| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0626902 |
| SMYD3 | SET and MYND domain containing 3 | 0.045336 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.041907 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0389728 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0385843 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0377164 |
| CENPF | centromere protein F, 350/400kDa | 0.0370299 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0364052 |
| DST | dystonin | 0.033141 |
| HMGB2 | high mobility group box 2 | 0.032962 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0329192 |
| CALR | calreticulin | 0.0311076 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0298973 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0294327 |
| POTEF | POTE ankyrin domain family, member F | 0.0292836 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0287897 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0284733 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0270147 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0263199 |
| SPIDR | scaffolding protein involved in DNA repair | 0.025831 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0252877 |
| CANX | calnexin | 0.0250296 |
| CADM2 | cell adhesion molecule 2 | 0.0247995 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0244468 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.023595 |
| H1-0 | H1.0 linker histone | 0.023374 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0233244 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0231755 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0231279 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0229862 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0226245 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0225705 |
| COL3A1 | collagen, type III, alpha 1 | 0.0223763 |
| ECT2 | epithelial cell transforming 2 | 0.0218232 |
| SNX6 | sorting nexin 6 | 0.0216206 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0212855 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0210421 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0204874 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0204414 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0203958 |
| CFL2 | cofilin 2 (muscle) | 0.0203769 |
| PHF21A | PHD finger protein 21A | 0.0203545 |
| GOLGB1 | golgin B1 | 0.020307 |
| MKI67 | marker of proliferation Ki-67 | 0.0200726 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0199377 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0198321 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0197922 |
| TEX11 | testis expressed 11 | 0.0196999 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0196927 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0194575 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0190173 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0189433 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0188771 |
| FOXN3 | forkhead box N3 | 0.0188506 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0185373 |
| EZR | ezrin | 0.0184619 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0184396 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0183381 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0183039 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0182353 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0181468 |
| MTF2 | metal response element binding transcription factor 2 | 0.0179039 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0178696 |
| PREPL | prolyl endopeptidase-like | 0.0178485 |
| RAB21 | RAB21, member RAS oncogene family | 0.0172713 |
| RPS2 | ribosomal protein S2 | 0.0172667 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0172205 |
| COG5 | component of oligomeric golgi complex 5 | 0.0171765 |
| MDFIC | MyoD family inhibitor domain containing | 0.0171324 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0170646 |
| CCNG2 | cyclin G2 | 0.0168849 |
| RRM2 | ribonucleotide reductase M2 | 0.0167268 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0167241 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0166828 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0166747 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0166371 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | 0.0165804 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0165407 |
| PDS5A | PDS5 cohesin associated factor A | 0.0165304 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0163831 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.016274 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.0162279 |
| NKTR | natural killer cell triggering receptor | 0.0162274 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0160114 |
| TPX2 | TPX2, microtubule-associated | 0.015846 |
| OGA | O-GlcNAcase | 0.0158177 |
| CCNA2 | cyclin A2 | 0.0157151 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0156811 |
| ZFR | zinc finger RNA binding protein | 0.0155737 |
| CBX5 | chromobox homolog 5 | 0.0154685 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0153924 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0153813 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0153185 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0152417 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0151919 |
| PTMA | prothymosin, alpha | 0.0151622 |
| CALU | calumenin | 0.0151602 |
| DIAPH3 | diaphanous-related formin 3 | 0.0151307 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0150464 |
| FIGN | fidgetin | 0.01504 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | -0.186939 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.104391 |
| PCDH9 | protocadherin 9 | -0.0947568 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0825162 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0810487 |
| VIM | vimentin | -0.0790178 |
| ITGAV | integrin, alpha V | -0.0744122 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0728762 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0719176 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0662652 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0656396 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0654504 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0615017 |
| LRRC4C | leucine rich repeat containing 4C | -0.0605134 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0603122 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0539782 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0536151 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0501616 |
| MYO10 | myosin X | -0.0468679 |
| GPC3 | glypican 3 | -0.046734 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0464622 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0454525 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0416528 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0403839 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.038431 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0382164 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0381435 |
| PHIP | pleckstrin homology domain interacting protein | -0.0374179 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0363453 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0361917 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0360925 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.035396 |
| HDAC9 | histone deacetylase 9 | -0.034789 |
| TENM3 | teneurin transmembrane protein 3 | -0.0346359 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0336693 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0326839 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0326196 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0321419 |
| CDH19 | cadherin 19, type 2 | -0.0318156 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0316526 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0312284 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0306296 |
| ZNF608 | zinc finger protein 608 | -0.0302323 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0300055 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0294465 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0293177 |
| ZNF385D | zinc finger protein 385D | -0.0290408 |
| TMSB10 | thymosin beta 10 | -0.0289581 |
| PGK1 | phosphoglycerate kinase 1 | -0.0285973 |
| ENO1 | enolase 1, (alpha) | -0.0285481 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0284627 |
| ZNF217 | zinc finger protein 217 | -0.0282453 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0281241 |
| PRELID2 | PRELI domain containing 2 | -0.0280788 |
| SALL4 | spalt-like transcription factor 4 | -0.0279101 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0275271 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.02747 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0274372 |
| RAB30 | RAB30, member RAS oncogene family | -0.0274259 |
| HMCN1 | hemicentin 1 | -0.0271635 |
| SLC44A5 | solute carrier family 44, member 5 | -0.027087 |
| UPP1 | uridine phosphorylase 1 | -0.0269362 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0268711 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0266124 |
| TOX | thymocyte selection-associated high mobility group box | -0.0263918 |
| FST | follistatin | -0.0256312 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0254536 |
| LDHA | lactate dehydrogenase A | -0.02527 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0249874 |
| RNF130 | ring finger protein 130 | -0.0247957 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0247947 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0246188 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0246162 |
| RBM20 | RNA binding motif protein 20 | -0.0240974 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0240455 |
| CALCR | calcitonin receptor | -0.0238691 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0238449 |
| ZNF292 | zinc finger protein 292 | -0.0237441 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0236447 |
| RPS8 | ribosomal protein S8 | -0.0231759 |
| PRTG | protogenin | -0.0228736 |
| PFN1 | profilin 1 | -0.0226557 |
| CDC73 | cell division cycle 73 | -0.0222729 |
| PLPP1 | phospholipid phosphatase 1 | -0.0222582 |
| SYT1 | synaptotagmin I | -0.0221341 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0220448 |
| MAP4 | microtubule-associated protein 4 | -0.0219554 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0219266 |
| SHROOM3 | shroom family member 3 | -0.0218797 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0214359 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0213855 |
| RBM33 | RNA binding motif protein 33 | -0.0213079 |
| TMEM131 | transmembrane protein 131 | -0.0209907 |
| CORO1C | coronin, actin binding protein, 1C | -0.020789 |
| TGFB2 | transforming growth factor, beta 2 | -0.0205632 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0205183 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0203194 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0202809 |
| RPS3 | ribosomal protein S3 | -0.0201941 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0200415 |
