Lynch Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C2931459
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Genes

93 genes associated with the disease Lynch Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AIP aryl hydrocarbon receptor interacting protein
ALK anaplastic lymphoma receptor tyrosine kinase
ANXA10 annexin A10
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
ATAD1 ATPase family, AAA domain containing 1
ATM ATM serine/threonine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CD274 CD274 molecule
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHEK2 checkpoint kinase 2
COL11A2 collagen, type XI, alpha 2
COMT catechol-O-methyltransferase
CTCF CCCTC-binding factor (zinc finger protein)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMB embigin
EPCAM epithelial cell adhesion molecule
EPHB1 EPH receptor B1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
FAP fibroblast activation protein, alpha
GJA8 gap junction protein, alpha 8, 50kDa
GREM1 gremlin 1, DAN family BMP antagonist
GSTK1 glutathione S-transferase kappa 1
GSTP1 glutathione S-transferase pi 1
HEPACAM hepatic and glial cell adhesion molecule
ITGA9 integrin, alpha 9
KAT2A K(lysine) acetyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MAP2K7 mitogen-activated protein kinase kinase 7
MAT2A methionine adenosyltransferase II, alpha
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MMP7 matrix metallopeptidase 7
MRC1 mannose receptor, C type 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC16 mucin 16, cell surface associated
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NLRP2 NLR family, pyrin domain containing 2
NPTN neuroplastin
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PTEN phosphatase and tensin homolog
PTPRG protein tyrosine phosphatase, receptor type, G
RAD51C RAD51 paralog C
RINT1 RAD50 interactor 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF43 ring finger protein 43
SEC63 SEC63 homolog (S. cerevisiae)
SGSM3 small G protein signaling modulator 3
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMAD7 SMAD family member 7
SOCS1 suppressor of cytokine signaling 1
STK11 serine/threonine kinase 11
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP2 TIMP metallopeptidase inhibitor 2
TP53 tumor protein p53
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
ZEB1 zinc finger E-box binding homeobox 1