MAP1B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description microtubule-associated protein 1B|This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4131)
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Genes

337 genes differentially expressed following the MAP1B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPR75 G protein-coupled receptor 75 2.70969
PLCH2 phospholipase C, eta 2 2.70969
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.70969
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.70969
GIMAP4 GTPase, IMAP family member 4 2.70969
CA6 carbonic anhydrase VI 2.70969
GUCY2F guanylate cyclase 2F, retinal 2.70969
PCDH8 protocadherin 8 2.70969
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.70969
LRRC10B leucine rich repeat containing 10B 2.70969
PAX8 paired box 8 2.70969
IFI44L interferon-induced protein 44-like 2.70969
RAX retina and anterior neural fold homeobox 2.70969
CD274 CD274 molecule 2.70969
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.70969
FGD1 FYVE, RhoGEF and PH domain containing 1 2.70969
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.70969
SLC46A3 solute carrier family 46, member 3 2.70969
GNLY granulysin 2.70969
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.70969
CAMP cathelicidin antimicrobial peptide 2.70969
CELA3B chymotrypsin-like elastase family, member 3B 2.70969
UBA7 ubiquitin-like modifier activating enzyme 7 2.70969
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.70969
LVRN laeverin 2.70969
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.70969
OR56A5 olfactory receptor, family 56, subfamily A, member 5 2.70969
FAM9B family with sequence similarity 9, member B 2.70969
RNASE6 ribonuclease, RNase A family, k6 2.70969
AMELX amelogenin, X-linked 2.70969
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.70969
MEIG1 meiosis/spermiogenesis associated 1 2.70969
ZC2HC1B zinc finger, C2HC-type containing 1B 2.70969
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.70969
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.70969
LDHC lactate dehydrogenase C 2.70969
SOWAHB sosondowah ankyrin repeat domain family member B 2.70969
HBZ hemoglobin, zeta 2.70969
HBM hemoglobin, mu 2.70969
KRT72 keratin 72, type II 2.70969
BFSP2 beaded filament structural protein 2, phakinin 2.70969
IL2RA interleukin 2 receptor, alpha 2.70969
MPO myeloperoxidase 2.70969
SMLR1 small leucine-rich protein 1 2.70969
SP6 Sp6 transcription factor 2.70969
CD3G CD3g molecule, gamma (CD3-TCR complex) 2.70969
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.70969
DRC11L dynein regulatory complex subunit 11 like 2.70969
AVPR1B arginine vasopressin receptor 1B 2.70969
OPRM1 opioid receptor, mu 1 2.70969
GPR35 G protein-coupled receptor 35 2.70969
RCVRN recoverin 2.70969
HTRA4 HtrA serine peptidase 4 2.70969
KRT80 keratin 80, type II 2.70969
FMO2 flavin containing monooxygenase 2 (non-functional) 2.70969
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.70969
LMNTD1 lamin tail domain containing 1 2.70969
H3-5 H3.5 histone 2.70969
HTD2 hydroxyacyl-thioester dehydratase type 2 2.70969
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.70969
NOTCH2NLB notch 2 N-terminal like B 2.70969
C8ORF90 chromosome 8 open reading frame 90 2.70969
H2BK1 H2B.K variant histone 1 2.70969
CFAP276 cilia and flagella associated protein 276 2.70969
CFAP107 cilia and flagella associated protein 107 2.70969
H2BW1 H2B.W histone 1 2.70969
PLPP4 phospholipid phosphatase 4 2.70969
MINAR2 membrane integral NOTCH2 associated receptor 2 2.70969
CCDC198 coiled-coil domain containing 198 2.70969
PROX2 prospero homeobox 2 2.70969
WNT16 wingless-type MMTV integration site family, member 16 2.70969
MSX2 msh homeobox 2 2.70969
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.70969
OLAH oleoyl-ACP hydrolase 2.70969
MAL mal, T-cell differentiation protein 2.70969
FAM43A family with sequence similarity 43, member A 2.70969
ITK IL2-inducible T-cell kinase 2.70969
PCDHB12 protocadherin beta 12 2.70969
DMP1 dentin matrix acidic phosphoprotein 1 2.70969
IFITM2 interferon induced transmembrane protein 2 2.70969
SIM2 single-minded family bHLH transcription factor 2 2.70969
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.70969
