Lupus Nephritis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982). (Experimental Factor Ontology, EFO_0005761)
External Link https://www.disgenet.org/browser/0/1/0/C0024143
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Genes

448 genes associated with the disease Lupus Nephritis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ACE angiotensin I converting enzyme
ACR acrosin
ACTB actin, beta
ACTN4 actinin, alpha 4
ADAM17 ADAM metallopeptidase domain 17
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADD2 adducin 2 (beta)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
AGA aspartylglucosaminidase
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHCY adenosylhomocysteinase
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AIRE autoimmune regulator
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
ANGPT2 angiopoietin 2
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANKRD50 ankyrin repeat domain 50
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA2 annexin A2
API5 apoptosis inhibitor 5
APOL1 apolipoprotein L, 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATF4 activating transcription factor 4
ATF7IP activating transcription factor 7 interacting protein
ATG5 autophagy related 5
ATN1 atrophin 1
AURKA aurora kinase A
AXIN2 axin 2
AXL AXL receptor tyrosine kinase
B2M beta-2-microglobulin
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG1 BCL2-associated athanogene
BAGE3 B melanoma antigen family, member 3
BARX2 BARX homeobox 2
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BGN biglycan
BLK BLK proto-oncogene, Src family tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
C1S complement component 1, s subcomponent
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5 complement component 5
C5AR1 complement component 5a receptor 1
CABIN1 calcineurin binding protein 1
CALR calreticulin
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARD9 caspase recruitment domain family, member 9
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL11 chemokine (C-C motif) ligand 11
CCL17 chemokine (C-C motif) ligand 17
CCL2 chemokine (C-C motif) ligand 2
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL5 chemokine (C-C motif) ligand 5
CCN2 cellular communication network factor 2
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD163 CD163 molecule
CD19 CD19 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD34 CD34 molecule
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD68 CD68 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFH complement factor H
CFHR3 complement factor H-related 3
CFHR5 complement factor H-related 5
CLEC4E C-type lectin domain family 4, member E
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
CMIP c-Maf inducing protein
CMKLR1 chemerin chemokine-like receptor 1
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COX2
CP ceruloplasmin (ferroxidase)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CST3 cystatin C
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR5 chemokine (C-X-C motif) receptor 5
CYCS cytochrome c, somatic
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDR1 discoidin domain receptor tyrosine kinase 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNASE1 deoxyribonuclease I
DNASE1L3 deoxyribonuclease I-like 3
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EDN1 endothelin 1
ELANE elastase, neutrophil expressed
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EMB embigin
ENO1 enolase 1, (alpha)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM167A family with sequence similarity 167, member A
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCAR Fc fragment of IgA receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FCRLA Fc receptor-like A
FEN1 flap structure-specific endonuclease 1
FGB fibrinogen beta chain
FGF23 fibroblast growth factor 23
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLII flightless I homolog (Drosophila)
FLT3LG fms-related tyrosine kinase 3 ligand
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXP3 forkhead box P3
FSTL1 follistatin-like 1
FTH1 ferritin, heavy polypeptide 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GC group-specific component (vitamin D binding protein)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRAP2 GRB2-related adaptor protein 2
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
GTF2I general transcription factor IIi
HAMP hepcidin antimicrobial peptide
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HDAC6 histone deacetylase 6
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HPSE heparanase
HPX hemopexin
HSPE1 heat shock 10kDa protein 1
HSPG2 heparan sulfate proteoglycan 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGBP1 immunoglobulin (CD79A) binding protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL13 interleukin 13
IL17A interleukin 17A
IL17B interleukin 17B
IL17F interleukin 17F
IL18 interleukin 18
IL18BP interleukin 18 binding protein
IL1B interleukin 1, beta
IL2 interleukin 2
IL20 interleukin 20
IL21 interleukin 21
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL2RA interleukin 2 receptor, alpha
IL32 interleukin 32
IL33 interleukin 33
IL34 interleukin 34
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
IRAK1 interleukin-1 receptor-associated kinase 1
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRGM immunity-related GTPase family, M
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein
JUN jun proto-oncogene
KL klotho
KLK1 kallikrein 1
KLK3 kallikrein-related peptidase 3
KLK4 kallikrein-related peptidase 4
KNG1 kininogen 1
KRT20 keratin 20, type I
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS9 lectin, galactoside-binding, soluble, 9
LONP1 lon peptidase 1, mitochondrial
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LY6E lymphocyte antigen 6 complex, locus E
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MBD2 methyl-CpG binding domain protein 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MPRIP myosin phosphatase Rho interacting protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1A metallothionein 1A
MT1B metallothionein 1B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MTMR3 myotubularin related protein 3
MTNR1A melatonin receptor 1A
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTTP microsomal triglyceride transfer protein
MUC20 mucin 20, cell surface associated
MX1 MX dynamin-like GTPase 1
MYDGF myeloid-derived growth factor
MYH9 myosin, heavy chain 9, non-muscle
NELL1 NEL-like 1 (chicken)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NIN ninein (GSK3B interacting protein)
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRP1 neuropilin 1
NT5C1A 5'-nucleotidase, cytosolic IA
OGG1 8-oxoguanine DNA glycosylase
OSM oncostatin M
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PADI4 peptidyl arginine deiminase, type IV
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PCNA proliferating cell nuclear antigen
PCSK9 proprotein convertase subtilisin/kexin type 9
PDCD1 programmed cell death 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PGM1 phosphoglucomutase 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLG plasminogen
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PODXL podocalyxin-like
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PON1 paraoxonase 1
PON2 paraoxonase 2
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
POTEF POTE ankyrin domain family, member F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCB protein kinase C, beta
PRL prolactin
PROCR protein C receptor, endothelial
PRTN3 proteinase 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTEN phosphatase and tensin homolog
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTPRZ2 protein tyrosine phosphatase, receptor-type, Z polypeptide 2
PTX3 pentraxin 3, long
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARB retinoic acid receptor, beta
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM45 RNA binding motif protein 45
RBP4 retinol binding protein 4, plasma
REN renin
RETN resistin
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIPK3 receptor-interacting serine-threonine kinase 3
RIPK4 receptor-interacting serine-threonine kinase 4
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RTN3 reticulon 3
S100A1 S100 calcium binding protein A1
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100B S100 calcium binding protein B
SAFB scaffold attachment factor B
SCARB1 scavenger receptor class B, member 1
SDC2 syndecan 2
SELE selectin E
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP2 SH3-domain binding protein 2
SIRT1 sirtuin 1
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMAD7 SMAD family member 7
SNRPE small nuclear ribonucleoprotein polypeptide E
SOCS1 suppressor of cytokine signaling 1
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SRSF1 serine/arginine-rich splicing factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
SYK spleen tyrosine kinase
TAT tyrosine aminotransferase
TET2 tet methylcytosine dioxygenase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TIMELESS timeless circadian clock
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TNIP2 TNFAIP3 interacting protein 2
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAP1 TNF receptor-associated protein 1
TRIM15 tripartite motif containing 15
TRIM21 tripartite motif containing 21
TRIM27 tripartite motif containing 27
TTC34 tetratricopeptide repeat domain 34
TTR transthyretin
TUBA1B tubulin, alpha 1b
TYROBP TYRO protein tyrosine kinase binding protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ULK1 unc-51 like autophagy activating kinase 1
USP2 ubiquitin specific peptidase 2
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR11 WD repeat domain 11
XKR6 XK, Kell blood group complex subunit-related family, member 6
ZNF546 zinc finger protein 546