Lumateperone (tosylate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.114719
AKAP12 A kinase (PRKA) anchor protein 12 0.109988
MCL1 myeloid cell leukemia 1 0.0752339
ERRFI1 ERBB receptor feedback inhibitor 1 0.0663561
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0567256
PRELID2 PRELI domain containing 2 0.0519639
INTS6 integrator complex subunit 6 0.0468519
AEBP2 AE binding protein 2 0.045542
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0451915
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0407751
PDLIM5 PDZ and LIM domain 5 0.0405518
AFF3 AF4/FMR2 family, member 3 0.0398908
WWOX WW domain containing oxidoreductase 0.0388059
HOMER1 homer scaffolding protein 1 0.0386351
PDE10A phosphodiesterase 10A 0.0382995
RIMS2 regulating synaptic membrane exocytosis 2 0.0381617
YBX3 Y box binding protein 3 0.0375546
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.03437
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0339555
FMNL2 formin-like 2 0.0334625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0329781
ELL2 elongation factor, RNA polymerase II, 2 0.0315873
ZSWIM6 zinc finger, SWIM-type containing 6 0.0293098
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0292232
DOCK5 dedicator of cytokinesis 5 0.0287079
PDE4D phosphodiesterase 4D, cAMP-specific 0.0284656
MYH9 myosin, heavy chain 9, non-muscle 0.0281414
PRH1 proline-rich protein HaeIII subfamily 1 0.0275971
SFPQ splicing factor proline/glutamine-rich 0.0275169
ATXN1 ataxin 1 0.027234
PRKCE protein kinase C, epsilon 0.027226
GRAMD1B GRAM domain containing 1B 0.0271388
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0270073
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0264936
HMGA2 high mobility group AT-hook 2 0.0257843
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.025463
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0249499
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0249298
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0247086
HSPA8 heat shock 70kDa protein 8 0.0242105
IGF1R insulin-like growth factor 1 receptor 0.0238249
VCL vinculin 0.023778
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0237001
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.02368
CAPRIN2 caprin family member 2 0.0236504
CTTN cortactin 0.0233208
WNT2B wingless-type MMTV integration site family, member 2B 0.0230439
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0227984
TRA2A transformer 2 alpha homolog (Drosophila) 0.0227647
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0214684
DOCK1 dedicator of cytokinesis 1 0.0214162
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0209932
EXOC4 exocyst complex component 4 0.0206997
RBM39 RNA binding motif protein 39 0.0204126
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0198241
RABGAP1L RAB GTPase activating protein 1-like 0.0194967
DST dystonin 0.019496
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0194194
WWTR1 WW domain containing transcription regulator 1 0.0193686
VMP1 vacuole membrane protein 1 0.0193164
HDAC4 histone deacetylase 4 0.0191912
NEK10 NIMA-related kinase 10 0.0191501
MBD5 methyl-CpG binding domain protein 5 0.0189294
THSD4 thrombospondin, type I, domain containing 4 0.0181554
YAP1 Yes-associated protein 1 0.0180988
FNDC3B fibronectin type III domain containing 3B 0.0180905
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0179067
EXT1 exostosin glycosyltransferase 1 0.0176644
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0176187
PYGL phosphorylase, glycogen, liver 0.0176149
USP34 ubiquitin specific peptidase 34 0.0175209
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0172435
DSCAM Down syndrome cell adhesion molecule 0.0171974
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0169964
OSMR oncostatin M receptor 0.0168724
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0168639
SDK1 sidekick cell adhesion molecule 1 0.0167848
USP9X ubiquitin specific peptidase 9, X-linked 0.016504
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0164823
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0164007
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0163864
TRIM59 tripartite motif containing 59 0.0162592
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0162005
ZYX zyxin 0.0161506
VCP valosin containing protein 0.0158744
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0158709
PCBP2 poly(rC) binding protein 2 0.0158488
CFAP44 cilia and flagella associated protein 44 0.0154894
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.015426
SRSF6 serine/arginine-rich splicing factor 6 0.0153883
INTS3 integrator complex subunit 3 0.0152946
PMM2 phosphomannomutase 2 0.015271
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0152597
STX8 syntaxin 8 0.0152513
TBC1D22A TBC1 domain family, member 22A 0.0150056
