Lumbar Disc Disease Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group aging (Genetic Association Database)
External Link https://www.disgenet.org/browser/0/1/0/C0221775
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Genes

44 genes associated with the disease Lumbar Disc Disease in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACAN aggrecan
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ASPN asporin
CASP9 caspase 9, apoptosis-related cysteine peptidase
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
COX2
DCT dopachrome tautomerase
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
GDF5 growth differentiation factor 5
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IL10 interleukin 10
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL4 interleukin 4
IL6 interleukin 6
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
PARK2 parkin RBR E3 ubiquitin protein ligase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTEN phosphatase and tensin homolog
RANBP2 RAN binding protein 2
SMAD4 SMAD family member 4
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSLP thymic stromal lymphopoietin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor