MAK Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description male germ cell-associated kinase|The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 4117)
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Genes

100 substrates of the kinase MAK from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
RABGAP1L RAB GTPase activating protein 1-like
SYNPO2L synaptopodin 2-like
NCF2 neutrophil cytosolic factor 2
FILIP1L filamin A interacting protein 1-like
KHNYN KH and NYN domain containing
RBM17 RNA binding motif protein 17
DNM3 dynamin 3
COL4A2 collagen, type IV, alpha 2
PCLO piccolo presynaptic cytomatrix protein
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
TBX18 T-box 18
MICALL2 MICAL-like 2
PPP1R10 protein phosphatase 1, regulatory subunit 10
RPUSD1 RNA pseudouridylate synthase domain containing 1
MKI67 marker of proliferation Ki-67
TRA2B transformer 2 beta homolog (Drosophila)
IRS2 insulin receptor substrate 2
UNC45A unc-45 homolog A (C. elegans)
TTN titin
SLBP stem-loop binding protein
C19ORF26 chromosome 19 open reading frame 26
PROB1 proline-rich basic protein 1
EPC1 enhancer of polycomb homolog 1 (Drosophila)
E2F4 E2F transcription factor 4, p107/p130-binding
ZZZ3 zinc finger, ZZ-type containing 3
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
STRN4 striatin, calmodulin binding protein 4
LSM11 LSM11, U7 small nuclear RNA associated
SH3BP1 SH3-domain binding protein 1
ZNF446 zinc finger protein 446
ADRB1 adrenoceptor beta 1
ZMYM3 zinc finger, MYM-type 3
GTF2I general transcription factor IIi
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
CASKIN1 CASK interacting protein 1
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J
PHLDB1 pleckstrin homology-like domain, family B, member 1
KIAA1429 KIAA1429
FAM178B family with sequence similarity 178, member B
AMPH amphiphysin
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
ZNF777 zinc finger protein 777
FLJ22184
CREBZF CREB/ATF bZIP transcription factor
NHSL1 NHS-like 1
DNMBP dynamin binding protein
C14ORF142 chromosome 14 open reading frame 142
MKL1 megakaryoblastic leukemia (translocation) 1
COL14A1 collagen, type XIV, alpha 1
MPLKIP M-phase specific PLK1 interacting protein
GATAD2A GATA zinc finger domain containing 2A
ZFPL1 zinc finger protein-like 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
SRRM1 serine/arginine repetitive matrix 1
SCAF11 SR-related CTD-associated factor 11
SPTBN1 spectrin, beta, non-erythrocytic 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
MORC2 MORC family CW-type zinc finger 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
ZNF219 zinc finger protein 219
WDR7 WD repeat domain 7
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
MAP1S microtubule-associated protein 1S
GAS2L1 growth arrest-specific 2 like 1
TBKBP1 TBK1 binding protein 1
ANAPC2 anaphase promoting complex subunit 2
SIPA1 signal-induced proliferation-associated 1
MTX1 metaxin 1
UBA6 ubiquitin-like modifier activating enzyme 6
RASL11A RAS-like, family 11, member A
FBXO46 F-box protein 46
KIAA1211 KIAA1211
CASS4 Cas scaffolding protein family member 4
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
MAST2 microtubule associated serine/threonine kinase 2
NUMA1 nuclear mitotic apparatus protein 1
DGKQ diacylglycerol kinase, theta 110kDa
CENPV centromere protein V
HIRIP3 HIRA interacting protein 3
FAM110A family with sequence similarity 110, member A
MAP2K1 mitogen-activated protein kinase kinase 1
WIZ widely interspaced zinc finger motifs
VCY variable charge, Y-linked
SPEN spen family transcriptional repressor
FBRS fibrosin
SHKBP1 SH3KBP1 binding protein 1
CTAG2 cancer/testis antigen 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
DAZAP1 DAZ associated protein 1
PPP1R3D protein phosphatase 1, regulatory subunit 3D
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
COL12A1 collagen, type XII, alpha 1
SETD1A SET domain containing 1A
ASCL2 achaete-scute family bHLH transcription factor 2
KIF1C kinesin family member 1C
MED9 mediator complex subunit 9
METTL14 methyltransferase like 14
SPEG SPEG complex locus