MA-43-MR37_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM (Novartis)
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Genes

697 genes differentially expressed following the MA-43-MR37_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 8.96651
S100A2 S100 calcium binding protein A2 8.9647
MT2A metallothionein 2A 6.76727
HRNR hornerin 5.44264
TMSB10 thymosin beta 10 5.13964
TAGLN transgelin 4.50019
UPP1 uridine phosphorylase 1 3.40979
CTSB cathepsin B 3.21399
KRT17 keratin 17, type I 3.08295
OCIAD2 OCIA domain containing 2 3.06971
MMP10 matrix metallopeptidase 10 3.02804
CD59 CD59 molecule, complement regulatory protein 2.9437
ESM1 endothelial cell-specific molecule 1 2.9437
TM4SF1 transmembrane 4 L six family member 1 2.76617
IER3 immediate early response 3 2.73787
S100A6 S100 calcium binding protein A6 2.71729
PFN1 profilin 1 2.6821
GNAS GNAS complex locus 2.52857
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.19542
PMEPA1 prostate transmembrane protein, androgen induced 1 2.17966
RHOC ras homolog family member C 2.10187
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.08239
HMGA1 high mobility group AT-hook 1 2.02648
KRTAP13-2 keratin associated protein 13-2 2.00152
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 1.99097
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 1.97846
S100A11 S100 calcium binding protein A11 1.85347
FOXD1 forkhead box D1 1.85177
CD63 CD63 molecule 1.83562
RHOB ras homolog family member B 1.81954
PDLIM4 PDZ and LIM domain 4 1.81577
EIF1 eukaryotic translation initiation factor 1 1.79069
POTEF POTE ankyrin domain family, member F 1.69151
TMBIM6 transmembrane BAX inhibitor motif containing 6 1.67258
KISS1 KiSS-1 metastasis-suppressor 1.5631
MYEOV myeloma overexpressed 1.54765
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.52228
CLIC1 chloride intracellular channel 1 1.47341
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 1.44937
GSTO1 glutathione S-transferase omega 1 1.44209
KRT6A keratin 6A, type II 1.43059
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.42224
MCL1 myeloid cell leukemia 1 1.39825
MMP1 matrix metallopeptidase 1 1.34141
GLRX glutaredoxin (thioltransferase) 1.28172
SPNS1 spinster homolog 1 (Drosophila) 1.27191
LGALS1 lectin, galactoside-binding, soluble, 1 1.25835
RHOA ras homolog family member A 1.24828
OSBP2 oxysterol binding protein 2 1.23522
SCG5 secretogranin V 1.20602
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 1.20575
MPRIP myosin phosphatase Rho interacting protein 1.18647
VIM vimentin 1.18549
PFDN2 prefoldin subunit 2 1.15976
IL11 interleukin 11 1.15674
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.13909
NME1-NME2 NME1-NME2 readthrough 1.13684
MFSD2B major facilitator superfamily domain containing 2B 1.13389
NDRG1 N-myc downstream regulated 1 1.13027
SLAMF9 SLAM family member 9 1.12927
AADAC arylacetamide deacetylase 1.1284
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.1118
MYL12B myosin, light chain 12B, regulatory 1.08808
ITGB5 integrin, beta 5 1.0682
TSPO translocator protein (18kDa) 1.06288
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 1.02171
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.01095
MT1H metallothionein 1H 1.00668
ACTG2 actin, gamma 2, smooth muscle, enteric 0.998179
RNF145 ring finger protein 145 0.984376
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.949966
FN1 fibronectin 1 0.946208
ISG20 interferon stimulated exonuclease gene 20kDa 0.93651
RHOF ras homolog family member F (in filopodia) 0.928259
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.919902
PHC2 polyhomeotic homolog 2 (Drosophila) 0.913343
FGF1 fibroblast growth factor 1 (acidic) 0.90594
MVP major vault protein 0.862337
SMAGP small cell adhesion glycoprotein 0.844991
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 0.833372
CRYAB crystallin, alpha B 0.81037
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.803084
CXCL8 chemokine (C-X-C motif) ligand 8 0.800462
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.795431
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.784856
CIB1 calcium and integrin binding 1 (calmyrin) 0.784856
UBALD2 UBA-like domain containing 2 0.784087
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 0.777335
FKBP1A FK506 binding protein 1A, 12kDa 0.773773
ERCC1 excision repair cross-complementation group 1 0.771385
ARHGAP22 Rho GTPase activating protein 22 0.771385
SNU13 small nuclear ribonucleoprotein 13 0.767278
PRDM1 PR domain containing 1, with ZNF domain 0.762809
FXYD5 FXYD domain containing ion transport regulator 5 0.762268
PLAU plasminogen activator, urokinase 0.755304
PRR9 proline rich 9 0.744601
SPOCD1 SPOC domain containing 1 0.744097
CSRP1 cysteine and glycine-rich protein 1 0.73391
VGF VGF nerve growth factor inducible 0.731045
TUBA1C tubulin, alpha 1c 0.723194
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.708386
CLTB clathrin, light chain B 0.706983
ANTXR2 anthrax toxin receptor 2 0.698331
OLAH oleoyl-ACP hydrolase 0.687028
PLEK2 pleckstrin 2 0.687028
PCSK7 proprotein convertase subtilisin/kexin type 7 0.682944
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.669327
PLEC plectin 0.66756
IFFO1 intermediate filament family orphan 1 0.654705
CCN2 cellular communication network factor 2 0.654705
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.653515
CORO2B coronin, actin binding protein, 2B 0.653378
PLAUR plasminogen activator, urokinase receptor 0.649311
GABARAPL1 GABA(A) receptor-associated protein like 1 0.643086
CTTN cortactin 0.634892
TPST1 tyrosylprotein sulfotransferase 1 0.613549
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 0.594631
EMP1 epithelial membrane protein 1 0.58802
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.575701
MFGE8 milk fat globule-EGF factor 8 protein 0.571702
SPHK1 sphingosine kinase 1 0.568009
CD44 CD44 molecule (Indian blood group) 0.559196
GRAMD1B GRAM domain containing 1B 0.553495
KLF2 Kruppel-like factor 2 0.549919
RHOG ras homolog family member G 0.544721
STMP1 short transmembrane mitochondrial protein 1 0.539317
DUSP12 dual specificity phosphatase 12 0.539317
CSNK1E casein kinase 1, epsilon 0.53929
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.534969
GCNA germ cell nuclear acidic peptidase 0.524486
ACTG1 actin gamma 1 0.524072
SOWAHC sosondowah ankyrin repeat domain family member C 0.519397
KIFC3 kinesin family member C3 0.519333
IER2 immediate early response 2 0.508559
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.507606
AREG amphiregulin 0.503587
NOP10 NOP10 ribonucleoprotein 0.502946
MMP3 matrix metallopeptidase 3 0.498743
CNIH4 cornichon family AMPA receptor auxiliary protein 4 0.497143
LAMC2 laminin, gamma 2 0.496366
IL24 interleukin 24 0.495869
TSC22D3 TSC22 domain family, member 3 0.492476
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.485577
RNASEH2A ribonuclease H2, subunit A 0.483033
FAM89B family with sequence similarity 89, member B 0.481844
HBEGF heparin-binding EGF-like growth factor 0.479655
CAPN2 calpain 2, (m/II) large subunit 0.475258
CA3 carbonic anhydrase III 0.474232
CCL3 chemokine (C-C motif) ligand 3 0.473655
ADAM19 ADAM metallopeptidase domain 19 0.47364
DVL1 dishevelled segment polarity protein 1 0.472426
AGO2 argonaute RISC catalytic component 2 0.470443
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.469918
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.457563
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.453778
PPY pancreatic polypeptide 0.448584
FBLIM1 filamin binding LIM protein 1 0.447459
FOS FBJ murine osteosarcoma viral oncogene homolog 0.446738
ETV4 ets variant 4 0.445533
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.436422
LIMS3 LIM and senescent cell antigen-like domains 3 0.432966
KRT34 keratin 34, type I 0.432423
PTTG1 pituitary tumor-transforming 1 0.430057
CLMB calcimembrin 0.428715
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.423171
FGF5 fibroblast growth factor 5 0.422856
BTG1 B-cell translocation gene 1, anti-proliferative 0.422709
CYSTM1 cysteine-rich transmembrane module containing 1 0.42246
SH3KBP1 SH3-domain kinase binding protein 1 0.422357
ZYX zyxin 0.421635
ZNHIT1 zinc finger, HIT-type containing 1 0.419866
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 0.419866
GLIPR1 GLI pathogenesis-related 1 0.418406
MT1E metallothionein 1E 0.416489
UNC13A unc-13 homolog A (C. elegans) 0.416489
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.416377
OSCAR osteoclast associated, immunoglobulin-like receptor 0.415843
