MAP2K2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase kinase 2|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5605)
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Genes

340 genes differentially expressed following the MAP2K2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.16679
GPR20 G protein-coupled receptor 20 3.16679
ADAD2 adenosine deaminase domain containing 2 3.16679
LYNX1 Ly6/neurotoxin 1 3.16679
REN renin 3.16679
BIRC3 baculoviral IAP repeat containing 3 3.16679
BHLHE40 basic helix-loop-helix family, member e40 3.16679
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.16679
NLRP10 NLR family, pyrin domain containing 10 3.16679
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.16679
UBA7 ubiquitin-like modifier activating enzyme 7 3.16679
MFAP5 microfibrillar associated protein 5 3.16679
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.16679
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.16679
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.16679
ASPDH aspartate dehydrogenase domain containing 3.16679
SPINK6 serine peptidase inhibitor, Kazal type 6 3.16679
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.16679
MBLAC1 metallo-beta-lactamase domain containing 1 3.16679
SOX18 SRY (sex determining region Y)-box 18 3.16679
GSTM5 glutathione S-transferase mu 5 3.16679
GJB5 gap junction protein, beta 5, 31.1kDa 3.16679
FOXR1 forkhead box R1 3.16679
GFAP glial fibrillary acidic protein 3.16679
GPR183 G protein-coupled receptor 183 3.16679
UMODL1 uromodulin-like 1 3.16679
BTBD16 BTB (POZ) domain containing 16 3.16679
RBP4 retinol binding protein 4, plasma 3.16679
WFDC11 WAP four-disulfide core domain 11 3.16679
CD3D CD3d molecule, delta (CD3-TCR complex) 3.16679
PITX3 paired-like homeodomain 3 3.16679
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.16679
APOA5 apolipoprotein A-V 3.16679
CLEC2A C-type lectin domain family 2, member A 3.16679
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.16679
PASD1 PAS domain containing 1 3.16679
PANO1 proapoptotic nucleolar protein 1 3.16679
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.16679
LVRN laeverin 3.16679
TMEM82 transmembrane protein 82 3.16679
LRRC63 leucine rich repeat containing 63 3.16679
HBZ hemoglobin, zeta 3.16679
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.16679
ZFYVE26 zinc finger, FYVE domain containing 26 3.16679
BMP2 bone morphogenetic protein 2 3.16679
MYO16 myosin XVI 3.16679
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.16679
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.16679
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 3.16679
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.16679
EXOC1L exocyst complex component 1 like 3.16679
SRGN serglycin 3.16679
FIMP1 fertilization-influencing membrane protein 1 3.16679
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.16679
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 3.16679
PAPOLB poly(A) polymerase beta (testis specific) 3.16679
SAG S-antigen; retina and pineal gland (arrestin) 3.16679
REP15 RAB15 effector protein 3.16679
GATA3 GATA binding protein 3 3.16679
LTA lymphotoxin alpha 3.16679
IL7R interleukin 7 receptor 3.16679
MGAM maltase-glucoamylase 3.16679
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.16679
ALDOB aldolase B, fructose-bisphosphate 3.16679
WASH8P WAS protein family homolog 8, pseudogene 3.16679
SYT15B synaptotagmin 15B 3.16679
H3C13 H3 clustered histone 13 3.16679
SMIM45 small integral membrane protein 45 3.16679
ARMH2 armadillo like helical domain containing 2 3.16679
FLACC1 flagellum associated containing coiled-coil domains 1 3.16679
DNAAF8 dynein axonemal assembly factor 8 3.16679
PLAAT4 phospholipase A and acyltransferase 4 3.16679
CCN3 cellular communication network factor 3 3.16679
H3-5 H3.5 histone 3.16679
IL1R1 interleukin 1 receptor, type I 3.16679
C7 complement component 7 3.16679
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.16679
SPMIP10 sperm microtubule inner protein 10 3.16679
NKX2-2 NK2 homeobox 2 3.16679
PCDHA3 protocadherin alpha 3 3.16679
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.16679
NRN1 neuritin 1 3.16679
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.16679
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.16679
INHBC inhibin, beta C 3.16679
CD96 CD96 molecule 3.16679
TMIE transmembrane inner ear 3.16679
IRF5 interferon regulatory factor 5 3.16679
IRF8 interferon regulatory factor 8 3.16679
S100G S100 calcium binding protein G 3.16679
C1QTNF1 C1q and tumor necrosis factor related protein 1 3.16679
CCK cholecystokinin 3.16679
PRRT4 proline-rich transmembrane protein 4 3.16679
BHLHA9 basic helix-loop-helix family, member a9 3.16679
MSX1 msh homeobox 1 3.16679
IDO2 indoleamine 2,3-dioxygenase 2 3.16679
MRPL3 mitochondrial ribosomal protein L3 3.16679
GOLGA6L4 golgin A6 family-like 4 3.16679
AMBP alpha-1-microglobulin/bikunin precursor 3.16679
FGF23 fibroblast growth factor 23 3.16679
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.16679
CATIP ciliogenesis associated TTC17 interacting protein 3.16679
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.16679
AKNAD1 AKNA domain containing 1 3.16679
ZGLP1 zinc finger, GATA-like protein 1 3.16679
PKDREJ polycystin (PKD) family receptor for egg jelly 3.16679
TPPP2 tubulin polymerization-promoting protein family member 2 3.16679
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.16679
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.16679
IL21R interleukin 21 receptor 3.16679
LY9 lymphocyte antigen 9 3.16679
AQP8 aquaporin 8 3.16679
ETNPPL ethanolamine-phosphate phospho-lyase 3.16679
NT5C1A 5'-nucleotidase, cytosolic IA 3.16679
PDCD1LG2 programmed cell death 1 ligand 2 3.16679
DQX1 DEAQ box RNA-dependent ATPase 1 3.16679
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 3.16679
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.16679
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.16679
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.16679
FBXO47 F-box protein 47 3.16679
KLK5 kallikrein-related peptidase 5 3.16679
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.16679
ISL2 ISL LIM homeobox 2 3.16679
HCK HCK proto-oncogene, Src family tyrosine kinase 3.16679
PCDHGA7 protocadherin gamma subfamily A, 7 3.16679
SAMD5 sterile alpha motif domain containing 5 3.16679
TTC9B tetratricopeptide repeat domain 9B 3.16679
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.16679
UTS2B urotensin 2B 3.16679
FGR FGR proto-oncogene, Src family tyrosine kinase 3.16679
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.16679
POU2AF1 POU class 2 associating factor 1 3.16679
OR52E4 olfactory receptor, family 52, subfamily E, member 4 3.16679
SNX31 sorting nexin 31 3.16679
CSF1R colony stimulating factor 1 receptor 3.16679
ZNF541 zinc finger protein 541 3.16679
FGF18 fibroblast growth factor 18 3.16679
STAB1 stabilin 1 3.16679
FAM25A family with sequence similarity 25, member A 3.16679
MAGEB17 melanoma antigen family B17 3.16679
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 3.16679
ECM1 extracellular matrix protein 1 3.16679
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.16679
FRMPD1 FERM and PDZ domain containing 1 3.16679
ESPNL espin-like 3.16679
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.16679
AQP1 aquaporin 1 (Colton blood group) 3.16679
GSDMA gasdermin A 3.16679
APOF apolipoprotein F 3.16679
PXT1 peroxisomal, testis specific 1 3.16679
RFPL1 ret finger protein-like 1 3.16679
PHACTR3 phosphatase and actin regulator 3 3.16679
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.16679
AMER3 APC membrane recruitment protein 3 3.16679
CCDC154 coiled-coil domain containing 154 3.16679
GPR150 G protein-coupled receptor 150 3.16679
PLA2G2C phospholipase A2, group IIC 3.16679
ADAM18 ADAM metallopeptidase domain 18 3.16679
CARD6 caspase recruitment domain family, member 6 3.16679
TP53I3 tumor protein p53 inducible protein 3 3.16019
RPS15 ribosomal protein S15 3.14753
RNF115 ring finger protein 115 3.10136
FAM3D family with sequence similarity 3, member D 3.09682
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 3.08275
MACROD1 MACRO domain containing 1 3.06546
GFY golgi-associated, olfactory signaling regulator 2.98936
H2BC4 H2B clustered histone 4 2.95274
SPIDR scaffolding protein involved in DNA repair 2.88492
SOX2 SRY (sex determining region Y)-box 2 2.83094
UQCRH ubiquinol-cytochrome c reductase hinge protein 2.82005
RPS27 ribosomal protein S27 2.80715
ACTC1 actin, alpha, cardiac muscle 1 2.79954
TP53BP1 tumor protein p53 binding protein 1 2.79056
INSIG1 insulin induced gene 1 2.77618
IRX2 iroquois homeobox 2 2.77239
ZNF48 zinc finger protein 48 2.77239
PLTP phospholipid transfer protein 2.75396
KRAS Kirsten rat sarcoma viral oncogene homolog 2.74633
RAB15 RAB15, member RAS oncogene family 2.71143
CLVS1 clavesin 1 2.69795
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.69795
PVR poliovirus receptor 2.6427
ATG14 autophagy related 14 2.6239
CTXN1 cortexin 1 2.61482
SLC25A39 solute carrier family 25, member 39 2.6036
DDB1 damage-specific DNA binding protein 1, 127kDa 2.60321
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 2.592
AKR1D1 aldo-keto reductase family 1, member D1 2.56199
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.56199
RRP1 ribosomal RNA processing 1 2.54052
TASOR transcription activation suppressor 2.53045
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.49565
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.49469
SCHIP1 schwannomin interacting protein 1 2.46748
CNGB3 cyclic nucleotide gated channel beta 3 2.44963
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 2.4384
GHITM growth hormone inducible transmembrane protein 2.43574
PLGLB1 plasminogen-like B1 2.42312
COX7C cytochrome c oxidase subunit VIIc 2.41062
RUFY1 RUN and FYVE domain containing 1 2.41062
APIP APAF1 interacting protein 2.40945
FOXM1 forkhead box M1 2.39298
DSTN destrin (actin depolymerizing factor) 2.3737
ZNF12 zinc finger protein 12 2.34688
HKDC1 hexokinase domain containing 1 2.33042
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.33042
GPS2 G protein pathway suppressor 2 2.30587
TTLL12 tubulin tyrosine ligase-like family member 12 2.29176
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.27929
RAG1 recombination activating gene 1 2.24225
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.24225
SHOX short stature homeobox 2.24225
TFF3 trefoil factor 3 (intestinal) 2.24225
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.23803
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.23569
PSPH phosphoserine phosphatase 2.23335
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.23335
ANKRD17 ankyrin repeat domain 17 2.21398
ZBTB8B zinc finger and BTB domain containing 8B 2.19778
ZNF572 zinc finger protein 572 2.18567
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 2.16785
KBTBD3 kelch repeat and BTB (POZ) domain containing 3 2.14074
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.11947
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 2.11651
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 2.10534
CDKL3 cyclin-dependent kinase-like 3 2.10404
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.10385
UBE3C ubiquitin protein ligase E3C 2.08074
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2.07192
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 2.05997
VASP vasodilator-stimulated phosphoprotein 2.05997
CRPPA CDP-L-ribitol pyrophosphorylase A 2.05982
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.05982
OGN osteoglycin 2.05982
KIAA0319 KIAA0319 2.05142
RNF175 ring finger protein 175 2.02351
IFITM2 interferon induced transmembrane protein 2 2.01248
GATAD2B GATA zinc finger domain containing 2B 2.0092
INMT indolethylamine N-methyltransferase 2.0092
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2.00722

decreased expression

Symbol Name Standardized Value
ADPRHL1 ADP-ribosylhydrolase like 1 -3.16679
OR2A5 olfactory receptor, family 2, subfamily A, member 5 -3.16679
IFI16 interferon, gamma-inducible protein 16 -3.16679
PLXDC1 plexin domain containing 1 -3.16679
CD300A CD300a molecule -3.16679
MYH2 myosin, heavy chain 2, skeletal muscle, adult -3.16679
MID2 midline 2 -3.16679
DGKE diacylglycerol kinase, epsilon 64kDa -3.16679
ZNF268 zinc finger protein 268 -3.16679
TP73 tumor protein p73 -3.16679
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 -3.16679
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -3.15044
