MAK Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description male germ cell-associated kinase|The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 4117)
External Link https://ncbi.nlm.nih.gov/gene/4117
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Genes

500 genes differentially expressed following the MAK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0164333
S100A9 S100 calcium binding protein A9 0.0160214
NUSAP1 nucleolar and spindle associated protein 1 0.0153662
KRT19 keratin 19, type I 0.0149929
S100A8 S100 calcium binding protein A8 0.0147796
PBX1 pre-B-cell leukemia homeobox 1 0.0117281
LYZ lysozyme 0.0117266
CDC20 cell division cycle 20 0.0115363
WDR61 WD repeat domain 61 0.0103928
PRC1 protein regulator of cytokinesis 1 0.0103921
KIF20A kinesin family member 20A 0.0102884
TYMS thymidylate synthetase 0.0100574
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.00999977
CDCA4 cell division cycle associated 4 0.00992625
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.00964982
S100A7 S100 calcium binding protein A7 0.00949675
ANXA6 annexin A6 0.00944804
SUB1 SUB1 homolog (S. cerevisiae) 0.00924726
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.00918339
LMNB1 lamin B1 0.00915799
OLFM4 olfactomedin 4 0.00911385
CPVL carboxypeptidase, vitellogenic-like 0.00908047
HMGB2 high mobility group box 2 0.00905416
NEK2 NIMA-related kinase 2 0.00898483
BIRC5 baculoviral IAP repeat containing 5 0.0089285
MCM6 minichromosome maintenance complex component 6 0.00888812
DLD dihydrolipoamide dehydrogenase 0.00888626
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.00884526
LTBP1 latent transforming growth factor beta binding protein 1 0.00872219
CCNB1 cyclin B1 0.00871444
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.00867556
CXCL9 chemokine (C-X-C motif) ligand 9 0.00850375
CCNA2 cyclin A2 0.00848074
PCNA proliferating cell nuclear antigen 0.00847146
PSIP1 PC4 and SFRS1 interacting protein 1 0.00842356
RRM2 ribonucleotide reductase M2 0.00840388
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.00819755
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.00816063
CRISP3 cysteine-rich secretory protein 3 0.00815429
H2AFV H2A histone family, member V 0.00815107
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.00804506
GINS1 GINS complex subunit 1 (Psf1 homolog) 0.00793054
LCN2 lipocalin 2 0.00774854
PTTG1 pituitary tumor-transforming 1 0.00774404
RAD23B RAD23 homolog B (S. cerevisiae) 0.00771936
TMSB15A thymosin beta 15a 0.00771569
NXN nucleoredoxin 0.00769577
SLPI secretory leukocyte peptidase inhibitor 0.0076824
CAMP cathelicidin antimicrobial peptide 0.00766459
PEG3 paternally expressed 3 0.00763139
CXCL12 chemokine (C-X-C motif) ligand 12 0.00759324
SLC35E2B solute carrier family 35, member E2B 0.00754602
PCLAF PCNA clamp associated factor 0.00750516
SFRP1 secreted frizzled-related protein 1 0.0074527
MMP9 matrix metallopeptidase 9 0.007448
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.00742777
HMBS hydroxymethylbilane synthase 0.00740481
NTS neurotensin 0.00734128
NDN necdin, melanoma antigen (MAGE) family member 0.00731105
SRSF6 serine/arginine-rich splicing factor 6 0.00728313
TPBG trophoblast glycoprotein 0.00727727
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.00727158
ITM2A integral membrane protein 2A 0.00727135
SEPHS1 selenophosphate synthetase 1 0.00723064
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.00719016
CDKN3 cyclin-dependent kinase inhibitor 3 0.0071899
S100A12 S100 calcium binding protein A12 0.00716787
GJA1 gap junction protein, alpha 1, 43kDa 0.00716513
ATP11B ATPase, class VI, type 11B 0.00711886
H2AX H2A.X variant histone 0.00702794
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.00701507
HMGB1 high mobility group box 1 0.00700691
FGFR3 fibroblast growth factor receptor 3 0.00699594
LTF lactotransferrin 0.00698857
CP ceruloplasmin (ferroxidase) 0.00695623
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.00693303
S100P S100 calcium binding protein P 0.00691222
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00690664
PITX1 paired-like homeodomain 1 0.00688564
CD40 CD40 molecule, TNF receptor superfamily member 5 0.0068692
METTL7A methyltransferase like 7A 0.00685222
FST follistatin 0.00683436