LINC02762 long intergenic non-protein coding RNA 2762 0.411283
KRT15 keratin 15, type I 0.411199
COL22A1 collagen, type XXII, alpha 1 0.407077
DOCK4 dedicator of cytokinesis 4 0.405281
SMOX spermine oxidase 0.401338
COL4A2 collagen, type IV, alpha 2 0.397941
VGLL3 vestigial-like family member 3 0.397566
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.395266
FURIN furin (paired basic amino acid cleaving enzyme) 0.395056
TUBA1A tubulin, alpha 1a 0.393947
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.390906
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.388555
CST3 cystatin C 0.386925
RFTN1 raftlin, lipid raft linker 1 0.386495
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.385427
FRMD8 FERM domain containing 8 0.384113
MUC12 mucin 12, cell surface associated 0.3838
INSL4 insulin-like 4 (placenta) 0.38156
GSTP1 glutathione S-transferase pi 1 0.380954
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.379585
ARC activity-regulated cytoskeleton-associated protein 0.379585
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 0.378962
A4GALT alpha 1,4-galactosyltransferase 0.378948
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.376644
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.374281
TGM2 transglutaminase 2 0.372687
EPHA2 EPH receptor A2 0.372494
TPI1 triosephosphate isomerase 1 0.368631
PGK1 phosphoglycerate kinase 1 0.368183
MTCH1 mitochondrial carrier 1 0.368183
DNMBP dynamin binding protein 0.365872
WNT7A wingless-type MMTV integration site family, member 7A 0.365446
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.364331
ZNF185 zinc finger protein 185 (LIM domain) 0.363646
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.361447
ETV5 ets variant 5 0.361447
SAR1A secretion associated, Ras related GTPase 1A 0.359505
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.358673
CD9 CD9 molecule 0.358359
RPL31 ribosomal protein L31 0.354738
ITM2C integral membrane protein 2C 0.352419
WDR45 WD repeat domain 45 0.352219
FBXO32 F-box protein 32 0.350462
EFHD2 EF-hand domain family, member D2 0.34875
CD99 CD99 molecule 0.347362
IFI27L2 interferon, alpha-inducible protein 27-like 2 0.345055
OASL 2'-5'-oligoadenylate synthetase-like 0.342479
BMP2 bone morphogenetic protein 2 0.341697
GUK1 guanylate kinase 1 0.341083
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.339715
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.338017
RGL2 ral guanine nucleotide dissociation stimulator-like 2 0.337865
PLXNA2 plexin A2 0.337865
PXDN peroxidasin 0.337674
ERRFI1 ERBB receptor feedback inhibitor 1 0.336921
DUSP7 dual specificity phosphatase 7 0.336816
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 0.336464
TWF2 twinfilin actin binding protein 2 0.335443
EGR4 early growth response 4 0.334953
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.334151
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.333854
TSPAN5 tetraspanin 5 0.33376
MED10 mediator complex subunit 10 0.333347
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 0.333097
TMEM171 transmembrane protein 171 0.333097
CDYL2 chromodomain protein, Y-like 2 0.331758
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.331269
BCAP31 B-cell receptor-associated protein 31 0.328134
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.325269
SSR4 signal sequence receptor, delta 0.323329
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.323024
RSL24D1 ribosomal L24 domain containing 1 0.321669
SERTAD1 SERTA domain containing 1 0.320339
S100A9 S100 calcium binding protein A9 0.318922
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.317837
SGK1 serum/glucocorticoid regulated kinase 1 0.316992
MCRIP1 MAPK regulated corepressor interacting protein 1 0.316482
TRIB1 tribbles pseudokinase 1 0.31647
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.314345
NLRP3 NLR family, pyrin domain containing 3 0.313144
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.312913
USB1 U6 snRNA biogenesis 1 0.312774
SPRY2 sprouty homolog 2 (Drosophila) 0.312001
HEBP2 heme binding protein 2 0.311965
KLF6 Kruppel-like factor 6 0.309005
VEGFC vascular endothelial growth factor C 0.308301
EXTL3 exostosin-like glycosyltransferase 3 0.307301
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.306992
