| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase 1|The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5604) |
| External Link | https://ncbi.nlm.nih.gov/gene/5604 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the MAP2K1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TFF3 | trefoil factor 3 (intestinal) | 0.0135895 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.0135707 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0127946 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.011826 |
| OLFM4 | olfactomedin 4 | 0.0110949 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0108238 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0104861 |
| FCGBP | Fc fragment of IgG binding protein | 0.00992674 |
| FASN | fatty acid synthase | 0.0097442 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00973426 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00959846 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00914935 |
| TXNIP | thioredoxin interacting protein | 0.00899368 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.00897109 |
| GPX2 | glutathione peroxidase 2 | 0.00888372 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00859163 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.00856767 |
| NTS | neurotensin | 0.00851581 |
| CLCA1 | chloride channel accessory 1 | 0.0082957 |
| H2AX | H2A.X variant histone | 0.00829172 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00820235 |
| PTCH1 | patched 1 | 0.00804053 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0079399 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 0.00778193 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00776932 |
| EPHB2 | EPH receptor B2 | 0.00743744 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00737969 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00734801 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.00728789 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00721302 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00717536 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00707374 |
| APOD | apolipoprotein D | 0.0070654 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00705239 |
| HEPH | hephaestin | 0.00704361 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00699376 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00697219 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.00693035 |
| C1R | complement component 1, r subcomponent | 0.00687219 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.00679376 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00671686 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.00667235 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.00666099 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.00665458 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00662701 |
| RTN1 | reticulon 1 | 0.00661447 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00656305 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.00653137 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 0.00650365 |
| MLPH | melanophilin | 0.00650223 |
| IL2RG | interleukin 2 receptor, gamma | 0.00647885 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.00637686 |
| SCD5 | stearoyl-CoA desaturase 5 | 0.00630112 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00625256 |
| DEK | DEK proto-oncogene | 0.00624665 |
| FABP1 | fatty acid binding protein 1, liver | 0.00624019 |
| HEXB | hexosaminidase B (beta polypeptide) | 0.00623569 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.00621772 |
| IL7R | interleukin 7 receptor | 0.00619178 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | 0.0061763 |
| ELAPOR1 | endosome-lysosome associated apoptosis and autophagy regulator 1 | 0.00614279 |
| PIGR | polymeric immunoglobulin receptor | 0.00613269 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00612991 |
| PIR | pirin (iron-binding nuclear protein) | 0.00612071 |
| MMP12 | matrix metallopeptidase 12 | 0.0060843 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | 0.00607176 |
| SDF4 | stromal cell derived factor 4 | 0.00602416 |
| TRMT5 | tRNA methyltransferase 5 | 0.00597081 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.00593326 |
| NMT2 | N-myristoyltransferase 2 | 0.00593081 |
| GSAP | gamma-secretase activating protein | 0.00589313 |
| TSPAN8 | tetraspanin 8 | 0.00587944 |
| MXRA7 | matrix-remodelling associated 7 | 0.00586617 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.00586091 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.0058431 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0058369 |
| APOC2 | apolipoprotein C-II | 0.00582662 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.00578921 |
| EFNB2 | ephrin-B2 | 0.00576204 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00576138 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00575381 |
| TOR3A | torsin family 3, member A | 0.00575275 |
| VDAC3 | voltage-dependent anion channel 3 | 0.00574537 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.00574196 |
| FAM53B | family with sequence similarity 53, member B | 0.00573477 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.00572481 |
| TTC38 | tetratricopeptide repeat domain 38 | 0.0057195 |
| PF4 | platelet factor 4 | 0.00568626 |
| DCT | dopachrome tautomerase | 0.00566836 |
| CCNF | cyclin F | 0.00566774 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.00565951 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.00565645 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.00564545 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.00563805 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.00561896 |
