MA-58-RR04_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, VU-0238429, M5 positive allosteric modulator targeting CHRM5 (Novartis, 42633508)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/42633508
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Genes

1073 genes differentially expressed following the MA-58-RR04_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
TAGLN transgelin 8.13075
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 5.68596
KRT17 keratin 17, type I 4.87268
HRNR hornerin 4.47757
MT2A metallothionein 2A 3.92121
UPP1 uridine phosphorylase 1 3.12758
TIMP1 TIMP metallopeptidase inhibitor 1 2.86216
SDC4 syndecan 4 2.84711
CSRP1 cysteine and glycine-rich protein 1 2.80771
SMAGP small cell adhesion glycoprotein 2.59498
RHOC ras homolog family member C 2.53257
CDC20 cell division cycle 20 2.49697
PLAUR plasminogen activator, urokinase receptor 2.40195
LINC02762 long intergenic non-protein coding RNA 2762 2.37601
CD63 CD63 molecule 2.28581
RANGAP1 Ran GTPase activating protein 1 2.17629
PDLIM4 PDZ and LIM domain 4 2.17629
PFN1 profilin 1 2.12632
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 2.04248
TSPO translocator protein (18kDa) 1.9822
TGM2 transglutaminase 2 1.86866
EIF6 eukaryotic translation initiation factor 6 1.72686
PCSK7 proprotein convertase subtilisin/kexin type 7 1.66117
KISS1 KiSS-1 metastasis-suppressor 1.64331
MRPS34 mitochondrial ribosomal protein S34 1.55223
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 1.53198
MT1E metallothionein 1E 1.50958
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 1.47977
CIB1 calcium and integrin binding 1 (calmyrin) 1.44316
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.43002
KRT18 keratin 18, type I 1.3881
CCL3 chemokine (C-C motif) ligand 3 1.37203
RHOF ras homolog family member F (in filopodia) 1.36064
C11ORF24 chromosome 11 open reading frame 24 1.35096
SYTL3 synaptotagmin-like 3 1.34527
TM4SF1 transmembrane 4 L six family member 1 1.34527
PHLDA2 pleckstrin homology-like domain, family A, member 2 1.32157
PFDN2 prefoldin subunit 2 1.30393
KIFC3 kinesin family member C3 1.28589
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 1.26984
INSL4 insulin-like 4 (placenta) 1.26476
KRT34 keratin 34, type I 1.21005
GLRX glutaredoxin (thioltransferase) 1.20428
ZYX zyxin 1.19521
MYL9 myosin, light chain 9, regulatory 1.19447
ADRM1 adhesion regulating molecule 1 1.18851
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 1.18548
RPS19BP1 ribosomal protein S19 binding protein 1 1.18484
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.16913
HMGA1 high mobility group AT-hook 1 1.16604
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.12341
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 1.1199
OCIAD2 OCIA domain containing 2 1.1157
SPHK1 sphingosine kinase 1 1.10789
FOXD1 forkhead box D1 1.08805
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.06193
MAP2K3 mitogen-activated protein kinase kinase 3 1.05727
ETV4 ets variant 4 1.03435
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 1.03241
AUP1 ancient ubiquitous protein 1 1.03003
PLEC plectin 1.02599
ZNHIT1 zinc finger, HIT-type containing 1 1.02403
CLMB calcimembrin 1.00549
SPNS1 spinster homolog 1 (Drosophila) 0.985312
KRTAP2-3 keratin associated protein 2-3 0.982591
RNF145 ring finger protein 145 0.96394
CLIC1 chloride intracellular channel 1 0.958994
TOMM34 translocase of outer mitochondrial membrane 34 0.942321
EPHA2 EPH receptor A2 0.937326
SLC66A2 solute carrier family 66 member 2 0.929021
IL11 interleukin 11 0.927901
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 0.923124
GUK1 guanylate kinase 1 0.909389
RUVBL2 RuvB-like AAA ATPase 2 0.907514
IL24 interleukin 24 0.895734
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.889868
NOP16 NOP16 nucleolar protein 0.886605
RPS15 ribosomal protein S15 0.886221
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.878799
OSBP2 oxysterol binding protein 2 0.874252
CTTN cortactin 0.867791
IFRD2 interferon-related developmental regulator 2 0.863199
COTL1 coactosin-like F-actin binding protein 1 0.85309
DVL1 dishevelled segment polarity protein 1 0.833161
PXDN peroxidasin 0.817436
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 0.813283
TMSB10 thymosin beta 10 0.811886
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 0.809992
EFHD2 EF-hand domain family, member D2 0.80044
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 0.800376
BCAP31 B-cell receptor-associated protein 31 0.79988
MTCH1 mitochondrial carrier 1 0.794915
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.785545
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.784434
CD59 CD59 molecule, complement regulatory protein 0.776005
ERCC1 excision repair cross-complementation group 1 0.772862
ZNF593 zinc finger protein 593 0.772773
MYDGF myeloid-derived growth factor 0.767681
FOSL1 FOS-like antigen 1 0.762957
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.757438
MYCT1 myc target 1 0.75734
IL18 interleukin 18 0.753776
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.752762
CLTB clathrin, light chain B 0.752185
EXOSC4 exosome component 4 0.751649
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.741848
BIRC5 baculoviral IAP repeat containing 5 0.741483
CIAO2B cytosolic iron-sulfur assembly component 2B 0.741483
FN1 fibronectin 1 0.739821
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.739004
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.738911
PTTG1 pituitary tumor-transforming 1 0.732883
COMMD5 COMM domain containing 5 0.731437
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.727573
CSNK1E casein kinase 1, epsilon 0.709128
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.701326
GSTO1 glutathione S-transferase omega 1 0.69901
TRPM2 transient receptor potential cation channel, subfamily M, member 2 0.697974
IRAK1 interleukin-1 receptor-associated kinase 1 0.68808
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 0.687957
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.684758
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 0.683488
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.676316
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.675858
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 0.67575
SSR4 signal sequence receptor, delta 0.67063
HMOX2 heme oxygenase 2 0.66796
UBTD1 ubiquitin domain containing 1 0.666079
TACC1 transforming, acidic coiled-coil containing protein 1 0.665566
ASB1 ankyrin repeat and SOCS box containing 1 0.663785
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.663785
TBRG4 transforming growth factor beta regulator 4 0.656279
TMEM147 transmembrane protein 147 0.650637