DCLK1 doublecortin-like kinase 1 0.306899
LRRC8A leucine rich repeat containing 8 family, member A 0.304989
KLF7 Kruppel-like factor 7 (ubiquitous) 0.303694
SMIM29 small integral membrane protein 29 0.30017
CEMIP cell migration inducing protein, hyaluronan binding 0.299854
FSCN1 fascin actin-bundling protein 1 0.297171
HMGA2 high mobility group AT-hook 2 0.29681
S100A10 S100 calcium binding protein A10 0.296597
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.296023
LGALS3 lectin, galactoside-binding, soluble, 3 0.294431
MAX MYC associated factor X 0.294208
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.292991
AVPI1 arginine vasopressin-induced 1 0.292101
ISG15 ISG15 ubiquitin-like modifier 0.292101
SEC61G Sec61 gamma subunit 0.290762
RPS19BP1 ribosomal protein S19 binding protein 1 0.290762
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.290644
BEGAIN brain-enriched guanylate kinase-associated 0.289387
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.287813
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.287237
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.286938
SRPX sushi-repeat containing protein, X-linked 0.28136
C3ORF52 chromosome 3 open reading frame 52 0.278851
EMC3 ER membrane protein complex subunit 3 0.278639
EHBP1L1 EH domain binding protein 1-like 1 0.278258
RPL37 ribosomal protein L37 0.278258
HPCAL1 hippocalcin-like 1 0.277357
TRNP1 TMF1-regulated nuclear protein 1 0.276761
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.27637
MYADM myeloid-associated differentiation marker 0.274428
TRIB3 tribbles pseudokinase 3 0.273638
STX1A syntaxin 1A (brain) 0.272906
TAGLN2 transgelin 2 0.272906
SELENOS selenoprotein S 0.271898
EMILIN2 elastin microfibril interfacer 2 0.270157
CRIP2 cysteine-rich protein 2 0.265996
TMEM219 transmembrane protein 219 0.26539
TRIM8 tripartite motif containing 8 0.264215
RPLP2 ribosomal protein, large, P2 0.263365
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.260973
MT1X metallothionein 1X 0.258537
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.256038
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.255319
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.253997
SLC66A1 solute carrier family 66 member 1 0.253997
MGST3 microsomal glutathione S-transferase 3 0.253609
MPG N-methylpurine-DNA glycosylase 0.253609
MYDGF myeloid-derived growth factor 0.253485
MRPL51 mitochondrial ribosomal protein L51 0.251925
SERINC3 serine incorporator 3 0.251701
CD3D CD3d molecule, delta (CD3-TCR complex) 0.250271
TPBG trophoblast glycoprotein 0.249881
EMP3 epithelial membrane protein 3 0.249597
POU2F2 POU class 2 homeobox 2 0.24956
PDPN podoplanin 0.249468
FERMT1 fermitin family member 1 0.247834
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.247608
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 0.245201
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.245034
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.244897
TLE5 TLE family member 5, transcriptional modulator 0.243625
TMEM154 transmembrane protein 154 0.242571
LAMB3 laminin, beta 3 0.242571
SDC4 syndecan 4 0.239803
NPAS2 neuronal PAS domain protein 2 0.239655
TUBA1B tubulin, alpha 1b 0.235823
PLK3 polo-like kinase 3 0.235684
ATG101 autophagy related 101 0.234593
SELENOM selenoprotein M 0.234168
MGLL monoglyceride lipase 0.233404
HHIP hedgehog interacting protein 0.232567
JUP junction plakoglobin 0.232567
TOX4 TOX high mobility group box family member 4 0.232567
SYP synaptophysin 0.232237
CIAO2B cytosolic iron-sulfur assembly component 2B 0.231902
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.231415
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.2314
CTPS1 CTP synthase 1 0.231061
CARD19 caspase recruitment domain family member 19 0.230989
P4HB prolyl 4-hydroxylase, beta polypeptide 0.23067
RPP21 ribonuclease P/MRP 21kDa subunit 0.228019
BIRC2 baculoviral IAP repeat containing 2 0.228019
IL4R interleukin 4 receptor 0.227985
GPSM3 G-protein signaling modulator 3 0.227731
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.227368
MLKL mixed lineage kinase domain-like 0.227024
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.226696
CD81 CD81 molecule 0.224627
