MAFK Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K|The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] (NCBI Entrez Gene Database, 7975)
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Genes

342 genes differentially expressed following the MAFK gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PTCRA pre T-cell antigen receptor alpha 3.05193
GALP galanin-like peptide 3.05193
TWIST1 twist family bHLH transcription factor 1 3.05193
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.05193
PRRT3 proline-rich transmembrane protein 3 3.05193
FGF7 fibroblast growth factor 7 3.05193
MIP major intrinsic protein of lens fiber 3.05193
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.05193
EPHB3 EPH receptor B3 3.05193
GDF10 growth differentiation factor 10 3.05193
ADGRG1 adhesion G protein-coupled receptor G1 3.05193
NHLRC4 NHL repeat containing 4 3.05193
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.05193
TPPP tubulin polymerization promoting protein 3.05193
ZIC4 Zic family member 4 3.05193
HMX3 H6 family homeobox 3 3.05193
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.05193
MRC1 mannose receptor, C type 1 3.05193
CREB3L3 cAMP responsive element binding protein 3-like 3 3.05193
ANKRD30A ankyrin repeat domain 30A 3.05193
IRX4 iroquois homeobox 4 3.05193
RTN4RL1 reticulon 4 receptor-like 1 3.05193
NNMT nicotinamide N-methyltransferase 3.05193
ZNF705D zinc finger protein 705D 3.05193
CLEC6A C-type lectin domain family 6, member A 3.05193
MSGN1 mesogenin 1 3.05193
FETUB fetuin B 3.05193
SOAT2 sterol O-acyltransferase 2 3.05193
COX8C cytochrome c oxidase subunit VIIIC 3.05193
TAS1R3 taste receptor, type 1, member 3 3.05193
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.05193
C7 complement component 7 3.05193
KIF19 kinesin family member 19 3.05193
ASCL2 achaete-scute family bHLH transcription factor 2 3.05193
RASAL3 RAS protein activator like 3 3.05193
C5ORF46 chromosome 5 open reading frame 46 3.05193
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.05193
MAGEC3 melanoma antigen family C3 3.05193
TAS2R19 taste receptor, type 2, member 19 3.05193
LRRC63 leucine rich repeat containing 63 3.05193
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.05193
ANGPT4 angiopoietin 4 3.05193
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.05193
TAS2R3 taste receptor, type 2, member 3 3.05193
GOLGA1 golgin A1 3.05193
VTN vitronectin 3.05193
GJB3 gap junction protein, beta 3, 31kDa 3.05193
DUXB double homeobox B 3.05193
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 3.05193
OR10A3 olfactory receptor, family 10, subfamily A, member 3 3.05193
PLIN4 perilipin 4 3.05193
TBX18 T-box 18 3.05193
UNC13C unc-13 homolog C (C. elegans) 3.05193
HORMAD1 HORMA domain containing 1 3.05193
ZNF467 zinc finger protein 467 3.05193
FOXA2 forkhead box A2 3.05193
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.05193
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.05193
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.05193
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.05193
NPIPA3 nuclear pore complex interacting protein family, member A3 3.05193
SHE Src homology 2 domain containing E 3.05193
CXCL17 chemokine (C-X-C motif) ligand 17 3.05193
CD79A CD79a molecule, immunoglobulin-associated alpha 3.05193
OR7C1 olfactory receptor, family 7, subfamily C, member 1 3.05193
CLEC5A C-type lectin domain family 5, member A 3.05193
TTLL2 tubulin tyrosine ligase-like family member 2 3.05193
CAPN14 calpain 14 3.05193
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.05193
LRRC10B leucine rich repeat containing 10B 3.05193
TMEM71 transmembrane protein 71 3.05193
SPMIP11 sperm microtubule inner protein 11 3.05193
RS1 retinoschisin 1 3.05193
TAL2 T-cell acute lymphocytic leukemia 2 3.05193
FPR2 formyl peptide receptor 2 3.05193
GPR21 G protein-coupled receptor 21 3.05193
ZNF98 zinc finger protein 98 3.05193
TRIM10 tripartite motif containing 10 3.05193
EXOC1L exocyst complex component 1 like 3.05193
SOSTDC1 sclerostin domain containing 1 3.05193
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.05193
LY9 lymphocyte antigen 9 3.05193
H4C13 H4 clustered histone 13 3.05193
NTN5 netrin 5 3.05193