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.648326
MT1H metallothionein 1H 0.647856
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.646657
HSPA8 heat shock 70kDa protein 8 0.64253
ARC activity-regulated cytoskeleton-associated protein 0.635099
ITGB5 integrin, beta 5 0.633893
PRELID1 PRELI domain containing 1 0.633692
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.623782
EXTL3 exostosin-like glycosyltransferase 3 0.620127
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.611317
FRMD6 FERM domain containing 6 0.610035
MAP7D1 MAP7 domain containing 1 0.606612
MCRIP1 MAPK regulated corepressor interacting protein 1 0.605988
ATG101 autophagy related 101 0.602816
RPS2 ribosomal protein S2 0.599597
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.591414
MFSD2B major facilitator superfamily domain containing 2B 0.58874
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.586263
WDR1 WD repeat domain 1 0.585493
UBALD2 UBA-like domain containing 2 0.575852
POTEF POTE ankyrin domain family, member F 0.573065
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.571304
NELFB negative elongation factor complex member B 0.567259
FXYD5 FXYD domain containing ion transport regulator 5 0.565757
EMILIN2 elastin microfibril interfacer 2 0.563911
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.563911
ZNF598 zinc finger protein 598 0.562742
SCG5 secretogranin V 0.562575
RPL35 ribosomal protein L35 0.5625
AVPI1 arginine vasopressin-induced 1 0.560021
PHC2 polyhomeotic homolog 2 (Drosophila) 0.55737
MRPS2 mitochondrial ribosomal protein S2 0.555961
CCNI cyclin I 0.555961
SMTN smoothelin 0.555731
B3GAT3 beta-1,3-glucuronyltransferase 3 0.555729
SH3GL1 SH3-domain GRB2-like 1 0.555719
SCAMP3 secretory carrier membrane protein 3 0.552985
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.551427
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 0.550789
COMMD7 COMM domain containing 7 0.550789
UBB ubiquitin B 0.55025
PUF60 poly-U binding splicing factor 60KDa 0.547861
GRAMD1B GRAM domain containing 1B 0.543761
ATG4B autophagy related 4B, cysteine peptidase 0.540868
EEF1AKMT4 EEF1A lysine methyltransferase 4 0.53783
NUDC nudC nuclear distribution protein 0.537553
ITM2C integral membrane protein 2C 0.537099
RPS9 ribosomal protein S9 0.534108
PPIF peptidylprolyl isomerase F 0.531623
KRT15 keratin 15, type I 0.529762
DNMBP dynamin binding protein 0.528818
SNU13 small nuclear ribonucleoprotein 13 0.517992
TMEM160 transmembrane protein 160 0.515394
CENPT centromere protein T 0.515394
MRPL4 mitochondrial ribosomal protein L4 0.514779
ATOX1 antioxidant 1 copper chaperone 0.514327
RBM42 RNA binding motif protein 42 0.507008
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 0.503363
TMED3 transmembrane emp24 protein transport domain containing 3 0.499418
TPST1 tyrosylprotein sulfotransferase 1 0.496829
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.49429
YDJC YdjC homolog (bacterial) 0.491618
ACTG2 actin, gamma 2, smooth muscle, enteric 0.490241
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.486798
CCNB1 cyclin B1 0.485723
FGF1 fibroblast growth factor 1 (acidic) 0.483439
UBE2S ubiquitin-conjugating enzyme E2S 0.481175
AADAC arylacetamide deacetylase 0.481005
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 0.474471
TXNL4A thioredoxin-like 4A 0.471466
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.471342
BOP1 block of proliferation 1 0.471316
C8ORF33 chromosome 8 open reading frame 33 0.468139
RELT RELT tumor necrosis factor receptor 0.467346
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.464203
SLAMF9 SLAM family member 9 0.464032
AMPD2 adenosine monophosphate deaminase 2 0.463056
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.462946
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.462312
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.4621
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 0.461875
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 0.460924
PLAU plasminogen activator, urokinase 0.458696
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.458696
COPE coatomer protein complex, subunit epsilon 0.458581
PLIN3 perilipin 3 0.458346
ARHGAP22 Rho GTPase activating protein 22 0.45808
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.457354
GALE UDP-galactose-4-epimerase 0.451456
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.449713
DCTPP1 dCTP pyrophosphatase 1 0.449713
FARSA phenylalanyl-tRNA synthetase, alpha subunit 0.44907
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.447399
RPL18A ribosomal protein L18a 0.447193
TROAP trophinin associated protein 0.447135
CYSTM1 cysteine-rich transmembrane module containing 1 0.445822
SELENOM selenoprotein M 0.445822
RSL1D1 ribosomal L1 domain containing 1 0.440728
ATAD3B ATPase family, AAA domain containing 3B 0.440728
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.438665
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.438406
LRRC8A leucine rich repeat containing 8 family, member A 0.437187
CUTA cutA divalent cation tolerance homolog (E. coli) 0.435186
BCL2A1 BCL2-related protein A1 0.434649
CUEDC1 CUE domain containing 1 0.43343
RPSA ribosomal protein SA 0.433281
PQBP1 polyglutamine binding protein 1 0.431813
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.431619
CSNK2B casein kinase 2, beta polypeptide 0.427343
WDR13 WD repeat domain 13 0.424747
SF3B5 splicing factor 3b, subunit 5, 10kDa 0.421584
HLA-E major histocompatibility complex, class I, E 0.415395
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.415041
SYNGR2 synaptogyrin 2 0.411276
EMC6 ER membrane protein complex subunit 6 0.408261
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.407677
MRPL12 mitochondrial ribosomal protein L12 0.407677
NANS N-acetylneuraminic acid synthase 0.407278
TMEM109 transmembrane protein 109 0.407146
CD44 CD44 molecule (Indian blood group) 0.405269
NOP10 NOP10 ribonucleoprotein 0.404004
PES1 pescadillo ribosomal biogenesis factor 1 0.402908
RNF181 ring finger protein 181 0.400049
DEF8 differentially expressed in FDCP 8 homolog (mouse) 0.399068
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.398905
CAVIN1 caveolae associated protein 1 0.398668
NOL6 nucleolar protein 6 (RNA-associated) 0.397784
PPY pancreatic polypeptide 0.397727
UBE2M ubiquitin-conjugating enzyme E2M 0.395964
GLIPR1 GLI pathogenesis-related 1 0.393601
CHPF chondroitin polymerizing factor 0.393372
RNASEK ribonuclease, RNase K 0.392874
TPD52L2 tumor protein D52-like 2 0.391419
GPR176 G protein-coupled receptor 176 0.390613
IFITM3 interferon induced transmembrane protein 3 0.389907
KLF16 Kruppel-like factor 16 0.389391
