| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.152348 |
| FRMD6 | FERM domain containing 6 | 0.144558 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0855723 |
| HMGA2 | high mobility group AT-hook 2 | 0.0834009 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0765995 |
| HDAC9 | histone deacetylase 9 | 0.0758908 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0678413 |
| FRMD4A | FERM domain containing 4A | 0.0548173 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0544647 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0538494 |
| NABP1 | nucleic acid binding protein 1 | 0.0494344 |
| RAD51B | RAD51 paralog B | 0.0483523 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0482754 |
| ZNF438 | zinc finger protein 438 | 0.0427718 |
| CORO1C | coronin, actin binding protein, 1C | 0.0424497 |
| FLNB | filamin B, beta | 0.04039 |
| CALR | calreticulin | 0.0399473 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0396103 |
| ASPH | aspartate beta-hydroxylase | 0.039498 |
| INTS6 | integrator complex subunit 6 | 0.0391544 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.038573 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0376811 |
| SP100 | SP100 nuclear antigen | 0.0368403 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0367165 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.036527 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0361954 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0361561 |
| NAV2 | neuron navigator 2 | 0.0353329 |
| SMYD3 | SET and MYND domain containing 3 | 0.0349519 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0348881 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0344049 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0333004 |
| FHIT | fragile histidine triad | 0.0329859 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0328727 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0325081 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0318266 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0297206 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0287918 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0285926 |
| TRIM44 | tripartite motif containing 44 | 0.0269288 |
| MTAP | methylthioadenosine phosphorylase | 0.0268598 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0267569 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0264083 |
| MYRFL | myelin regulatory factor-like | 0.0263129 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0261301 |
| DENND1A | DENN/MADD domain containing 1A | 0.0260645 |
| MSH4 | mutS homolog 4 | 0.0254989 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0254869 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0252926 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0251063 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0246884 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0246881 |
| EXOC4 | exocyst complex component 4 | 0.024548 |
| ANK2 | ankyrin 2, neuronal | 0.0245461 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0242351 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0239176 |
| CAST | calpastatin | 0.0237347 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0235288 |
| CEP250 | centrosomal protein 250kDa | 0.0232033 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.023007 |
| RNF213 | ring finger protein 213 | 0.0229593 |
| RPS12 | ribosomal protein S12 | 0.0228054 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0228008 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0225175 |
| CANX | calnexin | 0.0222789 |
| ATF4 | activating transcription factor 4 | 0.0220204 |
| CALU | calumenin | 0.0217986 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0217653 |
| HM13 | histocompatibility (minor) 13 | 0.0216581 |
| RRM2 | ribonucleotide reductase M2 | 0.0215289 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0213941 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0213602 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0212474 |
| DGKI | diacylglycerol kinase, iota | 0.0211771 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0209035 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0208418 |
| ERCC1 | excision repair cross-complementation group 1 | 0.0203912 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0203719 |
| DST | dystonin | 0.0203658 |
| PTMA | prothymosin, alpha | 0.0201372 |
| AHNAK | AHNAK nucleoprotein | 0.019814 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0197665 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0197084 |
| GPR75-ASB3 | GPR75-ASB3 readthrough | 0.0196577 |
| BPTF | bromodomain PHD finger transcription factor | 0.0195458 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0193632 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.0193466 |
| LMO7 | LIM domain 7 | 0.0193265 |
| SQSTM1 | sequestosome 1 | 0.0192153 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0189527 |
| PRELID2 | PRELI domain containing 2 | 0.0189502 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0187708 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0187142 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0185839 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0185428 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0185083 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0183462 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0183417 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0183148 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0182446 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DLC1 | DLC1 Rho GTPase activating protein | -0.153569 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.108948 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101141 |
| HMGA1 | high mobility group AT-hook 1 | -0.0953211 |
| PTK2 | protein tyrosine kinase 2 | -0.0863646 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0788896 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0744371 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0708908 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0679607 |
| RPS6 | ribosomal protein S6 | -0.0645421 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0608417 |
| POTEF | POTE ankyrin domain family, member F | -0.0580666 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.057348 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0533444 |
| SRPK2 | SRSF protein kinase 2 | -0.0509207 |
| USP3 | ubiquitin specific peptidase 3 | -0.0485676 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0475491 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0472025 |
| WDR43 | WD repeat domain 43 | -0.0470327 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0459201 |
| PKM | pyruvate kinase, muscle | -0.0443447 |
| EGR1 | early growth response 1 | -0.0443271 |
| ZNF207 | zinc finger protein 207 | -0.0432957 |
| NF1 | neurofibromin 1 | -0.041672 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0413893 |
| NUP58 | nucleoporin 58 | -0.0411975 |
| RPL8 | ribosomal protein L8 | -0.0409919 |
| RBM25 | RNA binding motif protein 25 | -0.0400935 |
| CALD1 | caldesmon 1 | -0.0400604 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0400294 |
| ATP13A3 | ATPase type 13A3 | -0.039886 |
| ZNF292 | zinc finger protein 292 | -0.0395714 |
| TXNRD1 | thioredoxin reductase 1 | -0.0387624 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0381857 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0378683 |
| TCERG1 | transcription elongation regulator 1 | -0.0375923 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0373618 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0372563 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0370715 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0368781 |
| FOSL1 | FOS-like antigen 1 | -0.0365842 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0360182 |
| RASA2 | RAS p21 protein activator 2 | -0.035273 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0350989 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0348895 |
| CD68 | CD68 molecule | -0.0345078 |
| TFG | TRK-fused gene | -0.0344358 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0343933 |
| RHOA | ras homolog family member A | -0.0343691 |
| ACTG1 | actin gamma 1 | -0.0338281 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0330766 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0328336 |
| PFN1 | profilin 1 | -0.0324484 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0320821 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.031988 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0319419 |
| MT2A | metallothionein 2A | -0.0318404 |
| SNX9 | sorting nexin 9 | -0.0315904 |
| SBF2 | SET binding factor 2 | -0.0312994 |
| RTN4 | reticulon 4 | -0.0312192 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0311428 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0311031 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0310097 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0309061 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0308943 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0308238 |
| RPS15 | ribosomal protein S15 | -0.0307716 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0306976 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.030647 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.030409 |
| DIAPH3 | diaphanous-related formin 3 | -0.0301996 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0301877 |
| MTMR3 | myotubularin related protein 3 | -0.0300475 |
| TTR | transthyretin | -0.0300121 |
| FAM120A | family with sequence similarity 120A | -0.0293443 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0293424 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0292027 |
| CCNL1 | cyclin L1 | -0.0289245 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0286406 |
| POU2F1 | POU class 2 homeobox 1 | -0.0284499 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0283432 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0283131 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0282221 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0281105 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.028079 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0275637 |
| FHL2 | four and a half LIM domains 2 | -0.0274931 |
| SETD5 | SET domain containing 5 | -0.027449 |
| RNF145 | ring finger protein 145 | -0.0272496 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0272441 |
| RBM33 | RNA binding motif protein 33 | -0.027002 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0266961 |
| RPS5 | ribosomal protein S5 | -0.0265829 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0264837 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0264015 |
| NUP153 | nucleoporin 153kDa | -0.0263422 |
| FOXO3 | forkhead box O3 | -0.0262941 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0262165 |
| RPL28 | ribosomal protein L28 | -0.0261722 |
| ZNF148 | zinc finger protein 148 | -0.0261514 |
