| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase 3|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5606) |
| External Link | https://ncbi.nlm.nih.gov/gene/5606 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the MAP2K3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0114812 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.0106534 |
| TRIB2 | tribbles pseudokinase 2 | 0.0103879 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0101835 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0099251 |
| IFI44L | interferon-induced protein 44-like | 0.00984953 |
| METTL7A | methyltransferase like 7A | 0.00975266 |
| S100A10 | S100 calcium binding protein A10 | 0.00970374 |
| IRS2 | insulin receptor substrate 2 | 0.00926356 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00889449 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.0087048 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00863828 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00824902 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00819602 |
| TBC1D31 | TBC1 domain family, member 31 | 0.00818846 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00817995 |
| RAB4A | RAB4A, member RAS oncogene family | 0.00809273 |
| ABLIM1 | actin binding LIM protein 1 | 0.0080283 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00769173 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00767607 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00752593 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00750232 |
| PRDX2 | peroxiredoxin 2 | 0.00748571 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.0074242 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.00732342 |
| MAOB | monoamine oxidase B | 0.00723614 |
| CNN3 | calponin 3, acidic | 0.00721002 |
| FN1 | fibronectin 1 | 0.00719734 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00718833 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | 0.00716541 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.00715572 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00714609 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.00710979 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00710552 |
| HTRA1 | HtrA serine peptidase 1 | 0.00702919 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00691813 |
| RTN1 | reticulon 1 | 0.00691619 |
| SMAD3 | SMAD family member 3 | 0.00682822 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00677476 |
| GANAB | glucosidase, alpha; neutral AB | 0.00676395 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.00674109 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.00672104 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.0067204 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00671937 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00668467 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00661524 |
| WWC1 | WW and C2 domain containing 1 | 0.00655162 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00647403 |
| RIN2 | Ras and Rab interactor 2 | 0.00646309 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00643383 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00642858 |
| TAOK3 | TAO kinase 3 | 0.0064083 |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.00639185 |
| PALLD | palladin, cytoskeletal associated protein | 0.00638616 |
| KRT7 | keratin 7, type II | 0.00637486 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0063473 |
| HNMT | histamine N-methyltransferase | 0.00633642 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.00630298 |
| IFI44 | interferon-induced protein 44 | 0.00628081 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00625881 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00623355 |
| MEIS1 | Meis homeobox 1 | 0.00622017 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.00621482 |
| CAST | calpastatin | 0.00621101 |
| KIF20A | kinesin family member 20A | 0.00620559 |
| SORD | sorbitol dehydrogenase | 0.00620497 |
| TNS3 | tensin 3 | 0.0061932 |
| S100A14 | S100 calcium binding protein A14 | 0.00615493 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.00615001 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.00614445 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.00607693 |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.00606533 |
| COL4A2 | collagen, type IV, alpha 2 | 0.00606212 |
| CD44 | CD44 molecule (Indian blood group) | 0.00604481 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00603988 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.00603122 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.00600106 |
| CD9 | CD9 molecule | 0.00599892 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.00599099 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00598741 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00597511 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 | 0.00596483 |
| PLAU | plasminogen activator, urokinase | 0.00594149 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00594075 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.00592924 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0058975 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00589463 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00588982 |
| XIC | X chromosome inactivation center | 0.00588791 |
| CANX | calnexin | 0.00588514 |
| AHNAK | AHNAK nucleoprotein | 0.00585533 |
| NFIB | nuclear factor I/B | 0.00585005 |
| CST1 | cystatin SN | 0.00582579 |
| OAT | ornithine aminotransferase | 0.00580665 |
| CD99 | CD99 molecule | 0.00579022 |
| CLEC7A | C-type lectin domain family 7, member A | 0.00578612 |
| MMP7 | matrix metallopeptidase 7 | 0.00576468 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.00575209 |
| EPAS1 | endothelial PAS domain protein 1 | 0.00572875 |
| MX2 | MX dynamin-like GTPase 2 | 0.00571082 |
| F2R | coagulation factor II (thrombin) receptor | 0.00569834 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.00568689 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.00566441 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.00565826 |
| CDC14B | cell division cycle 14B | 0.00565698 |
| GOLM1 | golgi membrane protein 1 | 0.00565089 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00562959 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00560806 |
| C1ORF115 | chromosome 1 open reading frame 115 | 0.00558571 |
| CPE | carboxypeptidase E | 0.00557799 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.00557256 |
| PRKCB | protein kinase C, beta | 0.00556863 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.00556428 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00556372 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | 0.00555773 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.00554793 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.00551558 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00550838 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.00550725 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00550114 |
| PFKM | phosphofructokinase, muscle | 0.00547754 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | 0.00547103 |
| ACO2 | aconitase 2, mitochondrial | 0.00545552 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | 0.0054382 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.0054212 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00540727 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00536527 |
| MX1 | MX dynamin-like GTPase 1 | 0.00535437 |
| TPM1 | tropomyosin 1 (alpha) | 0.00535338 |
| PDAP1 | PDGFA associated protein 1 | 0.00535193 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | 0.00535066 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.00533318 |
| NLRP2 | NLR family, pyrin domain containing 2 | 0.00532392 |
| GIMAP4 | GTPase, IMAP family member 4 | 0.00532167 |
| DUSP3 | dual specificity phosphatase 3 | 0.00532141 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.00531787 |
| GLUL | glutamate-ammonia ligase | 0.00530633 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.0052985 |
| BAG3 | BCL2-associated athanogene 3 | 0.005271 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00525377 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.00524039 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.00523896 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00522321 |
| CFI | complement factor I | 0.00520987 |
| SNX10 | sorting nexin 10 | 0.00520966 |
| GPX1 | glutathione peroxidase 1 | 0.00519148 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00518356 |
| NID1 | nidogen 1 | 0.00515355 |
| YBX3 | Y box binding protein 3 | 0.00514004 |
| RAB13 | RAB13, member RAS oncogene family | 0.00512915 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.00512735 |
| PSAP | prosaposin | 0.00511925 |
| SEPTIN8 | septin 8 | 0.00511885 |
| COLEC12 | collectin sub-family member 12 | 0.00511371 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.00511018 |
| COG7 | component of oligomeric golgi complex 7 | 0.00508918 |
| NPTXR | neuronal pentraxin receptor | 0.00508736 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.00505577 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 0.00504912 |
| RNF130 | ring finger protein 130 | 0.00504695 |
| GLUD2 | glutamate dehydrogenase 2 | 0.00504062 |
| NCALD | neurocalcin delta | 0.00503369 |
| RHOB | ras homolog family member B | 0.00503259 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 0.0050269 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00502199 |
| CKAP4 | cytoskeleton-associated protein 4 | 0.00502085 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.00500499 |
| C3 | complement component 3 | 0.00500412 |
| FOXN3 | forkhead box N3 | 0.00499606 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.00498958 |
| TJP2 | tight junction protein 2 | 0.00498488 |
| C1R | complement component 1, r subcomponent | 0.0049847 |
| PDGFC | platelet derived growth factor C | 0.00497708 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.00497664 |
| LAMP1 | lysosomal-associated membrane protein 1 | 0.00497283 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00496483 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 0.00496382 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.00493711 |
| DAP | death-associated protein | 0.00493318 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00492755 |
| FHL1 | four and a half LIM domains 1 | 0.00491443 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00489627 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.00487668 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.00487639 |
| EXT1 | exostosin glycosyltransferase 1 | 0.00483996 |
