| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INTS6 | integrator complex subunit 6 | 0.111403 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0974436 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0902356 |
| WWOX | WW domain containing oxidoreductase | 0.0865756 |
| PTMA | prothymosin, alpha | 0.0805886 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0789017 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0766656 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0690209 |
| RAD51B | RAD51 paralog B | 0.0683588 |
| TNS3 | tensin 3 | 0.0644348 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0641881 |
| NAV2 | neuron navigator 2 | 0.0589579 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0552663 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0545783 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0535928 |
| ACTN1 | actinin, alpha 1 | 0.0524169 |
| HDAC4 | histone deacetylase 4 | 0.0514333 |
| LMO7 | LIM domain 7 | 0.0513657 |
| SMAD3 | SMAD family member 3 | 0.0509089 |
| DSPP | dentin sialophosphoprotein | 0.0500862 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0486556 |
| EXOC4 | exocyst complex component 4 | 0.0462988 |
| PRELID2 | PRELI domain containing 2 | 0.0461576 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0456383 |
| MSI2 | musashi RNA-binding protein 2 | 0.0454813 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0438034 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0437061 |
| GLI3 | GLI family zinc finger 3 | 0.0421988 |
| FHIT | fragile histidine triad | 0.0417345 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0414963 |
| CENPF | centromere protein F, 350/400kDa | 0.0403295 |
| RRM2 | ribonucleotide reductase M2 | 0.0395947 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0395074 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0395017 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.039367 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0374819 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0372701 |
| BMP5 | bone morphogenetic protein 5 | 0.0368571 |
| YAP1 | Yes-associated protein 1 | 0.0367761 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0359488 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0358406 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0357 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0350337 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0337315 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.033616 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0335404 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0334963 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0326291 |
| RCOR1 | REST corepressor 1 | 0.0325331 |
| ACTN4 | actinin, alpha 4 | 0.0325261 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0324642 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0324514 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0322983 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0321932 |
| ECT2 | epithelial cell transforming 2 | 0.0319255 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0318406 |
| CEP112 | centrosomal protein 112kDa | 0.0318381 |
| ENO1 | enolase 1, (alpha) | 0.0313041 |
| EGFR | epidermal growth factor receptor | 0.0310662 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0310542 |
| AATF | apoptosis antagonizing transcription factor | 0.0305139 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0304448 |
| ASPH | aspartate beta-hydroxylase | 0.0303527 |
| FAT1 | FAT atypical cadherin 1 | 0.0302876 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0301233 |
| CEP128 | centrosomal protein 128kDa | 0.0298404 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.029635 |
| POTEF | POTE ankyrin domain family, member F | 0.0293751 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0289747 |
| PCM1 | pericentriolar material 1 | 0.0289535 |
| CADM1 | cell adhesion molecule 1 | 0.0285076 |
| ATXN1 | ataxin 1 | 0.028495 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.028251 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0281117 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0274353 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0273992 |
| CTBP2 | C-terminal binding protein 2 | 0.0270293 |
| CPNE1 | copine I | 0.0269529 |
| VCL | vinculin | 0.0267562 |
| SMC4 | structural maintenance of chromosomes 4 | 0.026716 |
| SYK | spleen tyrosine kinase | 0.0266982 |
| TPX2 | TPX2, microtubule-associated | 0.0265479 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0264903 |
| EFNB2 | ephrin-B2 | 0.0263332 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0262642 |
| ZNRF3 | zinc and ring finger 3 | 0.0261572 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0261567 |
| MYO1D | myosin ID | 0.025846 |
| MCC | mutated in colorectal cancers | 0.025766 |
| AFAP1L2 | actin filament associated protein 1-like 2 | 0.0254722 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0253483 |
| CD44 | CD44 molecule (Indian blood group) | 0.0253219 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.025141 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0251078 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0251016 |
| KRT18 | keratin 18, type I | 0.0250835 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0250307 |
| IGF1R | insulin-like growth factor 1 receptor | 0.024855 |