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.0068156
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.00678098
OIP5 Opa interacting protein 5 0.0067668
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.00673799
TRMT5 tRNA methyltransferase 5 0.00665586
GTPBP8 GTP-binding protein 8 (putative) 0.00664027
ELANE elastase, neutrophil expressed 0.00663578
NQO2 NAD(P)H dehydrogenase, quinone 2 0.00663187
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 0.00658174
CLC Charcot-Leyden crystal galectin 0.00656288
NCAPD2 non-SMC condensin I complex, subunit D2 0.00655758
VSNL1 visinin-like 1 0.00653413
COL1A2 collagen, type I, alpha 2 0.00652504
CBX5 chromobox homolog 5 0.00651685
LBR lamin B receptor 0.00647569
VCAM1 vascular cell adhesion molecule 1 0.00646014
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.00643157
PTCH1 patched 1 0.00638545
SDC1 syndecan 1 0.00634094
LTA4H leukotriene A4 hydrolase 0.00631119
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.00623377
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00623068
PRDX2 peroxiredoxin 2 0.00622852
NELL2 NEL-like 2 (chicken) 0.00620635
WNT5A wingless-type MMTV integration site family, member 5A 0.00619998
PPA2 pyrophosphatase (inorganic) 2 0.00609091
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.00607879
RAB25 RAB25, member RAS oncogene family 0.00606171
ATG3 autophagy related 3 0.00605092
KYNU kynureninase 0.00604751
MRPL12 mitochondrial ribosomal protein L12 0.00602228
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 0.00602008
PXDN peroxidasin 0.00600435
RNF130 ring finger protein 130 0.00599909
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.00599062
NIPSNAP2 nipsnap homolog 2 0.00598837
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0059862
ADCY3 adenylate cyclase 3 0.00597388
TAL1 T-cell acute lymphocytic leukemia 1 0.005918
DEFA4 defensin, alpha 4, corticostatin 0.00588666
NPR3 natriuretic peptide receptor 3 0.00587587
ANGPT1 angiopoietin 1 0.00587518
SEPP1 selenoprotein P, plasma, 1 0.00587322
SUCLG1 succinate-CoA ligase, alpha subunit 0.00585408
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.00583712
CES1 carboxylesterase 1 0.00583578
CADPS2 Ca++-dependent secretion activator 2 0.00582858
PRKD3 protein kinase D3 0.00582042
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.0058154
RFC3 replication factor C (activator 1) 3, 38kDa 0.00581111
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0058099
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00580756
KIF11 kinesin family member 11 0.0058028
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.00580089
H1-10 H1.10 linker histone 0.0057818
ZW10 zw10 kinetochore protein 0.00577517
PEX11A peroxisomal biogenesis factor 11 alpha 0.00574336
IGFBP5 insulin-like growth factor binding protein 5 0.00573653
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.00571184
ANKRD46 ankyrin repeat domain 46 0.00568112
PGD phosphogluconate dehydrogenase 0.00566681
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.00566206
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.00565547
TFDP1 transcription factor Dp-1 0.00562811
THYN1 thymocyte nuclear protein 1 0.00560913
CCNB2 cyclin B2 0.00558101
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.00557421
RPS4Y1 ribosomal protein S4, Y-linked 1 0.00557068
TST thiosulfate sulfurtransferase (rhodanese) 0.00556713
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.00552083
CDCA3 cell division cycle associated 3 0.00550263
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.0054789
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.00547091
MGP matrix Gla protein 0.00546394
HELLS helicase, lymphoid-specific 0.00545626
MCM2 minichromosome maintenance complex component 2 0.00545271
RXRA retinoid X receptor, alpha 0.0054508
NCAPG2 non-SMC condensin II complex, subunit G2 0.0054486
RACGAP1 Rac GTPase activating protein 1 0.00544412
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.00544304
DPY19L2P2 DPY19L2 pseudogene 2 0.00542134
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.00541529
KIAA0100 KIAA0100 0.00541449
CENPF centromere protein F, 350/400kDa 0.00540967
TBC1D16 TBC1 domain family, member 16 0.00539338
PI3 peptidase inhibitor 3, skin-derived 0.00537665
ELP1 elongator acetyltransferase complex subunit 1 0.00536879
RPIA ribose 5-phosphate isomerase A 0.00535805
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.00535328
SPATS2 spermatogenesis associated, serine-rich 2 0.00530806
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.00529401
MKKS McKusick-Kaufman syndrome 0.00529134
FGL2 fibrinogen-like 2 0.0052852
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.00528278
NDC80 NDC80 kinetochore complex component 0.00527018
SRSF7 serine/arginine-rich splicing factor 7 0.00526525
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.0052643
SRP72 signal recognition particle 72kDa 0.00525883
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.00525401
TMEM106C transmembrane protein 106C 0.00525166
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.00524886
HIRA histone cell cycle regulator 0.00524273
ACOX2 acyl-CoA oxidase 2, branched chain 0.0052327
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.00523
HDDC2 HD domain containing 2 0.00522491
OLFM1 olfactomedin 1 0.00520393
TPX2 TPX2, microtubule-associated 0.00519883
INSIG1 insulin induced gene 1 0.00519547
SIVA1 SIVA1, apoptosis-inducing factor 0.00515799
ELP4 elongator acetyltransferase complex subunit 4 0.00513951
TSPAN4 tetraspanin 4 0.00513442
LMNB2 lamin B2 0.00512827
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.00512102
BPI bactericidal/permeability-increasing protein 0.00511175
FLOT2 flotillin 2 0.00511163
IFT27 intraflagellar transport 27 0.00511038
CKAP4 cytoskeleton-associated protein 4 0.00510196
MFF mitochondrial fission factor 0.00510007
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0050995
ELP5 elongator acetyltransferase complex subunit 5 0.00508782
ATF1 activating transcription factor 1 0.00508365
BCLAF1 BCL2-associated transcription factor 1 0.00506915
CERK ceramide kinase 0.00506758
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.00506587
CFLAR CASP8 and FADD-like apoptosis regulator 0.00506125
CCKBR cholecystokinin B receptor 0.00505672
CCDC85B coiled-coil domain containing 85B 0.00505128
SNUPN snurportin 1 0.00503575
CLEC10A C-type lectin domain family 10, member A 0.00503155
MACROH2A2 macroH2A.2 histone 0.0050159
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.00501506
UNG uracil-DNA glycosylase 0.00500695
SNCAIP synuclein, alpha interacting protein 0.00499848
NPM3 nucleophosmin/nucleoplasmin 3 0.0049839
CDC42 cell division cycle 42 0.00498354
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.00498229
FANCL Fanconi anemia, complementation group L 0.00497599
DDHD2 DDHD domain containing 2 0.00496926
PLBD1 phospholipase B domain containing 1 0.00496453
CENPX centromere protein X 0.00496341
HBD hemoglobin, delta 0.0049597
CA11 carbonic anhydrase XI 0.00493675
SMC2 structural maintenance of chromosomes 2 0.00493109
N4BP2L2 NEDD4 binding protein 2-like 2 0.00492843
TMEM168 transmembrane protein 168 0.00492584
CRIP2 cysteine-rich protein 2 0.00492409
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00492035
RANBP1 RAN binding protein 1 0.00491942
UBAC1 UBA domain containing 1 0.00491799
PLPBP pyridoxal phosphate binding protein 0.00490793
DET1 de-etiolated homolog 1 (Arabidopsis) 0.00488747
ISOC1 isochorismatase domain containing 1 0.0048859
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.00487194
MAN1A2 mannosidase, alpha, class 1A, member 2 0.00486599
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.00486314
SMC4 structural maintenance of chromosomes 4 0.00485998
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.00485789
NMU neuromedin U 0.00485194
ISYNA1 inositol-3-phosphate synthase 1 0.00484787
DUT deoxyuridine triphosphatase 0.00484115
TLE2 transducin-like enhancer of split 2 0.00483954
HMGN1 high mobility group nucleosome binding domain 1 0.00482688
SPC25 SPC25, NDC80 kinetochore complex component 0.00482301
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 0.00482034
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 0.00481946
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.00481822
MPO myeloperoxidase 0.00480537
KRT13 keratin 13, type I 0.00479823

decreased expression

Symbol Name Standardized Value
IFI27 interferon, alpha-inducible protein 27 -0.0165321
HSPA1A heat shock 70kDa protein 1A -0.0148911
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.0144577
