MAP2K3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase kinase 3|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5606)
Similar Terms
Downloads & Tools

Genes

311 genes differentially expressed following the MAP2K3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMPRSS11D transmembrane protease, serine 11D 3.18392
NRAP nebulin-related anchoring protein 3.18392
CCDC68 coiled-coil domain containing 68 3.18392
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.18392
GJB3 gap junction protein, beta 3, 31kDa 3.18392
LRRC56 leucine rich repeat containing 56 3.18392
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.18392
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.18392
PAX6 paired box 6 3.18392
PAX7 paired box 7 3.18392
RIMBP2 RIMS binding protein 2 3.18392
ZNF662 zinc finger protein 662 3.18392
CARD16 caspase recruitment domain family, member 16 3.18392
CARD18 caspase recruitment domain family, member 18 3.18392
FAM180A family with sequence similarity 180, member A 3.18392
SCGN secretagogin, EF-hand calcium binding protein 3.18392
GIP gastric inhibitory polypeptide 3.18392
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.18392
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.18392
SLC16A11 solute carrier family 16, member 11 3.18392
PRELP proline/arginine-rich end leucine-rich repeat protein 3.18392
TYRP1 tyrosinase-related protein 1 3.18392
XCL1 chemokine (C motif) ligand 1 3.18392
SOWAHB sosondowah ankyrin repeat domain family member B 3.18392
OC90 otoconin 90 3.18392
HIPK4 homeodomain interacting protein kinase 4 3.18392
NPIPA8 nuclear pore complex interacting protein family, member A8 3.18392
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.18392
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.18392
BMP5 bone morphogenetic protein 5 3.18392
CLEC14A C-type lectin domain family 14, member A 3.18392
ETV2 ets variant 2 3.18392
MEIKIN meiotic kinetochore factor 3.18392
LCN15 lipocalin 15 3.18392
NFAM1 NFAT activating protein with ITAM motif 1 3.18392
UCN2 urocortin 2 3.18392
SSTR4 somatostatin receptor 4 3.18392
PLXNB3 plexin B3 3.18392
ALPK2 alpha-kinase 2 3.18392
PTGFR prostaglandin F receptor (FP) 3.18392
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.18392
TDRD6 tudor domain containing 6 3.18392
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.18392
ACY3 aminoacylase 3 3.18392
SPATA31H1 SPATA31 subfamily H member 1 3.18392
H2BC17 H2B clustered histone 17 3.18392
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.18392
TCIM transcriptional and immune response regulator 3.18392
DERPC DERPC proline and glycine rich nuclear protein 3.18392
MCHR2 melanin-concentrating hormone receptor 2 3.18392
AVPR1B arginine vasopressin receptor 1B 3.18392
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.18392
SMLR1 small leucine-rich protein 1 3.18392
SAG S-antigen; retina and pineal gland (arrestin) 3.18392
GARIN5B golgi associated RAB2 interactor family member 5B 3.18392
CLEC20A C-type lectin domain containing 20A 3.18392
LY6S lymphocyte antigen 6 family member S 3.18392
FAM240C family with sequence similarity 240 member C 3.18392
LRRC8C-DT LRRC8C divergent transcript 3.18392
PRRT1B proline rich transmembrane protein 1B 3.18392
TMEM238L transmembrane protein 238 like 3.18392
SMIM43 small integral membrane protein 43 3.18392
H3C14 H3 clustered histone 14 3.18392
MYMK myomaker, myoblast fusion factor 3.18392
GLYATL1B glycine-N-acyltransferase like 1B 3.18392
RDH8 retinol dehydrogenase 8 (all-trans) 3.18392
MYL10 myosin, light chain 10, regulatory 3.18392
C3ORF80 chromosome 3 open reading frame 80 3.18392
DSG1 desmoglein 1 3.18392
ITK IL2-inducible T-cell kinase 3.18392
IRF4 interferon regulatory factor 4 3.18392
CLDN5 claudin 5 3.18392
C1ORF87 chromosome 1 open reading frame 87 3.18392
PCDHB10 protocadherin beta 10 3.18392
ACOT1 acyl-CoA thioesterase 1 3.18392
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.18392
OLAH oleoyl-ACP hydrolase 3.18392
HOXC4 homeobox C4 3.18392
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.18392
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.18392
PNPLA1 patatin-like phospholipase domain containing 1 3.18392
OOSP1 oocyte secreted protein 1, pseudogene 3.18392
SASH3 SAM and SH3 domain containing 3 3.18392
PLB1 phospholipase B1 3.18392
CLDN23 claudin 23 3.18392
GZMM granzyme M (lymphocyte met-ase 1) 3.18392
ZIC4 Zic family member 4 3.18392
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.18392
CDH19 cadherin 19, type 2 3.18392
OBSL1 obscurin-like 1 3.18392
SVOP SV2 related protein homolog (rat) 3.18392
OTC ornithine carbamoyltransferase 3.18392
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.18392
ARHGAP20 Rho GTPase activating protein 20 3.18392
CD53 CD53 molecule 3.18392
PCDHGB2 protocadherin gamma subfamily B, 2 3.18392
PCDHGB5 protocadherin gamma subfamily B, 5 3.18392
APOD apolipoprotein D 3.18392
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.18392
CPO carboxypeptidase O 3.18392
ZC3H11D zinc finger CCCH-type containing 11D 3.18392
TRIM29 tripartite motif containing 29 3.18392
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.18392
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.18392
S100A14 S100 calcium binding protein A14 3.18392
BTNL2 butyrophilin-like 2 3.18392
AQP9 aquaporin 9 3.18392
C22ORF42 chromosome 22 open reading frame 42 3.18392
DRD5 dopamine receptor D5 3.18392
C2CD4A C2 calcium-dependent domain containing 4A 3.18392
PLET1 placenta expressed transcript 1 3.18392
CALHM2 calcium homeostasis modulator 2 3.18392
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.18392
LMOD2 leiomodin 2 (cardiac) 3.18392
NANOGNB NANOG neighbor homeobox 3.18392
CLEC18C C-type lectin domain family 18, member C 3.18392
TEKT1 tektin 1 3.18392
HSPA1L heat shock 70kDa protein 1-like 3.18392
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 3.18392
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.18392
C8ORF89 chromosome 8 open reading frame 89 3.18392
KLHL6 kelch-like family member 6 3.18392
MC5R melanocortin 5 receptor 3.18392
SLC7A4 solute carrier family 7, member 4 3.18392
RGS8 regulator of G-protein signaling 8 3.18392
MB myoglobin 3.18392
TPH1 tryptophan hydroxylase 1 3.18392
RHOJ ras homolog family member J 3.18392
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.18392
GSC2 goosecoid homeobox 2 3.18392
PSG9 pregnancy specific beta-1-glycoprotein 9 3.18392
MMEL1 membrane metallo-endopeptidase-like 1 3.18392
LAMB4 laminin, beta 4 3.18392
NKX6-1 NK6 homeobox 1 3.18392
IL37 interleukin 37 3.18392
IFNK interferon, kappa 3.18392
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.18392
SOSTDC1 sclerostin domain containing 1 3.18392
FGF16 fibroblast growth factor 16 3.18392
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.18392
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.18392
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.18392
CD80 CD80 molecule 3.18392
UTS2B urotensin 2B 3.18392
ZC3H12D zinc finger CCCH-type containing 12D 3.18392
PENK proenkephalin 3.18392
ADAM20 ADAM metallopeptidase domain 20 3.18392
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.18392
SYTL4 synaptotagmin-like 4 3.18392
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.18392
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.11357
AKAP3 A kinase (PRKA) anchor protein 3 3.11357
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.08408
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 3.0558
NPR2 natriuretic peptide receptor 2 2.984
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.95852
