| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.170493 |
| RCOR1 | REST corepressor 1 | 0.108254 |
| ATXN1 | ataxin 1 | 0.10689 |
| SMAD3 | SMAD family member 3 | 0.0703376 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0619011 |
| LAMA4 | laminin, alpha 4 | 0.059748 |
| PRELID2 | PRELI domain containing 2 | 0.0569057 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0568284 |
| RPS12 | ribosomal protein S12 | 0.0539658 |
| FAT1 | FAT atypical cadherin 1 | 0.0517396 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0470959 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0468709 |
| ENO1 | enolase 1, (alpha) | 0.0460159 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0443434 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0443362 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0440734 |
| CPOX | coproporphyrinogen oxidase | 0.0434962 |
| VCL | vinculin | 0.0427706 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0417112 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0404353 |
| SGMS2 | sphingomyelin synthase 2 | 0.0399149 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0385187 |
| SLC30A10 | solute carrier family 30, member 10 | 0.038425 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0377282 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0375221 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0360112 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0351222 |
| ATL2 | atlastin GTPase 2 | 0.0342847 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0339021 |
| ASPH | aspartate beta-hydroxylase | 0.0338762 |
| RPS3 | ribosomal protein S3 | 0.0330826 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0328559 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | 0.0321424 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0318736 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0317887 |
| EFNB2 | ephrin-B2 | 0.0313657 |
| SEPTIN9 | septin 9 | 0.0303328 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0302772 |
| FHL2 | four and a half LIM domains 2 | 0.0298069 |
| IGSF9B | immunoglobulin superfamily, member 9B | 0.0295099 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.029503 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0290079 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0287251 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0280169 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0280134 |
| ABR | active BCR-related | 0.0279353 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.027443 |
| YAP1 | Yes-associated protein 1 | 0.0274198 |
| CTSB | cathepsin B | 0.0261946 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0258241 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0257425 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0256023 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0255424 |
| FRMD5 | FERM domain containing 5 | 0.0252923 |
| HOMER1 | homer scaffolding protein 1 | 0.0252668 |
| RPS4X | ribosomal protein S4, X-linked | 0.0249378 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0249137 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0248644 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0244378 |
| ATF4 | activating transcription factor 4 | 0.0243616 |
| NUP50 | nucleoporin 50kDa | 0.0240835 |
| EGR3 | early growth response 3 | 0.0237659 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.023639 |
| SET | SET nuclear proto-oncogene | 0.0235481 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0235357 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0235025 |
| FAM107B | family with sequence similarity 107, member B | 0.0234524 |
| KITLG | KIT ligand | 0.0234047 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0233469 |
| TES | testin LIM domain protein | 0.023343 |
| CMIP | c-Maf inducing protein | 0.0232617 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0230791 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0230562 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0228267 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0226896 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0226316 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.022294 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0222675 |
| RRM2 | ribonucleotide reductase M2 | 0.0221381 |
| HDAC4 | histone deacetylase 4 | 0.0220392 |
| DSPP | dentin sialophosphoprotein | 0.0218841 |
| ECT2 | epithelial cell transforming 2 | 0.0218466 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0218334 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0214435 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0212832 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.021227 |
| SAMD5 | sterile alpha motif domain containing 5 | 0.0211687 |
| SQSTM1 | sequestosome 1 | 0.0209519 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.020879 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0207267 |
| UTRN | utrophin | 0.0205763 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0199171 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0196254 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0195407 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.019504 |
| CD9 | CD9 molecule | 0.0194174 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0191849 |
| KRT18 | keratin 18, type I | 0.018679 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0186561 |
| PCBP2 | poly(rC) binding protein 2 | 0.0186407 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.204688 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.154749 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.139689 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0895749 |
| ACTG1 | actin gamma 1 | -0.0802014 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.074547 |
| FERMT1 | fermitin family member 1 | -0.0733647 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0686414 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0654148 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0648758 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0640064 |
| GOLGA4 | golgin A4 | -0.0599853 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.056226 |
| HDAC2 | histone deacetylase 2 | -0.0551268 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0543477 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0535364 |
| FOSL1 | FOS-like antigen 1 | -0.0512409 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0494228 |
| NDRG1 | N-myc downstream regulated 1 | -0.0478881 |
| RPS6 | ribosomal protein S6 | -0.0470228 |
| PTMA | prothymosin, alpha | -0.0459437 |
| TXNRD1 | thioredoxin reductase 1 | -0.0437321 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0434228 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0426769 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0420079 |
| RPS8 | ribosomal protein S8 | -0.0416447 |
| RPL34 | ribosomal protein L34 | -0.0410937 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0408231 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0406888 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0400284 |
| LAMC2 | laminin, gamma 2 | -0.0384357 |
| RUNX2 | runt-related transcription factor 2 | -0.0379266 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0377922 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0361176 |
| AOPEP | aminopeptidase O (putative) | -0.0337447 |
| S100A10 | S100 calcium binding protein A10 | -0.0330701 |
| ITGB4 | integrin, beta 4 | -0.0323966 |
| MAP4 | microtubule-associated protein 4 | -0.0323599 |
| RREB1 | ras responsive element binding protein 1 | -0.0322412 |
| PARD3 | par-3 family cell polarity regulator | -0.0322197 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0322 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0317751 |
| OXR1 | oxidation resistance 1 | -0.031495 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0312791 |
| RPS19 | ribosomal protein S19 | -0.0312335 |
| S100A6 | S100 calcium binding protein A6 | -0.0310227 |
| IER3 | immediate early response 3 | -0.0310083 |
| BMP4 | bone morphogenetic protein 4 | -0.03096 |
| TOP1 | topoisomerase (DNA) I | -0.0306481 |
| RPL5 | ribosomal protein L5 | -0.0306439 |
| CANX | calnexin | -0.0305918 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0297331 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.0294585 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0288816 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0287639 |
| YOD1 | YOD1 deubiquitinase | -0.0281244 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0277016 |
| RPLP1 | ribosomal protein, large, P1 | -0.0275603 |
| LMO7 | LIM domain 7 | -0.0269135 |
| RFX7 | regulatory factor X, 7 | -0.0268277 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | -0.026726 |
| CCND1 | cyclin D1 | -0.026324 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.026057 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0259191 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0258979 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0257992 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0257258 |
| RBM25 | RNA binding motif protein 25 | -0.0255763 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0254763 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.0253821 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0252304 |
| AHNAK | AHNAK nucleoprotein | -0.0251849 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.0251622 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0251431 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0250955 |
| RPL8 | ribosomal protein L8 | -0.0250909 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0250314 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0245056 |
| RPS5 | ribosomal protein S5 | -0.0239993 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0237495 |
| SNX9 | sorting nexin 9 | -0.0236879 |
| RPL35A | ribosomal protein L35a | -0.0232587 |
| FLOT1 | flotillin 1 | -0.0232491 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0231402 |
| CD2AP | CD2-associated protein | -0.0229543 |
| EDAR | ectodysplasin A receptor | -0.0228378 |
| RPS2 | ribosomal protein S2 | -0.0227977 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0225303 |
| TMSB10 | thymosin beta 10 | -0.0223778 |
| FHIT | fragile histidine triad | -0.0216861 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0213774 |
| NUP58 | nucleoporin 58 | -0.0212033 |
| NFIA | nuclear factor I/A | -0.0211384 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0209825 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0209691 |
| RPLP2 | ribosomal protein, large, P2 | -0.0206983 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0205764 |
| NEMF | nuclear export mediator factor | -0.0205542 |
| ARF1 | ADP-ribosylation factor 1 | -0.0203716 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0202278 |