CD40 CD40 molecule, TNF receptor superfamily member 5 0.224387
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.223892
FOSL1 FOS-like antigen 1 0.223892
MAP3K7CL MAP3K7 C-terminal like 0.222254
RPSA ribosomal protein SA 0.221297
RNF181 ring finger protein 181 0.221171
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.217983
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.217165
TIMP2 TIMP metallopeptidase inhibitor 2 0.217136
GNG11 guanine nucleotide binding protein (G protein), gamma 11 0.216985
DUSP5 dual specificity phosphatase 5 0.216504
TMOD1 tropomodulin 1 0.215629
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.214566
FRMD4A FERM domain containing 4A 0.214395
ZNF782 zinc finger protein 782 0.214294
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.213107
UTP25 UTP25 small subunit processome component 0.213025
VASP vasodilator-stimulated phosphoprotein 0.212553
FKBP1C FK506 binding protein 1C 0.21237
TPM4 tropomyosin 4 0.21237
GADD45A growth arrest and DNA-damage-inducible, alpha 0.21237
RTN4 reticulon 4 0.211262
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.211235
RPLP1 ribosomal protein, large, P1 0.211127
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 0.210763
GNG5 guanine nucleotide binding protein (G protein), gamma 5 0.209444
SUN3 Sad1 and UNC84 domain containing 3 0.208831
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.207915
MAP2K3 mitogen-activated protein kinase kinase 3 0.207915
PRELID1 PRELI domain containing 1 0.207784
HLA-E major histocompatibility complex, class I, E 0.207667
COL4A1 collagen, type IV, alpha 1 0.207303
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.20721
AKAP12 A kinase (PRKA) anchor protein 12 0.206651
FAM177A1 family with sequence similarity 177, member A1 0.204576
LRP10 low density lipoprotein receptor-related protein 10 0.204172
TGFA transforming growth factor, alpha 0.204126
PODXL podocalyxin-like 0.203717
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.20309
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 0.201493
DGKD diacylglycerol kinase, delta 130kDa 0.20124
CKB creatine kinase, brain 0.201156
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.201156
SORBS2 sorbin and SH3 domain containing 2 0.200543
LRRC8C leucine rich repeat containing 8 family, member C 0.200458
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 0.200458
KDM7A lysine (K)-specific demethylase 7A 0.200176
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.200093

decreased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -7.55322
PCLO piccolo presynaptic cytomatrix protein -5.43824
CLPTM1L CLPTM1-like -4.4855
EDN2 endothelin 2 -4.19033
PDLIM1 PDZ and LIM domain 1 -3.73393
GSTM4 glutathione S-transferase mu 4 -3.34272
FDXR ferredoxin reductase -3.14024
CENPM centromere protein M -3.11861
TRIP6 thyroid hormone receptor interactor 6 -2.66004
PCLAF PCNA clamp associated factor -2.19333
FHL2 four and a half LIM domains 2 -1.91339
SDC2 syndecan 2 -1.85557
TNNT2 troponin T type 2 (cardiac) -1.77337
TCEAL2 transcription elongation factor A (SII)-like 2 -1.69471
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -1.55907
MAGED1 melanoma antigen family D1 -1.55197
HAPLN1 hyaluronan and proteoglycan link protein 1 -1.53752
BMP4 bone morphogenetic protein 4 -1.52728
LOXL4 lysyl oxidase-like 4 -1.46449
MCM3 minichromosome maintenance complex component 3 -1.45151
TYMS thymidylate synthetase -1.44421
TPM1 tropomyosin 1 (alpha) -1.44207
TMSB4X thymosin beta 4, X-linked -1.4394
ALOX5 arachidonate 5-lipoxygenase -1.39285
HSPA1A heat shock 70kDa protein 1A -1.37496
AP1M2 adaptor-related protein complex 1, mu 2 subunit -1.37159
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -1.35257
STMN1 stathmin 1 -1.3506
CDK4 cyclin-dependent kinase 4 -1.20851
MCM7 minichromosome maintenance complex component 7 -1.17398
TRIM16 tripartite motif containing 16 -1.14641
KRT80 keratin 80, type II -1.14227
TUBB tubulin, beta class I -1.13424
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -1.1307
TK1 thymidine kinase 1, soluble -1.10643
CPA4 carboxypeptidase A4 -1.08934
TNNI3 troponin I type 3 (cardiac) -1.06414
LAYN layilin -1.04091
MDK midkine (neurite growth-promoting factor 2) -1.01062
CRABP2 cellular retinoic acid binding protein 2 -0.990672