CDKN2A cyclin-dependent kinase inhibitor 2A 2.70969
DOK7 docking protein 7 2.70969
GRAP GRB2-related adaptor protein 2.70969
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.70969
F5 coagulation factor V (proaccelerin, labile factor) 2.70969
LTB lymphotoxin beta (TNF superfamily, member 3) 2.70969
SMCP sperm mitochondria-associated cysteine-rich protein 2.70969
PCDHGC5 protocadherin gamma subfamily C, 5 2.70969
OOSP1 oocyte secreted protein 1, pseudogene 2.70969
SAA4 serum amyloid A4, constitutive 2.70969
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.70969
PCDHGB4 protocadherin gamma subfamily B, 4 2.70969
OR1M1 olfactory receptor, family 1, subfamily M, member 1 2.70969
HAVCR1 hepatitis A virus cellular receptor 1 2.70969
APOC3 apolipoprotein C-III 2.70969
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.70969
TRIM54 tripartite motif containing 54 2.70969
C2CD4D C2 calcium-dependent domain containing 4D 2.70969
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.70969
ISL1 ISL LIM homeobox 1 2.70969
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.70969
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.70969
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.70969
KLHL41 kelch-like family member 41 2.70969
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.70969
PCDHGB5 protocadherin gamma subfamily B, 5 2.70969
PCDHGB1 protocadherin gamma subfamily B, 1 2.70969
LRCOL1 leucine rich colipase-like 1 2.70969
NPPA natriuretic peptide A 2.70969
FNDC9 fibronectin type III domain containing 9 2.70969
MRLN myoregulin 2.70969
EFCAB9 EF-hand calcium binding domain 9 2.70969
BTNL3 butyrophilin-like 3 2.70969
TEKT1 tektin 1 2.70969
TIPE2 TNF alpha induced protein 8 like 2 2.70969
RIPK3 receptor-interacting serine-threonine kinase 3 2.70969
RIN3 Ras and Rab interactor 3 2.70969
GPR142 G protein-coupled receptor 142 2.70969
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.70969
STRC stereocilin 2.70969
MB myoglobin 2.70969
NICN1 nicolin 1 2.70969
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.70969
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.70969
NMBR neuromedin B receptor 2.70969
TMPPE transmembrane protein with metallophosphoesterase domain 2.70969
LHX3 LIM homeobox 3 2.70969
RGCC regulator of cell cycle 2.70969
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.70969
PLA1A phospholipase A1 member A 2.70969
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.70969
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.70969
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.70969
ITGB7 integrin, beta 7 2.70969
TPPP3 tubulin polymerization-promoting protein family member 3 2.70969
PENK proenkephalin 2.70969
BCL2A1 BCL2-related protein A1 2.70969
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.70969
KIF12 kinesin family member 12 2.70969
TNRC18 trinucleotide repeat containing 18 2.70969
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.70969
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.70969
RNF224 ring finger protein 224 2.70969
NUTM2A NUT family member 2A 2.70969
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.70969
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.70969
ROM1 retinal outer segment membrane protein 1 2.70969
TMPRSS15 transmembrane protease, serine 15 2.70969
IRX4 iroquois homeobox 4 2.70969
PAGE2B P antigen family, member 2B 2.70969
FGF10 fibroblast growth factor 10 2.70969
HHIPL2 HHIP-like 2 2.70969
ABRA actin binding Rho activating protein 2.70969
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.70969
KRT15 keratin 15, type I 2.70969
HBA1 hemoglobin, alpha 1 2.70969
RNF222 ring finger protein 222 2.70969
GPR50 G protein-coupled receptor 50 2.70969
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.70969
IRX1 iroquois homeobox 1 2.70969
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 2.64877
MRPL1 mitochondrial ribosomal protein L1 2.6255
BHMT betaine--homocysteine S-methyltransferase 2.6255
FBN2 fibrillin 2 2.57525
USHBP1 Usher syndrome 1C binding protein 1 2.52938
PHF20L1 PHD finger protein 20-like 1 2.52938
EMG1 EMG1 N1-specific pseudouridine methyltransferase 2.51141
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 2.51141
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.50432
