MAGI1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description membrane associated guanylate kinase, WW and PDZ domain containing 1|The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9223)
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Genes

289 genes differentially expressed following the MAGI1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.71159
PKD2L1 polycystic kidney disease 2-like 1 2.71159
CD274 CD274 molecule 2.71159
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.71159
LEF1 lymphoid enhancer-binding factor 1 2.71159
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.71159
TMEM235 transmembrane protein 235 2.71159
OLAH oleoyl-ACP hydrolase 2.71159
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.71159
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.71159
BMX BMX non-receptor tyrosine kinase 2.71159
CD177 CD177 molecule 2.71159
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.71159
DSG3 desmoglein 3 2.71159
PRAP1 proline-rich acidic protein 1 2.71159
C1ORF146 chromosome 1 open reading frame 146 2.71159
ANXA1 annexin A1 2.71159
FGR FGR proto-oncogene, Src family tyrosine kinase 2.71159
ZNF835 zinc finger protein 835 2.71159
NOTCH2NLB notch 2 N-terminal like B 2.71159
NT5C1B 5'-nucleotidase, cytosolic IB 2.71159
KASH5 KASH domain containing 5 2.71159
ASB9 ankyrin repeat and SOCS box containing 9 2.71159
RNF227 ring finger protein 227 2.71159
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.67559
CIMAP1B ciliary microtubule associated protein 1B 2.58319
BLK BLK proto-oncogene, Src family tyrosine kinase 2.58319
SPACA7 sperm acrosome associated 7 2.58319
TBX15 T-box 15 2.58319
UNC13C unc-13 homolog C (C. elegans) 2.58319
MAGEA4 melanoma antigen family A4 2.58319
TMEM225B transmembrane protein 225B 2.58319
CAMP cathelicidin antimicrobial peptide 2.58319
GNLY granulysin 2.58319
DUXB double homeobox B 2.58319
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.58319
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.58319
PAX9 paired box 9 2.58319
PAX7 paired box 7 2.58319
PAX5 paired box 5 2.58319
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.58319
TAS2R19 taste receptor, type 2, member 19 2.58319
SHE Src homology 2 domain containing E 2.58319
ZNF343 zinc finger protein 343 2.58319
CD69 CD69 molecule 2.58319
UMODL1 uromodulin-like 1 2.58319
PRLH prolactin releasing hormone 2.58319
PNMA6F PNMA family member 6F 2.58319
SPEGNB SPEG neighbor 2.58319
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.58319
TRIM74 tripartite motif containing 74 2.58319
GYPB glycophorin B (MNS blood group) 2.58319
LRRC8C-DT LRRC8C divergent transcript 2.58319
SSTR5 somatostatin receptor 5 2.58319
XCL1 chemokine (C motif) ligand 1 2.58319
SIGLEC9 sialic acid binding Ig-like lectin 9 2.58319
UCN urocortin 2.58319
CREB3L3 cAMP responsive element binding protein 3-like 3 2.58319
SMIM43 small integral membrane protein 43 2.58319
OOSP1 oocyte secreted protein 1, pseudogene 2.58319
LRRC71 leucine rich repeat containing 71 2.58319
HNF1B HNF1 homeobox B 2.58319
CNTN6 contactin 6 2.58319
TUBA4B tubulin, alpha 4b 2.58319
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.58319
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.58319
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.58319
TSPAN1 tetraspanin 1 2.58319
OTOS otospiralin 2.58319
MYL10 myosin, light chain 10, regulatory 2.58319
SPMIP10 sperm microtubule inner protein 10 2.58319
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.58319
C3AR1 complement component 3a receptor 1 2.58319
FAM135B family with sequence similarity 135, member B 2.58319
GJD4 gap junction protein, delta 4, 40.1kDa 2.58319
C1QL4 complement component 1, q subcomponent-like 4 2.58319
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.58319
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.58319
SLC22A15 solute carrier family 22, member 15 2.58319
RAET1E retinoic acid early transcript 1E 2.58319
HHEX hematopoietically expressed homeobox 2.58319
PRB2 proline-rich protein BstNI subfamily 2 2.58319
TUBA3E tubulin, alpha 3e 2.58319
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 2.58319
H2AC19 H2A clustered histone 19 2.58319
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.58319
LIX1 Lix1 homolog (chicken) 2.58319
PMIS2 PMIS2 transmembrane protein 2.58319
IL6 interleukin 6 2.58319
ATP5PD ATP synthase peripheral stalk subunit d 2.58319
ERVW-1 endogenous retrovirus group W, member 1 2.58319
SPIC Spi-C transcription factor (Spi-1/PU.1 related) 2.58319
UFSP1 UFM1-specific peptidase 1 (non-functional) 2.58319
CD53 CD53 molecule 2.58319
SERINC4 serine incorporator 4 2.58319
