| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase 2|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5605) |
| External Link | https://ncbi.nlm.nih.gov/gene/5605 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the MAP2K2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 0.019909 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0196623 |
| DCN | decorin | 0.017824 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0160454 |
| THBS2 | thrombospondin 2 | 0.0158571 |
| KRT19 | keratin 19, type I | 0.0155494 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0154168 |
| AEBP1 | AE binding protein 1 | 0.0151151 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.0147734 |
| MFAP5 | microfibrillar associated protein 5 | 0.0146884 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0141186 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.0137597 |
| PLXNC1 | plexin C1 | 0.0134554 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.0133409 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.0133344 |
| TPSAB1 | tryptase alpha/beta 1 | 0.013279 |
| CSTA | cystatin A (stefin A) | 0.0131535 |
| COMP | cartilage oligomeric matrix protein | 0.0128538 |
| S100P | S100 calcium binding protein P | 0.0126131 |
| ASPN | asporin | 0.0125132 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.0125112 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 0.0124879 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0124107 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.012327 |
| ADIRF | adipogenesis regulatory factor | 0.0121952 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.0120492 |
| THBS1 | thrombospondin 1 | 0.012014 |
| SNAI2 | snail family zinc finger 2 | 0.0116017 |
| GAS1 | growth arrest-specific 1 | 0.0115284 |
| GAS6 | growth arrest-specific 6 | 0.011487 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.011463 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0112581 |
| NID2 | nidogen 2 (osteonidogen) | 0.0112022 |
| G0S2 | G0/G1 switch 2 | 0.0111632 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.0111321 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0111019 |
| KLK10 | kallikrein-related peptidase 10 | 0.0110785 |
| CTSD | cathepsin D | 0.0110344 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.011007 |
| STK10 | serine/threonine kinase 10 | 0.0110044 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0109145 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0108697 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.0107244 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.0106785 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.0103996 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0103942 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0103869 |
| PTK2B | protein tyrosine kinase 2 beta | 0.0102786 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.010246 |
| GPX3 | glutathione peroxidase 3 | 0.0101709 |
| CEL | carboxyl ester lipase | 0.0101098 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.0100772 |
| BICC1 | BicC family RNA binding protein 1 | 0.0100594 |
| ECM1 | extracellular matrix protein 1 | 0.0100384 |
| COL10A1 | collagen, type X, alpha 1 | 0.0100384 |
| TSPAN13 | tetraspanin 13 | 0.0100289 |
| KLK11 | kallikrein-related peptidase 11 | 0.00998348 |
| LXN | latexin | 0.00988667 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00986196 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00975937 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | 0.00974717 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0097435 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00964649 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00959387 |
| KRT8 | keratin 8, type II | 0.00958794 |
| IPO13 | importin 13 | 0.00955739 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00953605 |
| TGFA | transforming growth factor, alpha | 0.00948211 |
| REG1A | regenerating islet-derived 1 alpha | 0.00946904 |
| PERP | PERP, TP53 apoptosis effector | 0.00941608 |
| INHBA | inhibin, beta A | 0.00939152 |
| VCAN | versican | 0.0093285 |
| COL16A1 | collagen, type XVI, alpha 1 | 0.00930979 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.00930413 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00930409 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00930132 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00927129 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.00921703 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00919878 |
| C7 | complement component 7 | 0.00914827 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.00897164 |
| CLTB | clathrin, light chain B | 0.00894108 |
| EPCAM | epithelial cell adhesion molecule | 0.00890052 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | 0.00887371 |
| SPON2 | spondin 2, extracellular matrix protein | 0.00885852 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00885371 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 0.00879671 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00869879 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00864411 |
| CRYAB | crystallin, alpha B | 0.00862424 |
| AGR2 | anterior gradient 2 | 0.00860916 |
| ASS1 | argininosuccinate synthase 1 | 0.008601 |
| IL1R1 | interleukin 1 receptor, type I | 0.00855929 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.00855521 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.0085407 |
| HTRA1 | HtrA serine peptidase 1 | 0.00849097 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00847367 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00846881 |
