Lyme Disease Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. (Human Disease Ontology, DOID_11729)
External Link https://www.disgenet.org/browser/0/1/0/C0024198
Similar Terms
Downloads & Tools

Genes

157 genes associated with the disease Lyme Disease in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
AK6 adenylate kinase 6
ANXA1 annexin A1
AOC3 amine oxidase, copper containing 3
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BGN biglycan
BLZF1 basic leucine zipper nuclear factor 1
BRD4 bromodomain containing 4
CALR calreticulin
CANX calnexin
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNH cyclin H
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD180 CD180 molecule
CD1B CD1b molecule
CD28 CD28 molecule
CD300A CD300a molecule
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD48 CD48 molecule
CD68 CD68 molecule
CD8B CD8b molecule
CDCA5 cell division cycle associated 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CFH complement factor H
CHP1 calcineurin-like EF-hand protein 1
COX1
CPVL carboxypeptidase, vitellogenic-like
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCN decorin
DCTN3 dynactin 3 (p22)
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EBPL emopamil binding protein-like
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPHA5 EPH receptor A5
EXOSC1 exosome component 1
FAM20C family with sequence similarity 20, member C
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF1 fibroblast growth factor 1 (acidic)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXP3 forkhead box P3
GCHFR GTP cyclohydrolase I feedback regulator
GOLPH3 golgi phosphoprotein 3 (coat-protein)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK1 hexokinase 1
HLA-A major histocompatibility complex, class I, A
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IGH immunoglobulin heavy locus
IL10 interleukin 10
IL12A interleukin 12A
IL17A interleukin 17A
IL1B interleukin 1, beta
IL22 interleukin 22
IL23R interleukin 23 receptor
IL37 interleukin 37
IL6 interleukin 6
IRF7 interferon regulatory factor 7
JUN jun proto-oncogene
KARS1 lysyl-tRNA synthetase 1
KRT10 keratin 10, type I
LAMC2 laminin, gamma 2
LNPEP leucyl/cystinyl aminopeptidase
LOC105375355 uroplakin-3b
MAK16 MAK16 homolog (S. cerevisiae)
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MBL2 mannose-binding lectin (protein C) 2, soluble
MIP major intrinsic protein of lens fiber
MLIP muscular LMNA-interacting protein
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPZ myelin protein zero
NELFCD negative elongation factor complex member C/D
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOP53 NOP53 ribosome biogenesis factor
NRSN1 neurensin 1
NT5C2 5'-nucleotidase, cytosolic II
NUP37 nucleoporin 37kDa
PDLIM7 PDZ and LIM domain 7 (enigma)
PHB2 prohibitin 2
PLG plasminogen
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRF1 perforin 1 (pore forming protein)
PRH1 proline-rich protein HaeIII subfamily 1
PRH2 proline-rich protein HaeIII subfamily 2
PTBP1 polypyrimidine tract binding protein 1
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB22A RAB22A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAD51 RAD51 recombinase
RBM45 RNA binding motif protein 45
RBMS3 RNA binding motif, single stranded interacting protein 3
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RHOBTB2 Rho-related BTB domain containing 2
RNMT RNA (guanine-7-) methyltransferase
RRAS related RAS viral (r-ras) oncogene homolog
RRP1 ribosomal RNA processing 1
S100A8 S100 calcium binding protein A8
SELK selenoprotein K
SENP6 SUMO1/sentrin specific peptidase 6
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SGSM3 small G protein signaling modulator 3
SORBS1 sorbin and SH3 domain containing 1
SQSTM1 sequestosome 1
SRI sorcin
SRRM2 serine/arginine repetitive matrix 2
STIP1 stress-induced phosphoprotein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TPT1 tumor protein, translationally-controlled 1
TTN titin
TUFM Tu translation elongation factor, mitochondrial
UBXN2B UBX domain protein 2B
VCAM1 vascular cell adhesion molecule 1
VHLL von Hippel-Lindau tumor suppressor-like
YBX3 Y box binding protein 3