MAP2K2 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description mitogen-activated protein kinase kinase 2|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5605)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_MAP2K2
Similar Terms
Downloads & Tools

Genes

131 co-expressed genes for MAP2K2 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AFG3L2 AFG3-like AAA ATPase 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANAPC5 anaphase promoting complex subunit 5
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATXN10 ataxin 10
BANF1 barrier to autointegration factor 1
BCAP31 B-cell receptor-associated protein 31
BUB3 BUB3 mitotic checkpoint protein
CANX calnexin
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
COPE coatomer protein complex, subunit epsilon
COPS5 COP9 signalosome subunit 5
COX5B cytochrome c oxidase subunit Vb
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CS citrate synthase
CSNK2B casein kinase 2, beta polypeptide
CTDNEP1 CTD nuclear envelope phosphatase 1
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
DCTN2 dynactin 2 (p50)
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
DGKZ diacylglycerol kinase, zeta
DRG1 developmentally regulated GTP binding protein 1
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
ERP29 endoplasmic reticulum protein 29
FAM120A family with sequence similarity 120A
FIBP fibroblast growth factor (acidic) intracellular binding protein
GANAB glucosidase, alpha; neutral AB
GLB1 galactosidase, beta 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GPAA1 glycosylphosphatidylinositol anchor attachment 1
GPI glucose-6-phosphate isomerase
GPX4 glutathione peroxidase 4
H2AFZ H2A histone family, member Z
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HAX1 HCLS1 associated protein X-1
HCCS holocytochrome c synthase
HDAC2 histone deacetylase 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IFRD1 interferon-related developmental regulator 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
JTB jumping translocation breakpoint
KARS lysyl-tRNA synthetase
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAP2K2 mitogen-activated protein kinase kinase 2
MDH1 malate dehydrogenase 1, NAD (soluble)
MRPL9 mitochondrial ribosomal protein L9
MRPS18B mitochondrial ribosomal protein S18B
MTA1 metastasis associated 1
MTCP1 mature T-cell proliferation 1
MTDH metadherin
MYDGF myeloid-derived growth factor
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NONO non-POU domain containing, octamer-binding
NRD1 nardilysin (N-arginine dibasic convertase)
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUP188 nucleoporin 188kDa
PARK7 parkinson protein 7
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDHB pyruvate dehydrogenase (lipoamide) beta
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPT1 palmitoyl-protein thioesterase 1
PRDX3 peroxiredoxin 3
PRPF31 pre-mRNA processing factor 31
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTDSS1 phosphatidylserine synthase 1
PUF60 poly-U binding splicing factor 60KDa
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD23A RAD23 homolog A (S. cerevisiae)
RANGAP1 Ran GTPase activating protein 1
RHEB Ras homolog enriched in brain
RNPEP arginyl aminopeptidase (aminopeptidase B)
RPN1 ribophorin I
RUVBL2 RuvB-like AAA ATPase 2
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SET SET nuclear proto-oncogene
SF3B2 splicing factor 3b, subunit 2, 145kDa
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPE small nuclear ribonucleoprotein polypeptide E
SOD1 superoxide dismutase 1, soluble
SRSF9 serine/arginine-rich splicing factor 9
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STARD7 StAR-related lipid transfer (START) domain containing 7
TBL3 transducin (beta)-like 3
TCEA1 transcription elongation factor A (SII), 1
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM147 transmembrane protein 147
TRAPPC3 trafficking protein particle complex 3
TRIM28 tripartite motif containing 28
TUFM Tu translation elongation factor, mitochondrial
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2S ubiquitin-conjugating enzyme E2S
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
XPO7 exportin 7
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta