MAML1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mastermind-like 1 (Drosophila)|This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9794)
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Genes

349 genes differentially expressed following the MAML1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHA1 protocadherin alpha 1 3.19806
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.19806
TM4SF20 transmembrane 4 L six family member 20 3.19806
SIRPB2 signal-regulatory protein beta 2 3.19806
LUC7L2 LUC7-like 2 (S. cerevisiae) 3.19806
HBA1 hemoglobin, alpha 1 3.19806
CSTL1 cystatin-like 1 3.19806
DSG3 desmoglein 3 3.19806
PAX6 paired box 6 3.19806
GDNF glial cell derived neurotrophic factor 3.19806
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.19806
OPRL1 opiate receptor-like 1 3.19806
WNT3A wingless-type MMTV integration site family, member 3A 3.19806
RAX retina and anterior neural fold homeobox 3.19806
CAPN14 calpain 14 3.19806
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.19806
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.19806
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.19806
NDRG1 N-myc downstream regulated 1 3.19806
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 3.19806
FGF21 fibroblast growth factor 21 3.19806
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.19806
CTRC chymotrypsin C (caldecrin) 3.19806
SLC46A3 solute carrier family 46, member 3 3.19806
ZFP57 ZFP57 zinc finger protein 3.19806
PBOV1 prostate and breast cancer overexpressed 1 3.19806
CA1 carbonic anhydrase I 3.19806
TMEM121 transmembrane protein 121 3.19806
PNOC prepronociceptin 3.19806
LRRC63 leucine rich repeat containing 63 3.19806
PTK6 protein tyrosine kinase 6 3.19806
IL2RB interleukin 2 receptor, beta 3.19806
DIO1 deiodinase, iodothyronine, type I 3.19806
LGALS4 lectin, galactoside-binding, soluble, 4 3.19806
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 3.19806
SP6 Sp6 transcription factor 3.19806
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.19806
KCNU1 potassium channel, subfamily U, member 1 3.19806
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.19806
STX4 syntaxin 4 3.19806
DEFB106B defensin, beta 106B 3.19806
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.19806
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.19806
C3ORF22 chromosome 3 open reading frame 22 3.19806
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.19806
LCN12 lipocalin 12 3.19806
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.19806
FABP12 fatty acid binding protein 12 3.19806
TRIM47 tripartite motif containing 47 3.19806
SYCE3 synaptonemal complex central element protein 3 3.19806
TCP11 t-complex 11, testis-specific 3.19806
KIAA1755 KIAA1755 3.19806
LINC02268 long intergenic non-protein coding RNA 2268 3.19806
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 3.19806
BGN biglycan 3.19806
YIPF7 Yip1 domain family, member 7 3.19806
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.19806
SIM1 single-minded family bHLH transcription factor 1 3.19806
DUSP8 dual specificity phosphatase 8 3.19806
FMO1 flavin containing monooxygenase 1 3.19806
SPMIP11 sperm microtubule inner protein 11 3.19806
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.19806
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 3.19806
NHLH1 nescient helix loop helix 1 3.19806
MISP3 MISP family member 3 3.19806
TTLL13 tubulin tyrosine ligase like 13 3.19806
SRARP steroid receptor associated and regulated protein 3.19806
H4C14 H4 clustered histone 14 3.19806
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.19806
SERTM2 serine rich and transmembrane domain containing 2 3.19806
CFAP299 cilia and flagella associated protein 299 3.19806
CFAP206 cilia and flagella associated protein 206 3.19806
CLXN calaxin 3.19806
GK3 glycerol kinase 3 3.19806
LBHD2 LBH domain containing 2 3.19806
EPOP elongin BC and polycomb repressive complex 2 associated protein 3.19806
BICRA BRD4 interacting chromatin remodeling complex associated protein 3.19806
SAG S-antigen; retina and pineal gland (arrestin) 3.19806
MYL10 myosin, light chain 10, regulatory 3.19806
ZIC4 Zic family member 4 3.19806
CATSPERD catsper channel auxiliary subunit delta 3.19806
IDO2 indoleamine 2,3-dioxygenase 2 3.19806
MEOX1 mesenchyme homeobox 1 3.19806
OLAH oleoyl-ACP hydrolase 3.19806
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.19806
LTBP2 latent transforming growth factor beta binding protein 2 3.19806
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.19806
PRB2 proline-rich protein BstNI subfamily 2 3.19806
CCIN calicin 3.19806
NKX2-4 NK2 homeobox 4 3.19806
HAPLN2 hyaluronan and proteoglycan link protein 2 3.19806
TLR8 toll-like receptor 8 3.19806
TSPAN8 tetraspanin 8 3.19806
DYNLRB2 dynein, light chain, roadblock-type 2 3.19806
DLK1 delta-like 1 homolog (Drosophila) 3.19806
IL16 interleukin 16 3.19806
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.19806
LGSN lengsin, lens protein with glutamine synthetase domain 3.19806
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.19806
OOSP1 oocyte secreted protein 1, pseudogene 3.19806
TSPO2 translocator protein 2 3.19806
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 3.19806
LEF1 lymphoid enhancer-binding factor 1 3.19806
PCDHA7 protocadherin alpha 7 3.19806
PLGLB2 plasminogen-like B2 3.19806
KLF1 Kruppel-like factor 1 (erythroid) 3.19806
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.19806
TBC1D10C TBC1 domain family, member 10C 3.19806
SCT secretin 3.19806
HPX hemopexin 3.19806
FAM177B family with sequence similarity 177, member B 3.19806
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 3.19806
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.19806
CDH10 cadherin 10, type 2 (T2-cadherin) 3.19806
F11 coagulation factor XI 3.19806
C11ORF91 chromosome 11 open reading frame 91 3.19806
EHF ets homologous factor 3.19806
PMP2 peripheral myelin protein 2 3.19806
APOC4 apolipoprotein C-IV 3.19806
LRRC32 leucine rich repeat containing 32 3.19806
PCDHGB4 protocadherin gamma subfamily B, 4 3.19806
NPPA natriuretic peptide A 3.19806
MR1 major histocompatibility complex, class I-related 3.19806
NOG noggin 3.19806
CERS3 ceramide synthase 3 3.19806
CST7 cystatin F (leukocystatin) 3.19806
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.19806
MUC13 mucin 13, cell surface associated 3.19806
MUC15 mucin 15, cell surface associated 3.19806
BCL2L15 BCL2-like 15 3.19806
CD27 CD27 molecule 3.19806
CD28 CD28 molecule 3.19806
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.19806
IGIP IgA-inducing protein 3.19806
EXD1 exonuclease 3'-5' domain containing 1 3.19806
LMX1A LIM homeobox transcription factor 1, alpha 3.19806
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.19806
LRRC24 leucine rich repeat containing 24 3.19806
IDI2 isopentenyl-diphosphate delta isomerase 2 3.19806
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.19806
GSTA1 glutathione S-transferase alpha 1 3.19806
IL18 interleukin 18 3.19806
IL1A interleukin 1, alpha 3.19806
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.19806
CATIP ciliogenesis associated TTC17 interacting protein 3.19806
EGR3 early growth response 3 3.19806
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.19806
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 3.19806
CHIT1 chitinase 1 (chitotriosidase) 3.19806
TPPP3 tubulin polymerization-promoting protein family member 3 3.19806
MZB1 marginal zone B and B1 cell-specific protein 3.19806
NLRP4 NLR family, pyrin domain containing 4 3.19806
RERGL RERG/RAS-like 3.19806
CD226 CD226 molecule 3.19806
LRRC74B leucine rich repeat containing 74B 3.19806
FES FES proto-oncogene, tyrosine kinase 3.19806
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.19806
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 3.19806
C10ORF90 chromosome 10 open reading frame 90 3.19806
TMEM52B transmembrane protein 52B 3.19806
ISX intestine-specific homeobox 3.19806
PF4V1 platelet factor 4 variant 1 3.19806
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.19806
IRX1 iroquois homeobox 1 3.19806
MMP12 matrix metallopeptidase 12 3.19806
FOXG1 forkhead box G1 3.19806
PRCD progressive rod-cone degeneration 3.19806
RGS4 regulator of G-protein signaling 4 3.19806
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.19806
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.19806
SCIN scinderin 3.19806
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.19806
PRSS22 protease, serine, 22 3.19806
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.19806
MT1M metallothionein 1M 3.19806
