Lysosome Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. (Gene Ontology, GO_0005764)
External Link https://www.kegg.jp/entry/hsa04142
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Genes

132 proteins participating in the Lysosome pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACD adrenocortical dysplasia homolog (mouse)
ACP2 acid phosphatase 2, lysosomal
ACP5 acid phosphatase 5, tartrate resistant
AGA aspartylglucosaminidase
ANKRD44 ankyrin repeat domain 44
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP1M2 adaptor-related protein complex 1, mu 2 subunit
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP1S3 adaptor-related protein complex 1, sigma 3 subunit
AP3B1 adaptor-related protein complex 3, beta 1 subunit
AP3B2 adaptor-related protein complex 3, beta 2 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP3M1 adaptor-related protein complex 3, mu 1 subunit
AP3M2 adaptor-related protein complex 3, mu 2 subunit
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
AP4B1 adaptor-related protein complex 4, beta 1 subunit
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
AP4M1 adaptor-related protein complex 4, mu 1 subunit
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ARSA arylsulfatase A
ARSG arylsulfatase G
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
CD164 CD164 molecule, sialomucin
CD63 CD63 molecule
CD68 CD68 molecule
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CLTA clathrin, light chain A
CLTB clathrin, light chain B
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CTNS cystinosin, lysosomal cystine transporter
CTSA cathepsin A
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSE cathepsin E
CTSF cathepsin F
CTSG cathepsin G
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSO cathepsin O
CTSS cathepsin S
CTSV cathepsin V
CTSW cathepsin W
CTSZ cathepsin Z
DMXL1 Dmx-like 1
DMXL2 Dmx-like 2
DNASE2 deoxyribonuclease II, lysosomal
DNASE2B deoxyribonuclease II beta
EGFL7 EGF-like-domain, multiple 7
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GALNS galactosamine (N-acetyl)-6-sulfatase
GBA1 glucosylceramidase beta 1
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLB1 galactosidase, beta 1
GM2A GM2 ganglioside activator
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit
GNS glucosamine (N-acetyl)-6-sulfatase
GUSB glucuronidase, beta
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
HYAL4 hyaluronoglucosaminidase 4
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IGF2R insulin-like growth factor 2 receptor
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LAPTM4A lysosomal protein transmembrane 4 alpha
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LGMN legumain
LITAF lipopolysaccharide-induced TNF factor
M6PR mannose-6-phosphate receptor (cation dependent)
MAN2B1 mannosidase, alpha, class 2B, member 1
MANBA mannosidase, beta A, lysosomal
MCOLN1 mucolipin 1
MEAK7 MTOR associated protein, eak-7 homolog
MFSD8 major facilitator superfamily domain containing 8
NAGA N-acetylgalactosaminidase, alpha-
NAGLU N-acetylglucosaminidase, alpha
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAPSA napsin A aspartic peptidase
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCOA7 nuclear receptor coactivator 7
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
PLA2G15 phospholipase A2, group XV
PPT1 palmitoyl-protein thioesterase 1
PPT2 palmitoyl-protein thioesterase 2
PSAPL1 prosaposin-like 1 (gene/pseudogene)
SCARB2 scavenger receptor class B, member 2
SCGB1D1 secretoglobin, family 1D, member 1
SFTPA2 surfactant protein A2
SGSH N-sulfoglucosamine sulfohydrolase
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SORT1 sortilin 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SUMF1 sulfatase modifying factor 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
WDR7 WD repeat domain 7