| PFKL | phosphofructokinase, liver | 0.00561129 |
| PCP4 | Purkinje cell protein 4 | 0.00560771 |
| MARCKSL1 | MARCKS-like 1 | 0.00559018 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.0055868 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.00558204 |
| DUOX2 | dual oxidase 2 | 0.00558006 |
| TRIM8 | tripartite motif containing 8 | 0.00556196 |
| PLK1 | polo-like kinase 1 | 0.00555897 |
| DGKZ | diacylglycerol kinase, zeta | 0.00555856 |
| TG | thyroglobulin | 0.00554803 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.005527 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00550019 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.005498 |
| EIF2D | eukaryotic translation initiation factor 2D | 0.00548328 |
| CRLF1 | cytokine receptor-like factor 1 | 0.00547781 |
| CCNB1 | cyclin B1 | 0.00547741 |
| LOXL2 | lysyl oxidase-like 2 | 0.00544471 |
| COQ8A | coenzyme Q8A | 0.0054176 |
| CD320 | CD320 molecule | 0.00541294 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.00541039 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.00540273 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 0.00538816 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00537985 |
| SORD | sorbitol dehydrogenase | 0.0053733 |
| NIPSNAP2 | nipsnap homolog 2 | 0.00537301 |
| H1-10 | H1.10 linker histone | 0.0053725 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | 0.00535655 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | 0.00533805 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.00531317 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00531013 |
| CTSK | cathepsin K | 0.00530952 |
| INSIG1 | insulin induced gene 1 | 0.00530309 |
| TOB1 | transducer of ERBB2, 1 | 0.00529081 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00529032 |
| NOX1 | NADPH oxidase 1 | 0.00528185 |
| CD2 | CD2 molecule | 0.0052736 |
| IL2RB | interleukin 2 receptor, beta | 0.00527207 |
| RNF43 | ring finger protein 43 | 0.00526225 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | 0.00523027 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.00522439 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00519497 |
| R3HDM2 | R3H domain containing 2 | 0.00519125 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.00518785 |
| ADAP1 | ArfGAP with dual PH domains 1 | 0.00518201 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00518175 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00517016 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | 0.00515652 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | 0.00515252 |
| NMB | neuromedin B | 0.00511913 |
| SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | 0.0051144 |
| PRKCA | protein kinase C, alpha | 0.00510986 |
| HNMT | histamine N-methyltransferase | 0.00510857 |
| FLOT2 | flotillin 2 | 0.0050902 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | 0.005088 |
| ERLIN2 | ER lipid raft associated 2 | 0.00508647 |
| TMEM106C | transmembrane protein 106C | 0.00507349 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00506566 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.00505681 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.0050567 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.00504723 |
| EFHD2 | EF-hand domain family, member D2 | 0.0050472 |
| AGR2 | anterior gradient 2 | 0.00503275 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.00502263 |
| MRPS27 | mitochondrial ribosomal protein S27 | 0.00501703 |
| MINPP1 | multiple inositol-polyphosphate phosphatase 1 | 0.00501574 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00500035 |
| PMEL | premelanosome protein | 0.00498927 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00498659 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.00498389 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00496761 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | 0.00495658 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00492688 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00492636 |
| DMD | dystrophin | 0.00492349 |
| GALC | galactosylceramidase | 0.00492198 |
| TBC1D4 | TBC1 domain family, member 4 | 0.00491802 |
| CST3 | cystatin C | 0.00489808 |
| OCRL | oculocerebrorenal syndrome of Lowe | 0.00489804 |
| CREBL2 | cAMP responsive element binding protein-like 2 | 0.00489419 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | 0.00487497 |
| EPCAM | epithelial cell adhesion molecule | 0.00487443 |
| MACROD1 | MACRO domain containing 1 | 0.00487439 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | 0.00487358 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.00486872 |
| TSPAN4 | tetraspanin 4 | 0.00486424 |
| TESC | tescalcin | 0.00484422 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 0.00482272 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00482145 |
| RAD21 | RAD21 homolog (S. pombe) | 0.00482013 |
| CROCCP2 | ciliary rootlet coiled-coil, rootletin pseudogene 2 | 0.00481089 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00480701 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00479643 |
| PTGDR | prostaglandin D2 receptor (DP) | 0.00478829 |
| HDAC1 | histone deacetylase 1 | 0.00478747 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00477416 |
| CBX7 | chromobox homolog 7 | 0.0047699 |
| NDRG3 | NDRG family member 3 | 0.00476658 |
| GPM6A | glycoprotein M6A | 0.00476592 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | 0.00475551 |
| SV2A | synaptic vesicle glycoprotein 2A | 0.00475497 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.0047537 |
