Lumateperone (tosylate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRELID2 PRELI domain containing 2 0.0672128
NAV1 neuron navigator 1 0.061129
VCL vinculin 0.0556051
NRXN3 neurexin 3 0.0470182
COL7A1 collagen, type VII, alpha 1 0.0455343
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0430366
KYNU kynureninase 0.0345762
INTS6 integrator complex subunit 6 0.0342416
POTEF POTE ankyrin domain family, member F 0.0338848
MYH9 myosin, heavy chain 9, non-muscle 0.0326508
TGFBI transforming growth factor, beta-induced, 68kDa 0.0313214
FNIP1 folliculin interacting protein 1 0.0312209
FTH1 ferritin, heavy polypeptide 1 0.0307042
MBNL1 muscleblind-like splicing regulator 1 0.0298573
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0293731
GLS2 glutaminase 2 (liver, mitochondrial) 0.0293111
ATXN1 ataxin 1 0.0292749
WWTR1 WW domain containing transcription regulator 1 0.028677
PRICKLE2 prickle homolog 2 (Drosophila) 0.0264353
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0263794
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0262832
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0249078
VEGFC vascular endothelial growth factor C 0.0247679
MACF1 microtubule-actin crosslinking factor 1 0.0245905
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0242266
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0239231
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.023425
EPS8 epidermal growth factor receptor pathway substrate 8 0.0225156
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0219972
SEC24A SEC24 family member A 0.0218286
CAMTA1 calmodulin binding transcription activator 1 0.0215972
ZSWIM6 zinc finger, SWIM-type containing 6 0.0209124
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0208889
F3 coagulation factor III (thromboplastin, tissue factor) 0.0207493
TNRC6B trinucleotide repeat containing 6B 0.0205266
TRIP12 thyroid hormone receptor interactor 12 0.0201167
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0200279
MSN moesin 0.0197516
NCOR2 nuclear receptor corepressor 2 0.0197145
DUSP10 dual specificity phosphatase 10 0.0193426
ALK anaplastic lymphoma receptor tyrosine kinase 0.019341
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0193306
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0193289
ANO6 anoctamin 6 0.0191718
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.019161
ATG10 autophagy related 10 0.0188438
RUNX1 runt-related transcription factor 1 0.0188359
DPYD dihydropyrimidine dehydrogenase 0.018798
NECTIN3 nectin cell adhesion molecule 3 0.018778
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0185521
NPTN neuroplastin 0.0184146
HMGA2 high mobility group AT-hook 2 0.0184072
NFE2L1 nuclear factor, erythroid 2-like 1 0.0183461
MTERF1 mitochondrial transcription termination factor 1 0.0183302
CBX5 chromobox homolog 5 0.017806
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0173621
KRIT1 KRIT1, ankyrin repeat containing 0.0172751
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0172693
RCOR1 REST corepressor 1 0.0170062
ASPH aspartate beta-hydroxylase 0.0169044
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0168627
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0167952
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0167683
GLIS3 GLIS family zinc finger 3 0.0167423
DCLK2 doublecortin-like kinase 2 0.0166906
COL5A1 collagen, type V, alpha 1 0.0165909
SETBP1 SET binding protein 1 0.016506
TBC1D22A TBC1 domain family, member 22A 0.0164863
EXOC4 exocyst complex component 4 0.0163847
MTMR2 myotubularin related protein 2 0.0162797
CUL3 cullin 3 0.0162623
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0162534
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0160962
FAT1 FAT atypical cadherin 1 0.0159781
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0159693
ITGAV integrin, alpha V 0.015918
FAM107B family with sequence similarity 107, member B 0.015851
NRDC nardilysin convertase 0.0158321
PLK2 polo-like kinase 2 0.0155721
STX12 syntaxin 12 0.0155232
SEPTIN9 septin 9 0.0154291
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0154057
RAD51B RAD51 paralog B 0.0153457
DNAH11 dynein, axonemal, heavy chain 11 0.0153187
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0152915
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0151773
APOLD1 apolipoprotein L domain containing 1 0.0150144
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0149788
GLRX glutaredoxin (thioltransferase) 0.0148686
MKI67 marker of proliferation Ki-67 0.0148684
CD59 CD59 molecule, complement regulatory protein 0.0148611
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0147685
BET1 Bet1 golgi vesicular membrane trafficking protein 0.0147627
SAMD9 sterile alpha motif domain containing 9 0.0145265
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.014517
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0144873
TRIO trio Rho guanine nucleotide exchange factor 0.0144363
