Lumateperone (tosylate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0631153
DSPP dentin sialophosphoprotein 0.0619157
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0525127
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0520379
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0487714
HSPA8 heat shock 70kDa protein 8 0.0482233
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0450267
VCL vinculin 0.0424586
RAD21 RAD21 homolog (S. pombe) 0.0369135
NCKAP1 NCK-associated protein 1 0.0353292
AFDN afadin, adherens junction formation factor 0.0333649
SMAD3 SMAD family member 3 0.0324463
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0317074
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0315539
USP9X ubiquitin specific peptidase 9, X-linked 0.0311203
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0308362
HMGB2 high mobility group box 2 0.0303991
UBQLN1 ubiquilin 1 0.0298265
PICALM phosphatidylinositol binding clathrin assembly protein 0.0297464
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0296977
OGA O-GlcNAcase 0.0296013
CTBP2 C-terminal binding protein 2 0.0294021
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0290592
EZR ezrin 0.0283756
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0283467
TES testin LIM domain protein 0.0272894
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.027228
TOP2B topoisomerase (DNA) II beta 180kDa 0.0263417
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0263152
PDIA4 protein disulfide isomerase family A, member 4 0.0257703
FAR1 fatty acyl CoA reductase 1 0.0255955
MYH9 myosin, heavy chain 9, non-muscle 0.0255485
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0252905
XPO1 exportin 1 0.0241669
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0240173
MKRN1 makorin ring finger protein 1 0.0236185
BZW1 basic leucine zipper and W2 domains 1 0.0231702
OSBPL10 oxysterol binding protein-like 10 0.0228876
HBP1 HMG-box transcription factor 1 0.022876
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0227501
DIDO1 death inducer-obliterator 1 0.0226356
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0225073
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0224617
FAM13B family with sequence similarity 13, member B 0.022288
EPS8 epidermal growth factor receptor pathway substrate 8 0.0222218
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.021945
IFRD1 interferon-related developmental regulator 1 0.0216601
LRRC1 leucine rich repeat containing 1 0.0215418
SERINC1 serine incorporator 1 0.0213119
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0211444
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0210112
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0209553
CRY1 cryptochrome circadian clock 1 0.0205757
SPAG9 sperm associated antigen 9 0.0202697
ANO6 anoctamin 6 0.0202406
ATP13A3 ATPase type 13A3 0.0202089
APLP2 amyloid beta (A4) precursor-like protein 2 0.0198325
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0196934
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0195964
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0187382
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.01873
CORO1C coronin, actin binding protein, 1C 0.0186955
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0179899
TRIM44 tripartite motif containing 44 0.0177149
EIF4A2 eukaryotic translation initiation factor 4A2 0.0176546
HYOU1 hypoxia up-regulated 1 0.0176325
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0175752
EIF5 eukaryotic translation initiation factor 5 0.0175008
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0173471
ECT2 epithelial cell transforming 2 0.0171279
TNPO1 transportin 1 0.0171239
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0170222
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0169004
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0167542
EXT1 exostosin glycosyltransferase 1 0.0166822
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0166814
SCAF8 SR-related CTD-associated factor 8 0.0166376
TLN1 talin 1 0.0165997
FAM107B family with sequence similarity 107, member B 0.016456
RBM33 RNA binding motif protein 33 0.0164304
YAP1 Yes-associated protein 1 0.0164258
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0163693
KDM6A lysine (K)-specific demethylase 6A 0.0163052
ARHGAP42 Rho GTPase activating protein 42 0.0162703
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0162559
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0162094
PARD3B par-3 family cell polarity regulator beta 0.0158878
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0157967
TMEM39A transmembrane protein 39A 0.0157269
ASPH aspartate beta-hydroxylase 0.0154045
KAT6A K(lysine) acetyltransferase 6A 0.0152261
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0152079
MAPK8 mitogen-activated protein kinase 8 0.0151977
ZSWIM6 zinc finger, SWIM-type containing 6 0.0151647
IPO7 importin 7 0.015125
