MACC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description metastasis associated in colon cancer 1|MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009] (NCBI Entrez Gene Database, 346389)
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Genes

252 genes differentially expressed following the MACC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NOXRED1 NADP-dependent oxidoreductase domain containing 1 2.2092
UFSP1 UFM1-specific peptidase 1 (non-functional) 2.15434
KCTD4 potassium channel tetramerization domain containing 4 2.15434
ZNF467 zinc finger protein 467 2.15434
TGM3 transglutaminase 3 2.15434
KLK14 kallikrein-related peptidase 14 2.15434
SPAG8 sperm associated antigen 8 2.15434
SCRT2 scratch family zinc finger 2 2.15434
VCX variable charge, X-linked 2.15434
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.15434
SFTPD surfactant protein D 2.15434
LY86 lymphocyte antigen 86 2.15434
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.15434
AKAP3 A kinase (PRKA) anchor protein 3 2.15434
LOC124906010 uncharacterized LOC124906010 2.15434
LOC122526780 uncharacterized LOC122526780 2.15434
RFPL2 ret finger protein-like 2 2.15434
SMIM35 small integral membrane protein 35 2.15434
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.15434
CFAP276 cilia and flagella associated protein 276 2.15434
GMFG glia maturation factor, gamma 2.15434
FAM178B family with sequence similarity 178, member B 2.15434
TBC1D7-LOC100130357 TBC1D7-LOC100130357 readthrough 2.11656
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.11498
CARD16 caspase recruitment domain family, member 16 2.08599
SLC46A2 solute carrier family 46, member 2 2.08599
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.08599
MYBPHL myosin binding protein H-like 2.08599
FBXL8 F-box and leucine-rich repeat protein 8 2.08599
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 2.08599
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.08599
CLEC12A C-type lectin domain family 12, member A 2.08599
PARP3 poly (ADP-ribose) polymerase family, member 3 2.08599
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.08599
CDH5 cadherin 5, type 2 (vascular endothelium) 2.08599
GNLY granulysin 2.08599
CD1C CD1c molecule 2.08599
NANOS2 nanos homolog 2 (Drosophila) 2.08599
ADGB androglobin 2.08599
KCNRG potassium channel regulator 2.08599
NUGGC nuclear GTPase, germinal center associated 2.08599
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.08599
NNT nicotinamide nucleotide transhydrogenase 2.08599
GDNF glial cell derived neurotrophic factor 2.08599
FKTN fukutin 2.08599
SLC16A6 solute carrier family 16, member 6 2.08599
SLC15A5 solute carrier family 15, member 5 2.08599
PAX5 paired box 5 2.08599
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.08599
SLC25A45 solute carrier family 25, member 45 2.08599
SLC25A47 solute carrier family 25, member 47 2.08599
DRICH1 aspartate-rich 1 2.08599
PCDHB9 protocadherin beta 9 2.08599
RAX retina and anterior neural fold homeobox 2.08599
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.08599
MUC6 mucin 6, oligomeric mucus/gel-forming 2.08599
SBK3 SH3 domain binding kinase family, member 3 2.08599
EPCIP exosomal polycystin 1 interacting protein 2.08599
SLF2 SMC5-SMC6 complex localization factor 2 2.08599
SPATS1 spermatogenesis associated, serine-rich 1 2.08599
YIPF7 Yip1 domain family, member 7 2.08599
ROPN1B rhophilin associated tail protein 1B 2.08599
AVPR1B arginine vasopressin receptor 1B 2.08599
CCER2 coiled-coil glutamate-rich protein 2 2.08599
STX11 syntaxin 11 2.08599
SMLR1 small leucine-rich protein 1 2.08599
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.08599
SMIM41 small integral membrane protein 41 2.08599
DEPP1 DEPP autophagy regulator 1 2.08599
C1ORF232 chromosome 1 open reading frame 230 2.08599
RHEX regulator of hemoglobinization and erythroid cell expansion 2.08599
SEPTIN12 septin 12 2.08599
TMEM225B transmembrane protein 225B 2.08599
DNAAF6 dynein axonemal assembly factor 6 2.08599
ODAPH odontogenesis associated phosphoprotein 2.08599
VXN vexin 2.08599
TAFA3 TAFA chemokine like family member 3 2.08599
KASH5 KASH domain containing 5 2.08599