| CLEC3B | C-type lectin domain family 3, member B | 0.00837693 |
| GPX2 | glutathione peroxidase 2 | 0.0083747 |
| PLK2 | polo-like kinase 2 | 0.00837102 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00834443 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.0083297 |
| ESR1 | estrogen receptor 1 | 0.00832913 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00832368 |
| GATA6 | GATA binding protein 6 | 0.00829357 |
| EPS8L1 | EPS8-like 1 | 0.00825811 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | 0.00825605 |
| BGN | biglycan | 0.00825348 |
| AHR | aryl hydrocarbon receptor | 0.0082065 |
| SCG5 | secretogranin V | 0.00819983 |
| LYZ | lysozyme | 0.00819864 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00818964 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | 0.00812001 |
| CAPN1 | calpain 1, (mu/I) large subunit | 0.00805238 |
| PRSS3 | protease, serine, 3 | 0.00804785 |
| LRRC15 | leucine rich repeat containing 15 | 0.00803147 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00802294 |
| MGLL | monoglyceride lipase | 0.00801674 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00800233 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00799614 |
| MYRF | myelin regulatory factor | 0.00799318 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.0079862 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00798002 |
| FST | follistatin | 0.00796766 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00795083 |
| CFD | complement factor D (adipsin) | 0.00792145 |
| DEFB1 | defensin, beta 1 | 0.00780883 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00775963 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.00775362 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00773714 |
| UPP1 | uridine phosphorylase 1 | 0.00773662 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00772772 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.00771818 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00770635 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.00767723 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00765813 |
| RPS27L | ribosomal protein S27-like | 0.00762434 |
| TRAPPC6A | trafficking protein particle complex 6A | 0.00761532 |
| KLK5 | kallikrein-related peptidase 5 | 0.00759263 |
| AMOTL2 | angiomotin like 2 | 0.00758156 |
| CCNA2 | cyclin A2 | 0.00758124 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00754809 |
| GDF15 | growth differentiation factor 15 | 0.00752446 |
| OGN | osteoglycin | 0.0075229 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.00750663 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.00748598 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00746279 |
| PRKCI | protein kinase C, iota | 0.00745795 |
| SDC1 | syndecan 1 | 0.00745496 |
| CCNG2 | cyclin G2 | 0.00744837 |
| CTSA | cathepsin A | 0.00742643 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 0.00741111 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0074039 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00738563 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00738025 |
| XYLT1 | xylosyltransferase I | 0.00737538 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.00735019 |
| NPTX2 | neuronal pentraxin II | 0.00734259 |
| KLK8 | kallikrein-related peptidase 8 | 0.00733155 |
| PSCA | prostate stem cell antigen | 0.00732863 |
| LSP1 | lymphocyte-specific protein 1 | 0.00731399 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00729161 |
| LAMA2 | laminin, alpha 2 | 0.00729054 |
| TSPAN8 | tetraspanin 8 | 0.00727742 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.00724188 |
| MXRA5 | matrix-remodelling associated 5 | 0.00723715 |
| TUFT1 | tuftelin 1 | 0.00723546 |
| TESC | tescalcin | 0.00722584 |
| TAGLN | transgelin | 0.00720977 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | 0.00720421 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.00720211 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.00719137 |
| TTC39A | tetratricopeptide repeat domain 39A | 0.00718812 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00717056 |
| SGCE | sarcoglycan, epsilon | 0.00716697 |
| GPR137B | G protein-coupled receptor 137B | 0.00715115 |
| CCN2 | cellular communication network factor 2 | 0.00710814 |
| THBS4 | thrombospondin 4 | 0.00709493 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | 0.00704096 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00703932 |
| SERINC5 | serine incorporator 5 | 0.0070301 |
| HOXC6 | homeobox C6 | 0.00701802 |
| TOB1 | transducer of ERBB2, 1 | 0.00701511 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.00700823 |
| ANXA4 | annexin A4 | 0.00699603 |
| SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | 0.0069881 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.0069851 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00696964 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00696773 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 0.006945 |
| LSR | lipolysis stimulated lipoprotein receptor | 0.00693982 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.00693273 |
| ELOC | elongin C | 0.00690983 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00690636 |
| TFF1 | trefoil factor 1 | 0.00690014 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00689532 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0068297 |
| PLS3 | plastin 3 | 0.00682661 |