CRIPT cysteine-rich PDZ-binding protein 2.92699
SLCO2A1 solute carrier organic anion transporter family, member 2A1 2.89454
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.84294
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.80294
STRN striatin, calmodulin binding protein 2.79859
BGN biglycan 2.75399
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.739
PMFBP1 polyamine modulated factor 1 binding protein 1 2.70765
ZNF830 zinc finger protein 830 2.64086
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.62574
BDKRB2 bradykinin receptor B2 2.52013
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.52013
EAPP E2F-associated phosphoprotein 2.45783
NPPC natriuretic peptide C 2.45501
SNTG1 syntrophin, gamma 1 2.38713
SRI sorcin 2.38711
PHACTR2 phosphatase and actin regulator 2 2.33589
RTN4RL2 reticulon 4 receptor-like 2 2.31861
EPHA3 EPH receptor A3 2.31071
APOA1 apolipoprotein A-I 2.31071
AP3M1 adaptor-related protein complex 3, mu 1 subunit 2.28519
ZFP57 ZFP57 zinc finger protein 2.26664
ZNF207 zinc finger protein 207 2.26664
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.26664
HLA-G major histocompatibility complex, class I, G 2.26664
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.26664
PLPP3 phospholipid phosphatase 3 2.20273
PIKFYVE phosphoinositide kinase, FYVE finger containing 2.20273
RAVER2 ribonucleoprotein, PTB-binding 2 2.20201
DNLZ DNL-type zinc finger 2.20103
U2AF1 U2 small nuclear RNA auxiliary factor 1 2.1833
MRGBP MRG/MORF4L binding protein 2.1833
ERI1 exoribonuclease 1 2.18056
NAAA N-acylethanolamine acid amidase 2.17667
TAPBPL TAP binding protein-like 2.17667
GRIK3 glutamate receptor, ionotropic, kainate 3 2.17667
RAB23 RAB23, member RAS oncogene family 2.15843
CHID1 chitinase domain containing 1 2.15032
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 2.14244
PXDNL peroxidasin-like 2.13261
NUCB2 nucleobindin 2 2.13261
ZNF354C zinc finger protein 354C 2.081
CHMP5 charged multivesicular body protein 5 2.07989
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 2.07664
AFG3L2 AFG3-like AAA ATPase 2 2.06679
AZI2 5-azacytidine induced 2 2.06342
RBBP7 retinoblastoma binding protein 7 2.02981
CORO1C coronin, actin binding protein, 1C 2.02981
DCLRE1B DNA cross-link repair 1B 2.02268
RNF170 ring finger protein 170 2.00888
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2.0066

decreased expression

Symbol Name Standardized Value
ZC3HC1 zinc finger, C3HC-type containing 1 -3.18392
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -3.18392
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -3.18392
IL17C interleukin 17C -3.18392
S100A2 S100 calcium binding protein A2 -3.18392
AMT aminomethyltransferase -3.18392
PXDC1 PX domain containing 1 -3.18392
HSH2D hematopoietic SH2 domain containing -3.18392
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -3.18392
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.00686
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -3.00686
MEIOB meiosis specific with OB domains -3.00686
KIF1C-AS1 KIF1C antisense RNA 1 -3.00686
FNDC8 fibronectin type III domain containing 8 -3.00686
BMX BMX non-receptor tyrosine kinase -3.00686
STAB1 stabilin 1 -3.00686
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -3.00686
LEP leptin -3.00686
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -3.00686
MST1 macrophage stimulating 1 -3.00686
GPR162 G protein-coupled receptor 162 -3.00686
GDA guanine deaminase -3.00686
SV2C synaptic vesicle glycoprotein 2C -3.00686
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.00686
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -3.00686
MEIG1 meiosis/spermiogenesis associated 1 -3.00686
HLA-DOB major histocompatibility complex, class II, DO beta -3.00686
PRSS36 protease, serine, 36 -3.00686
