| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.108403 |
| SMAD3 | SMAD family member 3 | 0.107887 |
| RPS16 | ribosomal protein S16 | 0.0886081 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0871189 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0805936 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.078164 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0768266 |
| ACTN4 | actinin, alpha 4 | 0.0745628 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0742081 |
| SFTPA2 | surfactant protein A2 | 0.0737969 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0735722 |
| DST | dystonin | 0.0722214 |
| MYOF | myoferlin | 0.0700238 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0686057 |
| ASPH | aspartate beta-hydroxylase | 0.0669011 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0638097 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0615188 |
| ANO6 | anoctamin 6 | 0.0594886 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0589505 |
| ENO1 | enolase 1, (alpha) | 0.0554184 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0532093 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0529622 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0528433 |
| TXNRD1 | thioredoxin reductase 1 | 0.0523388 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0515082 |
| ARRDC3 | arrestin domain containing 3 | 0.0511192 |
| ANXA2 | annexin A2 | 0.0509015 |
| SEPTIN9 | septin 9 | 0.0504953 |
| AFAP1 | actin filament associated protein 1 | 0.0499228 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0474016 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.046581 |
| RPLP0 | ribosomal protein, large, P0 | 0.0465212 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.045657 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0456305 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0452146 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0434786 |
| MED13L | mediator complex subunit 13-like | 0.0427881 |
| IPO7 | importin 7 | 0.042699 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0423422 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0419281 |
| PTK2 | protein tyrosine kinase 2 | 0.0419111 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0415808 |
| RPS12 | ribosomal protein S12 | 0.0414615 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0414304 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0404205 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.040051 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.039864 |
| ATXN1 | ataxin 1 | 0.0393641 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0387229 |
| PCBP2 | poly(rC) binding protein 2 | 0.0384158 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0382376 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0382083 |
| ZNF780B | zinc finger protein 780B | 0.0381971 |
| PRELID2 | PRELI domain containing 2 | 0.0372152 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0369587 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.03685 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0366742 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0362938 |
| CTBP2 | C-terminal binding protein 2 | 0.0359509 |
| JMJD1C | jumonji domain containing 1C | 0.0355687 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0355514 |
| EFNA5 | ephrin-A5 | 0.0354305 |
| OGA | O-GlcNAcase | 0.0353384 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0350214 |
| AHNAK | AHNAK nucleoprotein | 0.0337952 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0335005 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0333181 |
| PDE10A | phosphodiesterase 10A | 0.0331615 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0328795 |
| SMYD3 | SET and MYND domain containing 3 | 0.0321091 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0320331 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0317164 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0314613 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0311745 |
| APP | amyloid beta (A4) precursor protein | 0.0308831 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0308098 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0308013 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0306522 |
| YAP1 | Yes-associated protein 1 | 0.0305182 |
| CD44 | CD44 molecule (Indian blood group) | 0.0303986 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0303113 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0302989 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0302975 |
| FAT1 | FAT atypical cadherin 1 | 0.0299949 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0299375 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0297854 |
| USP12 | ubiquitin specific peptidase 12 | 0.0297268 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0296135 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0293123 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.029187 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.028937 |
| ATP13A3 | ATPase type 13A3 | 0.0289144 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0286887 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0286548 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0285648 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0280876 |
| VMP1 | vacuole membrane protein 1 | 0.0275265 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0271975 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0271847 |
| XPO1 | exportin 1 | 0.0271746 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.103913 |
| VCL | vinculin | -0.103077 |
| EGR1 | early growth response 1 | -0.0986083 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0962172 |
| PTMA | prothymosin, alpha | -0.0915242 |
| VIM | vimentin | -0.0823115 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0434117 |
| MCL1 | myeloid cell leukemia 1 | -0.0355913 |
| RTN4 | reticulon 4 | -0.0352217 |
| FOSL1 | FOS-like antigen 1 | -0.0348017 |
| HMGA1 | high mobility group AT-hook 1 | -0.0308702 |
| MAP1B | microtubule-associated protein 1B | -0.0301554 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0292101 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0285363 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0254176 |
| RPL35A | ribosomal protein L35a | -0.0245514 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0234208 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0227772 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0211329 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.021091 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0210545 |
| JUN | jun proto-oncogene | -0.0209463 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0208185 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.02071 |
| MYO1E | myosin IE | -0.0204097 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0197128 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.019699 |
| ZFP36 | ZFP36 ring finger protein | -0.0190438 |
| IER3 | immediate early response 3 | -0.0186388 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0185881 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0184873 |
| CTSD | cathepsin D | -0.017755 |
| HDAC9 | histone deacetylase 9 | -0.0168491 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0156257 |
| ACTG1 | actin gamma 1 | -0.0155575 |
| HMGB1 | high mobility group box 1 | -0.0153944 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.0151767 |
| TPM1 | tropomyosin 1 (alpha) | -0.0151164 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0150982 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0146953 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.01451 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0144634 |
| FTL | ferritin, light polypeptide | -0.0144519 |
| WASF2 | WAS protein family, member 2 | -0.0137544 |
| GOLT1A | golgi transport 1A | -0.0136648 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0131906 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.013163 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0130932 |
| HLA-B | major histocompatibility complex, class I, B | -0.0130642 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0129103 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0129035 |
| MYADM | myeloid-associated differentiation marker | -0.0128912 |
| DSTN | destrin (actin depolymerizing factor) | -0.0128765 |
| RNF220 | ring finger protein 220 | -0.0128535 |
| TMEM165 | transmembrane protein 165 | -0.0126648 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0116559 |
| ARF4 | ADP-ribosylation factor 4 | -0.0116231 |
| CSTB | cystatin B (stefin B) | -0.0116085 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0115816 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.0113951 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0113628 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0113589 |
| SESN2 | sestrin 2 | -0.011155 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0109651 |
| PLAU | plasminogen activator, urokinase | -0.0107995 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.0107518 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | -0.0106446 |
| PFN1 | profilin 1 | -0.0105501 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.0105354 |
| VDAC1 | voltage-dependent anion channel 1 | -0.010527 |
| BCL10 | B-cell CLL/lymphoma 10 | -0.0104777 |
| RPS13 | ribosomal protein S13 | -0.0104759 |
| TUBA1C | tubulin, alpha 1c | -0.010459 |
| TP53 | tumor protein p53 | -0.0104162 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0103634 |
| ATG7 | autophagy related 7 | -0.0102994 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0101096 |
| POMP | proteasome maturation protein | -0.0100686 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.00996946 |
| IGF2 | insulin-like growth factor 2 | -0.00991919 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.00991613 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00987024 |
| NABP1 | nucleic acid binding protein 1 | -0.00971495 |
| ZNF546 | zinc finger protein 546 | -0.00969759 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.00967357 |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | -0.00960806 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00951825 |
| DEK | DEK proto-oncogene | -0.00949696 |
| RPS10 | ribosomal protein S10 | -0.00945501 |
| MDM4 | MDM4, p53 regulator | -0.00941708 |
| ADM | adrenomedullin | -0.00941304 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00940731 |
| SEC24A | SEC24 family member A | -0.00924993 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.00922699 |
| WDR1 | WD repeat domain 1 | -0.00904216 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | -0.00898671 |
| RPF2 | ribosome production factor 2 homolog (S. cerevisiae) | -0.00897869 |
| TMSB10 | thymosin beta 10 | -0.0089548 |
| FAF2 | Fas associated factor family member 2 | -0.00893527 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.00879044 |