| SMYD3 | SET and MYND domain containing 3 | 0.024726 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0246145 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.233524 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.138204 |
| RPS6 | ribosomal protein S6 | -0.105999 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.101387 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0955035 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0898514 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0792861 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0771815 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0768576 |
| HMGA1 | high mobility group AT-hook 1 | -0.062233 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0613152 |
| ITGB4 | integrin, beta 4 | -0.0608803 |
| EGR1 | early growth response 1 | -0.0602034 |
| GLG1 | golgi glycoprotein 1 | -0.0557766 |
| PERP | PERP, TP53 apoptosis effector | -0.0542306 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.052893 |
| GOLGA4 | golgin A4 | -0.0522794 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0506951 |
| CDH13 | cadherin 13 | -0.050547 |
| ITGA6 | integrin, alpha 6 | -0.0481124 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.047731 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0474198 |
| SBF2 | SET binding factor 2 | -0.0471108 |
| SNX9 | sorting nexin 9 | -0.0459254 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0450784 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0441995 |
| TPM4 | tropomyosin 4 | -0.04397 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0415136 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0392999 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0390517 |
| JMJD1C | jumonji domain containing 1C | -0.0383722 |
| TMEM41B | transmembrane protein 41B | -0.0382794 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0382732 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0382079 |
| CANX | calnexin | -0.0380984 |
| EMP1 | epithelial membrane protein 1 | -0.0376073 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0360962 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0359678 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0358883 |
| TMSB4X | thymosin beta 4, X-linked | -0.0358804 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0353629 |
| MORF4L2 | mortality factor 4 like 2 | -0.0353222 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0350784 |
| ARF4 | ADP-ribosylation factor 4 | -0.0350296 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0349111 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0340562 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0333394 |
| COG5 | component of oligomeric golgi complex 5 | -0.0330936 |
| RPL32 | ribosomal protein L32 | -0.0329929 |
| TXNIP | thioredoxin interacting protein | -0.0329925 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0326721 |
| NKTR | natural killer cell triggering receptor | -0.0320463 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0318062 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0316741 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0313153 |
| CCND1 | cyclin D1 | -0.0311203 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0310882 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0310793 |
| CDCP1 | CUB domain containing protein 1 | -0.0309333 |
| RPL37 | ribosomal protein L37 | -0.0308269 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0308069 |
| RPS2 | ribosomal protein S2 | -0.0306118 |
| RACK1 | receptor for activated C kinase 1 | -0.0300203 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0299406 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0299206 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0298168 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0296649 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.029658 |
| TMEM123 | transmembrane protein 123 | -0.02957 |
| MATR3 | matrin 3 | -0.0293184 |
| GNAS | GNAS complex locus | -0.0292492 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0290895 |
| RPL27A | ribosomal protein L27a | -0.0290296 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0286729 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0285519 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0283957 |
| RPL30 | ribosomal protein L30 | -0.0283827 |
| ANXA2 | annexin A2 | -0.0278735 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0276473 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0274877 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0274288 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0271885 |
| FOSL1 | FOS-like antigen 1 | -0.0270182 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.027017 |
| MXD1 | MAX dimerization protein 1 | -0.0269783 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0267718 |
| RPLP1 | ribosomal protein, large, P1 | -0.0265905 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0264681 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0264334 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0263585 |
| RPL5 | ribosomal protein L5 | -0.0263222 |
| WASF2 | WAS protein family, member 2 | -0.0262336 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0260436 |
| ZNF292 | zinc finger protein 292 | -0.0260199 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0257967 |
| CFDP1 | craniofacial development protein 1 | -0.0250958 |
| RPLP0 | ribosomal protein, large, P0 | -0.0246457 |
| RPL39 | ribosomal protein L39 | -0.0245642 |
| RPL35 | ribosomal protein L35 | -0.0245434 |
| PFN1 | profilin 1 | -0.0245224 |