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.013395
ISG15 ISG15 ubiquitin-like modifier -0.0125186
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0121215
MX1 MX dynamin-like GTPase 1 -0.0117355
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0112874
IFI6 interferon, alpha-inducible protein 6 -0.0112164
CXCL14 chemokine (C-X-C motif) ligand 14 -0.0112145
MVP major vault protein -0.01119
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0107449
IFI44L interferon-induced protein 44-like -0.0104972
BHLHE41 basic helix-loop-helix family, member e41 -0.0102686
TM4SF1 transmembrane 4 L six family member 1 -0.010074
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.00972334
SPINK1 serine peptidase inhibitor, Kazal type 1 -0.00966219
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.00961429
OASL 2'-5'-oligoadenylate synthetase-like -0.00959041
ISG20 interferon stimulated exonuclease gene 20kDa -0.00948162
AKAP12 A kinase (PRKA) anchor protein 12 -0.00946439
GAB2 GRB2-associated binding protein 2 -0.00934951
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.00930301
TAC1 tachykinin, precursor 1 -0.00929421
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.00928339
PLA1A phospholipase A1 member A -0.00917035
TENT5A terminal nucleotidyltransferase 5A -0.00892655
C8ORF4 chromosome 8 open reading frame 4 -0.00891943
SST somatostatin -0.00891521
BAG3 BCL2-associated athanogene 3 -0.00890965
SP110 SP110 nuclear body protein -0.00884583
MX2 MX dynamin-like GTPase 2 -0.00880523
GADD45A growth arrest and DNA-damage-inducible, alpha -0.00877892
NRIP3 nuclear receptor interacting protein 3 -0.00871764
HIST1H2BD histone cluster 1, H2bd -0.00867124
RTP4 receptor (chemosensory) transporter protein 4 -0.00867098
IFIH1 interferon induced with helicase C domain 1 -0.00862439
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.00850549
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.00850147
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00849379
DIPK1A divergent protein kinase domain 1A -0.00848691
HSPB8 heat shock 22kDa protein 8 -0.00846321
RRAGC Ras-related GTP binding C -0.00843066
NT5E 5'-nucleotidase, ecto (CD73) -0.00838204
EGR1 early growth response 1 -0.00835165
ACOT9 acyl-CoA thioesterase 9 -0.00828948
TGFBR3 transforming growth factor, beta receptor III -0.00828061
IFI44 interferon-induced protein 44 -0.00821567
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 -0.00817842
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -0.00817477
AQP3 aquaporin 3 (Gill blood group) -0.00813354
IFI16 interferon, gamma-inducible protein 16 -0.00806723
IL6R interleukin 6 receptor -0.00805473
IRF7 interferon regulatory factor 7 -0.00801112
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.00800356
GPNMB glycoprotein (transmembrane) nmb -0.00792792
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.00788732
HSPA2 heat shock 70kDa protein 2 -0.00785763
LBH limb bud and heart development -0.00780492
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -0.00779255
KLK11 kallikrein-related peptidase 11 -0.00777478
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.0077625
RNPS1 RNA binding protein S1, serine-rich domain -0.0077128
CLIC5 chloride intracellular channel 5 -0.00765111
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00757551
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.00756748
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.00755115
SORBS1 sorbin and SH3 domain containing 1 -0.0075458
CXCL2 chemokine (C-X-C motif) ligand 2 -0.00750007
SAT1 spermidine/spermine N1-acetyltransferase 1 -0.00748601
OXTR oxytocin receptor -0.00746847
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -0.00741578
STK10 serine/threonine kinase 10 -0.00740294
CFB complement factor B -0.00735572
ATF3 activating transcription factor 3 -0.00735446
EGR2 early growth response 2 -0.0073292
KLF6 Kruppel-like factor 6 -0.00730872
TRIM22 tripartite motif containing 22 -0.0072988
GDF15 growth differentiation factor 15 -0.00729435
DNMBP dynamin binding protein -0.00725241
QDPR quinoid dihydropteridine reductase -0.00719952
MYO1B myosin IB -0.00717007
SP100 SP100 nuclear antigen -0.00712696
VDAC1 voltage-dependent anion channel 1 -0.00712141
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.00711785