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.388441
ILK integrin-linked kinase 0.387942
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 0.387114
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.386995
FGF5 fibroblast growth factor 5 0.386658
LIMK2 LIM domain kinase 2 0.386658
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.38306
MTLN mitoregulin 0.381207
WDR45 WD repeat domain 45 0.379793
ZNRD2 zinc ribbon domain containing 2 0.379072
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.377614
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.377316
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.376195
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.37528
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.375086
MVP major vault protein 0.371741
HBEGF heparin-binding EGF-like growth factor 0.371741
PLPP2 phospholipid phosphatase 2 0.371368
NHP2 NHP2 ribonucleoprotein 0.37006
MRPL15 mitochondrial ribosomal protein L15 0.36899
SERF2 small EDRK-rich factor 2 0.368935
HPCAL1 hippocalcin-like 1 0.368082
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.367376
MFAP5 microfibrillar associated protein 5 0.366399
CST3 cystatin C 0.366399
GPSM1 G-protein signaling modulator 1 0.366319
ELOVL1 ELOVL fatty acid elongase 1 0.366251
VGF VGF nerve growth factor inducible 0.366081
NNMT nicotinamide N-methyltransferase 0.364805
NOSIP nitric oxide synthase interacting protein 0.363297
TMEM205 transmembrane protein 205 0.362766
TSSC4 tumor suppressing subtransferable candidate 4 0.36262
TRAP1 TNF receptor-associated protein 1 0.361821
BIN3 bridging integrator 3 0.361673
RHOG ras homolog family member G 0.360918
CORO2B coronin, actin binding protein, 2B 0.360918
MRPL41 mitochondrial ribosomal protein L41 0.359263
MRPL52 mitochondrial ribosomal protein L52 0.359166
SFT2D1 SFT2 domain containing 1 0.358962
CD81 CD81 molecule 0.358962
TRIB3 tribbles pseudokinase 3 0.358362
PTGES3L-AARSD1 PTGES3L-AARSD1 readthrough 0.358026
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 0.357814
PPP6R1 protein phosphatase 6, regulatory subunit 1 0.357457
PRDX5 peroxiredoxin 5 0.356665
CTPS1 CTP synthase 1 0.355998
METTL26 methyltransferase like 26 0.353338
WWC1 WW and C2 domain containing 1 0.351216
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.350777
SLC25A39 solute carrier family 25, member 39 0.349945
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 0.349599
PTPRF protein tyrosine phosphatase, receptor type, F 0.347203
SCYL1 SCY1-like 1 (S. cerevisiae) 0.347005
MT1X metallothionein 1X 0.345051
ATP5MC1 ATP synthase membrane subunit c locus 1 0.345051
DUSP12 dual specificity phosphatase 12 0.344733
CORO1C coronin, actin binding protein, 1C 0.34451
MAF1 MAF1 homolog (S. cerevisiae) 0.344444
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.344142
RRP1B ribosomal RNA processing 1B 0.343253
LY6E lymphocyte antigen 6 complex, locus E 0.34313
DGKD diacylglycerol kinase, delta 130kDa 0.343105
ALG3 ALG3, alpha-1,3- mannosyltransferase 0.34308
TMEM208 transmembrane protein 208 0.34283
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.34261
FBXW5 F-box and WD repeat domain containing 5 0.340678
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.340079
INF2 inverted formin, FH2 and WH2 domain containing 0.340079
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.340079
MZT2B mitotic spindle organizing protein 2B 0.339677
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.33955
ALPL alkaline phosphatase, liver/bone/kidney 0.339032
NLRP3 NLR family, pyrin domain containing 3 0.338788
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.338521
MYL12B myosin, light chain 12B, regulatory 0.338521
COL13A1 collagen, type XIII, alpha 1 0.337746
LRRC59 leucine rich repeat containing 59 0.336872
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 0.336766
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.335766
EMP3 epithelial membrane protein 3 0.33524
TRAF4 TNF receptor-associated factor 4 0.335208
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.334916
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.334382
DPH2 DPH2 homolog (S. cerevisiae) 0.334226
GRWD1 glutamate-rich WD repeat containing 1 0.332881
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.332807
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.331899
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 0.331899
MED15 mediator complex subunit 15 0.331717
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.330268
STOML2 stomatin (EPB72)-like 2 0.33002
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 0.329405
CANT1 calcium activated nucleotidase 1 0.329334
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.3278
NIBAN2 niban apoptosis regulator 2 0.3278
TMEM171 transmembrane protein 171 0.327184
CAPN2 calpain 2, (m/II) large subunit 0.326972
JMJD6 jumonji domain containing 6 0.32571
SLC25A38 solute carrier family 25, member 38 0.325263
MGLL monoglyceride lipase 0.324691
GPATCH4 G patch domain containing 4 0.324022
LBHD1 LBH domain containing 1 0.323111
NSUN5 NOP2/Sun domain family, member 5 0.322819
RPL28 ribosomal protein L28 0.321465
BAD BCL2-associated agonist of cell death 0.32121
ATP5F1B ATP synthase F1 subunit beta 0.321172
SLC39A13 solute carrier family 39 (zinc transporter), member 13 0.320122
LSM10 LSM10, U7 small nuclear RNA associated 0.319805
TBL3 transducin (beta)-like 3 0.319564
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.319496
S100A6 S100 calcium binding protein A6 0.319142
EVA1A eva-1 homolog A (C. elegans) 0.318749
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.318013
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.317934
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.315568
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.314664
CSRNP1 cysteine-serine-rich nuclear protein 1 0.313827
S100A9 S100 calcium binding protein A9 0.313827
DNLZ DNL-type zinc finger 0.313827
GSK3A glycogen synthase kinase 3 alpha 0.313352
RFTN1 raftlin, lipid raft linker 1 0.312042
AURKAIP1 aurora kinase A interacting protein 1 0.309529
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.30945
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.308672
TAGLN3 transgelin 3 0.308511
RPLP2 ribosomal protein, large, P2 0.308301
MRPS17 mitochondrial ribosomal protein S17 0.308301
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 0.308301
GATAD2A GATA zinc finger domain containing 2A 0.308301
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.307532
TRAF1 TNF receptor-associated factor 1 0.306568
TANK TRAF family member-associated NFKB activator 0.30611
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 0.304037