CLPSL1 colipase-like 1 3.19806
VKORC1 vitamin K epoxide reductase complex, subunit 1 3.18493
MVP major vault protein 3.17913
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 3.16187
EPRS1 glutamyl-prolyl-tRNA synthetase 1 3.1617
PROX1 prospero homeobox 1 3.10748
CD52 CD52 molecule 3.10748
CCDC18 coiled-coil domain containing 18 3.03576
ZNF835 zinc finger protein 835 3.03143
KCTD3 potassium channel tetramerization domain containing 3 3.01701
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.95491
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 2.94772
KIF2A kinesin heavy chain member 2A 2.92312
UBN2 ubinuclein 2 2.91158
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.90567
DYNLL2 dynein, light chain, LC8-type 2 2.82425
MAVS mitochondrial antiviral signaling protein 2.76008
MALSU1 mitochondrial assembly of ribosomal large subunit 1 2.72757
CINP cyclin-dependent kinase 2 interacting protein 2.70727
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.70367
GPR34 G protein-coupled receptor 34 2.69746
TPO thyroid peroxidase 2.59879
IQCC IQ motif containing C 2.5826
HSF1 heat shock transcription factor 1 2.53244
TFF3 trefoil factor 3 (intestinal) 2.52205
FMR1 fragile X mental retardation 1 2.46623
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.46306
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.45662
NEXMIF neurite extension and migration factor 2.40477
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.40477
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) 2.39717
CNR2 cannabinoid receptor 2 (macrophage) 2.39488
POTEF POTE ankyrin domain family, member F 2.39488
MTMR7 myotubularin related protein 7 2.39479
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 2.38199
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.34534
MRPL52 mitochondrial ribosomal protein L52 2.32921
GTF2IRD1 GTF2I repeat domain containing 1 2.32646
RPS16 ribosomal protein S16 2.32342
EFCAB14 EF-hand calcium binding domain 14 2.30928
SPRY2 sprouty homolog 2 (Drosophila) 2.28777
ACLY ATP citrate lyase 2.26145
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.24432
ZFYVE9 zinc finger, FYVE domain containing 9 2.24432
CCNP cyclin P 2.24432
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.24432
FYB2 FYN binding protein 2 2.24432
CCDC177 coiled-coil domain containing 177 2.24432
MYL5 myosin, light chain 5, regulatory 2.24432
ARL3 ADP-ribosylation factor-like 3 2.24432
LRRC66 leucine rich repeat containing 66 2.24432
GLB1L galactosidase, beta 1-like 2.24432
WNK4 WNK lysine deficient protein kinase 4 2.24432
OSCAR osteoclast associated, immunoglobulin-like receptor 2.24432
SYT14 synaptotagmin XIV 2.22269
SNU13 small nuclear ribonucleoprotein 13 2.1935
MRPS23 mitochondrial ribosomal protein S23 2.189
SCAF11 SR-related CTD-associated factor 11 2.18798
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 2.1838
MCMBP minichromosome maintenance complex binding protein 2.18091
GON7 GON7 subunit of KEOPS complex 2.16172
PCED1A PC-esterase domain containing 1A 2.15888
ZNF789 zinc finger protein 789 2.14212
JDP2 Jun dimerization protein 2 2.14121
SPICE1 spindle and centriole associated protein 1 2.12493
DEPDC1B DEP domain containing 1B 2.11911
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 2.11779
HMGB1 high mobility group box 1 2.11061
NINJ2 ninjurin 2 2.0824
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.0824
TRIM62 tripartite motif containing 62 2.01842
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 2.00994
MRPS6 mitochondrial ribosomal protein S6 2.00994
GFRA2 GDNF family receptor alpha 2 2.00843
PHF1 PHD finger protein 1 2.00843

decreased expression

Symbol Name Standardized Value
TMPRSS11E transmembrane protease, serine 11E -3.19806
TRIM54 tripartite motif containing 54 -3.19806
RASGEF1C RasGEF domain family, member 1C -3.19806
ERN2 endoplasmic reticulum to nucleus signaling 2 -3.19806
SNX33 sorting nexin 33 -3.19806
AHNAK2 AHNAK nucleoprotein 2 -3.19806
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -3.19806
PLK4 polo-like kinase 4 -3.19806
TBCB tubulin folding cofactor B -3.05131
SACK1A scaffolding CK1 anchoring protein A -3.03576
TXLNB taxilin beta -3.03576
ZNF57 zinc finger protein 57 -3.03576
PCDHB4 protocadherin beta 4 -3.03576