XKRX XK, Kell blood group complex subunit-related, X-linked 2.08599
MYL10 myosin, light chain 10, regulatory 2.08599
SPATA25 spermatogenesis associated 25 2.08599
SIM2 single-minded family bHLH transcription factor 2 2.08599
CXCL16 chemokine (C-X-C motif) ligand 16 2.08599
EDAR ectodysplasin A receptor 2.08599
PCDHB11 protocadherin beta 11 2.08599
GDA guanine deaminase 2.08599
TMEM92 transmembrane protein 92 2.08599
NKX2-6 NK2 homeobox 6 2.08599
PCDHA3 protocadherin alpha 3 2.08599
LIPK lipase, family member K 2.08599
NHLRC4 NHL repeat containing 4 2.08599
BARHL1 BarH-like homeobox 1 2.08599
IMPG2 interphotoreceptor matrix proteoglycan 2 2.08599
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.08599
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.08599
CNTN3 contactin 3 (plasmacytoma associated) 2.08599
ZNF350 zinc finger protein 350 2.08599
OOSP1 oocyte secreted protein 1, pseudogene 2.08599
MPPED2 metallophosphoesterase domain containing 2 2.08599
C7 complement component 7 2.08599
CCR9 chemokine (C-C motif) receptor 9 2.08599
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.08599
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.08599
CALML6 calmodulin-like 6 2.08599
S100A14 S100 calcium binding protein A14 2.08599
CXCR5 chemokine (C-X-C motif) receptor 5 2.08599
ANKRD63 ankyrin repeat domain 63 2.08599
PCP2 Purkinje cell protein 2 2.08599
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.08599
PRM1 protamine 1 2.08599
WFDC6 WAP four-disulfide core domain 6 2.08599
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.08599
APOC2 apolipoprotein C-II 2.08599
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 2.08599
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.08599
EHF ets homologous factor 2.08599
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.08599
ACLY ATP citrate lyase 2.08599
PHOSPHO1 phosphatase, orphan 1 2.08599
PMP2 peripheral myelin protein 2 2.08599
FBXO38 F-box protein 38 2.08599
ZNF134 zinc finger protein 134 2.08599
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 2.08599
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.08599
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.08599
RANBP3L RAN binding protein 3-like 2.08599
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.08599
SLC38A3 solute carrier family 38, member 3 2.08599
GCGR glucagon receptor 2.08599
HMGB4 high mobility group box 4 2.08599
ADGRL2 adhesion G protein-coupled receptor L2 2.08599
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.08599
TNNT1 troponin T type 1 (skeletal, slow) 2.08599
C10ORF105 chromosome 10 open reading frame 105 2.08599
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.08599
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.08599
MYO15B myosin XVB 2.08599
PRSS37 protease, serine, 37 2.08599
IGF2 insulin-like growth factor 2 2.08599
DRD3 dopamine receptor D3 2.08599
IL1A interleukin 1, alpha 2.08599
TEKT1 tektin 1 2.08599
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.08599
HRCT1 histidine rich carboxyl terminus 1 2.08599
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.08599
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.08599
KLK15 kallikrein-related peptidase 15 2.08599
C20ORF144 chromosome 20 open reading frame 144 2.08599
GOLGA8M golgin A8 family, member M 2.08599
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.08599
ZSCAN22 zinc finger and SCAN domain containing 22 2.08599
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.08599
CCDC83 coiled-coil domain containing 83 2.08599
PITRM1 pitrilysin metallopeptidase 1 2.08599
IL23R interleukin 23 receptor 2.08599
SETD9 SET domain containing 9 2.08599
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.08599
NRSN1 neurensin 1 2.08599
RDH16 retinol dehydrogenase 16 (all-trans) 2.08599
DCST1 DC-STAMP domain containing 1 2.08599
IL18R1 interleukin 18 receptor 1 2.08599
NLRP3 NLR family, pyrin domain containing 3 2.08599
C9ORF152 chromosome 9 open reading frame 152 2.08599
CRX cone-rod homeobox 2.08599
F2 coagulation factor II (thrombin) 2.08599
TRIM44 tripartite motif containing 44 2.08599
TMEM89 transmembrane protein 89 2.08599
TRPC5OS TRPC5 opposite strand 2.08599