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0150708
NONO non-POU domain containing, octamer-binding 0.0150267
MARCHF6 membrane associated ring-CH-type finger 6 0.014981
MEMO1 mediator of cell motility 1 0.0149199
EIF4H eukaryotic translation initiation factor 4H 0.0149063

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.232936
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.187688
FTL ferritin, light polypeptide -0.173302
MAML2 mastermind-like 2 (Drosophila) -0.153606
TMSB10 thymosin beta 10 -0.131755
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.130016
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0931693
RPS6 ribosomal protein S6 -0.0881973
ZMYND8 zinc finger, MYND-type containing 8 -0.085039
RPL35A ribosomal protein L35a -0.0818568
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0793862
MACC1 metastasis associated in colon cancer 1 -0.0741107
NDRG1 N-myc downstream regulated 1 -0.0721762
HLA-A major histocompatibility complex, class I, A -0.0706351
EGR1 early growth response 1 -0.0706342
DLG1 discs, large homolog 1 (Drosophila) -0.0651193
ZBTB20 zinc finger and BTB domain containing 20 -0.0633281
SDK1 sidekick cell adhesion molecule 1 -0.0623321
HMGA1 high mobility group AT-hook 1 -0.0602478
ADNP activity-dependent neuroprotector homeobox -0.0595719
GNAS GNAS complex locus -0.0572148
RPS21 ribosomal protein S21 -0.0570972
B2M beta-2-microglobulin -0.0562603
ITGB4 integrin, beta 4 -0.0561776
RPLP2 ribosomal protein, large, P2 -0.0553483
RPS13 ribosomal protein S13 -0.0551864
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0549407
PKM pyruvate kinase, muscle -0.0542397
CST3 cystatin C -0.0537318
EHBP1 EH domain binding protein 1 -0.0528065
ESYT2 extended synaptotagmin-like protein 2 -0.052691
EIF1 eukaryotic translation initiation factor 1 -0.0525633
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0525252
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0523471
RPS19 ribosomal protein S19 -0.0516977
CCND1 cyclin D1 -0.0511192
PERP PERP, TP53 apoptosis effector -0.050657
LOC112694756 uncharaterized LOC112694756 -0.0504767
RPS25 ribosomal protein S25 -0.0490146
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0488525
S100A6 S100 calcium binding protein A6 -0.0477874
RPLP1 ribosomal protein, large, P1 -0.0472713
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0470151
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0463067
CTSD cathepsin D -0.0451496
SLC38A1 solute carrier family 38, member 1 -0.04457
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0436662
ZNRF3 zinc and ring finger 3 -0.0424209
KPNB1 karyopherin (importin) beta 1 -0.0422988
RPL8 ribosomal protein L8 -0.0409703
FNDC3B fibronectin type III domain containing 3B -0.0404916
FOSL1 FOS-like antigen 1 -0.0401886
CUX1 cut-like homeobox 1 -0.0401736
RPS29 ribosomal protein S29 -0.0400457
LMNA lamin A/C -0.039065
GMDS GDP-mannose 4,6-dehydratase -0.0385818
RPL28 ribosomal protein L28 -0.0384937
NFIA nuclear factor I/A -0.0380131
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0379929
RPL32 ribosomal protein L32 -0.0379193
RPL34 ribosomal protein L34 -0.0376592
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0375544
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0368441
FTH1 ferritin, heavy polypeptide 1 -0.0356635
RPS11 ribosomal protein S11 -0.0354834
SETD5 SET domain containing 5 -0.0349806
ACTN4 actinin, alpha 4 -0.0349446
RPL37A ribosomal protein L37a -0.0341861
SBF2 SET binding factor 2 -0.034177
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0339942
JUP junction plakoglobin -0.0339653
MXD1 MAX dimerization protein 1 -0.0336497
SVIL supervillin -0.0335594
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0334199
ATP9A ATPase, class II, type 9A -0.0330169
HM13 histocompatibility (minor) 13 -0.0328711
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0324608
ERBIN erbb2 interacting protein -0.0324025
RPL30 ribosomal protein L30 -0.0321891
ACTG1 actin gamma 1 -0.0319942
SRRM3 serine/arginine repetitive matrix 3 -0.0318893
RPL5 ribosomal protein L5 -0.0317921
KRT18 keratin 18, type I -0.0315907
GSTP1 glutathione S-transferase pi 1 -0.0315433
SRRM2 serine/arginine repetitive matrix 2 -0.0313523
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0313248
SCAF11 SR-related CTD-associated factor 11 -0.0312893
IER3 immediate early response 3 -0.0311899
IFITM1 interferon induced transmembrane protein 1 -0.0309858
PPARG peroxisome proliferator-activated receptor gamma -0.0309595
MYH14 myosin, heavy chain 14, non-muscle -0.0309134
RSF1 remodeling and spacing factor 1 -0.0308933
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0308494
RPL18 ribosomal protein L18 -0.0306734
UBE2H ubiquitin-conjugating enzyme E2H -0.0306307
RAB7A RAB7A, member RAS oncogene family -0.0306226
TPT1 tumor protein, translationally-controlled 1 -0.0304745
DEK DEK proto-oncogene -0.0303891
RPL7A ribosomal protein L7a -0.0299913
CLDN4 claudin 4 -0.0299048