| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0800023 |
| ICAM1 | intercellular adhesion molecule 1 | 0.073237 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0523712 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0411015 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0386301 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0377991 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0364648 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0353179 |
| DST | dystonin | 0.0342218 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0327169 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0309113 |
| ANGPTL4 | angiopoietin-like 4 | 0.0291324 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0273427 |
| SMAD3 | SMAD family member 3 | 0.0272826 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0268187 |
| PRELID2 | PRELI domain containing 2 | 0.0265973 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0260698 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0255271 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0238588 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0234224 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0233594 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0227124 |
| FGGY | FGGY carbohydrate kinase domain containing | 0.0221929 |
| PTK2 | protein tyrosine kinase 2 | 0.0216784 |
| EHBP1 | EH domain binding protein 1 | 0.0208114 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | 0.020686 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0205528 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.020233 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0201286 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0192679 |
| SERINC1 | serine incorporator 1 | 0.0190003 |
| AMOTL1 | angiomotin like 1 | 0.018496 |
| NRG3 | neuregulin 3 | 0.018478 |
| CDK6 | cyclin-dependent kinase 6 | 0.0181578 |
| ANXA2 | annexin A2 | 0.0178283 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0177847 |
| MELTF | melanotransferrin | 0.0177809 |
| CENPF | centromere protein F, 350/400kDa | 0.0175421 |
| AFDN | afadin, adherens junction formation factor | 0.0170661 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0169419 |
| ASPH | aspartate beta-hydroxylase | 0.016707 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0161578 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0159078 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0157704 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0157323 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0156941 |
| STC1 | stanniocalcin 1 | 0.0153979 |
| RUNX1 | runt-related transcription factor 1 | 0.0152029 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0151605 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0149273 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0148311 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0147976 |
| QKI | QKI, KH domain containing, RNA binding | 0.0146487 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0142384 |
| TNNC1 | troponin C type 1 (slow) | 0.0141693 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0141294 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.014028 |
| OPHN1 | oligophrenin 1 | 0.0137816 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0137188 |
| ZNF608 | zinc finger protein 608 | 0.0137173 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0135196 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0135193 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0134329 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0133953 |
| TASOR | transcription activation suppressor | 0.0132744 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0130597 |
| ANO6 | anoctamin 6 | 0.0130349 |
| CNKSR3 | CNKSR family member 3 | 0.0130292 |
| MT1X | metallothionein 1X | 0.0128976 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0128746 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0128308 |
| EZR | ezrin | 0.0126076 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0125436 |
| RNF145 | ring finger protein 145 | 0.0125344 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0125198 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0124601 |
| FAM78B | family with sequence similarity 78, member B | 0.0123837 |
| SFTPA2 | surfactant protein A2 | 0.0122925 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0122833 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0122818 |
| TUG1 | taurine up-regulated 1 (non-protein coding) | 0.0120845 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0120508 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0120201 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0119246 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.0118814 |
| MT2A | metallothionein 2A | 0.0117389 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0115938 |
| RRM2 | ribonucleotide reductase M2 | 0.0115181 |
| SETBP1 | SET binding protein 1 | 0.0113634 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0113132 |
| NBPF8 | neuroblastoma breakpoint family, member 8 | 0.0112951 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.0111972 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0111904 |
| TENM1 | teneurin transmembrane protein 1 | 0.011124 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0110653 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0110033 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0109402 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0106731 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0106386 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.0106208 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.225597 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.155244 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.130318 |
| LSAMP | limbic system-associated membrane protein | -0.116164 |
| UBC | ubiquitin C | -0.111607 |
| NLGN1 | neuroligin 1 | -0.110471 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0843265 |
| GOLGA4 | golgin A4 | -0.0706818 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0689497 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0688425 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0684749 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0599882 |
| RPS27A | ribosomal protein S27a | -0.0551763 |
| PTMA | prothymosin, alpha | -0.0546445 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0545898 |
| RPS3 | ribosomal protein S3 | -0.0515353 |
| SQSTM1 | sequestosome 1 | -0.0496523 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0491429 |
| PCBP2 | poly(rC) binding protein 2 | -0.0484168 |
| CCND1 | cyclin D1 | -0.0471574 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0467174 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0447105 |
| RPS6 | ribosomal protein S6 | -0.0442307 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0440417 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0410767 |
| RPS8 | ribosomal protein S8 | -0.0404234 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0395423 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0395195 |
| CALU | calumenin | -0.0376327 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0375849 |
| TMSB10 | thymosin beta 10 | -0.0373196 |
| RTN4 | reticulon 4 | -0.0364899 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0362914 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0360929 |
| RPL23 | ribosomal protein L23 | -0.0359825 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.035313 |
| RHOA | ras homolog family member A | -0.0349292 |
| PKM | pyruvate kinase, muscle | -0.0348063 |
| EP300 | E1A binding protein p300 | -0.0346424 |
| FLNA | filamin A, alpha | -0.0344167 |
| RPS13 | ribosomal protein S13 | -0.0342154 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0341972 |
| PRAME | preferentially expressed antigen in melanoma | -0.0309187 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0301793 |
| FTL | ferritin, light polypeptide | -0.0291941 |
| HLA-B | major histocompatibility complex, class I, B | -0.0289226 |
| GPHN | gephyrin | -0.0282965 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0273656 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0273477 |
| ACTG1 | actin gamma 1 | -0.0273356 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0273017 |
| DEK | DEK proto-oncogene | -0.0271277 |
| RPLP1 | ribosomal protein, large, P1 | -0.0269335 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -0.0268403 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0266425 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0266265 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0266101 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0264076 |
| HMGA1 | high mobility group AT-hook 1 | -0.0262809 |
| FHIT | fragile histidine triad | -0.0260077 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0258398 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.025796 |
| MAP4 | microtubule-associated protein 4 | -0.0254396 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0253216 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0252148 |
| S100A9 | S100 calcium binding protein A9 | -0.0247983 |
| RPS15 | ribosomal protein S15 | -0.0246809 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0246669 |
| RPL8 | ribosomal protein L8 | -0.0246016 |
| SRPK2 | SRSF protein kinase 2 | -0.0245583 |
| RPL5 | ribosomal protein L5 | -0.0244324 |
| CTTN | cortactin | -0.0243689 |
| RPL37A | ribosomal protein L37a | -0.0242819 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0242579 |
| RASAL2 | RAS protein activator like 2 | -0.024132 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0241081 |
| CALR | calreticulin | -0.0239121 |
| RBM25 | RNA binding motif protein 25 | -0.0238326 |
| NKTR | natural killer cell triggering receptor | -0.0237908 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0237302 |
| RPLP2 | ribosomal protein, large, P2 | -0.0237172 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0236824 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0235464 |
| ENO1 | enolase 1, (alpha) | -0.0235069 |
| EMP1 | epithelial membrane protein 1 | -0.0234479 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0231162 |
| POLR2F | polymerase (RNA) II (DNA directed) polypeptide F | -0.0229972 |
| WDR45B | WD repeat domain 45B | -0.022809 |
| TXNRD1 | thioredoxin reductase 1 | -0.0226938 |
| RPL34 | ribosomal protein L34 | -0.022513 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0222764 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0222328 |
| FUS | FUS RNA binding protein | -0.0221011 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0220929 |
| FSTL5 | follistatin-like 5 | -0.0220635 |
| COMMD10 | COMM domain containing 10 | -0.0219507 |
| HMGA2 | high mobility group AT-hook 2 | -0.021819 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0217736 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0217512 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0216163 |
