Lumateperone (tosylate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.140996
PM20D1 peptidase M20 domain containing 1 0.121623
ASPH aspartate beta-hydroxylase 0.117496
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.116949
COL5A2 collagen, type V, alpha 2 0.0911635
NAMPT nicotinamide phosphoribosyltransferase 0.0809671
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0787205
PDLIM5 PDZ and LIM domain 5 0.07369
PSD3 pleckstrin and Sec7 domain containing 3 0.073686
PDE10A phosphodiesterase 10A 0.073418
GRAMD1B GRAM domain containing 1B 0.0691244
MYOF myoferlin 0.0683214
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0640099
TRIO trio Rho guanine nucleotide exchange factor 0.0636657
EFNA5 ephrin-A5 0.0629806
KYNU kynureninase 0.0568319
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0568163
SH3KBP1 SH3-domain kinase binding protein 1 0.0563351
GDA guanine deaminase 0.0562504
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0551746
EZR ezrin 0.0528813
CXCL8 chemokine (C-X-C motif) ligand 8 0.0500881
ELL2 elongation factor, RNA polymerase II, 2 0.0499487
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0488358
DOCK4 dedicator of cytokinesis 4 0.0487204
PRKN parkin RBR E3 ubiquitin protein ligase 0.0485186
TGFBR1 transforming growth factor, beta receptor 1 0.0462072
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0449141
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0434356
COL8A1 collagen, type VIII, alpha 1 0.0434194
BZW1 basic leucine zipper and W2 domains 1 0.0430966
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0424184
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.04227
RAB3B RAB3B, member RAS oncogene family 0.0385816
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0382619
BASP1 brain abundant, membrane attached signal protein 1 0.0377444
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0371466
DST dystonin 0.0367055
TXNRD1 thioredoxin reductase 1 0.0362625
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0360131
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0356163
P3H2 prolyl 3-hydroxylase 2 0.0348812
CENPF centromere protein F, 350/400kDa 0.0334103
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0330269
COL4A5 collagen, type IV, alpha 5 0.032266
CD109 CD109 molecule 0.0321335
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0316042
NT5C2 5'-nucleotidase, cytosolic II 0.0313415
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0306777
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0305861
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0303374
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0297569
FN1 fibronectin 1 0.0289841
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0287437
INHBA inhibin, beta A 0.0285921
NEK7 NIMA-related kinase 7 0.0272533
RGS2 regulator of G-protein signaling 2 0.0271951
SLC38A2 solute carrier family 38, member 2 0.0271595
ZEB2 zinc finger E-box binding homeobox 2 0.0264975
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260114
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0254816
TPR translocated promoter region, nuclear basket protein 0.0248606
LSAMP limbic system-associated membrane protein 0.0236675
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0235865
IL6 interleukin 6 0.0235381
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0233534
FNDC3B fibronectin type III domain containing 3B 0.0223532
DGKD diacylglycerol kinase, delta 130kDa 0.0223332
ESYT2 extended synaptotagmin-like protein 2 0.0221416
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0221216
ATXN1 ataxin 1 0.022024
PRELID2 PRELI domain containing 2 0.0217591
DOCK5 dedicator of cytokinesis 5 0.0216554
HSPA8 heat shock 70kDa protein 8 0.0214393
STAG2 stromal antigen 2 0.0210791
ZSWIM6 zinc finger, SWIM-type containing 6 0.0205248
TPM3 tropomyosin 3 0.0204413
ZBTB38 zinc finger and BTB domain containing 38 0.0201919
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.020056
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0200339
SLF1 SMC5-SMC6 complex localization factor 1 0.0200049
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0197196
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0196947
MAML3 mastermind-like 3 (Drosophila) 0.0196247
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195744
AGTPBP1 ATP/GTP binding protein 1 0.0195653
EPHA4 EPH receptor A4 0.0195632
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0194174
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0192003
TFPI2 tissue factor pathway inhibitor 2 0.0191566
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0190945
FMNL2 formin-like 2 0.018985
ANTXR1 anthrax toxin receptor 1 0.0186893
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0186498
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0186186