| SCRIB | scribbled planar cell polarity protein | 0.00474431 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.004734 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00472946 |
| CALB2 | calbindin 2 | 0.00470455 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 0.00470368 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.00470357 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00470298 |
| ACSF2 | acyl-CoA synthetase family member 2 | 0.00469751 |
| PASK | PAS domain containing serine/threonine kinase | 0.00469332 |
| GFAP | glial fibrillary acidic protein | 0.00468935 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | 0.00466778 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.00465763 |
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | 0.00464873 |
| PFN2 | profilin 2 | 0.00464764 |
| CD38 | CD38 molecule | 0.00464494 |
| ZNF580 | zinc finger protein 580 | 0.00463844 |
| RAP2A | RAP2A, member of RAS oncogene family | 0.00463314 |
| CNTNAP2 | contactin associated protein-like 2 | 0.00462969 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00462595 |
| CD48 | CD48 molecule | 0.00461034 |
| MEIS2 | Meis homeobox 2 | 0.00460659 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | 0.00460593 |
| COL6A2 | collagen, type VI, alpha 2 | 0.00460382 |
| HMGB2 | high mobility group box 2 | 0.00460064 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.00459369 |
| KLHDC3 | kelch domain containing 3 | 0.00459271 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.00458933 |
| CIDEA | cell death-inducing DFFA-like effector a | 0.00458858 |
| CD247 | CD247 molecule | 0.00457865 |
| HELLS | helicase, lymphoid-specific | 0.00457481 |
| TMEM14B | transmembrane protein 14B | 0.00457041 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.0045636 |
| BCL2L14 | BCL2-like 14 (apoptosis facilitator) | 0.00455865 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.00454929 |
| SIGLEC15 | sialic acid binding Ig-like lectin 15 | 0.00453233 |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.00453213 |
| TMEM161A | transmembrane protein 161A | 0.00453153 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.00452818 |
| CHPT1 | choline phosphotransferase 1 | 0.00452744 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.00451842 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | 0.00451289 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00451195 |
| MT2A | metallothionein 2A | 0.00450995 |
| KRT20 | keratin 20, type I | 0.00450651 |
| NKG7 | natural killer cell granule protein 7 | 0.00450398 |
| PDE8B | phosphodiesterase 8B | 0.00450037 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | 0.00449662 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00449575 |
| FOXM1 | forkhead box M1 | 0.00449254 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00448317 |
| NEK2 | NIMA-related kinase 2 | 0.00448155 |
| BUB3 | BUB3 mitotic checkpoint protein | 0.00447437 |
| TRIM37 | tripartite motif containing 37 | 0.00446854 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DEFB1 | defensin, beta 1 | -0.0143261 |
| S100A8 | S100 calcium binding protein A8 | -0.0126153 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0125566 |
| RGCC | regulator of cell cycle | -0.0121604 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.0118759 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0117246 |
| S100A2 | S100 calcium binding protein A2 | -0.0115685 |
| S100A9 | S100 calcium binding protein A9 | -0.0114704 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.0110726 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.010976 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0107664 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0107172 |
| CRYAB | crystallin, alpha B | -0.0106802 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0104043 |
| ATF3 | activating transcription factor 3 | -0.0103391 |
| MX1 | MX dynamin-like GTPase 1 | -0.0103304 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.0101682 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0100822 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00997782 |
| CTSZ | cathepsin Z | -0.0099682 |
| MGLL | monoglyceride lipase | -0.00959868 |
| ANXA1 | annexin A1 | -0.0094757 |
| KLF6 | Kruppel-like factor 6 | -0.0094235 |
| IFI44 | interferon-induced protein 44 | -0.00938216 |
| SPRR3 | small proline-rich protein 3 | -0.00931312 |
| EMX2 | empty spiracles homeobox 2 | -0.00921505 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.00918038 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00896829 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00882142 |
| ASS1 | argininosuccinate synthase 1 | -0.00862441 |
| SPRR1B | small proline-rich protein 1B | -0.00855145 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.00852783 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.00848319 |
| EMP1 | epithelial membrane protein 1 | -0.00837404 |
| TPM4 | tropomyosin 4 | -0.0083457 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | -0.00824532 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00820687 |
| KRT14 | keratin 14, type I | -0.00813327 |
| IFI44L | interferon-induced protein 44-like | -0.00812333 |
| CSTA | cystatin A (stefin A) | -0.00810169 |
| IL1RN | interleukin 1 receptor antagonist | -0.00806853 |
| FRMD4B | FERM domain containing 4B | -0.00805619 |
| CUX1 | cut-like homeobox 1 | -0.00805308 |
| ZNF165 | zinc finger protein 165 | -0.00803189 |
| BEX4 | brain expressed, X-linked 4 | -0.00802295 |
| GNAS | GNAS complex locus | -0.00801753 |
| KRT7 | keratin 7, type II | -0.00801524 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.0079784 |
