| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.226306 |
| ASPH | aspartate beta-hydroxylase | 0.0948648 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0941214 |
| MMP1 | matrix metallopeptidase 1 | 0.0916248 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0878382 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0874696 |
| VCL | vinculin | 0.0733385 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0724548 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.067792 |
| CAVIN1 | caveolae associated protein 1 | 0.0672922 |
| SMAD3 | SMAD family member 3 | 0.0613955 |
| STC1 | stanniocalcin 1 | 0.0599556 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0589064 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0581363 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.055841 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.055114 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0545219 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0522191 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0492185 |
| TLN1 | talin 1 | 0.049033 |
| LOX | lysyl oxidase | 0.0486087 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0467886 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0461173 |
| AHNAK | AHNAK nucleoprotein | 0.0455233 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0445332 |
| DST | dystonin | 0.042788 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0426933 |
| ANO6 | anoctamin 6 | 0.0418883 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.041463 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0402658 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0398086 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0395396 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0375326 |
| MYOF | myoferlin | 0.0362875 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0360105 |
| ANXA2 | annexin A2 | 0.0345542 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0336286 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0334404 |
| LDHA | lactate dehydrogenase A | 0.0332984 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0326166 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0322371 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0307499 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0304189 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0304153 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0302742 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0289202 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0278816 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0264216 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0262317 |
| JAK1 | Janus kinase 1 | 0.0259095 |
| SPAG9 | sperm associated antigen 9 | 0.0254727 |
| SERINC1 | serine incorporator 1 | 0.0254597 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0254003 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0249383 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0245654 |
| DSPP | dentin sialophosphoprotein | 0.0244886 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0244466 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0243829 |
| APP | amyloid beta (A4) precursor protein | 0.0243256 |
| PGK1 | phosphoglycerate kinase 1 | 0.0240819 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0237977 |
| RAI14 | retinoic acid induced 14 | 0.0237783 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0234994 |
| FAT1 | FAT atypical cadherin 1 | 0.0234548 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.023301 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0217522 |
| CANX | calnexin | 0.0217058 |
| FMNL2 | formin-like 2 | 0.0214742 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0214705 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0214045 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.020688 |
| ENO1 | enolase 1, (alpha) | 0.0205711 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0202456 |
| HDAC9 | histone deacetylase 9 | 0.0202427 |
| RPS12 | ribosomal protein S12 | 0.0201264 |
| HDLBP | high density lipoprotein binding protein | 0.0200914 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0200048 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0196922 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0196484 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0195493 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0190462 |
| RAB31 | RAB31, member RAS oncogene family | 0.0189495 |
| FBN1 | fibrillin 1 | 0.0189161 |
| SET | SET nuclear proto-oncogene | 0.018907 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0187654 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0184482 |
| CD44 | CD44 molecule (Indian blood group) | 0.0183953 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0182939 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0178141 |
| TPR | translocated promoter region, nuclear basket protein | 0.0178105 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0177287 |
| GOLGB1 | golgin B1 | 0.0175111 |
| DUSP6 | dual specificity phosphatase 6 | 0.0172358 |
| NUMB | numb homolog (Drosophila) | 0.0172345 |
| CTSB | cathepsin B | 0.017234 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0172226 |
| FRMD6 | FERM domain containing 6 | 0.0169175 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0169079 |
| INTS6 | integrator complex subunit 6 | 0.0168885 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0168472 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.383014 |
| VIM | vimentin | -0.122838 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.11212 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.10922 |
| COL1A1 | collagen, type I, alpha 1 | -0.103221 |
| HLA-B | major histocompatibility complex, class I, B | -0.088413 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0872868 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0804452 |
| OXR1 | oxidation resistance 1 | -0.0798612 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0713402 |
| TMSB10 | thymosin beta 10 | -0.062936 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0600419 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0570063 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0543313 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0543291 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.053772 |
| COL1A2 | collagen, type I, alpha 2 | -0.0535096 |
| MMP12 | matrix metallopeptidase 12 | -0.053289 |
| GOLGA4 | golgin A4 | -0.0532853 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0513446 |
| FTL | ferritin, light polypeptide | -0.0504723 |
| TMEM165 | transmembrane protein 165 | -0.0477861 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0467632 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0453238 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0452755 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0425546 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0423865 |
| B2M | beta-2-microglobulin | -0.040819 |
| COL6A1 | collagen, type VI, alpha 1 | -0.039165 |
| MT2A | metallothionein 2A | -0.0379142 |
| CDH13 | cadherin 13 | -0.0365834 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0357195 |
| RPS6 | ribosomal protein S6 | -0.0353149 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0350246 |
| NPTX1 | neuronal pentraxin I | -0.0338584 |
| ATP13A3 | ATPase type 13A3 | -0.0330363 |
| PRRX1 | paired related homeobox 1 | -0.0330332 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0328483 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0324048 |
| RPS19 | ribosomal protein S19 | -0.031999 |
| PFN1 | profilin 1 | -0.0313367 |
| CCND1 | cyclin D1 | -0.0308939 |
| MAP1B | microtubule-associated protein 1B | -0.0302769 |
| RPLP1 | ribosomal protein, large, P1 | -0.0302621 |
| PDE8A | phosphodiesterase 8A | -0.0297249 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0291671 |
| RPL32 | ribosomal protein L32 | -0.0289708 |
| EMP1 | epithelial membrane protein 1 | -0.0288897 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | -0.0285245 |
| HLA-A | major histocompatibility complex, class I, A | -0.0284236 |
| RHOA | ras homolog family member A | -0.0282716 |
| RPS23 | ribosomal protein S23 | -0.0277082 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.02763 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0276116 |
| ACTG1 | actin gamma 1 | -0.0274857 |
| BSG | basigin (Ok blood group) | -0.0274665 |
| WASF2 | WAS protein family, member 2 | -0.0264794 |
| S100A9 | S100 calcium binding protein A9 | -0.0264757 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0261247 |
| HMGA1 | high mobility group AT-hook 1 | -0.0258954 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0256432 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0255367 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0251785 |
| DNER | delta/notch-like EGF repeat containing | -0.0247484 |
| HSPB6 | heat shock protein, alpha-crystallin-related, B6 | -0.0243395 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0242487 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0242178 |
| INSIG1 | insulin induced gene 1 | -0.0240588 |
| CD99 | CD99 molecule | -0.0239365 |
| RPL34 | ribosomal protein L34 | -0.0239269 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0236675 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0236316 |
| NKTR | natural killer cell triggering receptor | -0.0235287 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0234577 |
| RPS13 | ribosomal protein S13 | -0.0234082 |
| SETD5 | SET domain containing 5 | -0.0229999 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0229928 |
| VCAN | versican | -0.0229383 |
| CLMP | CXADR-like membrane protein | -0.0229129 |
| HMGA2 | high mobility group AT-hook 2 | -0.0228983 |
| ARHGAP10 | Rho GTPase activating protein 10 | -0.0225422 |
| RPL8 | ribosomal protein L8 | -0.0224518 |
| MEIS1 | Meis homeobox 1 | -0.0221851 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.022171 |
| CALD1 | caldesmon 1 | -0.022162 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.021905 |
| TPM2 | tropomyosin 2 (beta) | -0.0218107 |
| RPLP2 | ribosomal protein, large, P2 | -0.021277 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0210113 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0206823 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.020607 |
| SNX9 | sorting nexin 9 | -0.0205568 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0205564 |
| CALU | calumenin | -0.0204927 |
| UBC | ubiquitin C | -0.0204872 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0204546 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0204234 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0202946 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0197089 |
| FUS | FUS RNA binding protein | -0.0195397 |
