| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SSH2 | slingshot protein phosphatase 2 | 0.11774 |
| EGFR | epidermal growth factor receptor | 0.110817 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.100449 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0985647 |
| B2M | beta-2-microglobulin | 0.0981224 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0974742 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0964962 |
| FN1 | fibronectin 1 | 0.0939866 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0903934 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0901411 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0824193 |
| AHNAK | AHNAK nucleoprotein | 0.0800301 |
| NDRG1 | N-myc downstream regulated 1 | 0.0798373 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0793854 |
| CALD1 | caldesmon 1 | 0.0792476 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0788112 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0737255 |
| FAT1 | FAT atypical cadherin 1 | 0.0707058 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0695268 |
| FLNB | filamin B, beta | 0.0671262 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0647764 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0597777 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0576902 |
| DSPP | dentin sialophosphoprotein | 0.0572512 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0560964 |
| TXNRD1 | thioredoxin reductase 1 | 0.0560223 |
| SPAG9 | sperm associated antigen 9 | 0.0557656 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.055291 |
| NLGN1 | neuroligin 1 | 0.0539377 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0539191 |
| EFNA5 | ephrin-A5 | 0.0531788 |
| STC1 | stanniocalcin 1 | 0.0508979 |
| SMYD3 | SET and MYND domain containing 3 | 0.0505736 |
| CENPF | centromere protein F, 350/400kDa | 0.0502553 |
| GPHN | gephyrin | 0.0500512 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.050029 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0476897 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0476742 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0470628 |
| PCBP2 | poly(rC) binding protein 2 | 0.0469212 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0462575 |
| MED13L | mediator complex subunit 13-like | 0.0461988 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0457209 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0452268 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0448395 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0448109 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0447212 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0447184 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0438883 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0430801 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0428636 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0417091 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0414273 |
| CCNY | cyclin Y | 0.0404302 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0395183 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0379849 |
| GPC6 | glypican 6 | 0.0379102 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0378943 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0377837 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0374721 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0362706 |
| DENND1A | DENN/MADD domain containing 1A | 0.035535 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0354157 |
| ANXA2 | annexin A2 | 0.0350594 |
| MYO10 | myosin X | 0.0348174 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0347052 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0344014 |
| UTRN | utrophin | 0.034068 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0340528 |
| FNIP1 | folliculin interacting protein 1 | 0.0335232 |
| ATXN2 | ataxin 2 | 0.033025 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0323379 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0305637 |
| RNF213 | ring finger protein 213 | 0.0294715 |
| ATXN1 | ataxin 1 | 0.0290351 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0289561 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0280829 |
| PRELID2 | PRELI domain containing 2 | 0.0265296 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0264665 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0255258 |
| GRB10 | growth factor receptor-bound protein 10 | 0.024781 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0241635 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0235557 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0233335 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0231755 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0230124 |
| FAM13A | family with sequence similarity 13, member A | 0.022409 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0223597 |
| CD44 | CD44 molecule (Indian blood group) | 0.0220677 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0217282 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.021695 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0205065 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0188731 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0186485 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0185936 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0182646 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0166477 |
| ANKRD11 | ankyrin repeat domain 11 | 0.016438 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0152579 |
| NEMF | nuclear export mediator factor | 0.0152486 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.245776 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.17159 |
| RPL35A | ribosomal protein L35a | -0.155161 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.136206 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.135304 |
| LMO7 | LIM domain 7 | -0.100883 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0981928 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0937226 |
| PTMA | prothymosin, alpha | -0.0907029 |
| NAV2 | neuron navigator 2 | -0.085501 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0787894 |
| FTL | ferritin, light polypeptide | -0.0771726 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0728438 |
| RPS8 | ribosomal protein S8 | -0.0719959 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0688998 |
| JMJD1C | jumonji domain containing 1C | -0.0687181 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0684883 |
| CDK6 | cyclin-dependent kinase 6 | -0.067305 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0657951 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0616534 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0606966 |
| MCL1 | myeloid cell leukemia 1 | -0.0559356 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0557062 |
| TNS3 | tensin 3 | -0.0541761 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0529303 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0523863 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0506933 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0501891 |
| EGR1 | early growth response 1 | -0.0497855 |
| WASF2 | WAS protein family, member 2 | -0.0490502 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0480491 |
| RPS6 | ribosomal protein S6 | -0.0476702 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0440274 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0437782 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.043466 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0421579 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0420256 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0409888 |
| RPLP2 | ribosomal protein, large, P2 | -0.0406908 |
| IGF2 | insulin-like growth factor 2 | -0.0405795 |
| SNX9 | sorting nexin 9 | -0.04011 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0382197 |
| PDE10A | phosphodiesterase 10A | -0.0379648 |
| ZNF292 | zinc finger protein 292 | -0.0375551 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0372346 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0350561 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.033369 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0332895 |
| RPLP1 | ribosomal protein, large, P1 | -0.0322026 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0318662 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0309688 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0296534 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0295856 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0294449 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0278026 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0274819 |
| RPS16 | ribosomal protein S16 | -0.0273348 |
| SBF2 | SET binding factor 2 | -0.0273031 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0270884 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0262411 |
| PKM | pyruvate kinase, muscle | -0.0259686 |
| PGK1 | phosphoglycerate kinase 1 | -0.0251276 |
| STAG2 | stromal antigen 2 | -0.0248881 |
| RPS12 | ribosomal protein S12 | -0.0237594 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0226806 |
| RPL26 | ribosomal protein L26 | -0.0226712 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0226652 |
| VCL | vinculin | -0.0217888 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0216721 |
| RPL37 | ribosomal protein L37 | -0.0215431 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0214098 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0211817 |
| LAMA4 | laminin, alpha 4 | -0.0211727 |
| MED13 | mediator complex subunit 13 | -0.0210224 |
| MYO5B | myosin VB | -0.0203748 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0199139 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0192356 |
| KRT8 | keratin 8, type II | -0.0188168 |
| TMSB10 | thymosin beta 10 | -0.0185046 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0172709 |
| MT2A | metallothionein 2A | -0.0157069 |
| RPL23 | ribosomal protein L23 | -0.0156669 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0148956 |
| EZR | ezrin | -0.0141415 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0140119 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0135553 |
| NF1 | neurofibromin 1 | -0.0124961 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0124628 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0119878 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0119412 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.011936 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0111157 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0109347 |
| RPL37A | ribosomal protein L37a | -0.0105571 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.010179 |
| SP100 | SP100 nuclear antigen | -0.00922464 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00893067 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.00892817 |
| LAMB3 | laminin, beta 3 | -0.00758316 |
| TPM4 | tropomyosin 4 | -0.00614278 |