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -0.954622
NFIB nuclear factor I/B -0.906022
HRCT1 histidine rich carboxyl terminus 1 -0.902619
SIVA1 SIVA1, apoptosis-inducing factor -0.86902
ABLIM1 actin binding LIM protein 1 -0.854346
RRM2 ribonucleotide reductase M2 -0.852245
ANO2 anoctamin 2, calcium activated chloride channel -0.849984
TMEM106C transmembrane protein 106C -0.849984
WFS1 Wolfram syndrome 1 (wolframin) -0.849435
NONO non-POU domain containing, octamer-binding -0.845111
ZNF404 zinc finger protein 404 -0.82717
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.803546
MTUS1 microtubule associated tumor suppressor 1 -0.788875
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.784856
INKA2 inka box actin regulator 2 -0.768302
GXYLT2 glucoside xylosyltransferase 2 -0.766008
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -0.752442
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.744601
AKIP1 A kinase (PRKA) interacting protein 1 -0.7325
CD70 CD70 molecule -0.718313
RPP25L ribonuclease P/MRP 25kDa subunit-like -0.700987
CXCL14 chemokine (C-X-C motif) ligand 14 -0.6987
DTYMK deoxythymidylate kinase (thymidylate kinase) -0.690736
PLK2 polo-like kinase 2 -0.687768
TMEM37 transmembrane protein 37 -0.686383
KHK ketohexokinase (fructokinase) -0.674975
SAC3D1 SAC3 domain containing 1 -0.663136
ANXA10 annexin A10 -0.662327
RPS27L ribosomal protein S27-like -0.659885
PHGDH phosphoglycerate dehydrogenase -0.659885
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 -0.651472
DDB2 damage-specific DNA binding protein 2, 48kDa -0.648277
WNT11 wingless-type MMTV integration site family, member 11 -0.643086
REXO2 RNA exonuclease 2 -0.629119
GPX1 glutathione peroxidase 1 -0.621811
COL16A1 collagen, type XVI, alpha 1 -0.596538
CYB5A cytochrome b5 type A (microsomal) -0.588929
CTSH cathepsin H -0.584163
NPPB natriuretic peptide B -0.571723
GPC1 glypican 1 -0.570715
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.570598
ADORA2B adenosine A2b receptor -0.567846
LOXL1 lysyl oxidase-like 1 -0.565
MMP24 matrix metallopeptidase 24 (membrane-inserted) -0.563965
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.552364
DYSF dysferlin -0.544181
F2R coagulation factor II (thrombin) receptor -0.536145
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.527656
LAMA5 laminin, alpha 5 -0.52313
SSC4D scavenger receptor cysteine rich family, 4 domains -0.520245
CYFIP2 cytoplasmic FMR1 interacting protein 2 -0.513758
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.503145
MCM6 minichromosome maintenance complex component 6 -0.495853
PRPF19 pre-mRNA processing factor 19 -0.492476
GAMT guanidinoacetate N-methyltransferase -0.490257
MOB3B MOB kinase activator 3B -0.48813
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -0.487092
RAB26 RAB26, member RAS oncogene family -0.484237
RAD54L RAD54-like (S. cerevisiae) -0.481388
NIPSNAP1 nipsnap homolog 1 (C. elegans) -0.478525
FOXO6 forkhead box O6 -0.470184
C11ORF71 chromosome 11 open reading frame 71 -0.469918
CHD4 chromodomain helicase DNA binding protein 4 -0.469023
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 -0.44964
ATP5MC1 ATP synthase membrane subunit c locus 1 -0.4437
ACKR3 atypical chemokine receptor 3 -0.441869
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -0.439204
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -0.438486
TBC1D2 TBC1 domain family, member 2 -0.437706
RAB7B RAB7B, member RAS oncogene family -0.432321
LRRN1 leucine rich repeat neuronal 1 -0.431152
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -0.422856
TGFB2 transforming growth factor, beta 2 -0.421472
NAP1L1 nucleosome assembly protein 1-like 1 -0.419538
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.417073
DUT deoxyuridine triphosphatase -0.416489
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.41631
C1ORF198 chromosome 1 open reading frame 198 -0.414202
KANK2 KN motif and ankyrin repeat domains 2 -0.413298
ZNF395 zinc finger protein 395 -0.400942
FBL fibrillarin -0.400421
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.395056
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.391371
MCM5 minichromosome maintenance complex component 5 -0.389468
STRA6 stimulated by retinoic acid 6 -0.388555
