Lumateperone (tosylate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 0.100678
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0577049
ERRFI1 ERBB receptor feedback inhibitor 1 0.0534583
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0506516
MYH9 myosin, heavy chain 9, non-muscle 0.0503721
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0495357
ASPH aspartate beta-hydroxylase 0.0465107
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0463779
MCTP1 multiple C2 domains, transmembrane 1 0.0437069
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0401671
NBEA neurobeachin 0.039298
SMOC1 SPARC related modular calcium binding 1 0.0391569
RORA RAR-related orphan receptor A 0.03749
DOCK5 dedicator of cytokinesis 5 0.0352027
SNAP25 synaptosomal-associated protein, 25kDa 0.0349537
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0348984
NRG1 neuregulin 1 0.0343168
LCOR ligand dependent nuclear receptor corepressor 0.0342993
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0328216
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0317926
HOMER1 homer scaffolding protein 1 0.0298281
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0284639
ANKRD36C ankyrin repeat domain 36C 0.0282224
SETX senataxin 0.0281387
NANOS1 nanos homolog 1 (Drosophila) 0.0277386
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0272827
SDK1 sidekick cell adhesion molecule 1 0.0260492
ST18 suppression of tumorigenicity 18, zinc finger 0.0254167
KIF26B kinesin family member 26B 0.025037
RPH3AL rabphilin 3A-like (without C2 domains) 0.0244854
ADARB1 adenosine deaminase, RNA-specific, B1 0.0243802
VEGFA vascular endothelial growth factor A 0.0236857
SVIL supervillin 0.0233386
INTS6 integrator complex subunit 6 0.0223284
ZSWIM6 zinc finger, SWIM-type containing 6 0.0220549
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0212769
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0208696
FAM13A family with sequence similarity 13, member A 0.0207724
BACE2 beta-site APP-cleaving enzyme 2 0.0205132
DGKD diacylglycerol kinase, delta 130kDa 0.0203789
PRELID2 PRELI domain containing 2 0.0203123
ZFHX3 zinc finger homeobox 3 0.0198229
IVNS1ABP influenza virus NS1A binding protein 0.0197128
KLHL29 kelch-like family member 29 0.0196602
CTBP2 C-terminal binding protein 2 0.019546
MSN moesin 0.0190665
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0186044
GOLGB1 golgin B1 0.0181175
PCBP3 poly(rC) binding protein 3 0.0177377
EFNA5 ephrin-A5 0.0177019
SLC38A2 solute carrier family 38, member 2 0.0176382
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0174014
TOP1 topoisomerase (DNA) I 0.0173032
FNDC3B fibronectin type III domain containing 3B 0.0172675
SIK2 salt-inducible kinase 2 0.0172452
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0171284
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0170279
EXT1 exostosin glycosyltransferase 1 0.0169446
RNF144A ring finger protein 144A 0.0166929
MPRIP myosin phosphatase Rho interacting protein 0.01669
AHR aryl hydrocarbon receptor 0.0166424
CDK13 cyclin-dependent kinase 13 0.0165622
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.0164212
HDAC4 histone deacetylase 4 0.0163911
EGFR epidermal growth factor receptor 0.0163659
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0163251
SEC31A SEC31 homolog A (S. cerevisiae) 0.0162317
RUNX1 runt-related transcription factor 1 0.0162103
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0161024
NELL1 NEL-like 1 (chicken) 0.0160371
GRB10 growth factor receptor-bound protein 10 0.0157672
PGM3 phosphoglucomutase 3 0.0157552
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0155203
PTCHD4 patched domain containing 4 0.0152328
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.0152176
AUTS2 autism susceptibility candidate 2 0.0151181
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0150471
TRAPPC9 trafficking protein particle complex 9 0.0149098
RICTOR RPTOR independent companion of MTOR, complex 2 0.014633
AP3B2 adaptor-related protein complex 3, beta 2 subunit 0.0145597
ZNF638 zinc finger protein 638 0.0145596
TRAPPC12 trafficking protein particle complex 12 0.0145521
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0144298
EIPR1 EARP complex and GARP complex interacting protein 1 0.0144083
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.0143754
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0141666
NDRG1 N-myc downstream regulated 1 0.014139
ZZZ3 zinc finger, ZZ-type containing 3 0.0141176
ZMAT4 zinc finger, matrin-type 4 0.0137786
DSCAM Down syndrome cell adhesion molecule 0.0137552
HYOU1 hypoxia up-regulated 1 0.0137474
GPC6 glypican 6 0.0136698
HSPA8 heat shock 70kDa protein 8 0.013657
USP34 ubiquitin specific peptidase 34 0.0136376
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0136269
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0135256
PARM1 prostate androgen-regulated mucin-like protein 1 0.0132794