CCN2 cellular communication network factor 2 -0.00710213
SAMD9 sterile alpha motif domain containing 9 -0.00699126
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -0.00698169
AHR aryl hydrocarbon receptor -0.00697071
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.00696403
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -0.00695763
GLRX glutaredoxin (thioltransferase) -0.00695376
TIMP1 TIMP metallopeptidase inhibitor 1 -0.00695114
ABHD4 abhydrolase domain containing 4 -0.00692593
TOX3 TOX high mobility group box family member 3 -0.0068582
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.00684406
S100A10 S100 calcium binding protein A10 -0.00683418
GATA6 GATA binding protein 6 -0.00680986
NIBAN1 niban apoptosis regulator 1 -0.00680656
HNMT histamine N-methyltransferase -0.00680003
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.00679663
HMOX1 heme oxygenase 1 -0.00676693
TFF3 trefoil factor 3 (intestinal) -0.00676413
AQP1 aquaporin 1 (Colton blood group) -0.00675464
ADAM10 ADAM metallopeptidase domain 10 -0.00673424
RRAD Ras-related associated with diabetes -0.00672311
RPS27L ribosomal protein S27-like -0.00671972
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.00671455
CALCA calcitonin-related polypeptide alpha -0.00671309
OSBPL10 oxysterol binding protein-like 10 -0.00671282
IRF9 interferon regulatory factor 9 -0.00667796
APOD apolipoprotein D -0.00667445
THBD thrombomodulin -0.00665493
DRAM1 DNA-damage regulated autophagy modulator 1 -0.00664772
AMACR alpha-methylacyl-CoA racemase -0.00664175
KRT14 keratin 14, type I -0.00663384
CCN3 cellular communication network factor 3 -0.0066158
EGR3 early growth response 3 -0.00658699
FABP4 fatty acid binding protein 4, adipocyte -0.00657537
PRAME preferentially expressed antigen in melanoma -0.00654913
LYPD1 LY6/PLAUR domain containing 1 -0.00654725
LIF leukemia inhibitory factor -0.00650272
PARP12 poly (ADP-ribose) polymerase family, member 12 -0.00649856
RCAN1 regulator of calcineurin 1 -0.00649212
TSPAN1 tetraspanin 1 -0.00645828
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -0.00645492
STX3 syntaxin 3 -0.00645397
ARHGAP29 Rho GTPase activating protein 29 -0.00645357
XIC X chromosome inactivation center -0.00644541
E2F2 E2F transcription factor 2 -0.00644521
GEM GTP binding protein overexpressed in skeletal muscle -0.00644193
CRYAB crystallin, alpha B -0.00642604
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.006419
ZCCHC2 zinc finger, CCHC domain containing 2 -0.00641493
AMIGO2 adhesion molecule with Ig-like domain 2 -0.00641021
IL6 interleukin 6 -0.006366
IFITM1 interferon induced transmembrane protein 1 -0.00632803
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.00631098
TMEM140 transmembrane protein 140 -0.00630355
SLC44A4 solute carrier family 44, member 4 -0.00629515
PLIN2 perilipin 2 -0.00628561
CHIC2 cysteine-rich hydrophobic domain 2 -0.00626593
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0062655
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -0.00625606
BIK BCL2-interacting killer (apoptosis-inducing) -0.00624202
BTG1 B-cell translocation gene 1, anti-proliferative -0.00624113
FYN FYN proto-oncogene, Src family tyrosine kinase -0.00622813
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.00622311
SLC25A46 solute carrier family 25, member 46 -0.0062224
NAV2 neuron navigator 2 -0.00620182
SRPX sushi-repeat containing protein, X-linked -0.00620127
KANK1 KN motif and ankyrin repeat domains 1 -0.0061979
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.00618921
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.0061789
IER5 immediate early response 5 -0.00617632
TTC39A tetratricopeptide repeat domain 39A -0.00617218
CXADR coxsackie virus and adenovirus receptor -0.00613868
SWAP70 SWAP switching B-cell complex 70kDa subunit -0.00611633
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -0.00606534
PLAAT3 phospholipase A and acyltransferase 3 -0.00605505
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.00603737
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.00602586
KDM3A lysine (K)-specific demethylase 3A -0.0060172
RFTN1 raftlin, lipid raft linker 1 -0.00599969
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -0.00597209
PLP1 proteolipid protein 1 -0.00596581