IRAK3 interleukin-1 receptor-associated kinase 3 2.41916
G6PC3 glucose 6 phosphatase, catalytic, 3 2.40488
POU3F2 POU class 3 homeobox 2 2.38192
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.38192
DTNBP1 dystrobrevin binding protein 1 2.37683
PURB purine-rich element binding protein B 2.36508
SPATA22 spermatogenesis associated 22 2.35435
ZNF169 zinc finger protein 169 2.35435
EPHB3 EPH receptor B3 2.35435
NKAIN1 Na+/K+ transporting ATPase interacting 1 2.35435
YAE1 YAE1 maturation factor of ABCE1 2.34663
CAPRIN1 cell cycle associated protein 1 2.34102
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 2.30223
APAF1 apoptotic peptidase activating factor 1 2.29066
LDLRAD4 low density lipoprotein receptor class A domain containing 4 2.27897
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.26468
ZDHHC18 zinc finger, DHHC-type containing 18 2.25925
TIPRL TOR signaling pathway regulator 2.25288
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.24131
TIGD3 tigger transposable element derived 3 2.23487
ZNF451 zinc finger protein 451 2.23428
GTF3A general transcription factor IIIA 2.22473
UQCRH ubiquinol-cytochrome c reductase hinge protein 2.2202
KYAT3 kynurenine aminotransferase 3 2.21453
DAXX death-domain associated protein 2.21139
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.20667
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.20667
CCDC144A coiled-coil domain containing 144A 2.20667
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 2.20286
DMAP1 DNA methyltransferase 1 associated protein 1 2.19784
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.17803
GEM GTP binding protein overexpressed in skeletal muscle 2.16147
TAFA4 TAFA chemokine like family member 4 2.14455
ZNF724 zinc finger protein 724 2.13401
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 2.13292
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 2.10463
ZNF385B zinc finger protein 385B 2.10071
NANOG Nanog homeobox 2.08355
NFASC neurofascin 2.07331
ZNF680 zinc finger protein 680 2.0645
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 2.05958
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.05923
SFPQ splicing factor proline/glutamine-rich 2.05608
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.05349
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.04958
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 2.04958
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 2.04874
ZNF432 zinc finger protein 432 2.02659
TMEM200B transmembrane protein 200B 2.01453
NUTM1 NUT midline carcinoma, family member 1 2.01238
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.0101
INTS13 integrator complex subunit 13 2.0101

decreased expression

Symbol Name Standardized Value
PLXND1 plexin D1 -2.70969
KIAA0319L KIAA0319-like -2.70969
PTPRM protein tyrosine phosphatase, receptor type, M -2.70969
MYBPC1 myosin binding protein C, slow type -2.70969
CLDN1 claudin 1 -2.70969
IL11RA interleukin 11 receptor, alpha -2.70969
STXBP5 syntaxin binding protein 5 (tomosyn) -2.70969
POGLUT1 protein O-glucosyltransferase 1 -2.70969
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.70969
THSD4 thrombospondin, type I, domain containing 4 -2.70969
TFCP2L1 transcription factor CP2-like 1 -2.70969
A1CF APOBEC1 complementation factor -2.70969
SLITRK3 SLIT and NTRK-like family, member 3 -2.70969
CUL3 cullin 3 -2.69815
SLC30A8 solute carrier family 30 (zinc transporter), member 8 -2.66297
KLRG1 killer cell lectin-like receptor subfamily G, member 1 -2.66297
PRPF31 pre-mRNA processing factor 31 -2.64822
LRRC8C-DT LRRC8C divergent transcript -2.6255
FGF18 fibroblast growth factor 18 -2.6255
TICAM1 toll-like receptor adaptor molecule 1 -2.6255
CLCNKA chloride channel, voltage-sensitive Ka -2.6255
C17ORF113 chromosome 17 open reading frame 113 -2.6255
CACNG7 calcium channel, voltage-dependent, gamma subunit 7 -2.6255
SMIM43 small integral membrane protein 43 -2.6255
MGAM maltase-glucoamylase -2.6255
PRDM7 PR domain containing 7 -2.6255
GPR183 G protein-coupled receptor 183 -2.6255
SPRR2F small proline-rich protein 2F -2.6255
NXPE1 neurexophilin and PC-esterase domain family, member 1 -2.6255
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.6255
