| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | 0.0853941 |
| HDAC9 | histone deacetylase 9 | 0.0794657 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0768867 |
| SP100 | SP100 nuclear antigen | 0.0715927 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0677689 |
| B2M | beta-2-microglobulin | 0.0643996 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0642212 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0635586 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0592419 |
| EGR1 | early growth response 1 | 0.0575321 |
| HLA-B | major histocompatibility complex, class I, B | 0.057079 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0566173 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0561135 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0509224 |
| COL1A1 | collagen, type I, alpha 1 | 0.0506096 |
| SQSTM1 | sequestosome 1 | 0.0494321 |
| NAV1 | neuron navigator 1 | 0.0478371 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0474438 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0471806 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0459575 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0459102 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0455224 |
| CADM1 | cell adhesion molecule 1 | 0.0449223 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0435635 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.0434748 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0428522 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0419086 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0418905 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0415292 |
| FHIT | fragile histidine triad | 0.0403652 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0399609 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0397242 |
| FBXO32 | F-box protein 32 | 0.0396221 |
| RIGI | RNA sensor RIG-I | 0.0392388 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0389994 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0388266 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0379882 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0375531 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0367051 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0364805 |
| RND3 | Rho family GTPase 3 | 0.036249 |
| ADM | adrenomedullin | 0.0355689 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0348139 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0344734 |
| HLA-A | major histocompatibility complex, class I, A | 0.033704 |
| TMEM178B | transmembrane protein 178B | 0.0328427 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0324377 |
| DST | dystonin | 0.0320655 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0318048 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.031253 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0311177 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0310015 |
| CALR | calreticulin | 0.0299996 |
| IER3 | immediate early response 3 | 0.0298488 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0287994 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0285003 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0284518 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0282459 |
| FAT1 | FAT atypical cadherin 1 | 0.0280446 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0278445 |
| COL5A1 | collagen, type V, alpha 1 | 0.0274308 |
| RNF213 | ring finger protein 213 | 0.0272672 |
| IFI44L | interferon-induced protein 44-like | 0.0272082 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0270516 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0265438 |
| ATXN1 | ataxin 1 | 0.0264385 |
| EGFR | epidermal growth factor receptor | 0.0258549 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0253329 |
| MYOF | myoferlin | 0.0253128 |
| IRF1 | interferon regulatory factor 1 | 0.0252999 |
| HLA-E | major histocompatibility complex, class I, E | 0.0252365 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0250775 |
| SFTPA2 | surfactant protein A2 | 0.0243738 |
| WWOX | WW domain containing oxidoreductase | 0.0243608 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0241311 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0239958 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0239591 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0237245 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0233644 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.023022 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.022991 |
| COL5A3 | collagen, type V, alpha 3 | 0.0225104 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0222903 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0222865 |
| LRRC23 | leucine rich repeat containing 23 | 0.0222345 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0219522 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0219132 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0218841 |
| IER2 | immediate early response 2 | 0.0217759 |
| MX1 | MX dynamin-like GTPase 1 | 0.0213234 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0209805 |
| TNNC1 | troponin C type 1 (slow) | 0.020728 |
| PMP22 | peripheral myelin protein 22 | 0.0206759 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0206275 |
| JUN | jun proto-oncogene | 0.0205856 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0205747 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0203612 |
| H2AC6 | H2A clustered histone 6 | 0.0203367 |
| FRMD5 | FERM domain containing 5 | 0.0202732 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0201607 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.250159 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.21004 |
| VIM | vimentin | -0.171833 |
| STC1 | stanniocalcin 1 | -0.10137 |
| CD44 | CD44 molecule (Indian blood group) | -0.0922024 |
| ZNF292 | zinc finger protein 292 | -0.087086 |
| PGK1 | phosphoglycerate kinase 1 | -0.0853099 |
| NDRG1 | N-myc downstream regulated 1 | -0.0774606 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0719092 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0714642 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0666709 |
| CENPF | centromere protein F, 350/400kDa | -0.0662246 |
| PKM | pyruvate kinase, muscle | -0.0656447 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0632649 |
| MT2A | metallothionein 2A | -0.0617218 |
| GOLGA4 | golgin A4 | -0.0607044 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0599495 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0578844 |
| TGM2 | transglutaminase 2 | -0.0553225 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0536464 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.052627 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0517186 |
| FNDC3B | fibronectin type III domain containing 3B | -0.051127 |
| SETD5 | SET domain containing 5 | -0.0510987 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0509775 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0478746 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0477242 |
| RTN4 | reticulon 4 | -0.0455994 |
| COPA | coatomer protein complex, subunit alpha | -0.045519 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0454566 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0451216 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0449992 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.0421958 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0417386 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0406 |
| RNF24 | ring finger protein 24 | -0.0405452 |
| HPCAL1 | hippocalcin-like 1 | -0.0404195 |
| TPX2 | TPX2, microtubule-associated | -0.040025 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0398352 |
| GSK3B | glycogen synthase kinase 3 beta | -0.039753 |
| TFG | TRK-fused gene | -0.0393867 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0393264 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0384584 |
| HMGA2 | high mobility group AT-hook 2 | -0.0383647 |
| MKI67 | marker of proliferation Ki-67 | -0.0382711 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0370901 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0369995 |
| AFAP1 | actin filament associated protein 1 | -0.0365711 |
| FLNB | filamin B, beta | -0.036411 |
| ZNF148 | zinc finger protein 148 | -0.0361257 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0358667 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0355834 |
| DIAPH3 | diaphanous-related formin 3 | -0.0355474 |
| ASPH | aspartate beta-hydroxylase | -0.0352362 |
| NRP1 | neuropilin 1 | -0.0349601 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0346993 |
| CDCP1 | CUB domain containing protein 1 | -0.033618 |
| SBF2 | SET binding factor 2 | -0.0335555 |
| ACTN4 | actinin, alpha 4 | -0.0333392 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0330522 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0327806 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0323772 |
| ECT2 | epithelial cell transforming 2 | -0.0323678 |
| SEPTIN7 | septin 7 | -0.0322533 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0321728 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0321432 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0320202 |
| PTK2 | protein tyrosine kinase 2 | -0.0319848 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0318706 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0314107 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0313422 |
| NUMB | numb homolog (Drosophila) | -0.030935 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0308872 |
| NUP58 | nucleoporin 58 | -0.0302956 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.030051 |
| TMEM39A | transmembrane protein 39A | -0.0298372 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0297888 |
| RNF145 | ring finger protein 145 | -0.0297426 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.029568 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0295034 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0294204 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0292171 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0289477 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0286361 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.027982 |
| CALD1 | caldesmon 1 | -0.0278894 |
| QKI | QKI, KH domain containing, RNA binding | -0.0278756 |
| FAM162A | family with sequence similarity 162, member A | -0.0277777 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0277206 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.027695 |
| RBM39 | RNA binding motif protein 39 | -0.0276643 |
| KIF4A | kinesin family member 4A | -0.027654 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0275557 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0271493 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0270594 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0270058 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.026909 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0265878 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0265788 |
| WASF2 | WAS protein family, member 2 | -0.0265223 |