E2F2 E2F transcription factor 2 -0.386495
FBXO2 F-box protein 2 -0.384933
RAB11FIP4 RAB11 family interacting protein 4 (class II) -0.384278
DAAM2 dishevelled associated activator of morphogenesis 2 -0.384113
URGCP-MRPS24 URGCP-MRPS24 readthrough -0.383134
NINJ1 ninjurin 1 -0.382684
SCRN2 secernin 2 -0.382115
ZNF850 zinc finger protein 850 -0.379997
BIRC7 baculoviral IAP repeat containing 7 -0.378139
FEN1 flap structure-specific endonuclease 1 -0.375133
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.373897
TMEM45A transmembrane protein 45A -0.370973
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -0.368466
TACC3 transforming, acidic coiled-coil containing protein 3 -0.365872
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -0.362125
ACOD1 aconitate decarboxylase 1 -0.360352
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.356636
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -0.350311
FOXS1 forkhead box S1 -0.34875
XPC xeroderma pigmentosum, complementation group C -0.344615
BABAM2 BRISC and BRCA1 A complex member 2 -0.343817
CTSC cathepsin C -0.341232
PLAC8 placenta-specific 8 -0.340616
ASIC1 acid sensing (proton gated) ion channel 1 -0.338683
POMZP3 POM121 and ZP3 fusion -0.336558
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.335593
NTHL1 nth endonuclease III-like 1 (E. coli) -0.334674
UXT ubiquitously-expressed, prefoldin-like chaperone -0.334601
TELO2 telomere maintenance 2 -0.334151
CNPY4 canopy FGF signaling regulator 4 -0.334151
C1QTNF2 C1q and tumor necrosis factor related protein 2 -0.33254
MOV10 Mov10 RISC complex RNA helicase -0.331269
WDR7 WD repeat domain 7 -0.331269
ASTN2 astrotactin 2 -0.329897
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.326537
CDKN3 cyclin-dependent kinase inhibitor 3 -0.322136
TRIM28 tripartite motif containing 28 -0.321739
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -0.320648
WDR70 WD repeat domain 70 -0.316278
BAX BCL2-associated X protein -0.314822
MFSD3 major facilitator superfamily domain containing 3 -0.314345
CCDC80 coiled-coil domain containing 80 -0.308854
FLOT1 flotillin 1 -0.305953
GKN1 gastrokine 1 -0.30443
S100A4 S100 calcium binding protein A4 -0.30432
SFXN2 sideroflexin 2 -0.302143
TMSB15B thymosin beta 15B -0.299531
MRI1 methylthioribose-1-phosphate isomerase 1 -0.297616
CCDC62 coiled-coil domain containing 62 -0.29314
TRIM37 tripartite motif containing 37 -0.29314
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -0.292836
SMAD6 SMAD family member 6 -0.291546
HUNK hormonally up-regulated Neu-associated kinase -0.28867
TIMELESS timeless circadian clock -0.288421
GSDMD gasdermin D -0.284692
APLP1 amyloid beta (A4) precursor-like protein 1 -0.284567
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.284204
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.280227
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.279961
RHOBTB3 Rho-related BTB domain containing 3 -0.279758
RUNX2 runt-related transcription factor 2 -0.279538
PARP2 poly (ADP-ribose) polymerase 2 -0.279176
ZFP90 ZFP90 zinc finger protein -0.279009
NEIL1 nei endonuclease VIII-like 1 (E. coli) -0.277417
SDC1 syndecan 1 -0.276969
RNF187 ring finger protein 187 -0.273537
PPME1 protein phosphatase methylesterase 1 -0.272906
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.270157
CNFN cornifelin -0.267905
ARSI arylsulfatase family, member I -0.26646
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.26646
WDR76 WD repeat domain 76 -0.266291
CYB5RL cytochrome b5 reductase-like -0.26539
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 -0.265126
ANXA8L1 annexin A8-like 1 -0.263394
HMGB2 high mobility group box 2 -0.260973
C21ORF58 chromosome 21 open reading frame 58 -0.260613
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.25904
BPHL biphenyl hydrolase-like (serine hydrolase) -0.258193
TGM1 transglutaminase 1 -0.257096
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.257096
PER3 period circadian clock 3 -0.256914
PDLIM2 PDZ and LIM domain 2 (mystique) -0.255722
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.253997
PRPF8 pre-mRNA processing factor 8 -0.253997
VAMP5 vesicle-associated membrane protein 5 -0.253997
CHAF1B chromatin assembly factor 1, subunit B (p60) -0.250813
COL1A1 collagen, type I, alpha 1 -0.250813