| S100A7 | S100 calcium binding protein A7 | -0.00795344 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.0079377 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | -0.00787721 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00785757 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.00781549 |
| TRAM1 | translocation associated membrane protein 1 | -0.00781294 |
| TPD52L1 | tumor protein D52-like 1 | -0.0077984 |
| FOLR1 | folate receptor 1 (adult) | -0.00779803 |
| MAL | mal, T-cell differentiation protein | -0.00767721 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00764328 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00763488 |
| MCOLN1 | mucolipin 1 | -0.00762467 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.007593 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.00755408 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00754403 |
| CSRP2 | cysteine and glycine-rich protein 2 | -0.0075085 |
| KRT13 | keratin 13, type I | -0.00748079 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.0074385 |
| CLDN10 | claudin 10 | -0.00740551 |
| HMOX1 | heme oxygenase 1 | -0.00737469 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.00736594 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.00731449 |
| KRT6A | keratin 6A, type II | -0.00726231 |
| CAV2 | caveolin 2 | -0.00725241 |
| ZNF195 | zinc finger protein 195 | -0.00725126 |
| FHL1 | four and a half LIM domains 1 | -0.00723032 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00722781 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.00720773 |
| PDZK1 | PDZ domain containing 1 | -0.00719093 |
| SCEL | sciellin | -0.00718044 |
| ZNF281 | zinc finger protein 281 | -0.00716966 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00713301 |
| MYO1B | myosin IB | -0.00709374 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0070902 |
| CA2 | carbonic anhydrase II | -0.00705198 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00704341 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.00704032 |
| XIC | X chromosome inactivation center | -0.00701016 |
| EXOC5 | exocyst complex component 5 | -0.0069711 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00695056 |
| MIR22HG | MIR22 host gene | -0.0069037 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00690167 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00689068 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | -0.0068787 |
| CCL14 | chemokine (C-C motif) ligand 14 | -0.00687742 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0068607 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.00685821 |
| ACP1 | acid phosphatase 1, soluble | -0.00684886 |
| GAB2 | GRB2-associated binding protein 2 | -0.00684248 |
| MGP | matrix Gla protein | -0.00681997 |
| BPGM | 2,3-bisphosphoglycerate mutase | -0.00679744 |
| CD93 | CD93 molecule | -0.0067949 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.00679296 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.006755 |
| PNN | pinin, desmosome associated protein | -0.00671989 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.00668001 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00667701 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00664079 |
| EGR1 | early growth response 1 | -0.00663355 |
| WASF1 | WAS protein family, member 1 | -0.00663124 |
| OSBPL1A | oxysterol binding protein-like 1A | -0.00660482 |
| GLUL | glutamate-ammonia ligase | -0.00660343 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.00657505 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.0065428 |
| BHMT2 | betaine--homocysteine S-methyltransferase 2 | -0.00652224 |
| HIP1 | huntingtin interacting protein 1 | -0.00649961 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00649404 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00648806 |
| BTG3 | BTG family, member 3 | -0.00648579 |
| PLIN3 | perilipin 3 | -0.00644942 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00638042 |
| PRNP | prion protein | -0.00637734 |
| PELO | pelota homolog (Drosophila) | -0.00636843 |
| SPRR2B | small proline-rich protein 2B | -0.00635194 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.00633412 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00632144 |
| CDA | cytidine deaminase | -0.00631832 |
| SS18 | synovial sarcoma translocation, chromosome 18 | -0.00630622 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.00630178 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.00629075 |
| C5AR1 | complement component 5a receptor 1 | -0.00628946 |
| YIPF5 | Yip1 domain family, member 5 | -0.00628703 |
| CAPRIN1 | cell cycle associated protein 1 | -0.00628362 |
| PCBP1 | poly(rC) binding protein 1 | -0.00626818 |
| PITX1 | paired-like homeodomain 1 | -0.00626624 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.00624366 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.00622764 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.00622237 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.00619939 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.00619513 |
| TGFA | transforming growth factor, alpha | -0.00619091 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | -0.00619076 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00617632 |
| YBX3 | Y box binding protein 3 | -0.0061578 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.00614025 |
| THBD | thrombomodulin | -0.0061342 |
| ABHD6 | abhydrolase domain containing 6 | -0.0061338 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.00613146 |
| MED21 | mediator complex subunit 21 | -0.00610634 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00608987 |