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0149996
BNC2 basonuclin 2 0.0149574
MACF1 microtubule-actin crosslinking factor 1 0.0149346
SETX senataxin 0.0148604
MCTP1 multiple C2 domains, transmembrane 1 0.0148261

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.352175
TXNRD1 thioredoxin reductase 1 -0.102059
TFPI2 tissue factor pathway inhibitor 2 -0.0953932
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0952931
VIM vimentin -0.0733063
PTMA prothymosin, alpha -0.0669829
TPI1 triosephosphate isomerase 1 -0.0547632
RTN4 reticulon 4 -0.0512017
TMSB10 thymosin beta 10 -0.0502149
KTN1 kinectin 1 (kinesin receptor) -0.0460349
EEF2 eukaryotic translation elongation factor 2 -0.045522
RPL35A ribosomal protein L35a -0.0447259
PFN1 profilin 1 -0.0423493
EGR1 early growth response 1 -0.0415867
RPS8 ribosomal protein S8 -0.0395873
ATP5F1B ATP synthase F1 subunit beta -0.0383678
HMGA1 high mobility group AT-hook 1 -0.0375192
RPS21 ribosomal protein S21 -0.0373917
RPLP1 ribosomal protein, large, P1 -0.037208
RPL12 ribosomal protein L12 -0.0368495
SMC4 structural maintenance of chromosomes 4 -0.036693
PHIP pleckstrin homology domain interacting protein -0.0360342
YBX1 Y box binding protein 1 -0.03515
RPL37 ribosomal protein L37 -0.0342
LDHB lactate dehydrogenase B -0.034164
MYL12B myosin, light chain 12B, regulatory -0.0340109
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.033922
TRIO trio Rho guanine nucleotide exchange factor -0.0336196
GATAD2B GATA zinc finger domain containing 2B -0.0333234
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0331971
DEK DEK proto-oncogene -0.0331914
SBF2 SET binding factor 2 -0.0324956
SINHCAF SIN3-HDAC complex associated factor -0.0323947
SCAF11 SR-related CTD-associated factor 11 -0.0320513
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0314552
TMEM165 transmembrane protein 165 -0.030979
XPO1 exportin 1 -0.0309024
RPS6 ribosomal protein S6 -0.0307307
WASF2 WAS protein family, member 2 -0.0306693
RPS15 ribosomal protein S15 -0.0304229
ZFR zinc finger RNA binding protein -0.0301882
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0300662
RUSC2 RUN and SH3 domain containing 2 -0.029736
ZNF292 zinc finger protein 292 -0.0297001
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0294394
RPL26 ribosomal protein L26 -0.0293582
BSG basigin (Ok blood group) -0.0291283
RPLP0 ribosomal protein, large, P0 -0.028704
SENP6 SUMO1/sentrin specific peptidase 6 -0.0280485
CSDE1 cold shock domain containing E1, RNA-binding -0.0276109
RPL5 ribosomal protein L5 -0.0276108
BBX bobby sox homolog (Drosophila) -0.0273733
CBX3 chromobox homolog 3 -0.0273235
PKM pyruvate kinase, muscle -0.027261
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0271227
MKI67 marker of proliferation Ki-67 -0.026939
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0267092
RPL8 ribosomal protein L8 -0.026357
FTL ferritin, light polypeptide -0.0255445
GOLGA4 golgin A4 -0.0254934
RPS27 ribosomal protein S27 -0.02524
RPL34 ribosomal protein L34 -0.024931
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0247189
RSF1 remodeling and spacing factor 1 -0.0244649
MARCHF4 membrane associated ring-CH-type finger 4 -0.0242418
IGF2 insulin-like growth factor 2 -0.0242135
RPL37A ribosomal protein L37a -0.0242013
SEPTIN7 septin 7 -0.0241822
CENPF centromere protein F, 350/400kDa -0.0240219
ANKRD12 ankyrin repeat domain 12 -0.0239361
ADAR adenosine deaminase, RNA-specific -0.0236692
RPS19 ribosomal protein S19 -0.0234501
EIF5B eukaryotic translation initiation factor 5B -0.0231463
EIF1 eukaryotic translation initiation factor 1 -0.0230585
TUBA1B tubulin, alpha 1b -0.0229851
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0229467
TLK1 tousled-like kinase 1 -0.0228941
RB1CC1 RB1-inducible coiled-coil 1 -0.0228101
UBE2K ubiquitin-conjugating enzyme E2K -0.0227752
RPLP2 ribosomal protein, large, P2 -0.0225025
PTEN phosphatase and tensin homolog -0.0224162
RPS3 ribosomal protein S3 -0.0222808
GLO1 glyoxalase I -0.0222421
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0219937
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0218168
RPS24 ribosomal protein S24 -0.0217423
KCMF1 potassium channel modulatory factor 1 -0.0215488
RBM25 RNA binding motif protein 25 -0.0213098
MATR3 matrin 3 -0.0212662
RPL19 ribosomal protein L19 -0.0210716
NACA nascent polypeptide-associated complex alpha subunit -0.0210079
KDM2A lysine (K)-specific demethylase 2A -0.0209098
SRPK1 SRSF protein kinase 1 -0.0208843
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0207133
NOP58 NOP58 ribonucleoprotein -0.0206951
RPL32 ribosomal protein L32 -0.0206789
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0206725
ADGRG6 adhesion G protein-coupled receptor G6 -0.0206097
ATXN2 ataxin 2 -0.0205818
RNF38 ring finger protein 38 -0.020555