| LAMB1 | laminin, beta 1 | 0.00680502 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | 0.00680288 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.00679366 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | 0.00679336 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00679251 |
| CALB1 | calbindin 1, 28kDa | 0.00677438 |
| THY1 | Thy-1 cell surface antigen | 0.00677166 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.00669416 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00668738 |
| PLN | phospholamban | 0.00668122 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00665726 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 0.0066553 |
| MZB1 | marginal zone B and B1 cell-specific protein | 0.00663652 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 0.00663602 |
| DPP4 | dipeptidyl-peptidase 4 | 0.00661486 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00661061 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.00660688 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 0.00660484 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00659818 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00657863 |
| PTS | 6-pyruvoyltetrahydropterin synthase | 0.00656952 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.00656071 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.00655837 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 0.00654858 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.00654056 |
| AOC1 | amine oxidase, copper containing 1 | 0.00650644 |
| MSLN | mesothelin | 0.00650278 |
| ZNF706 | zinc finger protein 706 | 0.00649406 |
| PDE10A | phosphodiesterase 10A | 0.00649313 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.00647178 |
| NOTCH1 | notch 1 | 0.00646382 |
| ANXA9 | annexin A9 | 0.00646217 |
| CPE | carboxypeptidase E | 0.00644712 |
| RHOD | ras homolog family member D | 0.00644103 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.00643988 |
| C3 | complement component 3 | 0.00643695 |
| SST | somatostatin | 0.006417 |
| METTL7A | methyltransferase like 7A | 0.00641178 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.00639715 |
| GDPD3 | glycerophosphodiester phosphodiesterase domain containing 3 | 0.00638273 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00638243 |
| CFI | complement factor I | 0.00636825 |
| VNN1 | vanin 1 | 0.00636066 |
| CLIC5 | chloride intracellular channel 5 | 0.00635345 |
| MMP7 | matrix metallopeptidase 7 | 0.00634556 |
| FBLN1 | fibulin 1 | 0.00633954 |
| JUP | junction plakoglobin | 0.00633811 |
| MT1X | metallothionein 1X | 0.0063338 |
| ADRA2A | adrenoceptor alpha 2A | 0.00633344 |
| TSPAN15 | tetraspanin 15 | 0.0063328 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.0125957 |
| MMP12 | matrix metallopeptidase 12 | -0.0125145 |
| CHI3L2 | chitinase 3-like 2 | -0.0121865 |
| GLUL | glutamate-ammonia ligase | -0.0115612 |
| AQP4 | aquaporin 4 | -0.0115394 |
| SIRT3 | sirtuin 3 | -0.0114487 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0108354 |
| GPM6A | glycoprotein M6A | -0.0108123 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | -0.010642 |
| ZNF395 | zinc finger protein 395 | -0.010356 |
| NES | nestin | -0.0103559 |
| CHN1 | chimerin 1 | -0.0103503 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0103267 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | -0.0102501 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00993169 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.00968823 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00967413 |
| PRKCA | protein kinase C, alpha | -0.00959765 |
| MYBPC1 | myosin binding protein C, slow type | -0.00957152 |
| ACP6 | acid phosphatase 6, lysophosphatidic | -0.00953909 |
| GNAS | GNAS complex locus | -0.00953172 |
| KIF20A | kinesin family member 20A | -0.00935228 |
| FABP7 | fatty acid binding protein 7, brain | -0.00935123 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.00925147 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.00922873 |
| LTF | lactotransferrin | -0.00918503 |
| PGAP3 | post-GPI attachment to proteins 3 | -0.00901239 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00889425 |
| DIO2 | deiodinase, iodothyronine, type II | -0.00889039 |
| GDI2 | GDP dissociation inhibitor 2 | -0.00882221 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.00876304 |
| GFAP | glial fibrillary acidic protein | -0.0086107 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00849898 |
| CHKB | choline kinase beta | -0.00846695 |
| ADORA2B | adenosine A2b receptor | -0.00843596 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00838448 |
| SDC2 | syndecan 2 | -0.00837534 |
| DYNC1I1 | dynein, cytoplasmic 1, intermediate chain 1 | -0.00834522 |
| RPN2 | ribophorin II | -0.00833057 |
| COL1A2 | collagen, type I, alpha 2 | -0.00828952 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | -0.00826109 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00813925 |
| TPX2 | TPX2, microtubule-associated | -0.00811243 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.00811138 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00805995 |
| XPO7 | exportin 7 | -0.0080332 |
| GANAB | glucosidase, alpha; neutral AB | -0.00800081 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00798538 |
| CD59 | CD59 molecule, complement regulatory protein | -0.00792638 |
| MXI1 | MAX interactor 1, dimerization protein | -0.00780591 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00774051 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00768879 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00767594 |
| PRMT1 | protein arginine methyltransferase 1 | -0.00765695 |
| LAPTM5 | lysosomal protein transmembrane 5 | -0.00765618 |