| LAMB3 | laminin, beta 3 | -0.00606649 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | -0.00603365 |
| SASH1 | SAM and SH3 domain containing 1 | -0.00595453 |
| RIOK3 | RIO kinase 3 | -0.00593686 |
| NFYA | nuclear transcription factor Y, alpha | -0.00593406 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00593321 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | -0.00592983 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | -0.00591128 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00589503 |
| JAK1 | Janus kinase 1 | -0.00587445 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00587267 |
| RHOB | ras homolog family member B | -0.00585747 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00585104 |
| EFNA1 | ephrin-A1 | -0.00583046 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.00581882 |
| RGS5 | regulator of G-protein signaling 5 | -0.00580213 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00579573 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0057758 |
| KRT15 | keratin 15, type I | -0.00577282 |
| CERS2 | ceramide synthase 2 | -0.00577189 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00576811 |
| HIST1H2AC | histone cluster 1, H2ac | -0.0057639 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | -0.00575973 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.0057534 |
| MRPL18 | mitochondrial ribosomal protein L18 | -0.00574911 |
| HSPE1 | heat shock 10kDa protein 1 | -0.00574882 |
| MCL1 | myeloid cell leukemia 1 | -0.00573897 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00572427 |
| PRSS23 | protease, serine, 23 | -0.00572149 |
| ABHD17B | abhydrolase domain containing 17B | -0.00571911 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.00570217 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00568021 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.00567452 |
| PDZD2 | PDZ domain containing 2 | -0.00566081 |
| ANXA3 | annexin A3 | -0.00565887 |
| PLK2 | polo-like kinase 2 | -0.0056564 |
| TMEM135 | transmembrane protein 135 | -0.0056541 |
| RYBP | RING1 and YY1 binding protein | -0.00564753 |
| CXADR | coxsackie virus and adenovirus receptor | -0.00563956 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.00563784 |
| RANBP9 | RAN binding protein 9 | -0.00563244 |
| IL6ST | interleukin 6 signal transducer | -0.0056309 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.00562475 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00562158 |
| NELL1 | NEL-like 1 (chicken) | -0.00561865 |
| INSR | insulin receptor | -0.00560784 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.00560126 |
| FASTKD5 | FAST kinase domains 5 | -0.00558497 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.00555953 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0055568 |
| RRAD | Ras-related associated with diabetes | -0.00555536 |
| USP34 | ubiquitin specific peptidase 34 | -0.00554765 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.00554558 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00554411 |
| TSPAN1 | tetraspanin 1 | -0.00554096 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.00553985 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00553684 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.00553223 |
| PXDN | peroxidasin | -0.00553143 |
| ZNF232 | zinc finger protein 232 | -0.00552448 |
| RNFT1 | ring finger protein, transmembrane 1 | -0.00552303 |
| WBP4 | WW domain binding protein 4 | -0.00550903 |
| FHL2 | four and a half LIM domains 2 | -0.00550319 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.00549453 |
| PTER | phosphotriesterase related | -0.00548947 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.0054892 |
| CCNG2 | cyclin G2 | -0.00548579 |
| MEF2A | myocyte enhancer factor 2A | -0.00545493 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.00545268 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.00545169 |
| ZNF395 | zinc finger protein 395 | -0.00544733 |
| RPS26 | ribosomal protein S26 | -0.0054429 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00543736 |
| GPX7 | glutathione peroxidase 7 | -0.00543664 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.00542716 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00542051 |
| SPRR1A | small proline-rich protein 1A | -0.00540852 |
| RRAGD | Ras-related GTP binding D | -0.00540076 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00539821 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.00538449 |
| GOT1 | glutamic-oxaloacetic transaminase 1, soluble | -0.00537552 |
| MYO5C | myosin VC | -0.00537493 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.00536704 |
| KLHL24 | kelch-like family member 24 | -0.00536266 |
| TNS1 | tensin 1 | -0.00534922 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.00534186 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.00534072 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.00533186 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.00532531 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00532519 |
| MAP7 | microtubule-associated protein 7 | -0.005321 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.00530434 |
| INHBA | inhibin, beta A | -0.00529869 |
| ZNF430 | zinc finger protein 430 | -0.00529268 |
| TRIM22 | tripartite motif containing 22 | -0.00528987 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00528839 |
| HOXC6 | homeobox C6 | -0.0052667 |
| IFNGR1 | interferon gamma receptor 1 | -0.0052627 |
| AREG | amphiregulin | -0.00523982 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00523775 |
| MBD1 | methyl-CpG binding domain protein 1 | -0.00522107 |
| NCF2 | neutrophil cytosolic factor 2 | -0.00521902 |