FLNC filamin C, gamma 0.303245
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.303175
SFXN3 sideroflexin 3 0.302015
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 0.300745
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.300303
RPUSD1 RNA pseudouridylate synthase domain containing 1 0.299853
TBCB tubulin folding cofactor B 0.298836
GSTP1 glutathione S-transferase pi 1 0.297768
LGALS1 lectin, galactoside-binding, soluble, 1 0.297278
LEPROTL1 leptin receptor overlapping transcript-like 1 0.295556
MIIP migration and invasion inhibitory protein 0.2952
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.294766
TTLL12 tubulin tyrosine ligase-like family member 12 0.292668
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.292668
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 0.291494
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.290341
SERTAD1 SERTA domain containing 1 0.287523
TPM2 tropomyosin 2 (beta) 0.287309
IL32 interleukin 32 0.287091
SCO2 SCO2 cytochrome c oxidase assembly protein 0.286548
RPL29 ribosomal protein L29 0.28592
WDR54 WD repeat domain 54 0.285295
EIF3C eukaryotic translation initiation factor 3, subunit C 0.283657
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.283389
LMNA lamin A/C 0.283389
MRPS25 mitochondrial ribosomal protein S25 0.283389
SAA2 serum amyloid A2 0.282895
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.281752
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 0.281455
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.279957
EHBP1L1 EH domain binding protein 1-like 1 0.279361
CORO7-PAM16 CORO7-PAM16 readthrough 0.278362
DMKN dermokine 0.278291
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.277249
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.275278
TPRA1 transmembrane protein, adipocyte asscociated 1 0.274999
LDHA lactate dehydrogenase A 0.274799
WDR46 WD repeat domain 46 0.274799
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.274669
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.274319
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 0.27311
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.27311
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.272948
RANBP1 RAN binding protein 1 0.272948
AREG amphiregulin 0.272328
LAMA1 laminin, alpha 1 0.271959
TEAD4 TEA domain family member 4 0.27148
TM4SF19 transmembrane 4 L six family member 19 0.271206
MEAK7 MTOR associated protein, eak-7 homolog 0.270699
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.270168
WDR74 WD repeat domain 74 0.269598
CLUH clustered mitochondria (cluA/CLU1) homolog 0.268093
OAZ1 ornithine decarboxylase antizyme 1 0.267864
C12ORF42 chromosome 12 open reading frame 42 0.267792
MLXIP MLX interacting protein 0.267754
CD151 CD151 molecule (Raph blood group) 0.26748
INPPL1 inositol polyphosphate phosphatase-like 1 0.267229
SLC12A9 solute carrier family 12, member 9 0.267016
NPDC1 neural proliferation, differentiation and control, 1 0.267016
BUD31 BUD31 homolog (S. cerevisiae) 0.266581
RPL37 ribosomal protein L37 0.265758
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 0.265582
HLA-B major histocompatibility complex, class I, B 0.264539
NUBP2 nucleotide binding protein 2 0.264539
ATAD3A ATPase family, AAA domain containing 3A 0.264056
CCDC86 coiled-coil domain containing 86 0.263908
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 0.26386
EIF3G eukaryotic translation initiation factor 3, subunit G 0.26361
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.263459
NME1-NME2 NME1-NME2 readthrough 0.263437
HYAL2 hyaluronoglucosaminidase 2 0.263327
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.262903
CISD1 CDGSH iron sulfur domain 1 0.262635
AGO2 argonaute RISC catalytic component 2 0.262455
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.262176
ESRRA estrogen-related receptor alpha 0.262015
COX5B cytochrome c oxidase subunit Vb 0.26201
BSG basigin (Ok blood group) 0.261939
FAAP20 FA core complex associated protein 20 0.260764
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.260594
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.260594
DPEP3 dipeptidase 3 0.259984
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.259882
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.259827
DGKI diacylglycerol kinase, iota 0.259229
SYP synaptophysin 0.259229
RIPOR1 RHO family interacting cell polarization regulator 1 0.258677
NRIP3 nuclear receptor interacting protein 3 0.258095
ABHD14A-ACY1 ABHD14A-ACY1 readthrough (NMD candidate) 0.257893
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 0.256394
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.255497
CD274 CD274 molecule 0.255474
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.254316
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 0.254049
COPRS coordinator of PRMT5, differentiation stimulator 0.254048
DCXR dicarbonyl/L-xylulose reductase 0.25346
MFSD12 major facilitator superfamily domain containing 12 0.253368
MRM3 mitochondrial rRNA methyltransferase 3 0.252346
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.251264
RBM8A RNA binding motif protein 8A 0.251222
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.251222
EBNA1BP2 EBNA1 binding protein 2 0.250831
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 0.250777
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.250367
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 0.249403
ATP5F1D ATP synthase F1 subunit delta 0.249403
DCTD dCMP deaminase 0.2492
NCLN nicalin 0.249062
EIF3K eukaryotic translation initiation factor 3, subunit K 0.248208
REEP5 receptor accessory protein 5 0.246867
EIF1 eukaryotic translation initiation factor 1 0.246851
TGFB1 transforming growth factor, beta 1 0.245484
PRMT1 protein arginine methyltransferase 1 0.245311
RPS5 ribosomal protein S5 0.244973
ERGIC3 ERGIC and golgi 3 0.244832
CORO1B coronin, actin binding protein, 1B 0.243588
TMEM51 transmembrane protein 51 0.243341
HLA-A major histocompatibility complex, class I, A 0.242835
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.242487
ARMC6 armadillo repeat containing 6 0.24228
RALY RALY heterogeneous nuclear ribonucleoprotein 0.241721
TMX2 thioredoxin-related transmembrane protein 2 0.240988
SURF4 surfeit 4 0.240421
DUSP2 dual specificity phosphatase 2 0.240216
ANTXR2 anthrax toxin receptor 2 0.240182
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.239887
TXNL4B thioredoxin-like 4B 0.239332
UCK2 uridine-cytidine kinase 2 0.239175
TNIP1 TNFAIP3 interacting protein 1 0.239175
MRPL13 mitochondrial ribosomal protein L13 0.23864
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.237944
