0.030921
S100A10 S100 calcium binding protein A10 -0.0307763
YBX1 Y box binding protein 1 -0.0304095
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0293772
RPL36 ribosomal protein L36 -0.0293285
LOC112694756 uncharaterized LOC112694756 -0.0292795
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0288572
RPL28 ribosomal protein L28 -0.0271795
PKM pyruvate kinase, muscle -0.0268953
GNAS GNAS complex locus -0.0264226
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0261415
CYRIB CYFIP related Rac1 interactor B -0.0261357
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0259856
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0259809
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0258467
OSMR oncostatin M receptor -0.0255974
EEF1G eukaryotic translation elongation factor 1 gamma -0.0255603
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.025253
RPS6 ribosomal protein S6 -0.0252192
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.025213
NAMPT nicotinamide phosphoribosyltransferase -0.0251795
OSBPL9 oxysterol binding protein-like 9 -0.0244896
SERF2 small EDRK-rich factor 2 -0.0243705
BMPR1B bone morphogenetic protein receptor, type IB -0.0242262
CHN1 chimerin 1 -0.0241069
RPS16 ribosomal protein S16 -0.0239975
RPL11 ribosomal protein L11 -0.0232477
RPS20 ribosomal protein S20 -0.0231412
AFTPH aftiphilin -0.0230356
RPS29 ribosomal protein S29 -0.0229461
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0228555
RPS14 ribosomal protein S14 -0.0226748
CD99 CD99 molecule -0.0225227
MTMR3 myotubularin related protein 3 -0.0224222
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0222104
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0221937
RPL35A ribosomal protein L35a -0.0221845
SRGN serglycin -0.02164
LMNA lamin A/C -0.0215796
RPL32 ribosomal protein L32 -0.02148
RPS27 ribosomal protein S27 -0.0213748
WASF2 WAS protein family, member 2 -0.0213376
RPS11 ribosomal protein S11 -0.0212347
TAGLN2 transgelin 2 -0.0212323
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0209174
S100A9 S100 calcium binding protein A9 -0.0199813
RPL37 ribosomal protein L37 -0.0199689
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0199198
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0198948
RPL5 ribosomal protein L5 -0.0196545
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.019593
SMAD2 SMAD family member 2 -0.0194034
HMGA1 high mobility group AT-hook 1 -0.0193751
TMEM123 transmembrane protein 123 -0.0193464
RPL7 ribosomal protein L7 -0.0188468