PSD3 pleckstrin and Sec7 domain containing 3 -0.250813
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.250221
SOCS1 suppressor of cytokine signaling 1 -0.250071
OLFML3 olfactomedin-like 3 -0.24958
YBX2 Y box binding protein 2 -0.24956
MTMR4 myotubularin related protein 4 -0.249344
AURKB aurora kinase B -0.248745
EIF3B eukaryotic translation initiation factor 3, subunit B -0.247706
ILDR2 immunoglobulin-like domain containing receptor 2 -0.247433
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.247236
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.245201
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -0.242272
BEX3 brain expressed X-linked 3 -0.242211
CCHCR1 coiled-coil alpha-helical rod protein 1 -0.242056
MAB21L4 mab-21 like 4 -0.241861
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.241722
FGF21 fibroblast growth factor 21 -0.241709
SERTAD4 SERTA domain containing 4 -0.240227
PNMA6A paraneoplastic Ma antigen family member 6A -0.236634
TPD52L1 tumor protein D52-like 1 -0.236306
SETMAR SET domain and mariner transposase fusion gene -0.235947
ROGDI rogdi homolog (Drosophila) -0.235411
GPNMB glycoprotein (transmembrane) nmb -0.232783
KRT75 keratin 75, type II -0.232432
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -0.232188
SAFB scaffold attachment factor B -0.231596
TFDP1 transcription factor Dp-1 -0.231231
MACROD1 MACRO domain containing 1 -0.230989
LMCD1 LIM and cysteine-rich domains 1 -0.230146
NXN nucleoredoxin -0.229677
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 -0.228435
NTPCR nucleoside-triphosphatase, cancer-related -0.228314
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -0.227985
RASD2 RASD family, member 2 -0.227985
SNRPA small nuclear ribonucleoprotein polypeptide A -0.227074
ZXDB zinc finger, X-linked, duplicated B -0.226591
CCDC85B coiled-coil domain containing 85B -0.225479
UCK1 uridine-cytidine kinase 1 -0.224721
COMMD4 COMM domain containing 4 -0.224627
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit -0.224387
CCDC71 coiled-coil domain containing 71 -0.22412
WNT6 wingless-type MMTV integration site family, member 6 -0.222481
STAC SH3 and cysteine rich domain -0.222254
SPIRE2 spire-type actin nucleation factor 2 -0.221463
TRIM5 tripartite motif containing 5 -0.219126
SHOC1 shortage in chiasmata 1 -0.219126
FBXO22 F-box protein 22 -0.218322
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 -0.217291
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.216298
SHISA9 shisa family member 9 -0.216023
MN1 meningioma (disrupted in balanced translocation) 1 -0.215868
TLCD4 TLC domain containing 4 -0.214601
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -0.214575
INAFM1 InaF-motif containing 1 -0.213878
EPB41 erythrocyte membrane protein band 4.1 -0.213568
PDE7A phosphodiesterase 7A -0.2134
NELFE negative elongation factor complex member E -0.213063
IGSF9 immunoglobulin superfamily, member 9 -0.212675
NDN necdin, melanoma antigen (MAGE) family member -0.211914
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -0.211207
PTGES2 prostaglandin E synthase 2 -0.210763
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -0.210664
PTOV1 prostate tumor overexpressed 1 -0.210175
GLIS2 GLIS family zinc finger 2 -0.210145
RING1 ring finger protein 1 -0.209979
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -0.208703
DCHS2 dachsous cadherin-related 2 -0.207832
KREMEN2 kringle containing transmembrane protein 2 -0.207451
TEDC2 tubulin epsilon and delta complex 2 -0.206651
PALLD palladin, cytoskeletal associated protein -0.206651
MYLK myosin light chain kinase -0.206319
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -0.206134
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -0.205291
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -0.204215
CBX1 chromobox homolog 1 -0.204193
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.204172
CAV1 caveolin 1, caveolae protein, 22kDa -0.203812
CREB3L4 cAMP responsive element binding protein 3-like 4 -0.20309
KAT14 lysine acetyltransferase 14 -0.20309
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -0.202379
PLCE1 phospholipase C, epsilon 1 -0.202176
TXNRD3 thioredoxin reductase 3 -0.201666
DIPK1B divergent protein kinase domain 1B -0.200909