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.237574
FXR2 fragile X mental retardation, autosomal homolog 2 0.237524
RABAC1 Rab acceptor 1 (prenylated) 0.237345
ASL argininosuccinate lyase 0.237145
CKS2 CDC28 protein kinase regulatory subunit 2 0.237075
EIF3D eukaryotic translation initiation factor 3, subunit D 0.237033
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.236429
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.236386
PEA15 phosphoprotein enriched in astrocytes 15 0.235767
INTS11 integrator complex subunit 11 0.235547
POLRMT polymerase (RNA) mitochondrial (DNA directed) 0.234691
SMIM13 small integral membrane protein 13 0.233911
EGFL7 EGF-like-domain, multiple 7 0.233687
TCIM transcriptional and immune response regulator 0.232768
POMP proteasome maturation protein 0.232657
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 0.232271
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.232259
MMP3 matrix metallopeptidase 3 0.230474
ELOB elongin B 0.230474
USP36 ubiquitin specific peptidase 36 0.2288
NT5C3B 5'-nucleotidase, cytosolic IIIB 0.228751
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 0.227965
MRPL24 mitochondrial ribosomal protein L24 0.227773
RAB35 RAB35, member RAS oncogene family 0.227215
C19ORF53 chromosome 19 open reading frame 53 0.226574
DUSP7 dual specificity phosphatase 7 0.22651
SH2D5 SH2 domain containing 5 0.226047
LY6K lymphocyte antigen 6 complex, locus K 0.225939
STX1A syntaxin 1A (brain) 0.225939
MRPL36 mitochondrial ribosomal protein L36 0.225572
SYNJ2 synaptojanin 2 0.225144
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.22505
IL6R interleukin 6 receptor 0.224947
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.22481
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 0.224039
MPG N-methylpurine-DNA glycosylase 0.223912
ZMPSTE24 zinc metallopeptidase STE24 0.223261
IFITM2 interferon induced transmembrane protein 2 0.223261
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.222429
HMG20B high mobility group 20B 0.222429
MPST mercaptopyruvate sulfurtransferase 0.222429
GPR3 G protein-coupled receptor 3 0.222429
EXT1 exostosin glycosyltransferase 1 0.221825
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 0.221736
SLAMF7 SLAM family member 7 0.221616
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.220076
ANKRD13D ankyrin repeat domain 13 family, member D 0.219944
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.219926
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.217589
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.217589
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.217333
TMUB1 transmembrane and ubiquitin-like domain containing 1 0.216786
EMP1 epithelial membrane protein 1 0.21663
ANOS1 anosmin 1 0.216476
DNPEP aspartyl aminopeptidase 0.216357
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.215946
PYCR1 pyrroline-5-carboxylate reductase 1 0.215695
RABGGTA Rab geranylgeranyltransferase, alpha subunit 0.214325
SELENOS selenoprotein S 0.214184
A2M alpha-2-macroglobulin 0.213683
BCL2L12 BCL2-like 12 (proline rich) 0.213215
FSD1 fibronectin type III and SPRY domain containing 1 0.213087
MYEOV myeloma overexpressed 0.212555
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.212555
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.212555
FAM174C family with sequence similarity 174 member C 0.212478
SLC35F6 solute carrier family 35, member F6 0.212349
TLNRD1 talin rod domain containing 1 0.212324
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 0.212284
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.212184
MLEC malectin 0.211954
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.211383
NPAS2 neuronal PAS domain protein 2 0.210554
ZFAND2A zinc finger, AN1-type domain 2A 0.209505
TEX261 testis expressed 261 0.209416
E4F1 E4F transcription factor 1 0.208634
PPP1R16A protein phosphatase 1, regulatory subunit 16A 0.208352
PRR9 proline rich 9 0.208082
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 0.208044
NECAB1 N-terminal EF-hand calcium binding protein 1 0.207235
LZTR1 leucine-zipper-like transcription regulator 1 0.207107
GRK6 G protein-coupled receptor kinase 6 0.206987
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.206232
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.20598
RACK1 receptor for activated C kinase 1 0.205927
TPSB2 tryptase beta 2 (gene/pseudogene) 0.205362
SEPTIN9 septin 9 0.205362
PLEKHJ1 pleckstrin homology domain containing, family J member 1 0.205039
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.204582
CARD19 caspase recruitment domain family member 19 0.204352
VSTM1 V-set and transmembrane domain containing 1 0.204295
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.204091
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 0.204065
CAPN15 calpain 15 0.204065
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 0.203403
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.202346
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.202343
LPXN leupaxin 0.202272
ARFRP1 ADP-ribosylation factor related protein 1 0.202089
IER3 immediate early response 3 0.202002
FHOD1 formin homology 2 domain containing 1 0.201969
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.200805
AAMP angio-associated, migratory cell protein 0.20051
SZRD1 SUZ RNA binding domain containing 1 0.200386
LAS1L LAS1-like (S. cerevisiae) 0.200226

decreased expression

Symbol Name Standardized Value
TUBB tubulin, beta class I -11.4576
DHRS2 dehydrogenase/reductase (SDR family) member 2 -5.6929
CLPTM1L CLPTM1-like -4.43846
TPM1 tropomyosin 1 (alpha) -4.34358
EDN2 endothelin 2 -4.34358
PCLAF PCNA clamp associated factor -3.95385
TMSB4X thymosin beta 4, X-linked -3.59726
BMP4 bone morphogenetic protein 4 -2.61827
MAGED1 melanoma antigen family D1 -2.56104
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.47297
GADD45B growth arrest and DNA-damage-inducible, beta -2.3054
CPA4 carboxypeptidase A4 -2.16722
TUBA3C tubulin, alpha 3c -2.15292
LOXL4 lysyl oxidase-like 4 -2.07001
KREMEN2 kringle containing transmembrane protein 2 -1.99266
PCLO piccolo presynaptic cytomatrix protein -1.96378
TUBA1B tubulin, alpha 1b -1.87537
RRM2 ribonucleotide reductase M2 -1.83574
F2R coagulation factor II (thrombin) receptor -1.7418
TPT1 tumor protein, translationally-controlled 1 -1.72566
TUBB4B tubulin, beta 4B class IVb -1.70573
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -1.69926
TMEM37 transmembrane protein 37 -1.63539
TOP2A topoisomerase (DNA) II alpha 170kDa -1.60668
MCM6 minichromosome maintenance complex component 6 -1.55058
PTMA prothymosin, alpha -1.53198
MCM3 minichromosome maintenance complex component 3 -1.51272
PDLIM1 PDZ and LIM domain 1 -1.51272
TRIM16 tripartite motif containing 16 -1.51272
GSTM4 glutathione S-transferase mu 4 -1.4716
TUBB2B tubulin, beta 2B class IIb -1.39083
COL1A1 collagen, type I, alpha 1 -1.37097
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -1.344
HSPA1A heat shock 70kDa protein 1A -1.30235
TYMS thymidylate synthetase -1.26484
SOX4 SRY (sex determining region Y)-box 4 -1.25191
LMCD1 LIM and cysteine-rich domains 1 -1.23705
CXCL14 chemokine (C-X-C motif) ligand 14 -1.1929
NDN necdin, melanoma antigen (MAGE) family member -1.1929
STMN1 stathmin 1 -1.18494
MINDY4 MINDY lysine 48 deubiquitinase 4 -1.18193
KRT80 keratin 80, type II -1.16584
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -1.15821
LAMA5 laminin, alpha 5 -1.13078
RHOBTB3 Rho-related BTB domain containing 3 -1.1199
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -1.11988
PLK2 polo-like kinase 2 -1.11493
ANXA8L1 annexin A8-like 1 -1.08382
MDK midkine (neurite growth-promoting factor 2) -1.06726
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -1.04429
CNPY4 canopy FGF signaling regulator 4 -1.02858
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -1.01529
PLCD1 phospholipase C, delta 1 -1.01493
TUBA1A tubulin, alpha 1a -0.994092
CAV1 caveolin 1, caveolae protein, 22kDa -0.989481
WNT11 wingless-type MMTV integration site family, member 11 -0.965254
HAPLN1 hyaluronan and proteoglycan link protein 1 -0.946963
BEX3 brain expressed X-linked 3 -0.918679
ALOX5 arachidonate 5-lipoxygenase -0.886547
MUSK muscle, skeletal, receptor tyrosine kinase -0.876767
JUND jun D proto-oncogene -0.870262
DDIT4 DNA-damage-inducible transcript 4 -0.859388
E2F1 E2F transcription factor 1 -0.85895
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -0.843812
FDXR ferredoxin reductase -0.843426
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.842214
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.836151
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.833161
MCM5 minichromosome maintenance complex component 5 -0.830963
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -0.829333
TPGS2 tubulin polyglutamylase complex subunit 2 -0.827989
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -0.827302
RNF187 ring finger protein 187 -0.821038
MCM7 minichromosome maintenance complex component 7 -0.820791
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.817647
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.817272
CARHSP1 calcium regulated heat stable protein 1, 24kDa -0.814909
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.80044
SUMO2 small ubiquitin-like modifier 2 -0.791573
SMAD6 SMAD family member 6 -0.776193
GSN gelsolin -0.773725
DUT deoxyuridine triphosphatase -0.772196
ADGRG1 adhesion G protein-coupled receptor G1 -0.767681
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.763806
CRIP2 cysteine-rich protein 2 -0.750282
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -0.747178
ERG28 ergosterol biosynthesis 28 homolog -0.739504
ARL4C ADP-ribosylation factor-like 4C -0.709293
TRIR telomerase RNA component interacting RNase -0.703056
C1ORF198 chromosome 1 open reading frame 198 -0.685905
MN1 meningioma (disrupted in balanced translocation) 1 -0.679734
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.67903
CCDC80 coiled-coil domain containing 80 -0.676316
NREP neuronal regeneration related protein -0.675925
PRAME preferentially expressed antigen in melanoma -0.674202
RAB7B RAB7B, member RAS oncogene family -0.672786
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.670986
RMI2 RecQ mediated genome instability 2 -0.664715
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.64538
TCP11L1 t-complex 11, testis-specific-like 1 -0.633192
SNRPN small nuclear ribonucleoprotein polypeptide N -0.6316
TMSB15B thymosin beta 15B -0.62963
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.623782
FOXS1 forkhead box S1 -0.620991
FEN1 flap structure-specific endonuclease 1 -0.620127
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.615933
MAB21L4 mab-21 like 4 -0.613342
HR hair growth associated -0.609085
MAGED4B melanoma antigen family D4B -0.606372
HMGN3 high mobility group nucleosomal binding domain 3 -0.604291
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -0.600681
SMIM29 small integral membrane protein 29 -0.600403
ERBIN erbb2 interacting protein -0.593318
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.591892
VMP1 vacuole membrane protein 1 -0.589325
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.585169
CTSL cathepsin L -0.582001
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -0.58176
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.574607
GNAS GNAS complex locus -0.566453
CNFN cornifelin -0.565841
CYB5A cytochrome b5 type A (microsomal) -0.564459
SKA2 spindle and kinetochore associated complex subunit 2 -0.55938
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.55737
AKIP1 A kinase (PRKA) interacting protein 1 -0.557309
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.545666
KRT8 keratin 8, type II -0.545609
PLAC8 placenta-specific 8 -0.537553
AHNAK2 AHNAK nucleoprotein 2 -0.536293
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.531796
MYH10 myosin, heavy chain 10, non-muscle -0.52841
PFN2 profilin 2 -0.527089
NEFL neurofilament, light polypeptide -0.518837
COL16A1 collagen, type XVI, alpha 1 -0.517689
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.515861
SCRN2 secernin 2 -0.514327
FOLR2 folate receptor 2 (fetal) -0.513214
SERTAD4 SERTA domain containing 4 -0.511099
CTSH cathepsin H -0.508899
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.504116
DDB2 damage-specific DNA binding protein 2, 48kDa -0.503363
S100A10 S100 calcium binding protein A10 -0.501802
IL31RA interleukin 31 receptor A -0.500127
NMT2 N-myristoyltransferase 2 -0.498041
GLS2 glutaminase 2 (liver, mitochondrial) -0.493996
TMPO thymopoietin -0.493139
NIPSNAP1 nipsnap homolog 1 (C. elegans) -0.490241
TFDP1 transcription factor Dp-1 -0.490137
SSC4D scavenger receptor cysteine rich family, 4 domains -0.48603
DERA deoxyribose-phosphate aldolase (putative) -0.486003
EPDR1 ependymin related 1 -0.485885
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -0.480153
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.478738
CIRBP cold inducible RNA binding protein -0.47332
XPC xeroderma pigmentosum, complementation group C -0.470211
SERINC1 serine incorporator 1 -0.468135
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.468135
GKN1 gastrokine 1 -0.467606
MXD3 MAX dimerization protein 3 -0.467501
AMIGO2 adhesion molecule with Ig-like domain 2 -0.465447
