Lymphopenia Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood. (Human Disease Ontology, DOID_614)
External Link https://www.disgenet.org/browser/0/1/0/C0024312
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Genes

230 genes associated with the disease Lymphopenia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACE angiotensin I converting enzyme
ACR acrosin
ACTB actin, beta
ADA adenosine deaminase
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGPS alkylglycerone phosphate synthase
AK2 adenylate kinase 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALLC allantoicase
ATG5 autophagy related 5
ATG7 autophagy related 7
ATM ATM serine/threonine kinase
ATN1 atrophin 1
ATR ATR serine/threonine kinase
B3GAT1 beta-1,3-glucuronyltransferase 1
BCHE butyrylcholinesterase
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG3 BTG family, member 3
BTK Bruton agammaglobulinemia tyrosine kinase
C1QA complement component 1, q subcomponent, A chain
C1R complement component 1, r subcomponent
C3 complement component 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCBE1 collagen and calcium binding EGF domains 1
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCL22 chemokine (C-C motif) ligand 22
CCL28 chemokine (C-C motif) ligand 28
CCL5 chemokine (C-C motif) ligand 5
CD19 CD19 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD34 CD34 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD40LG CD40 ligand
CD52 CD52 molecule
CD6 CD6 molecule
CD69 CD69 molecule
CD81 CD81 molecule
CDCA7 cell division cycle associated 7
CHD1L chromodomain helicase DNA binding protein 1-like
CHD7 chromodomain helicase DNA binding protein 7
CORO1A coronin, actin binding protein, 1A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTPS1 CTP synthase 1
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAXX death-domain associated protein
DCLRE1C DNA cross-link repair 1C
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
EOMES eomesodermin
ESR1 estrogen receptor 1
EXTL3 exostosin-like glycosyltransferase 3
FAS Fas cell surface death receptor
FAT4 FAT atypical cadherin 4
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF7 fibroblast growth factor 7
FOXI3 forkhead box I3
FOXJ1 forkhead box J1
FOXN1 forkhead box N1
FOXP3 forkhead box P3
G6PC3 glucose 6 phosphatase, catalytic, 3
GATA2 GATA binding protein 2
GFI1 growth factor independent 1 transcription repressor
GH1 growth hormone 1
GHRH growth hormone releasing hormone
GIMAP5 GTPase, IMAP family member 5
GIMAP7 GTPase, IMAP family member 7
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSTK1 glutathione S-transferase kappa 1
HELLS helicase, lymphoid-specific
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLF hepatic leukemia factor
HMGB1 high mobility group box 1
HOXD13 homeobox D13
ICOS inducible T-cell co-stimulator
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNL1 interferon, lambda 1
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IL6 interleukin 6
IL7 interleukin 7
IL7R interleukin 7 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INS insulin
IRAK1 interleukin-1 receptor-associated kinase 1
ISG20 interferon stimulated exonuclease gene 20kDa
JAK3 Janus kinase 3
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KRT20 keratin 20, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS8 lectin, galactoside-binding, soluble, 8
LIG4 ligase IV, DNA, ATP-dependent
LYPD1 LY6/PLAUR domain containing 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCL1 myeloid cell leukemia 1
MED23 mediator complex subunit 23
MERTK MER proto-oncogene, tyrosine kinase
MLF1 myeloid leukemia factor 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSN moesin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYD88 myeloid differentiation primary response 88
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK myosin light chain kinase
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NBN nibrin
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKAP NFKB activating protein
NLRP2 NLR family, pyrin domain containing 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGM3 phosphoglucomutase 3
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G10 phospholipase A2, group X
PML promyelocytic leukemia
PNP purine nucleoside phosphorylase
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POTEF POTE ankyrin domain family, member F
POU1F1 POU class 1 homeobox 1
PRKCD protein kinase C, delta
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRC protein tyrosine phosphatase, receptor type, C
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAG1 recombination activating gene 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM45 RNA binding motif protein 45
RHOH ras homolog family member H
RNPC3 RNA-binding region (RNP1, RRM) containing 3
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RTEL1 regulator of telomere elongation helicase 1
S1PR1 sphingosine-1-phosphate receptor 1
S1PR5 sphingosine-1-phosphate receptor 5
SAMD9 sterile alpha motif domain containing 9
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SETD1B SET domain containing 1B
SGPL1 sphingosine-1-phosphate lyase 1
SIRT1 sirtuin 1
SIRT6 sirtuin 6
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLAMF7 SLAM family member 7
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SOD1 superoxide dismutase 1, soluble
SP110 SP110 nuclear body protein
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPNS2 spinster homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SRP54 signal recognition particle 54kDa
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STK4 serine/threonine kinase 4
SYCN syncollin
TAT tyrosine aminotransferase
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TCN2 transcobalamin II
TERT telomerase reverse transcriptase
TFR2 transferrin receptor 2
TG thyroglobulin
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP63 tumor protein p63
TPP2 tripeptidyl peptidase II
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1
TTC37 tetratricopeptide repeat domain 37
TTC7A tetratricopeptide repeat domain 7A
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC119 unc-119 homolog (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WDR1 WD repeat domain 1
WIPF1 WAS/WASL interacting protein family, member 1
XCL1 chemokine (C motif) ligand 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB24 zinc finger and BTB domain containing 24