| RHOA | ras homolog family member A | -0.007652 |
| SET | SET nuclear proto-oncogene | -0.00763342 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | -0.00759425 |
| OLFM1 | olfactomedin 1 | -0.00758595 |
| MTARC2 | mitochondrial amidoxime reducing component 2 | -0.00749714 |
| IQCG | IQ motif containing G | -0.00748606 |
| RDX | radixin | -0.00747512 |
| AUTS2 | autism susceptibility candidate 2 | -0.00744662 |
| PRPF19 | pre-mRNA processing factor 19 | -0.00743067 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | -0.00741099 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | -0.00735895 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | -0.00733291 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.00732579 |
| MLEC | malectin | -0.00722964 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | -0.00722843 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.00722048 |
| B3GNT1 | -0.00721138 | |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | -0.00718482 |
| NDRG3 | NDRG family member 3 | -0.00716137 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.00715143 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.00713646 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -0.00712843 |
| ANOS1 | anosmin 1 | -0.0071132 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | -0.00711199 |
| GLO1 | glyoxalase I | -0.00708305 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00707098 |
| CCL4 | chemokine (C-C motif) ligand 4 | -0.00705109 |
| IL2RB | interleukin 2 receptor, beta | -0.00701738 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | -0.00699537 |
| ACACA | acetyl-CoA carboxylase alpha | -0.00697869 |
| GPM6B | glycoprotein M6B | -0.00697585 |
| ECI2 | enoyl-CoA delta isomerase 2 | -0.00696675 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | -0.0069497 |
| TUBB2B | tubulin, beta 2B class IIb | -0.00685211 |
| KIFAP3 | kinesin-associated protein 3 | -0.00683367 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00682304 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00680454 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.00679507 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | -0.00679173 |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | -0.00679147 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.00677507 |
| TNC | tenascin C | -0.0067498 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -0.00674868 |
| MTMR4 | myotubularin related protein 4 | -0.0067436 |
| ETNPPL | ethanolamine-phosphate phospho-lyase | -0.00672704 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.0066857 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00667861 |
| A2M | alpha-2-macroglobulin | -0.0066768 |
| MAPK1 | mitogen-activated protein kinase 1 | -0.00666694 |
| FABP1 | fatty acid binding protein 1, liver | -0.00665874 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00664322 |
| STOM | stomatin | -0.00662248 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00659485 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | -0.00659357 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.00657555 |
| KLF9 | Kruppel-like factor 9 | -0.00655208 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.00654907 |
| CDC42 | cell division cycle 42 | -0.00652466 |
| S100A7 | S100 calcium binding protein A7 | -0.00651727 |
| PTCH1 | patched 1 | -0.00651702 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0065054 |
| SYNM | synemin, intermediate filament protein | -0.00650508 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.00649403 |
| CYBRD1 | cytochrome b reductase 1 | -0.00648572 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0064683 |
| SEPTIN9 | septin 9 | -0.00646053 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | -0.00645894 |
| SEMA4C | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | -0.00644438 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.00640517 |
| POSTN | periostin, osteoblast specific factor | -0.00638381 |
| UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | -0.00638276 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -0.00637374 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00635807 |
| MEX3D | mex-3 RNA binding family member D | -0.00631693 |
| EXOC5 | exocyst complex component 5 | -0.00631627 |
| CA11 | carbonic anhydrase XI | -0.00631586 |
| WIF1 | WNT inhibitory factor 1 | -0.00629479 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00627945 |
| HCP5 | HLA complex P5 (non-protein coding) | -0.00626341 |
| RBMX | RNA binding motif protein, X-linked | -0.00624065 |
| CD99 | CD99 molecule | -0.00624051 |
| DAZAP2 | DAZ associated protein 2 | -0.00621645 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -0.00620518 |
| PFKP | phosphofructokinase, platelet | -0.00620148 |
| CNN3 | calponin 3, acidic | -0.00619985 |
| PRAME | preferentially expressed antigen in melanoma | -0.00619566 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | -0.00617115 |
| CD2 | CD2 molecule | -0.00617063 |
| CBX1 | chromobox homolog 1 | -0.00617005 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0061312 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.00612973 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.00612713 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | -0.00612039 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | -0.00610667 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00609767 |
| FUS | FUS RNA binding protein | -0.0060939 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.00609306 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.00607423 |