VXN vexin 3.05193
AMN amnion associated transmembrane protein 3.05193
BDKRB2 bradykinin receptor B2 3.05193
CCN6 cellular communication network factor 6 3.05193
KLK11 kallikrein-related peptidase 11 3.05193
CFAP65 cilia and flagella associated protein 65 3.05193
EVPLL envoplakin-like 3.05193
MCCD1 mitochondrial coiled-coil domain 1 3.05193
PCDHGA3 protocadherin gamma subfamily A, 3 3.05193
POU2AF1 POU class 2 associating factor 1 3.05193
MT3 metallothionein 3 3.05193
CLEC4D C-type lectin domain family 4, member D 3.05193
DND1 DND microRNA-mediated repression inhibitor 1 3.05193
SH2D1B SH2 domain containing 1B 3.05193
CSF1R colony stimulating factor 1 receptor 3.05193
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.05193
SLC36A3 solute carrier family 36, member 3 3.05193
RAD9B RAD9 homolog B (S. pombe) 3.05193
CFAP299 cilia and flagella associated protein 299 3.05193
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.05193
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.05193
OR52N1 olfactory receptor, family 52, subfamily N, member 1 3.05193
GOLGA8Q golgin A8 family, member Q 3.05193
GOLGA8M golgin A8 family, member M 3.05193
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.05193
EVI2A ecotropic viral integration site 2A 3.05193
CCDC197 coiled-coil domain containing 197 3.05193
DRC7 dynein regulatory complex subunit 7 3.05193
CLEC18B C-type lectin domain family 18, member B 3.05193
DNAAF6 dynein axonemal assembly factor 6 3.05193
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.05193
MOBP myelin-associated oligodendrocyte basic protein 3.05193
SPATA4 spermatogenesis associated 4 3.05193
CALHM3 calcium homeostasis modulator 3 3.05193
DNAAF1 dynein, axonemal, assembly factor 1 3.05193
PKD2L1 polycystic kidney disease 2-like 1 3.05193
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.05193
TECRL trans-2,3-enoyl-CoA reductase-like 3.05193
NUTM2A NUT family member 2A 3.05193
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 3.05193
LST1 leukocyte specific transcript 1 3.05193
FITM1 fat storage-inducing transmembrane protein 1 3.05193
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.05193
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.05193
PATE2 prostate and testis expressed 2 3.05193
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.05193
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.05193
APOL4 apolipoprotein L, 4 3.05193
CHAD chondroadherin 3.05193
MIOX myo-inositol oxygenase 3.05193
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.05193
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.05193
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.05193
PLA2G4E phospholipase A2, group IVE 3.05193
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.05193
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.05193
OTOA otoancorin 3.05193
MAP3K13 mitogen-activated protein kinase kinase kinase 13 3.05193
TPSG1 tryptase gamma 1 3.05193
SMIM23 small integral membrane protein 23 3.05193
CXCR6 chemokine (C-X-C motif) receptor 6 3.05193
HHATL hedgehog acyltransferase-like 3.05193
SPANXD SPANX family, member D 3.05193
GPX6 glutathione peroxidase 6 3.05193
CSTA cystatin A (stefin A) 3.05193
CT55 cancer/testis antigen 55 3.05193
BRDT bromodomain, testis-specific 3.05193
GPX5 glutathione peroxidase 5 3.05193
MYF6 myogenic factor 6 (herculin) 3.05193
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.05193
PNLIPRP2 pancreatic lipase-related protein 2 3.05193
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.05193
KIF12 kinesin family member 12 3.03955
TAAR2 trace amine associated receptor 2 3.03955
ANGPTL4 angiopoietin-like 4 3.03955
MORC2 MORC family CW-type zinc finger 2 3.02243
CD109 CD109 molecule 2.94221
MAGED4 melanoma antigen family D4 2.88897
MMP9 matrix metallopeptidase 9 2.78554
C21ORF91 chromosome 21 open reading frame 91 2.72494
NHSL2 NHS-like 2 2.71844
ZNG1F Zn regulated GTPase metalloprotein activator 1F 2.62052
MANSC4 MANSC domain containing 4 2.62008
ADRA2B adrenoceptor alpha 2B 2.56139
TBC1D22A TBC1 domain family, member 22A 2.5242
GSDMD gasdermin D 2.48383
HARBI1 harbinger transposase derived 1 2.45033
LPAR5 lysophosphatidic acid receptor 5 2.43744
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 2.43744
ZNF446 zinc finger protein 446 2.42527
EXOSC8 exosome component 8 2.4193
TBCD tubulin folding cofactor D 2.41379
GPRC5C G protein-coupled receptor, class C, group 5, member C 2.4091
SMG7 SMG7 nonsense mediated mRNA decay factor 2.40357
DERL1 derlin 1 2.40202
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.40083
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 2.36107
TIMP2 TIMP metallopeptidase inhibitor 2 2.35631
ADM5 adrenomedullin 5 (putative) 2.35217
ERCC3 excision repair cross-complementation group 3 2.35217
PRSS21 protease, serine, 21 (testisin) 2.32369
SHISA3 shisa family member 3 2.32369
LDB3 LIM domain binding 3 2.25796
BIVM basic, immunoglobulin-like variable motif containing 2.25243
C1ORF159 chromosome 1 open reading frame 159 2.23352
SHARPIN SHANK-associated RH domain interactor 2.2241
CCDC85C coiled-coil domain containing 85C 2.21298
ATXN2 ataxin 2 2.19825
SUMF2 sulfatase modifying factor 2 2.19569
PGAP2 post-GPI attachment to proteins 2 2.19372
WSCD1 WSC domain containing 1 2.18977
MIER2 mesoderm induction early response 1, family member 2 2.17862
ZNG1E Zn regulated GTPase metalloprotein activator 1E 2.16261
GPATCH2L G patch domain containing 2-like 2.16261
SUSD5 sushi domain containing 5 2.16261
SAP30BP SAP30 binding protein 2.15409
IFT172 intraflagellar transport 172 2.1443
OPA1 optic atrophy 1 (autosomal dominant) 2.13734
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.11951
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.11951
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.11951
NTNG2 netrin G2 2.11951
BOLL boule-like RNA-binding protein 2.11951
SMTNL1 smoothelin-like 1 2.11951
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.11951
IGFL4 IGF-like family member 4 2.11951
KCTD7 potassium channel tetramerization domain containing 7 2.11531
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.11315
FBXL19 F-box and leucine-rich repeat protein 19 2.10076
ZNF510 zinc finger protein 510 2.09805
MORN4 MORN repeat containing 4 2.09279
RABL2B RAB, member of RAS oncogene family-like 2B 2.0829
RNF212 ring finger protein 212 2.0829
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 2.0829
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.07642
PCDH1 protocadherin 1 2.07642
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 2.04296
RDH16 retinol dehydrogenase 16 (all-trans) 2.04296
ADCY5 adenylate cyclase 5 2.03194
ZNF609 zinc finger protein 609 2.03114
ATP5MJ ATP synthase membrane subunit j 2.00303

decreased expression

Symbol Name Standardized Value
COG4 component of oligomeric golgi complex 4 -3.05193
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -3.05193
NGF nerve growth factor (beta polypeptide) -3.05193
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -3.05193
TCL1A T-cell leukemia/lymphoma 1A -3.05193
ACTL6B actin-like 6B -3.05193
WDR48 WD repeat domain 48 -3.05193
TMEM272 transmembrane protein 272 -3.05193
IL4I1 interleukin 4 induced 1 -3.05193
NIM1K NIM1 serine/threonine protein kinase -3.03955
TTPA tocopherol (alpha) transfer protein -3.03955
DNAH10 dynein, axonemal, heavy chain 10 -3.03955
CCR3 chemokine (C-C motif) receptor 3 -3.03955
EBF4 early B-cell factor 4 -3.03955
FNDC1 fibronectin type III domain containing 1 -3.03955
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -3.03955
LAMP3 lysosomal-associated membrane protein 3 -3.03955
TTC36 tetratricopeptide repeat domain 36 -3.03955
CPB2 carboxypeptidase B2 (plasma) -3.03955
PCDHB10 protocadherin beta 10 -3.03955
IRF8 interferon regulatory factor 8 -3.03955
HRG histidine-rich glycoprotein -3.03955
LKAAEAR1 LKAAEAR motif containing 1 -3.03955
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -3.03955
ASCL5 achaete-scute family bHLH transcription factor 5 -3.03955
CRLF2 cytokine receptor-like factor 2 -3.03955
NPIPA8 nuclear pore complex interacting protein family, member A8 -3.03955
NTSR1 neurotensin receptor 1 (high affinity) -3.03955
SIAH3 siah E3 ubiquitin protein ligase family member 3 -3.03955
SPRR2F small proline-rich protein 2F -3.03955
PCDHAC1 protocadherin alpha subfamily C, 1 -3.03955
CXCL13 chemokine (C-X-C motif) ligand 13 -3.03955