LGALS4 lectin, galactoside-binding, soluble, 4 2.08599
TMC8 transmembrane channel-like 8 2.08599
SCN8A sodium channel, voltage gated, type VIII alpha subunit 2.08599
CDCP2 CUB domain containing protein 2 2.08599
C5AR2 complement component 5a receptor 2 2.08599
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.08599
SLC7A4 solute carrier family 7, member 4 2.08599
SLC51B solute carrier family 51, beta subunit 2.08599
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.08599
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.08599
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.08599
HHIPL2 HHIP-like 2 2.08599
DLG3 discs, large homolog 3 (Drosophila) 2.08599
NR2E1 nuclear receptor subfamily 2, group E, member 1 2.08599
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.08599
CIB3 calcium and integrin binding family member 3 2.08599
ANGPTL3 angiopoietin-like 3 2.08599
CARD9 caspase recruitment domain family, member 9 2.08599
TGM6 transglutaminase 6 2.08599
TTC36 tetratricopeptide repeat domain 36 2.08599
IFNE interferon, epsilon 2.08599
TMEM156 transmembrane protein 156 2.08599
CCDC166 coiled-coil domain containing 166 2.08599
DENND3 DENN/MADD domain containing 3 2.07798
PRDM2 PR domain containing 2, with ZNF domain 2.06919
KIAA0408 KIAA0408 2.05782
SDK2 sidekick cell adhesion molecule 2 2.04868
ATG10 autophagy related 10 2.02962
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 2.02576
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M 2.0195
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.00149

decreased expression

Symbol Name Standardized Value
CCDC88B coiled-coil domain containing 88B -2.2092
PPID peptidylprolyl isomerase D -2.15434
STXBP6 syntaxin binding protein 6 (amisyn) -2.15434
MYO18B myosin XVIIIB -2.15434
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -2.15434
CCDC110 coiled-coil domain containing 110 -2.15434
FNBP1 formin binding protein 1 -2.15434
TXN thioredoxin -2.15434
EXOC1 exocyst complex component 1 -2.11498
MANSC1 MANSC domain containing 1 -2.11498
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.11498
RECQL5 RecQ protein-like 5 -2.08599
RUNDC3A RUN domain containing 3A -2.08599
DYNLT2 dynein light chain Tctex-type 2 -2.08599
WTIP Wilms tumor 1 interacting protein -2.08599
JUND jun D proto-oncogene -2.08599
C13ORF42 chromosome 13 open reading frame 42 -2.08599
CFAP418 cilia and flagella associated protein 418 -2.08599
GIPC1 GIPC PDZ domain containing family, member 1 -2.08599
ZCWPW2 zinc finger, CW type with PWWP domain 2 -2.08599
SCN4B sodium channel, voltage gated, type IV beta subunit -2.08599
TMEM234 transmembrane protein 234 -2.08599
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.08599
TOX3 TOX high mobility group box family member 3 -2.08599
COL23A1 collagen, type XXIII, alpha 1 -2.08599
FAS Fas cell surface death receptor -2.08599
LUC7L2 LUC7-like 2 (S. cerevisiae) -2.08599
TFPI2 tissue factor pathway inhibitor 2 -2.08599
FAM194C family with sequence similarity 149 member C -2.08599
KLHL14 kelch-like family member 14 -2.08599
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.08599
ANAPC1 anaphase promoting complex subunit 1 -2.08599
HSPA4L heat shock 70kDa protein 4-like -2.08599
ADGRD2 adhesion G protein-coupled receptor D2 -2.08599
ZNF410 zinc finger protein 410 -2.08599
FBXO41 F-box protein 41 -2.08599
SORCS2 sortilin-related VPS10 domain containing receptor 2 -2.08599
PITPNB phosphatidylinositol transfer protein, beta -2.08599
ANKRD7 ankyrin repeat domain 7 -2.08599
PLS3 plastin 3 -2.08599
PCIF1 PDX1 C-terminal inhibiting factor 1 -2.08599
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -2.08599
CD101 CD101 molecule -2.08599
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.08599
IRAG1 inositol 1,4,5-triphosphate receptor associated 1 -2.08059
RPSA2 ribosomal protein SA 2 -2.08059
ZMYM4 zinc finger, MYM-type 4 -2.08059
MAMDC2 MAM domain containing 2 -2.07345
ZNF311 zinc finger protein 311 -2.04415
IGSF9 immunoglobulin superfamily, member 9 -2.03887
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.0195
SSH3 slingshot protein phosphatase 3 -2.0052
MEGF11 multiple EGF-like-domains 11 -2.00149