AADACL3 arylacetamide deacetylase-like 3 -3.03576
LRRC43 leucine rich repeat containing 43 -3.03576
SLC16A6 solute carrier family 16, member 6 -3.03576
TTBK1 tau tubulin kinase 1 -3.03576
SERF1B small EDRK-rich factor 1B (centromeric) -3.03576
PLK5 polo-like kinase 5 -3.03576
CD8A CD8a molecule -3.03576
ANGPTL7 angiopoietin-like 7 -3.03576
TMC2 transmembrane channel-like 2 -3.03576
RNASE4 ribonuclease, RNase A family, 4 -3.03576
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -3.03576
LOC124903233 uncharacterized LOC124903233 -3.03576
RIBC1 RIB43A domain with coiled-coils 1 -3.03576
C4ORF50 chromosome 4 open reading frame 50 -3.03576
CFAP61 cilia and flagella associated protein 61 -3.03576
IL6ST-DT IL6ST divergent transcript -3.03576
S100B S100 calcium binding protein B -3.03576
GTF2A1L general transcription factor IIA, 1-like -3.03576
FAM240C family with sequence similarity 240 member C -3.03576
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -3.03576
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.03576
CLEC4G C-type lectin domain family 4, member G -3.03576
FAM163A family with sequence similarity 163, member A -3.03576
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -3.03576
C17ORF114 chromosome 17 open reading frame 114 -3.03576
PCGF1 polycomb group ring finger 1 -2.86546
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.69746
NALCN sodium leak channel, non selective -2.6846
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -2.643
PRR36 proline rich 36 -2.59879
HHIPL1 HHIP-like 1 -2.57648
FOXO3 forkhead box O3 -2.56231
EPHA1 EPH receptor A1 -2.55475
APC adenomatous polyposis coli -2.529
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.5198
IQUB IQ motif and ubiquitin domain containing -2.5198
SPRED3 sprouty-related, EVH1 domain containing 3 -2.49562
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.49448
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit -2.43642
TBX6 T-box 6 -2.43642
SLC7A6OS solute carrier family 7, member 6 opposite strand -2.43071
HNF4G hepatocyte nuclear factor 4, gamma -2.42568
FHL3 four and a half LIM domains 3 -2.39488
COL14A1 collagen, type XIV, alpha 1 -2.36925
ZNF574 zinc finger protein 574 -2.32342
FRMPD3 FERM and PDZ domain containing 3 -2.32342
TSHZ3 teashirt zinc finger homeobox 3 -2.30928
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.2891
ARL4D ADP-ribosylation factor-like 4D -2.28583
ABTB3 ankyrin repeat and BTB domain containing 3 -2.27396
FTH1 ferritin, heavy polypeptide 1 -2.27024
MRPL38 mitochondrial ribosomal protein L38 -2.26491
ZDHHC22 zinc finger, DHHC-type containing 22 -2.26308
KLF10 Kruppel-like factor 10 -2.26145
TPX2 TPX2, microtubule-associated -2.26145
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.25681
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.25541
ZNG1E Zn regulated GTPase metalloprotein activator 1E -2.24585
RPS19BP1 ribosomal protein S19 binding protein 1 -2.24432
EIF2A eukaryotic translation initiation factor 2A, 65kDa -2.19549
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -2.1935
KCTD9 potassium channel tetramerization domain containing 9 -2.1935
C7ORF25 chromosome 7 open reading frame 25 -2.18781
USF1 upstream transcription factor 1 -2.17356
IFI30 interferon, gamma-inducible protein 30 -2.16833
N4BP2L1 NEDD4 binding protein 2-like 1 -2.16833
ZMYM2 zinc finger, MYM-type 2 -2.15888
DUSP6 dual specificity phosphatase 6 -2.15565
FRMD3 FERM domain containing 3 -2.14212
LBP lipopolysaccharide binding protein -2.12311
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.12311
CLTRN collectrin, amino acid transport regulator -2.12311
HCFC2 host cell factor C2 -2.12311
GLOD4 glyoxalase domain containing 4 -2.1165
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.09023
MRTFB myocardin related transcription factor B -2.08125
RERG RAS-like, estrogen-regulated, growth inhibitor -2.05556
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -2.05264
KLHL15 kelch-like family member 15 -2.05264
TUBG2 tubulin, gamma 2 -2.03652
GAB1 GRB2-associated binding protein 1 -2.0356
PSMC3IP PSMC3 interacting protein -2.01346
MEGF9 multiple EGF-like-domains 9 -2.01062
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.00994
IL6R interleukin 6 receptor -2.00994
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -2.00994