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0144181
CD44 CD44 molecule (Indian blood group) 0.0142068
SDK1 sidekick cell adhesion molecule 1 0.0141929

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.30632
MT2A metallothionein 2A -0.136034
COL1A2 collagen, type I, alpha 2 -0.134224
TMSB10 thymosin beta 10 -0.127051
HLA-B major histocompatibility complex, class I, B -0.120494
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.119738
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.118438
COL1A1 collagen, type I, alpha 1 -0.117777
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109928
COL6A3 collagen, type VI, alpha 3 -0.0877538
PTMA prothymosin, alpha -0.0828208
CALU calumenin -0.079477
FTL ferritin, light polypeptide -0.0793175
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0631276
B2M beta-2-microglobulin -0.0628086
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0619288
HLA-C major histocompatibility complex, class I, C -0.0578729
PDIA3 protein disulfide isomerase family A, member 3 -0.056257
NAMPT nicotinamide phosphoribosyltransferase -0.0554906
TPM4 tropomyosin 4 -0.0496678
RPS6 ribosomal protein S6 -0.0478241
TPT1 tumor protein, translationally-controlled 1 -0.0456519
COL3A1 collagen, type III, alpha 1 -0.0449379
LOX lysyl oxidase -0.0448848
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0428251
UBC ubiquitin C -0.0426852
JMJD1C jumonji domain containing 1C -0.0419928
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.041405
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0412515
RAB1A RAB1A, member RAS oncogene family -0.0391425
RPS24 ribosomal protein S24 -0.0390927
COL5A2 collagen, type V, alpha 2 -0.038783
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0382099
GOLGA4 golgin A4 -0.0375719
CAVIN1 caveolae associated protein 1 -0.0368043
S100A9 S100 calcium binding protein A9 -0.0357059
ESYT2 extended synaptotagmin-like protein 2 -0.0354138
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0349745
STC1 stanniocalcin 1 -0.0345415
S100A6 S100 calcium binding protein A6 -0.0334102
H3-3B H3.3 histone B -0.0333948
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0333869
CALD1 caldesmon 1 -0.0333628
IL6 interleukin 6 -0.0329468
HLA-A major histocompatibility complex, class I, A -0.0329171
AHNAK AHNAK nucleoprotein -0.0318632
CFDP1 craniofacial development protein 1 -0.0317252
RPS11 ribosomal protein S11 -0.0314311
AUTS2 autism susceptibility candidate 2 -0.0310481
RPL26 ribosomal protein L26 -0.0308706
CD99 CD99 molecule -0.0308332
CANX calnexin -0.0306585
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0305276
RACK1 receptor for activated C kinase 1 -0.0303673
IGFBP7 insulin-like growth factor binding protein 7 -0.0301676
RPL35A ribosomal protein L35a -0.0301103
RPL34 ribosomal protein L34 -0.0293377
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0291813
SRP54 signal recognition particle 54kDa -0.0290412
TM4SF1 transmembrane 4 L six family member 1 -0.0289494
RTN4 reticulon 4 -0.0286768
TMEM165 transmembrane protein 165 -0.0285883
ACTG1 actin gamma 1 -0.0285381
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0285188
FNDC3A fibronectin type III domain containing 3A -0.0283786
MAP1B microtubule-associated protein 1B -0.0282588
FN1 fibronectin 1 -0.0279447
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0277688
CDK6 cyclin-dependent kinase 6 -0.0276766
RPS8 ribosomal protein S8 -0.0276719
ARRDC3 arrestin domain containing 3 -0.0275416
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0274725
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0273154
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0272049
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0271245
GARS1 glycyl-tRNA synthetase 1 -0.0270412
EIF1 eukaryotic translation initiation factor 1 -0.0269965
NOP58 NOP58 ribonucleoprotein -0.026959
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0268423
TM9SF3 transmembrane 9 superfamily member 3 -0.0264771
THOC2 THO complex 2 -0.0264337
ANKRD11 ankyrin repeat domain 11 -0.0264271
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0258314
TNPO1 transportin 1 -0.02573
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.025666
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0256435
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0253856
PRRC2C proline-rich coiled-coil 2C -0.0253609
GANAB glucosidase, alpha; neutral AB -0.0253313
BASP1 brain abundant, membrane attached signal protein 1 -0.0250092
TMSB4X thymosin beta 4, X-linked -0.0247631
GNAS GNAS complex locus -0.0245684
GCC2 GRIP and coiled-coil domain containing 2 -0.0244059
COL6A1 collagen, type VI, alpha 1 -0.0243752
TTC3 tetratricopeptide repeat domain 3 -0.0243717
PDIA6 protein disulfide isomerase family A, member 6 -0.0241844
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0240986
DDIT4 DNA-damage-inducible transcript 4 -0.0240468
VIM vimentin -0.023904
PLAUR plasminogen activator, urokinase receptor -0.0238202