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.460726
RTN4R reticulon 4 receptor -0.458696
ACKR3 atypical chemokine receptor 3 -0.458399
TUBB6 tubulin, beta 6 class V -0.458399
SIN3A SIN3 transcription regulator family member A -0.458291
ANXA10 annexin A10 -0.457354
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.456238
SLC38A2 solute carrier family 38, member 2 -0.454088
SDC2 syndecan 2 -0.453215
SCX scleraxis basic helix-loop-helix transcription factor -0.452366
CREB3L1 cAMP responsive element binding protein 3-like 1 -0.445891
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.440068
PGRMC2 progesterone receptor membrane component 2 -0.439629
MID1IP1 MID1 interacting protein 1 -0.435642
VASN vasorin -0.435186
SVIP small VCP/p97-interacting protein -0.435186
ASS1 argininosuccinate synthase 1 -0.435028
LRRN1 leucine rich repeat neuronal 1 -0.434526
ZNF664 zinc finger protein 664 -0.432939
RPL5 ribosomal protein L5 -0.43288
APLP1 amyloid beta (A4) precursor-like protein 1 -0.430887
CCNL2 cyclin L2 -0.425912
CDK4 cyclin-dependent kinase 4 -0.424747
FSCN1 fascin actin-bundling protein 1 -0.424194
HPS4 Hermansky-Pudlak syndrome 4 -0.420854
ZNF467 zinc finger protein 467 -0.420854
CENPM centromere protein M -0.415487
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -0.414183
CCNE1 cyclin E1 -0.412852
TGM1 transglutaminase 1 -0.412798
TMEM106B transmembrane protein 106B -0.409486
ZCCHC3 zinc finger, CCHC domain containing 3 -0.404004
ZNF580 zinc finger protein 580 -0.403396
UXT ubiquitously-expressed, prefoldin-like chaperone -0.402366
CD70 CD70 molecule -0.401397
KANK2 KN motif and ankyrin repeat domains 2 -0.401289
KTN1 kinectin 1 (kinesin receptor) -0.398668
CCNG1 cyclin G1 -0.397079
PALLD palladin, cytoskeletal associated protein -0.396183
TUBA4A tubulin, alpha 4a -0.391158
SLBP stem-loop binding protein -0.390613
C1QTNF2 C1q and tumor necrosis factor related protein 2 -0.389907
WDR76 WD repeat domain 76 -0.389178
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.388122
CRELD2 cysteine-rich with EGF-like domains 2 -0.387735
RCOR3 REST corepressor 3 -0.385249
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -0.379731
TUBA1C tubulin, alpha 1c -0.378099
C19ORF81 chromosome 19 open reading frame 81 -0.374613
SMAD7 SMAD family member 7 -0.374356
HRCT1 histidine rich carboxyl terminus 1 -0.373393
TP53INP1 tumor protein p53 inducible nuclear protein 1 -0.371287
ZMYM3 zinc finger, MYM-type 3 -0.371258
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.371027
FKBP9 FK506 binding protein 9, 63 kDa -0.371027
AP1M2 adaptor-related protein complex 1, mu 2 subunit -0.364805
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.363589
DPYSL3 dihydropyrimidinase-like 3 -0.362496
HMGB2 high mobility group box 2 -0.359263
TRIM6-TRIM34 TRIM6-TRIM34 readthrough -0.359263
MAGEF1 melanoma antigen family F1 -0.357964
GLI2 GLI family zinc finger 2 -0.35609
UBE2I ubiquitin-conjugating enzyme E2I -0.355378
ABLIM1 actin binding LIM protein 1 -0.355238
CBX2 chromobox homolog 2 -0.355175
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.352286
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.35203
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.351615
TK1 thymidine kinase 1, soluble -0.351351
IP6K2 inositol hexakisphosphate kinase 2 -0.350247
CDC6 cell division cycle 6 -0.348599
GPC2 glypican 2 -0.347613
IRS1 insulin receptor substrate 1 -0.345051
NONO non-POU domain containing, octamer-binding -0.344598
EID1 EP300 interacting inhibitor of differentiation 1 -0.344591
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.344304
SEPTIN3 septin 3 -0.34371
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.34371
MELK maternal embryonic leucine zipper kinase -0.343651
PHGDH phosphoglycerate dehydrogenase -0.34283
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.342365
UBL4A ubiquitin-like 4A -0.341155
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.33955
NFIB nuclear factor I/B -0.339032
TNNT2 troponin T type 2 (cardiac) -0.338115
RABL2A RAB, member of RAS oncogene family-like 2A -0.335292
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.33524
BEST1 bestrophin 1 -0.334435
DCLRE1B DNA cross-link repair 1B -0.332881
ARLN allregulin -0.331701
ADNP activity-dependent neuroprotector homeobox -0.330654
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -0.33002
SHOC1 shortage in chiasmata 1 -0.329942
AMPH amphiphysin -0.32963
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 -0.32902
TUFT1 tuftelin 1 -0.328903
NPPC natriuretic peptide C -0.3278
NADK2 NAD kinase 2, mitochondrial -0.3278
ARID1A AT rich interactive domain 1A (SWI-like) -0.327523
ZXDB zinc finger, X-linked, duplicated B -0.325739
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -0.324691
TRIM5 tripartite motif containing 5 -0.323706
CPA5 carboxypeptidase A5 -0.323706
NAP1L1 nucleosome assembly protein 1-like 1 -0.323535
PARD6G par-6 family cell polarity regulator gamma -0.323387
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.322686
SAC3D1 SAC3 domain containing 1 -0.317872
TNNI3 troponin I type 3 (cardiac) -0.316702
XPO1 exportin 1 -0.316702
RPL12 ribosomal protein L12 -0.315568
TCF12 transcription factor 12 -0.31555
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.314951
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.314918
TLN1 talin 1 -0.313782
MAP1B microtubule-associated protein 1B -0.313468
MORF4L1 mortality factor 4 like 1 -0.312532
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.312422
GABARAP GABA(A) receptor-associated protein -0.311293
FZD2 frizzled class receptor 2 -0.30945
RUSC1 RUN and SH3 domain containing 1 -0.30945
TRIM37 tripartite motif containing 37 -0.309054
CHMP1B charged multivesicular body protein 1B -0.309009
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.306297
CKAP5 cytoskeleton associated protein 5 -0.306297
CBX1 chromobox homolog 1 -0.305919
KPNB1 karyopherin (importin) beta 1 -0.305749
ROGDI rogdi homolog (Drosophila) -0.305193
TMEM106C transmembrane protein 106C -0.30447
GAS6 growth arrest-specific 6 -0.303055
DSN1 DSN1, MIS12 kinetochore complex component -0.302015
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -0.301395
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -0.301395
ZNF345 zinc finger protein 345 -0.300017
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -0.298449
MGME1 mitochondrial genome maintenance exonuclease 1 -0.298268
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -0.296366
RPS27L ribosomal protein S27-like -0.296366
CAPRIN1 cell cycle associated protein 1 -0.293567
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.292608
NFIA nuclear factor I/A -0.291987