TMX4 thioredoxin-related transmembrane protein 4 0.0184782
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0184015
BCAR3 breast cancer anti-estrogen resistance 3 0.0182849
BMP6 bone morphogenetic protein 6 0.0181468
NRG1 neuregulin 1 0.0180742

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.197586
FTL ferritin, light polypeptide -0.0908386
RPS6 ribosomal protein S6 -0.0811639
RPL31 ribosomal protein L31 -0.079488
RPS23 ribosomal protein S23 -0.0675207
TMSB10 thymosin beta 10 -0.0636415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0623968
VIM vimentin -0.0570846
RPL35A ribosomal protein L35a -0.0536133
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0525989
RPS19 ribosomal protein S19 -0.0501338
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0496948
RPS27 ribosomal protein S27 -0.0450085
RPLP1 ribosomal protein, large, P1 -0.0445512
RPL37A ribosomal protein L37a -0.0443129
PTMA prothymosin, alpha -0.0423642
RPS29 ribosomal protein S29 -0.0406288
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.038239
RPL5 ribosomal protein L5 -0.0364945
RPS13 ribosomal protein S13 -0.0347658
TPT1 tumor protein, translationally-controlled 1 -0.0340504
RPS21 ribosomal protein S21 -0.0339081
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0338851
RPL9 ribosomal protein L9 -0.033331
RPS8 ribosomal protein S8 -0.0332955
GNAS GNAS complex locus -0.0321259
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0319346
S100A6 S100 calcium binding protein A6 -0.031874
RPS25 ribosomal protein S25 -0.0318066
RPS27A ribosomal protein S27a -0.0317551
ADGRD1 adhesion G protein-coupled receptor D1 -0.0307025
RPL38 ribosomal protein L38 -0.0299456
RPS11 ribosomal protein S11 -0.0294832
RPS10 ribosomal protein S10 -0.0293668
IGFBP3 insulin-like growth factor binding protein 3 -0.0291814
RPS14 ribosomal protein S14 -0.0291667
RPL7A ribosomal protein L7a -0.0291058
RPL26 ribosomal protein L26 -0.0285816
RPS24 ribosomal protein S24 -0.0282961
RPS16 ribosomal protein S16 -0.0282295
RPS15 ribosomal protein S15 -0.0281538
RPL23 ribosomal protein L23 -0.0278681
INTS6 integrator complex subunit 6 -0.0272445
HILPDA hypoxia inducible lipid droplet-associated -0.0267861
RPL34 ribosomal protein L34 -0.0262539
RPL36 ribosomal protein L36 -0.0260234
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0257723
HLA-A major histocompatibility complex, class I, A -0.0256941
FTH1 ferritin, heavy polypeptide 1 -0.0254569
RPLP2 ribosomal protein, large, P2 -0.0247685
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0245644
ASTN2 astrotactin 2 -0.0245531
RPL19 ribosomal protein L19 -0.0245349
RPL36A ribosomal protein L36a -0.0239302
RPS12 ribosomal protein S12 -0.0236845
RPL11 ribosomal protein L11 -0.0233302
RPL28 ribosomal protein L28 -0.0229518
RPL37 ribosomal protein L37 -0.0227077
RPS5 ribosomal protein S5 -0.0223154
NCKAP5 NCK-associated protein 5 -0.0216022
PFN1 profilin 1 -0.0214286
S100A10 S100 calcium binding protein A10 -0.0207513
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0199567
TMEM165 transmembrane protein 165 -0.0198878
RPS2 ribosomal protein S2 -0.0193924
RPS17 ribosomal protein S17 -0.0192981
PKM pyruvate kinase, muscle -0.019136
GOLGA4 golgin A4 -0.0190239
PDIA3 protein disulfide isomerase family A, member 3 -0.0187054
NBEAL1 neurobeachin-like 1 -0.0185907
EEF2 eukaryotic translation elongation factor 2 -0.0185531
DSTN destrin (actin depolymerizing factor) -0.0185025
LMNA lamin A/C -0.0184461
DENND1A DENN/MADD domain containing 1A -0.0184179
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0182959
PAIP2 poly(A) binding protein interacting protein 2 -0.0180467
RCOR1 REST corepressor 1 -0.0179334
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0177092
RAP1B RAP1B, member of RAS oncogene family -0.0175788
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0175634
RPS3 ribosomal protein S3 -0.0175375
ATP5F1B ATP synthase F1 subunit beta -0.0174977
ACBD3 acyl-CoA binding domain containing 3 -0.0173949
UBC ubiquitin C -0.0172596
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0170107
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0169814
RACK1 receptor for activated C kinase 1 -0.0169702
SBF2 SET binding factor 2 -0.0168997
HLA-B major histocompatibility complex, class I, B -0.0168498
ZNF207 zinc finger protein 207 -0.0167646
VDAC1 voltage-dependent anion channel 1 -0.0166236
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0165135
HM13 histocompatibility (minor) 13 -0.0162876
CUX1 cut-like homeobox 1 -0.0161191
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0160197
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0159278
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0159206
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0158517
SCFD1 sec1 family domain containing 1 -0.0157203
NALF1 NALCN channel auxiliary factor 1 -0.0156589