TRDN triadin -3.0353
CHRM5 cholinergic receptor, muscarinic 5 -2.99431
ASCL5 achaete-scute family bHLH transcription factor 5 -2.98936
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.98936
NBPF8 neuroblastoma breakpoint family, member 8 -2.98936
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.98936
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.98936
TMEM176A transmembrane protein 176A -2.98936
PCDHGA12 protocadherin gamma subfamily A, 12 -2.98936
ZFP57 ZFP57 zinc finger protein -2.98936
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.98936
TTC36 tetratricopeptide repeat domain 36 -2.98936
IL17C interleukin 17C -2.98936
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.98936
NPIPB15 nuclear pore complex interacting protein family, member B15 -2.98936
CNR2 cannabinoid receptor 2 (macrophage) -2.98936
CFAP141 cilia and flagella associated protein 141 -2.98936
LIF leukemia inhibitory factor -2.98936
FAM107A family with sequence similarity 107, member A -2.98936
SAMD11 sterile alpha motif domain containing 11 -2.98936
BARX1 BARX homeobox 1 -2.98936
BTLA B and T lymphocyte associated -2.98936
IL1A interleukin 1, alpha -2.98936
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.98936
COL7A1 collagen, type VII, alpha 1 -2.98936
ZNF540 zinc finger protein 540 -2.98936
PLET1 placenta expressed transcript 1 -2.98936
ARG1 arginase 1 -2.98936
SPMIP9 sperm microtubule inner protein 9 -2.98936
LMF1 lipase maturation factor 1 -2.98936
CDH10 cadherin 10, type 2 (T2-cadherin) -2.98936
GJD3 gap junction protein, delta 3, 31.9kDa -2.98936
CHMP1A charged multivesicular body protein 1A -2.88492
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.85926
TWIST2 twist family bHLH transcription factor 2 -2.82673
PRSS35 protease, serine, 35 -2.82673
KCP kielin/chordin-like protein -2.78784
INO80D INO80 complex subunit D -2.76324
CCDC148 coiled-coil domain containing 148 -2.75913
ZMYM6 zinc finger, MYM-type 6 -2.74092
CPA6 carboxypeptidase A6 -2.61272
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.56199
ATP5F1D ATP synthase F1 subunit delta -2.55664
CCDC141 coiled-coil domain containing 141 -2.53045
CKAP2 cytoskeleton associated protein 2 -2.50082
USP6 ubiquitin specific peptidase 6 -2.48824
FGF22 fibroblast growth factor 22 -2.42864
TRIM54 tripartite motif containing 54 -2.42864
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.33042
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -2.31809
SCG3 secretogranin III -2.31211
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.30981
PANX1 pannexin 1 -2.30981
RYK receptor-like tyrosine kinase -2.30981
SPATA2L spermatogenesis associated 2-like -2.3044
REEP4 receptor accessory protein 4 -2.3044
CLTRN collectrin, amino acid transport regulator -2.3044
LOC124904542 uncharacterized LOC124904542 -2.25187
TLR5 toll-like receptor 5 -2.25187
DHFR2 dihydrofolate reductase 2 -2.24598
ETV6 ets variant 6 -2.22795
UGDH UDP-glucose 6-dehydrogenase -2.22795
TSLIG3C tRNA splicing ligase complex subunit 3C -2.22049
RNF19B ring finger protein 19B -2.21491
RNGTT RNA guanylyltransferase and 5'-phosphatase -2.21398
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -2.20539
ZNF621 zinc finger protein 621 -2.20539
NCOA5 nuclear receptor coactivator 5 -2.18081
GPNMB glycoprotein (transmembrane) nmb -2.14847
ANKRD11 ankyrin repeat domain 11 -2.14642
FYN FYN proto-oncogene, Src family tyrosine kinase -2.14074
SFT2D3 SFT2 domain containing 3 -2.11907
TRIM2 tripartite motif containing 2 -2.10404
MMP25 matrix metallopeptidase 25 -2.09932
TWF1 twinfilin actin binding protein 1 -2.09932
SDC1 syndecan 1 -2.0949
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -2.08534
MYO9A myosin IXA -2.08074
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.07192
CENPE centromere protein E, 312kDa -2.06301
MAP2K2 mitogen-activated protein kinase kinase 2 -2.05982
C2CD2 C2 calcium-dependent domain containing 2 -2.05982
SNX29 sorting nexin 29 -2.05172
FBXO10 F-box protein 10 -2.04863
TANGO6 transport and golgi organization 6 homolog (Drosophila) -2.03776
MYO15B myosin XVB -2.0188
TRAPPC12 trafficking protein particle complex 12 -2.00722