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -2.6255
BTN1A1 butyrophilin, subfamily 1, member A1 -2.6255
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.6255
ELF4 E74-like factor 4 (ets domain transcription factor) -2.6255
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) -2.6255
HRCT1 histidine rich carboxyl terminus 1 -2.6255
ERICH6 glutamate-rich 6 -2.6255
S100A14 S100 calcium binding protein A14 -2.6255
MORN5 MORN repeat containing 5 -2.6255
CFI complement factor I -2.6255
SIAH3 siah E3 ubiquitin protein ligase family member 3 -2.6255
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 -2.6255
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.6255
CXCR4 chemokine (C-X-C motif) receptor 4 -2.6255
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.6255
C3ORF49 chromosome 3 open reading frame 49 -2.6255
GPR146 G protein-coupled receptor 146 -2.6255
SLITRK1 SLIT and NTRK-like family, member 1 -2.6255
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -2.6255
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.59111
PDE9A phosphodiesterase 9A -2.58203
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.56783
DENND3 DENN/MADD domain containing 3 -2.56307
TLCD4 TLC domain containing 4 -2.56215
FGF12 fibroblast growth factor 12 -2.56144
ICAM3 intercellular adhesion molecule 3 -2.54164
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.51342
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.51257
MSH3 mutS homolog 3 -2.50352
NPIPB15 nuclear pore complex interacting protein family, member B15 -2.48939
FLT4 fms-related tyrosine kinase 4 -2.48939
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 -2.43569
ZNF583 zinc finger protein 583 -2.40195
PLK4 polo-like kinase 4 -2.36807
CYTL1 cytokine-like 1 -2.35435
GARRE1 granule associated Rac and RHOG effector 1 -2.31932
TRAPPC9 trafficking protein particle complex 9 -2.30172
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -2.24367
PCNX1 pecanex 1 -2.23937
COQ4 coenzyme Q4 -2.23568
FAM229A family with sequence similarity 229, member A -2.2278
ADGRE5 adhesion G protein-coupled receptor E5 -2.2278
SOX10 SRY (sex determining region Y)-box 10 -2.2278
GPR87 G protein-coupled receptor 87 -2.2278
FBXO4 F-box protein 4 -2.2278
AP4B1 adaptor-related protein complex 4, beta 1 subunit -2.2202
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -2.21842
LDAH lipid droplet associated hydrolase -2.20889
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.19784
IQCE IQ motif containing E -2.17976
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.17889
AKAP13 A kinase (PRKA) anchor protein 13 -2.17889
HEXA hexosaminidase A (alpha polypeptide) -2.17803
MSL3 male-specific lethal 3 homolog (Drosophila) -2.17803
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.16147
ZBTB47 zinc finger and BTB domain containing 47 -2.15726
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.14455
LPCAT2 lysophosphatidylcholine acyltransferase 2 -2.13857
ZDHHC11B zinc finger, DHHC-type containing 11B -2.13727
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.13448
SLIT2 slit homolog 2 (Drosophila) -2.12516
AKAP10 A kinase (PRKA) anchor protein 10 -2.11753
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.11346
CCDC196 coiled-coil domain containing 196 -2.11346
C22ORF23 chromosome 22 open reading frame 23 -2.11346
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.11346
PAAF1 proteasomal ATPase-associated factor 1 -2.11346
C3ORF18 chromosome 3 open reading frame 18 -2.11346
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.11096
TATDN2 TatD DNase domain containing 2 -2.09615
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.08219
RAI2 retinoic acid induced 2 -2.08219
GUCD1 guanylyl cyclase domain containing 1 -2.08044
MCF2L MCF.2 cell line derived transforming sequence-like -2.07981
NAP1L2 nucleosome assembly protein 1-like 2 -2.07768
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -2.07625
MAP1B microtubule-associated protein 1B -2.07331
ZNHIT2 zinc finger, HIT-type containing 2 -2.06273
ZNF888 zinc finger protein 888 -2.05923
PRR12 proline rich 12 -2.05608
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -2.05349
THOC5 THO complex 5 -2.0316
AKNA AT-hook transcription factor -2.0316
WASHC2A WASH complex subunit 2A -2.02455