ELAVL1 ELAV like RNA binding protein 1 -0.291339
ABHD4 abhydrolase domain containing 4 -0.290341
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.28968
TNS3 tensin 3 -0.289556
EFNA1 ephrin-A1 -0.288617
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.288514
PGRMC1 progesterone receptor membrane component 1 -0.287523
GTPBP3 GTP binding protein 3 (mitochondrial) -0.285121
S100A4 S100 calcium binding protein A4 -0.28496
ADD3 adducin 3 (gamma) -0.284485
SLTM SAFB-like, transcription modulator -0.283389
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -0.282268
TMEM200C transmembrane protein 200C -0.281631
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -0.280873
CXXC5 CXXC finger protein 5 -0.280824
RIMS3 regulating synaptic membrane exocytosis 3 -0.279921
ZNF227 zinc finger protein 227 -0.279361
TP53I11 tumor protein p53 inducible protein 11 -0.279361
PINK1 PTEN induced putative kinase 1 -0.278291
RPL34 ribosomal protein L34 -0.278081
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.277736
TARDBP TAR DNA binding protein -0.276521
PIANP PILR alpha associated neural protein -0.275568
FHL2 four and a half LIM domains 2 -0.274664
PSAT1 phosphoserine aminotransferase 1 -0.271919
FOXO6 forkhead box O6 -0.271549
AK5 adenylate kinase 5 -0.271206
HBP1 HMG-box transcription factor 1 -0.268232
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -0.267754
OSBPL10 oxysterol binding protein-like 10 -0.267747
DAAM2 dishevelled associated activator of morphogenesis 2 -0.267686
PGM1 phosphoglucomutase 1 -0.26728
NCOA3 nuclear receptor coactivator 3 -0.266293
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 -0.265582
PBX1 pre-B-cell leukemia homeobox 1 -0.264011
TRIP10 thyroid hormone receptor interactor 10 -0.262806
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -0.260782
RAP2B RAP2B, member of RAS oncogene family -0.260594
KRT10 keratin 10, type I -0.260594
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -0.259457
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -0.257997
PPME1 protein phosphatase methylesterase 1 -0.257997
GPR146 G protein-coupled receptor 146 -0.257893
CA12 carbonic anhydrase XII -0.256097
DAND5 DAN domain family member 5, BMP antagonist -0.255731
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -0.255306
NINJ1 ninjurin 1 -0.254135
TMEM91 transmembrane protein 91 -0.252421
CCDC34 coiled-coil domain containing 34 -0.251264
ZNF404 zinc finger protein 404 -0.250831
LONP1 lon peptidase 1, mitochondrial -0.250831
CHD4 chromodomain helicase DNA binding protein 4 -0.250777
SVBP small vasohibin binding protein -0.250399
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.249062
SRSF3 serine/arginine-rich splicing factor 3 -0.248467
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -0.248391
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.248184
ZFYVE26 zinc finger, FYVE domain containing 26 -0.247046
MCM4 minichromosome maintenance complex component 4 -0.246024
MRFAP1 Morf4 family associated protein 1 -0.24555
ZNF528 zinc finger protein 528 -0.245535
FNBP1 formin binding protein 1 -0.245311
SRSF2 serine/arginine-rich splicing factor 2 -0.245142
TEAD2 TEA domain family member 2 -0.244326
CSDC2 cold shock domain containing C2, RNA binding -0.243923
TMEM255A transmembrane protein 255A -0.243341
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.24313
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -0.241953
UGP2 UDP-glucose pyrophosphorylase 2 -0.241103
ARL3 ADP-ribosylation factor-like 3 -0.240683
EID2B EP300 interacting inhibitor of differentiation 2B -0.240182
TENM3 teneurin transmembrane protein 3 -0.239332
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.237524
CNTRL centriolin -0.237524
CREBZF CREB/ATF bZIP transcription factor -0.237252
SIVA1 SIVA1, apoptosis-inducing factor -0.236814
ZWILCH zwilch kinetochore protein -0.23572
ZNF45 zinc finger protein 45 -0.235202
CBX4 chromobox homolog 4 -0.234741
EFNA4 ephrin-A4 -0.234723
NCOA1 nuclear receptor coactivator 1 -0.234576
THSD8 thrombospondin type 1 domain containing 8 -0.233917
FAM111B family with sequence similarity 111, member B -0.232768
NBR1 neighbor of BRCA1 gene 1 -0.232761
GPX8 glutathione peroxidase 8 (putative) -0.231479
CSDE1 cold shock domain containing E1, RNA-binding -0.230474
FTO fat mass and obesity associated -0.230463
SYNPO synaptopodin -0.229421
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -0.228961
C1QTNF12 C1q and TNF related 12 -0.228551
SPACA6 sperm acrosome associated 6 -0.228456
TEF thyrotrophic embryonic factor -0.228456
SYTL1 synaptotagmin-like 1 -0.228356
PRR12 proline rich 12 -0.225939
MARK1 MAP/microtubule affinity-regulating kinase 1 -0.225188
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -0.223394
MOV10 Mov10 RISC complex RNA helicase -0.223303
HUNK hormonally up-regulated Neu-associated kinase -0.223107
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -0.22246
SLC22A17 solute carrier family 22, member 17 -0.222429
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -0.221443
KRT14 keratin 14, type I -0.220076
NTM neurotrimin -0.219472
FAM120B family with sequence similarity 120B -0.217887
GAMT guanidinoacetate N-methyltransferase -0.217172
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -0.216631
OLFML3 olfactomedin-like 3 -0.215946
HMX2 H6 family homeobox 2 -0.215862
L1CAM L1 cell adhesion molecule -0.215712
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -0.215436
NANOS3 nanos homolog 3 (Drosophila) -0.214609
RPL23A ribosomal protein L23a -0.212555
USP39 ubiquitin specific peptidase 39 -0.212184
NCAPD2 non-SMC condensin I complex, subunit D2 -0.212184
TLCD4 TLC domain containing 4 -0.211594
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -0.211005
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.211005
PRMT6 protein arginine methyltransferase 6 -0.210595
NKTR natural killer cell triggering receptor -0.209574
LYPD1 LY6/PLAUR domain containing 1 -0.209216
NXN nucleoredoxin -0.209091
AP4M1 adaptor-related protein complex 4, mu 1 subunit -0.207555
ZNF260 zinc finger protein 260 -0.206502
NHSL2 NHS-like 2 -0.206408
SRSF4 serine/arginine-rich splicing factor 4 -0.205602
STEAP3 STEAP family member 3, metalloreductase -0.205559
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B -0.205224
CFH complement factor H -0.203646
SREBF1 sterol regulatory element binding transcription factor 1 -0.203249
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -0.2032
ARHGAP29 Rho GTPase activating protein 29 -0.202744
PDIA6 protein disulfide isomerase family A, member 6 -0.202343
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 -0.202298
UNG uracil-DNA glycosylase -0.202232
CLDN4 claudin 4 -0.201618