USP9X ubiquitin specific peptidase 9, X-linked 0.0132521
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0132233
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.0132141

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.167153
CALCA calcitonin-related polypeptide alpha -0.119024
PEG10 paternally expressed 10 -0.111784
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.10969
NALF1 NALCN channel auxiliary factor 1 -0.100297
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0819896
FTL ferritin, light polypeptide -0.0789698
TENM1 teneurin transmembrane protein 1 -0.0705006
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0697537
MT2A metallothionein 2A -0.0678581
RPS21 ribosomal protein S21 -0.0603819
CENPF centromere protein F, 350/400kDa -0.0596463
SYT1 synaptotagmin I -0.0593294
RPS3 ribosomal protein S3 -0.0585344
ENO1 enolase 1, (alpha) -0.0580551
RPL26 ribosomal protein L26 -0.0547204
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0537567
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0537378
RPS8 ribosomal protein S8 -0.0534055
SASH1 SAM and SH3 domain containing 1 -0.0526499
SINHCAF SIN3-HDAC complex associated factor -0.0508844
RPL11 ribosomal protein L11 -0.0506489
PDE4B phosphodiesterase 4B, cAMP-specific -0.0502488
IFI6 interferon, alpha-inducible protein 6 -0.0493127
ADGRL2 adhesion G protein-coupled receptor L2 -0.0483328
RPS6 ribosomal protein S6 -0.0462204
RIT2 Ras-like without CAAX 2 -0.0457322
RPL8 ribosomal protein L8 -0.043966
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0437211
RPLP1 ribosomal protein, large, P1 -0.0435364
RPL23 ribosomal protein L23 -0.0421077
ATP5F1E ATP synthase F1 subunit epsilon -0.0420129
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0416188
LOC112694756 uncharaterized LOC112694756 -0.0416152
RAD21 RAD21 homolog (S. pombe) -0.0415291
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0415242
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0412034
FOXC1 forkhead box C1 -0.0411354
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0406845
TMSB4X thymosin beta 4, X-linked -0.0404159
S100A9 S100 calcium binding protein A9 -0.0398023
NIPSNAP2 nipsnap homolog 2 -0.039153
RPLP0 ribosomal protein, large, P0 -0.0383336
RPL30 ribosomal protein L30 -0.0381205
MAP1B microtubule-associated protein 1B -0.0379364
RPL37A ribosomal protein L37a -0.0378353
MATR3 matrin 3 -0.037692
GNAS GNAS complex locus -0.0371392
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0369771
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0369435
RPL37 ribosomal protein L37 -0.0367462
PEX5L peroxisomal biogenesis factor 5-like -0.0366326
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0361059
TUBB tubulin, beta class I -0.0357893
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0356483
RACK1 receptor for activated C kinase 1 -0.0350746
RPS16 ribosomal protein S16 -0.0345709
NFIA nuclear factor I/A -0.0345156
TMSB10 thymosin beta 10 -0.0344485
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0341247
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0338852
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0338458
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0336109
KPNB1 karyopherin (importin) beta 1 -0.0334386
RPL12 ribosomal protein L12 -0.0329408
MIS18BP1 MIS18 binding protein 1 -0.0325939
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0325067
RPS27 ribosomal protein S27 -0.0324043
RPL5 ribosomal protein L5 -0.0323917
TXNRD1 thioredoxin reductase 1 -0.0323431
RPL35 ribosomal protein L35 -0.032184
RTN4 reticulon 4 -0.0320929
HMGB1 high mobility group box 1 -0.0320089
RBM25 RNA binding motif protein 25 -0.0319293
TPT1 tumor protein, translationally-controlled 1 -0.0318437
RPS27A ribosomal protein S27a -0.0315573
ARB2A ARB2 cotranscriptional regulator A -0.0313397
CPE carboxypeptidase E -0.0312219
TUBB4B tubulin, beta 4B class IVb -0.0307505
RPS19 ribosomal protein S19 -0.030593
RPS12 ribosomal protein S12 -0.0305436
UBB ubiquitin B -0.0302667
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0301995
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0300875
NCOR1 nuclear receptor corepressor 1 -0.0297291
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0295426
RPL19 ribosomal protein L19 -0.029515
CCDC88A coiled-coil domain containing 88A -0.0294056
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0291146
EIF1 eukaryotic translation initiation factor 1 -0.0289931
ISG15 ISG15 ubiquitin-like modifier -0.0288134
RPL32 ribosomal protein L32 -0.0285384
NAP1L1 nucleosome assembly protein 1-like 1 -0.0285254
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0284122
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0283774
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0283714
ZNF292 zinc finger protein 292 -0.0283046
RPL35A ribosomal protein L35a -0.0280983
RPL31 ribosomal protein L31 -0.027458
CHD7 chromodomain helicase DNA binding protein 7 -0.0272706