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 -3.00686
PIWIL3 piwi-like RNA-mediated gene silencing 3 -3.00686
EPOP elongin BC and polycomb repressive complex 2 associated protein -3.00686
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.00686
SPAG8 sperm associated antigen 8 -3.00686
E2F5 E2F transcription factor 5, p130-binding -3.00686
NPNT nephronectin -3.00686
MMP3 matrix metallopeptidase 3 -3.00686
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 -2.98138
EID3 EP300 interacting inhibitor of differentiation 3 -2.96785
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.93949
ITSN1 intersectin 1 (SH3 domain protein) -2.92699
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -2.92457
CRHR2 corticotropin releasing hormone receptor 2 -2.87733
SLITRK3 SLIT and NTRK-like family, member 3 -2.87733
TMEM229B transmembrane protein 229B -2.87733
ITGB4 integrin, beta 4 -2.83841
IFT74 intraflagellar transport 74 -2.79859
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.77559
LIMS2 LIM and senescent cell antigen-like domains 2 -2.7749
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 -2.77458
RBM38 RNA binding motif protein 38 -2.74595
NUCB1 nucleobindin 1 -2.72616
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.68104
FAS Fas cell surface death receptor -2.66425
SRGAP2B SLIT-ROBO Rho GTPase activating protein 2B -2.66425
INSL3 insulin-like 3 (Leydig cell) -2.64685
ODC1 ornithine decarboxylase 1 -2.52943
DMWD dystrophia myotonica, WD repeat containing -2.47291
TRIM33 tripartite motif containing 33 -2.46104
TMEM81 transmembrane protein 81 -2.45501
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.45497
PRR11 proline rich 11 -2.35249
GPX1 glutathione peroxidase 1 -2.3495
ADAM9 ADAM metallopeptidase domain 9 -2.34506
ZNF793 zinc finger protein 793 -2.33778
CA10 carbonic anhydrase X -2.33589
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.32623
MUC19 mucin 19, oligomeric -2.31428
ASPG asparaginase -2.31428
LRPPRC leucine-rich pentatricopeptide repeat containing -2.31428
FRYL FRY-like -2.30783
CTCF CCCTC-binding factor (zinc finger protein) -2.26664
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -2.26664
DGKI diacylglycerol kinase, iota -2.26098
RIOX1 ribosomal oxygenase 1 -2.22094
MSS51 MSS51 mitochondrial translational activator -2.21428
MANSC4 MANSC domain containing 4 -2.21428
HHAT hedgehog acyltransferase -2.21428
TEX11 testis expressed 11 -2.21375
TMEM175 transmembrane protein 175 -2.21138
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -2.20273
ZIM3 zinc finger, imprinted 3 -2.20201
PTPA protein phosphatase 2 phosphatase activator -2.20075
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 -2.20075
ZFPM2 zinc finger protein, FOG family member 2 -2.19192
ARMCX1 armadillo repeat containing, X-linked 1 -2.19177
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -2.18831
NUP98 nucleoporin 98kDa -2.1833
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -2.17866
ATN1 atrophin 1 -2.17667
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -2.17667
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -2.16798
FAAH fatty acid amide hydrolase -2.1324
RBP5 retinol binding protein 5, cellular -2.1324
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) -2.12443
FAM3B family with sequence similarity 3, member B -2.11021
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.081
ABI3BP ABI family, member 3 (NESH) binding protein -2.081
DPH2 DPH2 homolog (S. cerevisiae) -2.081
PPCS phosphopantothenoylcysteine synthetase -2.07321
RPSA2 ribosomal protein SA 2 -2.06885
RNF24 ring finger protein 24 -2.04682
DMTF1 cyclin D binding myb-like transcription factor 1 -2.03805
ZNF565 zinc finger protein 565 -2.02425
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.02268