| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT17 | keratin 17, type I | 0.0661352 |
| TXNRD1 | thioredoxin reductase 1 | 0.0527713 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0524051 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0509815 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0464331 |
| TOP1 | topoisomerase (DNA) I | 0.0458318 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0441707 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0438944 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0431957 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0424227 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0418793 |
| JUP | junction plakoglobin | 0.0395758 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0374909 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0374438 |
| TPR | translocated promoter region, nuclear basket protein | 0.0361082 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0352748 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0343342 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0342485 |
| SETBP1 | SET binding protein 1 | 0.0340406 |
| TGM2 | transglutaminase 2 | 0.0334829 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.0334753 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0332245 |
| PCBP2 | poly(rC) binding protein 2 | 0.0331979 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0328147 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0324451 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0320973 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0319086 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0317612 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0314864 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.0303023 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0301622 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0300628 |
| GRB10 | growth factor receptor-bound protein 10 | 0.030057 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0299861 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0298603 |
| ATP11A | ATPase, class VI, type 11A | 0.029802 |
| NMD3 | NMD3 ribosome export adaptor | 0.0297994 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0296499 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.029549 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0293947 |
| ZNF654 | zinc finger protein 654 | 0.0291818 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0290608 |
| RIOK3 | RIO kinase 3 | 0.0289539 |
| FBXW11 | F-box and WD repeat domain containing 11 | 0.0289222 |
| RREB1 | ras responsive element binding protein 1 | 0.0287721 |
| DICER1 | dicer 1, ribonuclease type III | 0.0285713 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0285685 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0285333 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0283572 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0282288 |
| DUSP10 | dual specificity phosphatase 10 | 0.028216 |
| MAMLD1 | mastermind-like domain containing 1 | 0.0281314 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0280099 |
| NEO1 | neogenin 1 | 0.027387 |
| KIAA1671 | KIAA1671 | 0.0273114 |
| CMIP | c-Maf inducing protein | 0.0273033 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | 0.0271414 |
| ITSN2 | intersectin 2 | 0.0270089 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0269414 |
| TPCN1 | two pore segment channel 1 | 0.0268261 |
| LAMA4 | laminin, alpha 4 | 0.0267841 |
| SPPL2A | signal peptide peptidase like 2A | 0.0267347 |
| RBM15 | RNA binding motif protein 15 | 0.0267244 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.0266379 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0262816 |
| SFSWAP | splicing factor, suppressor of white-apricot family | 0.0262203 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0261991 |
| USP6NL | USP6 N-terminal like | 0.0261452 |
| SPOPL | speckle-type POZ protein-like | 0.0261085 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0260957 |
| RASA2 | RAS p21 protein activator 2 | 0.0260652 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0258589 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0258545 |
| OPHN1 | oligophrenin 1 | 0.0257849 |
| IFI44 | interferon-induced protein 44 | 0.0256238 |
| GNPAT | glyceronephosphate O-acyltransferase | 0.0255545 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0255168 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0254898 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0253769 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0250579 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0249925 |
| EGFR | epidermal growth factor receptor | 0.024983 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0247775 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0247739 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0247546 |
| AHI1 | Abelson helper integration site 1 | 0.0244826 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0244284 |
| ENKUR | enkurin, TRPC channel interacting protein | 0.0243852 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0243801 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0242783 |
| RASAL2 | RAS protein activator like 2 | 0.0242287 |
| PCGF5 | polycomb group ring finger 5 | 0.0241322 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0241062 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0240503 |
| FOXJ3 | forkhead box J3 | 0.0239326 |
| SSH2 | slingshot protein phosphatase 2 | 0.0239325 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0239003 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.023883 |
