MAP2K1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description mitogen-activated protein kinase kinase 1|The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5604)
External Link http://www.ncbi.nlm.nih.gov/gene/5604
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284 interacting proteins for MAP2K1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABLIM1 actin binding LIM protein 1
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AGTR1 angiotensin II receptor, type 1
AMPD2 adenosine monophosphate deaminase 2
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARRB2 arrestin, beta 2
AURKA aurora kinase A
AURKB aurora kinase B
BAD BCL2-associated agonist of cell death
BAIAP2 BAI1-associated protein 2
BIRC6 baculoviral IAP repeat containing 6
BLVRA biliverdin reductase A
BMP2K BMP2 inducible kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRAP BRCA1 associated protein
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CALR calreticulin
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC6 coiled-coil domain containing 6
CDC25C cell division cycle 25C
CDC37 cell division cycle 37
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK1 cyclin-dependent kinase 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CDK5 cyclin-dependent kinase 5
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CPNE1 copine I
CPNE4 copine IV
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCC DCC netrin 1 receptor
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1A DENN/MADD domain containing 1A
DENND4A DENN/MADD domain containing 4A
DENND4C DENN/MADD domain containing 4C
DMTN dematin actin binding protein
DOCK11 dedicator of cytokinesis 11
EDC3 enhancer of mRNA decapping 3
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
EGFR epidermal growth factor receptor
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ELAVL1 ELAV like RNA binding protein 1
ELK1 ELK1, member of ETS oncogene family
EP300 E1A binding protein p300
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EXO1 exonuclease 1
FER fer (fps/fes related) tyrosine kinase
FOXM1 forkhead box M1
FOXO3 forkhead box O3
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAK cyclin G associated kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
GRIP1 glutamate receptor interacting protein 1
GSK3B glycogen synthase kinase 3 beta
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HLA-B major histocompatibility complex, class I, B
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL17RD interleukin 17 receptor D
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIAA0355 KIAA0355
KIAA0930 KIAA0930
KIAA1671 KIAA1671
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
KLC2 kinesin light chain 2
KLC4 kinesin light chain 4
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT8 keratin 8, type II
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LARP1 La ribonucleoprotein domain family, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LIMA1 LIM domain and actin binding 1
LIMK1 LIM domain kinase 1
LMO7 LIM domain 7
LSP1 lymphocyte-specific protein 1
LUZP1 leucine zipper protein 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MAST2 microtubule associated serine/threonine kinase 2
MTMR12 myotubularin related protein 12
MYC v-myc avian myelocytomatosis viral oncogene homolog
NADK NAD kinase
NAV1 neuron navigator 1
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NEK11 NIMA-related kinase 11
NEK9 NIMA-related kinase 9
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NTN1 netrin 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAQR3 progestin and adipoQ receptor family member III
PARP8 poly (ADP-ribose) polymerase family, member 8
PARVA parvin, alpha
PDPK1 3-phosphoinositide dependent protein kinase 1
PEBP1 phosphatidylethanolamine binding protein 1
PEBP4 phosphatidylethanolamine-binding protein 4
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHKB phosphorylase kinase, beta
PHKG2 phosphorylase kinase, gamma 2 (testis)
PHLDB2 pleckstrin homology-like domain, family B, member 2
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PKM pyruvate kinase, muscle
PKP2 plakophilin 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PUM1 pumilio RNA-binding family member 1
R3HDM1 R3H domain containing 1
R3HDM2 R3H domain containing 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASAL2 RAS protein activator like 2
REEP4 receptor accessory protein 4
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RTKN rhotekin
RUSC1 RUN and SH3 domain containing 1
SACK1B scaffolding CK1 anchoring protein B
SAMD4A sterile alpha motif domain containing 4A
SAMD4B sterile alpha motif domain containing 4B
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHH sonic hedgehog
SHKBP1 SH3KBP1 binding protein 1
SHROOM3 shroom family member 3
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
SUMO1 small ubiquitin-like modifier 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBC1D22B TBC1 domain family, member 22B
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TBK1 TANK-binding kinase 1
TNK1 tyrosine kinase, non-receptor, 1
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM32 tripartite motif containing 32
TSC2 tuberous sclerosis 2
TTC28 tetratricopeptide repeat domain 28
TYK2 tyrosine kinase 2
UBC ubiquitin C
UHRF1BP1L UHRF1 binding protein 1-like
ULK3 unc-51 like kinase 3
USP54 ubiquitin specific peptidase 54
USP8 ubiquitin specific peptidase 8
VAV1 vav 1 guanine nucleotide exchange factor
VCP valosin containing protein
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VRK2 vaccinia related kinase 2
WDR83 WD repeat domain 83
WNK1 WNK lysine deficient protein kinase 1
YAP1 Yes-associated protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2