| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.184497 |
| LAMB3 | laminin, beta 3 | 0.132344 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.116042 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0936048 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0763572 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0758201 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0745621 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0677437 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0673354 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0668994 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0585189 |
| CANX | calnexin | 0.0573374 |
| NAV2 | neuron navigator 2 | 0.0553764 |
| VCL | vinculin | 0.0523908 |
| EFNA5 | ephrin-A5 | 0.0499019 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0487971 |
| RPL35A | ribosomal protein L35a | 0.0478985 |
| SMAD3 | SMAD family member 3 | 0.0476909 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0464064 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0457865 |
| RPL34 | ribosomal protein L34 | 0.0437547 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0431237 |
| INTS6 | integrator complex subunit 6 | 0.0429473 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0423419 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0420623 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0405615 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0405022 |
| SDC4 | syndecan 4 | 0.0403255 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0401219 |
| PLEC | plectin | 0.0397339 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.039563 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0373449 |
| TMSB4X | thymosin beta 4, X-linked | 0.0373298 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0370461 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0365624 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.036334 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0358061 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.03512 |
| GOLGB1 | golgin B1 | 0.0350273 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0348985 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0338114 |
| LMO7 | LIM domain 7 | 0.0337131 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0335261 |
| SPAG9 | sperm associated antigen 9 | 0.033522 |
| KIAA1217 | KIAA1217 | 0.0331641 |
| DSPP | dentin sialophosphoprotein | 0.0325038 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0324404 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0314696 |
| ATXN1 | ataxin 1 | 0.0313503 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0311961 |
| DOCK5 | dedicator of cytokinesis 5 | 0.030703 |
| NABP1 | nucleic acid binding protein 1 | 0.0300559 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0294774 |
| PRKCA | protein kinase C, alpha | 0.0293936 |
| PALLD | palladin, cytoskeletal associated protein | 0.02879 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0287871 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0287598 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0284719 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0278735 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0277098 |
| RPLP0 | ribosomal protein, large, P0 | 0.0274043 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0273136 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0270269 |
| ANO6 | anoctamin 6 | 0.0270243 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0267324 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0266614 |
| FAM193A | family with sequence similarity 193, member A | 0.026577 |
| SGMS2 | sphingomyelin synthase 2 | 0.0265542 |
| TJP1 | tight junction protein 1 | 0.0260979 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0257793 |
| MYOF | myoferlin | 0.0257617 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0257607 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0257569 |
| LAMC2 | laminin, gamma 2 | 0.0257359 |
| CTBP2 | C-terminal binding protein 2 | 0.0254329 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0253334 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0250498 |
| IGF2 | insulin-like growth factor 2 | 0.0249571 |
| MED13 | mediator complex subunit 13 | 0.0248278 |
| DUSP10 | dual specificity phosphatase 10 | 0.0247582 |
| RYBP | RING1 and YY1 binding protein | 0.0246075 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0245625 |
| RPL14 | ribosomal protein L14 | 0.024499 |
| RPLP1 | ribosomal protein, large, P1 | 0.024326 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0241575 |
| PSEN1 | presenilin 1 | 0.0241084 |
| RPL11 | ribosomal protein L11 | 0.023993 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0239712 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0239619 |
| STEAP4 | STEAP family member 4 | 0.0238935 |
| FBXO34 | F-box protein 34 | 0.0236648 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.023605 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0234124 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.023373 |
| PCNX1 | pecanex 1 | 0.0231754 |
| FLNB | filamin B, beta | 0.0227679 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0226996 |
| CDK13 | cyclin-dependent kinase 13 | 0.022681 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | 0.0226494 |
| HBP1 | HMG-box transcription factor 1 | 0.0224991 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.219524 |
| FN1 | fibronectin 1 | -0.148214 |
| FTL | ferritin, light polypeptide | -0.132293 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.106131 |
| TMSB10 | thymosin beta 10 | -0.101381 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0912411 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0879253 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0876462 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0814715 |
| S100A6 | S100 calcium binding protein A6 | -0.0792049 |
| LDHA | lactate dehydrogenase A | -0.0772646 |
| MT2A | metallothionein 2A | -0.069355 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0681381 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0657617 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0630551 |
| FBXO32 | F-box protein 32 | -0.061112 |
| HMGA1 | high mobility group AT-hook 1 | -0.0592896 |
| PTMA | prothymosin, alpha | -0.0580282 |
| PKM | pyruvate kinase, muscle | -0.0567095 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.055638 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.054313 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0524818 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0510728 |
| TFG | TRK-fused gene | -0.0495739 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0484475 |
| HLA-A | major histocompatibility complex, class I, A | -0.0478068 |
| TPM4 | tropomyosin 4 | -0.0473471 |
| MAP1B | microtubule-associated protein 1B | -0.0454104 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0441278 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0440104 |
| ADAR | adenosine deaminase, RNA-specific | -0.0432936 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0430414 |
| S100A11 | S100 calcium binding protein A11 | -0.0427835 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0425915 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0425872 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0425169 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0408625 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0398528 |
| CD2AP | CD2-associated protein | -0.0397753 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0397657 |
| SLMAP | sarcolemma associated protein | -0.0395006 |
| G0S2 | G0/G1 switch 2 | -0.0394726 |
| FAM3C | family with sequence similarity 3, member C | -0.0394198 |
| PGK1 | phosphoglycerate kinase 1 | -0.0390239 |
| RNF145 | ring finger protein 145 | -0.0390186 |
| FRMD5 | FERM domain containing 5 | -0.0389538 |
| CCND1 | cyclin D1 | -0.0389476 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0386985 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0384768 |
| POTEF | POTE ankyrin domain family, member F | -0.0371488 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0369849 |
| TPI1 | triosephosphate isomerase 1 | -0.0365766 |
| ERBIN | erbb2 interacting protein | -0.0364085 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0363787 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0359708 |
| RAI14 | retinoic acid induced 14 | -0.0358598 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0355269 |
| CLDN4 | claudin 4 | -0.0352851 |
| TMEM165 | transmembrane protein 165 | -0.0351896 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0348092 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0346485 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0342705 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0334403 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0334131 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0333445 |
| TPM3 | tropomyosin 3 | -0.0332734 |
| TMEM123 | transmembrane protein 123 | -0.0331135 |
| MAP4 | microtubule-associated protein 4 | -0.0327439 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0322965 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0319377 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0316539 |
| HLA-B | major histocompatibility complex, class I, B | -0.0313422 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0313367 |
| TRAM1 | translocation associated membrane protein 1 | -0.0309938 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0309733 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0308293 |
| SBF2 | SET binding factor 2 | -0.0307683 |
| MXD1 | MAX dimerization protein 1 | -0.0306434 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0299715 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0294839 |
| ZNF207 | zinc finger protein 207 | -0.02942 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0285912 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0285111 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0283362 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.0282771 |
| RHOA | ras homolog family member A | -0.028231 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0281086 |
| VIM | vimentin | -0.0280413 |
| TAPBP | TAP binding protein (tapasin) | -0.0278959 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0278114 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0277525 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0277292 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.027606 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0270825 |
| ACTG1 | actin gamma 1 | -0.0268983 |
| TXNIP | thioredoxin interacting protein | -0.0268739 |
| TAGLN2 | transgelin 2 | -0.0267506 |
| CTSS | cathepsin S | -0.0267031 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0265563 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0265262 |