| HPS5 | Hermansky-Pudlak syndrome 5 | 0.0238476 |
| STRN | striatin, calmodulin binding protein | 0.0237424 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.201609 |
| FNDC3B | fibronectin type III domain containing 3B | -0.105817 |
| NDRG1 | N-myc downstream regulated 1 | -0.0765593 |
| JMJD1C | jumonji domain containing 1C | -0.0760555 |
| ANXA2 | annexin A2 | -0.0755316 |
| IGF2 | insulin-like growth factor 2 | -0.0723579 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0716258 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0714791 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0691527 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0659777 |
| LMO7 | LIM domain 7 | -0.0659177 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0653845 |
| VIM | vimentin | -0.0643517 |
| PTMA | prothymosin, alpha | -0.0641458 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0584091 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.05819 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0576709 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.056 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0546681 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0545978 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0545838 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0540343 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0531542 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0517881 |
| HLA-B | major histocompatibility complex, class I, B | -0.0498142 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0496508 |
| ACTG1 | actin gamma 1 | -0.0494544 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0487665 |
| ZNF217 | zinc finger protein 217 | -0.0451522 |
| RTN4 | reticulon 4 | -0.0440025 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0439884 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0435 |
| VCL | vinculin | -0.0430769 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0426042 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0425341 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0423876 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0423151 |
| FN1 | fibronectin 1 | -0.0421712 |
| LAMB3 | laminin, beta 3 | -0.0415534 |
| CCNI | cyclin I | -0.0409814 |
| RORA | RAR-related orphan receptor A | -0.0407205 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0404984 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0398598 |
| RPL34 | ribosomal protein L34 | -0.0396844 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0393171 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0392124 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0391555 |
| CD44 | CD44 molecule (Indian blood group) | -0.0385541 |
| SPAG9 | sperm associated antigen 9 | -0.0379199 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0376103 |
| TCF12 | transcription factor 12 | -0.0372824 |
| SMYD3 | SET and MYND domain containing 3 | -0.0371483 |
| FOXO3 | forkhead box O3 | -0.0370181 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0362685 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0361987 |
| HLA-A | major histocompatibility complex, class I, A | -0.0358714 |
| USP15 | ubiquitin specific peptidase 15 | -0.0347197 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0343687 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0341777 |
| OSMR | oncostatin M receptor | -0.0337081 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0332722 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.033066 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.032897 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0327735 |
| RPS6 | ribosomal protein S6 | -0.0325296 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0324828 |
| FNIP1 | folliculin interacting protein 1 | -0.0323971 |
| ENO1 | enolase 1, (alpha) | -0.0322916 |
| PARD3 | par-3 family cell polarity regulator | -0.0319862 |
| MYO1E | myosin IE | -0.0317772 |
| USP34 | ubiquitin specific peptidase 34 | -0.0315268 |
| TJP1 | tight junction protein 1 | -0.0314462 |
| STC1 | stanniocalcin 1 | -0.0312593 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0310674 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0307548 |
| AK1 | adenylate kinase 1 | -0.0306854 |
| DST | dystonin | -0.0304778 |
| ERBIN | erbb2 interacting protein | -0.0302511 |
| FAM107B | family with sequence similarity 107, member B | -0.0301098 |
| S100A10 | S100 calcium binding protein A10 | -0.0300682 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0299212 |
| FOXP1 | forkhead box P1 | -0.0296026 |
| AHNAK | AHNAK nucleoprotein | -0.0295974 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0295303 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0293363 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0290182 |
| IER3 | immediate early response 3 | -0.0287821 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0286658 |
| VCAN | versican | -0.0283161 |
| TMEM87A | transmembrane protein 87A | -0.028209 |
| MED13L | mediator complex subunit 13-like | -0.0279936 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0278818 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0273888 |
| CLDN4 | claudin 4 | -0.0273395 |
| CLMP | CXADR-like membrane protein | -0.0273042 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0272041 |
| RPS21 | ribosomal protein S21 | -0.0271074 |
| PRSS23 | protease, serine, 23 | -0.0269185 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0265622 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0264191 |