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -3.03955
EPHA10 EPH receptor A10 -3.03955
CCN3 cellular communication network factor 3 -3.03955
LMX1B LIM homeobox transcription factor 1, beta -3.03955
SEZ6L seizure related 6 homolog (mouse)-like -3.03955
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -3.03955
C11ORF96 chromosome 11 open reading frame 96 -3.03955
OAZ3 ornithine decarboxylase antizyme 3 -3.03955
CAGE1 cancer antigen 1 -3.03955
MYNN myoneurin -3.01522
TRIM62 tripartite motif containing 62 -2.94221
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.9258
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.76564
SOCS2 suppressor of cytokine signaling 2 -2.75417
MPV17L2 MPV17 mitochondrial membrane protein-like 2 -2.71509
TMEM11 transmembrane protein 11 -2.71103
GDAP2 ganglioside induced differentiation associated protein 2 -2.58328
PPP2R1B protein phosphatase 2, regulatory subunit A, beta -2.58328
ISCA1 iron-sulfur cluster assembly 1 -2.5755
ANAPC4 anaphase promoting complex subunit 4 -2.54644
LYPD6 LY6/PLAUR domain containing 6 -2.52004
IQCJ IQ motif containing J -2.49232
PCDHB12 protocadherin beta 12 -2.49232
INHBE inhibin, beta E -2.49073
PEBP4 phosphatidylethanolamine-binding protein 4 -2.49008
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -2.49008
SRSF7 serine/arginine-rich splicing factor 7 -2.48289
BTBD2 BTB (POZ) domain containing 2 -2.43155
SOX10 SRY (sex determining region Y)-box 10 -2.43155
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.43155
DEAF1 DEAF1 transcription factor -2.39233
BCAN brevican -2.38542
SMG8 SMG8 nonsense mediated mRNA decay factor -2.32756
DZIP1 DAZ interacting zinc finger protein 1 -2.32135
PRAF2 PRA1 domain family, member 2 -2.31207
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -2.29124
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -2.28757
PRCP prolylcarboxypeptidase (angiotensinase C) -2.28579
RC3H2 ring finger and CCCH-type domains 2 -2.26722
TRAPPC3 trafficking protein particle complex 3 -2.23352
HSDL1 hydroxysteroid dehydrogenase like 1 -2.19825
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.19461
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -2.19461
LRG1 leucine-rich alpha-2-glycoprotein 1 -2.19461
ULK2 unc-51 like autophagy activating kinase 2 -2.18324
SLC67A1 solute carrier family 67 member 1 -2.16552
EFHD2 EF-hand domain family, member D2 -2.16552
MYO5C myosin VC -2.16552
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.16261
ZFP28 ZFP28 zinc finger protein -2.16261
FNDC7 fibronectin type III domain containing 7 -2.16261
TMEM109 transmembrane protein 109 -2.15893
DUT deoxyuridine triphosphatase -2.1581
DUSP12 dual specificity phosphatase 12 -2.15409
CFAP69 cilia and flagella associated protein 69 -2.15409
SLC10A3 solute carrier family 10, member 3 -2.15409
GTF2IRD1 GTF2I repeat domain containing 1 -2.1373
TRIB3 tribbles pseudokinase 3 -2.13375
PFN1 profilin 1 -2.12942
CNTN5 contactin 5 -2.11951
GGACT gamma-glutamylamine cyclotransferase -2.11951
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase -2.11951
NR6A1 nuclear receptor subfamily 6, group A, member 1 -2.11689
PPID peptidylprolyl isomerase D -2.11019
SNX3 sorting nexin 3 -2.08705
TMC5 transmembrane channel-like 5 -2.0829
TTLL5 tubulin tyrosine ligase-like family member 5 -2.07611
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.07359
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.07144
CNTLN centlein, centrosomal protein -2.06963
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.06896
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -2.06426
PPIF peptidylprolyl isomerase F -2.03749
ANAPC16 anaphase promoting complex subunit 16 -2.03605
ATXN2L ataxin 2-like -2.03194
API5 apoptosis inhibitor 5 -2.00903
RAN RAN, member RAS oncogene family -2.00903
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.00431
TNS2 tensin 2 -2.00431
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -2.00431
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.00431
TMEM233 transmembrane protein 233 -2.00431
NME5 NME/NM23 family member 5 -2.00431
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.00431
GPX7 glutathione peroxidase 7 -2.00244