| CS | citrate synthase | -0.0060697 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00606957 |
| CCDC176 | coiled-coil domain containing 176 | -0.00606263 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | -0.00605728 |
| ABITRAM | actin binding transcription modulator | -0.00605118 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.00604346 |
| TRAF1 | TNF receptor-associated factor 1 | -0.00603411 |
| ENSA | endosulfine alpha | -0.0060311 |
| NCAN | neurocan | -0.00602036 |
| TSC22D1 | TSC22 domain family, member 1 | -0.00601777 |
| MED22 | mediator complex subunit 22 | -0.00599804 |
| GSAP | gamma-secretase activating protein | -0.00599069 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.00597495 |
| CHRM3 | cholinergic receptor, muscarinic 3 | -0.0059744 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.00596931 |
| SULT1E1 | sulfotransferase family 1E, estrogen-preferring, member 1 | -0.00596548 |
| LMAN1 | lectin, mannose-binding, 1 | -0.00596305 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.00594854 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00590873 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.00590788 |
| ELAVL1 | ELAV like RNA binding protein 1 | -0.0059039 |
| PMP2 | peripheral myelin protein 2 | -0.00588877 |
| BAALC | brain and acute leukemia, cytoplasmic | -0.00587736 |
| ODAM | odontogenic, ameloblast asssociated | -0.00586224 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0058592 |
| FAR2 | fatty acyl CoA reductase 2 | -0.00585385 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | -0.00584557 |
| CCL14 | chemokine (C-C motif) ligand 14 | -0.00582913 |
| HMBOX1 | homeobox containing 1 | -0.00582901 |
| ELP1 | elongator acetyltransferase complex subunit 1 | -0.00582845 |
| RALGDS | ral guanine nucleotide dissociation stimulator | -0.00582177 |
| NEFH | neurofilament, heavy polypeptide | -0.00580939 |
| HSPA8 | heat shock 70kDa protein 8 | -0.00580204 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.00579594 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.00578644 |
| NKX3-1 | NK3 homeobox 1 | -0.00577997 |
| PLCG1 | phospholipase C, gamma 1 | -0.00577489 |
| ERGIC3 | ERGIC and golgi 3 | -0.00577064 |
| COPA | coatomer protein complex, subunit alpha | -0.00575511 |
| CNTNAP2 | contactin associated protein-like 2 | -0.00575258 |
| IGSF3 | immunoglobulin superfamily, member 3 | -0.00574921 |
| GTF2I | general transcription factor IIi | -0.00574437 |
| CAPN7 | calpain 7 | -0.00573087 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00572222 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.00571787 |
| CEP70 | centrosomal protein 70kDa | -0.00571462 |
| RXRA | retinoid X receptor, alpha | -0.00570628 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | -0.00570537 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | -0.00569502 |
| PRKCB | protein kinase C, beta | -0.00567684 |
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | -0.00567599 |
| CCKBR | cholecystokinin B receptor | -0.00567131 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.00565393 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | -0.00565097 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00564062 |
| MCM6 | minichromosome maintenance complex component 6 | -0.00562166 |
| FAM107A | family with sequence similarity 107, member A | -0.00562126 |
| RAB13 | RAB13, member RAS oncogene family | -0.00561981 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | -0.00561651 |
| WFDC1 | WAP four-disulfide core domain 1 | -0.00561568 |
| PIP | prolactin-induced protein | -0.00561423 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.00561299 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.00561294 |
| TYRP1 | tyrosinase-related protein 1 | -0.00560337 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.00559783 |
| YME1L1 | YME1-like 1 ATPase | -0.00559218 |
| DCTN4 | dynactin 4 (p62) | -0.00558723 |
| LMNB1 | lamin B1 | -0.00558446 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.00558265 |
| S100A3 | S100 calcium binding protein A3 | -0.00557533 |
| ESD | esterase D | -0.00556922 |
| USP18 | ubiquitin specific peptidase 18 | -0.00556531 |
| ADGRE1 | adhesion G protein-coupled receptor E1 | -0.00555844 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00555628 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 | -0.00555232 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | -0.00554173 |
| SYNGR3 | synaptogyrin 3 | -0.00554077 |
| OXTR | oxytocin receptor | -0.00553411 |
| KCTD20 | potassium channel tetramerization domain containing 20 | -0.00552611 |
| VSNL1 | visinin-like 1 | -0.00551524 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.00551316 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | -0.00551016 |
| PDE8B | phosphodiesterase 8B | -0.00550995 |
| SRP72 | signal recognition particle 72kDa | -0.00550586 |
| NRN1 | neuritin 1 | -0.00550408 |
| SI | sucrase-isomaltase (alpha-glucosidase) | -0.00550287 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.00549861 |
| ARG2 | arginase 2 | -0.00549678 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | -0.0054898 |
| RRAGA | Ras-related GTP binding A | -0.00548748 |
| GIMAP5 | GTPase, IMAP family member 5 | -0.00548488 |
| CTSZ | cathepsin Z | -0.00546972 |
| PLAGL2 | pleiomorphic adenoma gene-like 2 | -0.00546886 |
| HNMT | histamine N-methyltransferase | -0.00546208 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | -0.00543855 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -0.00541967 |