TROAP trophinin associated protein 2.58319
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.58319
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.58319
CDHR5 cadherin-related family member 5 2.58319
CYSLTR1 cysteinyl leukotriene receptor 1 2.58319
SPANXC SPANX family, member C 2.58319
LAMB4 laminin, beta 4 2.58319
HCRT hypocretin (orexin) neuropeptide precursor 2.58319
RAD51AP2 RAD51 associated protein 2 2.58319
F10 coagulation factor X 2.58319
HAMP hepcidin antimicrobial peptide 2.58319
FNDC8 fibronectin type III domain containing 8 2.58319
FBXO39 F-box protein 39 2.58319
HGFAC HGF activator 2.58319
CCDC7 coiled-coil domain containing 7 2.58319
TBXA2R thromboxane A2 receptor 2.58319
DRD2 dopamine receptor D2 2.58319
ALOXE3 arachidonate lipoxygenase 3 2.58319
SLC36A3 solute carrier family 36, member 3 2.58319
SEZ6L seizure related 6 homolog (mouse)-like 2.58319
GOLGA8M golgin A8 family, member M 2.58319
BTG4 B-cell translocation gene 4 2.58319
PLA2G2C phospholipase A2, group IIC 2.58319
NOTCH4 notch 4 2.58319
PRSS38 protease, serine, 38 2.58319
SIGLEC11 sialic acid binding Ig-like lectin 11 2.58319
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.58319
ITGB7 integrin, beta 7 2.58319
UTS2R urotensin 2 receptor 2.58319
HK3 hexokinase 3 (white cell) 2.58319
KLK7 kallikrein-related peptidase 7 2.58319
EGR2 early growth response 2 2.58319
KIAA1210 KIAA1210 2.58319
PATE4 prostate and testis expressed 4 2.58319
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.58319
FEZF2 FEZ family zinc finger 2 2.58319
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.58319
C5AR2 complement component 5a receptor 2 2.58319
ADGRF5 adhesion G protein-coupled receptor F5 2.58319
USP17L7 ubiquitin specific peptidase 17-like family member 7 2.58319
FGF17 fibroblast growth factor 17 2.58319
GPBAR1 G protein-coupled bile acid receptor 1 2.58319
ITPKB inositol-trisphosphate 3-kinase B 2.58319
PTCRA pre T-cell antigen receptor alpha 2.58319
MMP12 matrix metallopeptidase 12 2.58319
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.58319
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.58319
TDO2 tryptophan 2,3-dioxygenase 2.58319
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.58319
ZXDA zinc finger, X-linked, duplicated A 2.58319
TBC1D26 TBC1 domain family, member 26 2.58319
FZD1 frizzled class receptor 1 2.58319
KRT17 keratin 17, type I 2.58319
TSPAN31 tetraspanin 31 2.58319
PRSS55 protease, serine, 55 2.58319
MAGEB17 melanoma antigen family B17 2.58319
CARD9 caspase recruitment domain family, member 9 2.58319
PRSS54 protease, serine, 54 2.58319
TRIM41 tripartite motif containing 41 2.57315
OPCML opioid binding protein/cell adhesion molecule-like 2.52385
DENND2D DENN/MADD domain containing 2D 2.4968
CFAP73 cilia and flagella associated protein 73 2.4968
TEX11 testis expressed 11 2.4968
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 2.47939
NT5C3A 5'-nucleotidase, cytosolic IIIA 2.47939
AOC3 amine oxidase, copper containing 3 2.47608
RHPN1 rhophilin, Rho GTPase binding protein 1 2.44174
RICTOR RPTOR independent companion of MTOR, complex 2 2.41631
ZNF317 zinc finger protein 317 2.37898
AKR1C2 aldo-keto reductase family 1, member C2 2.37201
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.37201
TMEM31 transmembrane protein 31 2.36587
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 2.33216
NHSL2 NHS-like 2 2.33216
VAT1 vesicle amine transport 1 2.33216
PHLDB3 pleckstrin homology-like domain, family B, member 3 2.26307
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.2286
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.22728
EIPR1 EARP complex and GARP complex interacting protein 1 2.1981
CHD1 chromodomain helicase DNA binding protein 1 2.1981
ICA1 islet cell autoantigen 1, 69kDa 2.1981
MAP2K1 mitogen-activated protein kinase kinase 1 2.18063
LDOC1 leucine zipper, down-regulated in cancer 1 2.16849
PEDS1 plasmanylethanolamine desaturase 1 2.1391
TTC1 tetratricopeptide repeat domain 1 2.13069
MMP19 matrix metallopeptidase 19 2.12914
LIPT2-AS1 LIPT2 antisense RNA 1 2.12914
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 2.12696
C2ORF92 chromosome 2 open reading frame 92 2.11846
RPL35A ribosomal protein L35a 2.11117
SMAD6 SMAD family member 6 2.09548
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.09251
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.0713
RBPJ recombination signal binding protein for immunoglobulin kappa J region 2.06995
COG5 component of oligomeric golgi complex 5 2.05747
GRK4 G protein-coupled receptor kinase 4 2.05747
PRMT2IP PRMT2 interacting protein 2.03991
TDRD5 tudor domain containing 5 2.02728
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.01396