GPR137B G protein-coupled receptor 137B -0.00592794
SECISBP2L SECIS binding protein 2-like -0.00590717
ZEB2 zinc finger E-box binding homeobox 2 -0.00589776
UPP1 uridine phosphorylase 1 -0.00589542
PRSS23 protease, serine, 23 -0.00588782
SYBU syntabulin (syntaxin-interacting) -0.00588384
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.00587158
KLF4 Kruppel-like factor 4 (gut) -0.00586999
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial -0.00586606
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.00586242
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.00585189
S100A11 S100 calcium binding protein A11 -0.00583867
RIPOR2 RHO family interacting cell polarization regulator 2 -0.00583717
DEFB1 defensin, beta 1 -0.00582946
OPTN optineurin -0.00582899
TMPRSS2 transmembrane protease, serine 2 -0.00581365
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.00581299
KIAA0226L KIAA0226-like -0.005812
UBFD1 ubiquitin family domain containing 1 -0.00580175
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1 -0.00579772
TXNDC9 thioredoxin domain containing 9 -0.0057936
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.00579304
COL4A1 collagen, type IV, alpha 1 -0.00578944
LAMP1 lysosomal-associated membrane protein 1 -0.00578822
JAG1 jagged 1 -0.00578308
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0057775
CAVIN3 caveolae associated protein 3 -0.00575383
CAPN3 calpain 3, (p94) -0.00573597
PPAP2A phosphatidic acid phosphatase type 2A -0.0057288
KLK6 kallikrein-related peptidase 6 -0.0057253
IRS2 insulin receptor substrate 2 -0.00571426
CTH cystathionine gamma-lyase -0.00570266
USP6NL USP6 N-terminal like -0.00569752
SEC61G Sec61 gamma subunit -0.00568497
ZMAT3 zinc finger, matrin-type 3 -0.00565595
MEN1 multiple endocrine neoplasia I -0.00565461
ECM1 extracellular matrix protein 1 -0.00565261
FOXO1 forkhead box O1 -0.00563745
IGF1R insulin-like growth factor 1 receptor -0.00563502
MCAM melanoma cell adhesion molecule -0.00562746
BAMBI BMP and activin membrane-bound inhibitor -0.00562435
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -0.00562102
ACLY ATP citrate lyase -0.00561876
TUFT1 tuftelin 1 -0.0056091
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0055722
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00554674
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.00553781
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -0.00553293
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0055252
SMS spermine synthase -0.00551706
TDRD7 tudor domain containing 7 -0.00551009
TKTL1 transketolase-like 1 -0.00550014
TMEM255A transmembrane protein 255A -0.00548282
TUBB2A tubulin, beta 2A class IIa -0.00545736
BCAS1 breast carcinoma amplified sequence 1 -0.00544955
KLHL24 kelch-like family member 24 -0.00544767
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00544375
TCTA T-cell leukemia translocation altered -0.00543968
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.00542951
AIM2 absent in melanoma 2 -0.0054215
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -0.00541882
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -0.00541
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -0.00540332
DST dystonin -0.00539087
TPP1 tripeptidyl peptidase I -0.00539048
ATP5F1E ATP synthase F1 subunit epsilon -0.00539042
HBEGF heparin-binding EGF-like growth factor -0.00538902
LGALS3 lectin, galactoside-binding, soluble, 3 -0.00538683
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.00537766
TSC22D1 TSC22 domain family, member 1 -0.005372
A2M alpha-2-macroglobulin -0.00536934
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.00536292
KDM5A lysine (K)-specific demethylase 5A -0.00535882
ATOX1 antioxidant 1 copper chaperone -0.00535075
WLS wntless Wnt ligand secretion mediator -0.00534913
CD36 CD36 molecule (thrombospondin receptor) -0.0053469
DCLK1 doublecortin-like kinase 1 -0.00534311
PAEP progestagen-associated endometrial protein -0.00534241
XAF1 XIAP associated factor 1 -0.00534061
TUT7 terminal uridylyl transferase 7 -0.00533921
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -0.00531636
DUSP10 dual specificity phosphatase 10 -0.00530623
NEFH neurofilament, heavy polypeptide -0.00529818
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0052839