RFX1 regulatory factor X, 1 (influences HLA class II expression) 2.01055
ZNF302 zinc finger protein 302 2.00954
RIMS3 regulating synaptic membrane exocytosis 3 2.00178

decreased expression

Symbol Name Standardized Value
MIXL1 Mix paired-like homeobox -2.71159
CA3 carbonic anhydrase III -2.71159
TYMP thymidine phosphorylase -2.71159
ECSIT ECSIT signalling integrator -2.67559
ACP4 acid phosphatase 4 -2.59778
PTX3 pentraxin 3, long -2.59778
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -2.59778
FSCN3 fascin actin-bundling protein 3, testicular -2.59778
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.58319
FAM53A family with sequence similarity 53, member A -2.58319
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.58319
ESRRA estrogen-related receptor alpha -2.58319
DENND1A DENN/MADD domain containing 1A -2.58319
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.54571
ZNF470 zinc finger protein 470 -2.529
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -2.4968
TRIM38 tripartite motif containing 38 -2.4968
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.48712
ACTL8 actin-like 8 -2.47608
C17ORF114 chromosome 17 open reading frame 114 -2.47608
LEP leptin -2.47608
CAPS calcyphosine -2.47608
FOXJ1 forkhead box J1 -2.47608
MEIKIN meiotic kinetochore factor -2.47608
C1ORF202 chromosome 1 open reading frame 202 -2.47608
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B -2.47608
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.47608
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.47608
RAG2 recombination activating gene 2 -2.47608
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.47608
ADAD2 adenosine deaminase domain containing 2 -2.47608
SLC45A2 solute carrier family 45, member 2 -2.47608
GRXCR2 glutaredoxin, cysteine rich 2 -2.47608
CASP4 caspase 4, apoptosis-related cysteine peptidase -2.47608
EGFL6 EGF-like-domain, multiple 6 -2.47608
B4GAT1-DT B4GAT1 divergent transcript -2.47608
ANKRD42-DT ANKRD42 divergent transcript -2.47608
CD80 CD80 molecule -2.47608
DAPL1 death associated protein-like 1 -2.47608
EFCAB5 EF-hand calcium binding domain 5 -2.47608
GPATCH2L G patch domain containing 2-like -2.47608
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.47608
MAB21L1 mab-21-like 1 (C. elegans) -2.47608
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.47608
PENK proenkephalin -2.47608
C19ORF84 chromosome 19 open reading frame 84 -2.47608
TEX19 testis expressed 19 -2.47608
RIN1 Ras and Rab interactor 1 -2.47608
ZNF534 zinc finger protein 534 -2.47608
ADAM12 ADAM metallopeptidase domain 12 -2.47608
H4C3 H4 clustered histone 3 -2.47231
TJP2 tight junction protein 2 -2.46921
PANX2 pannexin 2 -2.4531
CCDC149 coiled-coil domain containing 149 -2.44017
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.37898
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase -2.36036
NPY neuropeptide Y -2.35675
TMEM52 transmembrane protein 52 -2.34553
ZWINT ZW10 interacting kinetochore protein -2.33442
NANOGP8 Nanog homeobox pseudogene 8 -2.33216
SIGLEC10 sialic acid binding Ig-like lectin 10 -2.33216
XG Xg blood group -2.33216
PRADC1 protease-associated domain containing 1 -2.31199
CD47 CD47 molecule -2.28785
NFE2L3 nuclear factor, erythroid 2-like 3 -2.26307
JUP junction plakoglobin -2.26307
PELI1 pellino E3 ubiquitin protein ligase 1 -2.23893
ERRFI1 ERBB receptor feedback inhibitor 1 -2.23507
TMPO thymopoietin -2.23059
H2AC16 H2A clustered histone 16 -2.2286
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.22221
NCR1 natural cytotoxicity triggering receptor 1 -2.22221
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.12743
FAM217B family with sequence similarity 217, member B -2.12696
SAFB2 scaffold attachment factor B2 -2.12604
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -2.11333
OSER1 oxidative stress responsive serine-rich 1 -2.1081
EFNA3 ephrin-A3 -2.09539
ELF4 E74-like factor 4 (ets domain transcription factor) -2.09539
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.09539
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.09539
PLCD4 phospholipase C, delta 4 -2.08727
DPEP1 dipeptidase 1 (renal) -2.08727
CMC1 C-x(9)-C motif containing 1 -2.08727
ZBTB20 zinc finger and BTB domain containing 20 -2.07916
SYBU syntabulin (syntaxin-interacting) -2.04209
SLC25A46 solute carrier family 25, member 46 -2.04059
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -2.04059
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.03251
SWAP70 SWAP switching B-cell complex 70kDa subunit -2.02728
SH3GLB1 SH3-domain GRB2-like endophilin B1 -2.02244
TAS2R20 taste receptor, type 2, member 20 -2.02214