| SCARB2 | scavenger receptor class B, member 2 | 0.00482125 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00481027 |
| ANOS1 | anosmin 1 | 0.00478229 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.00477104 |
| CCDC92 | coiled-coil domain containing 92 | 0.00476491 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00476479 |
| PCTP | phosphatidylcholine transfer protein | 0.00476365 |
| ACTN1 | actinin, alpha 1 | 0.00472621 |
| GATA3 | GATA binding protein 3 | 0.00472376 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.00471303 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.00466742 |
| SCP2 | sterol carrier protein 2 | 0.00465668 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.00465247 |
| VCAN | versican | 0.00464314 |
| VDAC1 | voltage-dependent anion channel 1 | 0.00464279 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00463796 |
| PDZK1 | PDZ domain containing 1 | 0.00462895 |
| RTP4 | receptor (chemosensory) transporter protein 4 | 0.00458005 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00457649 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.00457184 |
| LTF | lactotransferrin | 0.00456717 |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.00455916 |
| NELL2 | NEL-like 2 (chicken) | 0.00454328 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.00453821 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.00453665 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00453365 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | 0.00453168 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.00453011 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.00452542 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 | 0.00451709 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00450902 |
| TYMP | thymidine phosphorylase | 0.00450153 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.00449866 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.004495 |
| GM2A | GM2 ganglioside activator | 0.00448694 |
| COL7A1 | collagen, type VII, alpha 1 | 0.00446091 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.00444617 |
| SIRPA | signal-regulatory protein alpha | 0.00443627 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0044357 |
| PDLIM3 | PDZ and LIM domain 3 | 0.00443191 |
| LAT2 | linker for activation of T cells family, member 2 | 0.00443121 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.00442483 |
| MMP11 | matrix metallopeptidase 11 | 0.00440715 |
| STON1 | stonin 1 | 0.00440443 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.00440408 |
| CD93 | CD93 molecule | 0.00437816 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 0.00436961 |
| DEFB1 | defensin, beta 1 | 0.00436604 |
| GNLY | granulysin | 0.00436363 |
| DAZAP2 | DAZ associated protein 2 | 0.0043622 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.00435633 |
| AIF1 | allograft inflammatory factor 1 | 0.00435205 |
| C1RL | complement component 1, r subcomponent-like | 0.00433735 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.00433624 |
| HEXB | hexosaminidase B (beta polypeptide) | 0.0043318 |
| ARF3 | ADP-ribosylation factor 3 | 0.00433084 |
| USP18 | ubiquitin specific peptidase 18 | 0.00432385 |
| S100A2 | S100 calcium binding protein A2 | 0.004323 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00432297 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00430629 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | 0.00429451 |
| CSF1R | colony stimulating factor 1 receptor | 0.00428836 |
| ANXA2 | annexin A2 | 0.00428544 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00427069 |
| PF4 | platelet factor 4 | 0.00426595 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PENK | proenkephalin | -0.00785541 |
| TXNDC9 | thioredoxin domain containing 9 | -0.00770609 |
| AREG | amphiregulin | -0.00746947 |
| TAC1 | tachykinin, precursor 1 | -0.00743067 |
| DNASE1L3 | deoxyribonuclease I-like 3 | -0.00731881 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.00694006 |
| GLS | glutaminase | -0.00680202 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00672838 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00671651 |
| IFRD1 | interferon-related developmental regulator 1 | -0.00664851 |
| PCP4 | Purkinje cell protein 4 | -0.00662765 |
| STC2 | stanniocalcin 2 | -0.00653984 |
| RELN | reelin | -0.00648997 |
| JMJD6 | jumonji domain containing 6 | -0.0063507 |
| TVP23B | trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) | -0.00624456 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.0061926 |
| MALL | mal, T-cell differentiation protein-like | -0.00608158 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00587294 |
| MCOLN1 | mucolipin 1 | -0.00587135 |
| STMN2 | stathmin 2 | -0.00584722 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | -0.00584333 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00580394 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00575157 |
| SPAG7 | sperm associated antigen 7 | -0.00575106 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00562582 |
| PCNA | proliferating cell nuclear antigen | -0.00561017 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00560202 |
| FOXD1 | forkhead box D1 | -0.00558562 |
| CA4 | carbonic anhydrase IV | -0.00555275 |
| FAM3C | family with sequence similarity 3, member C | -0.00555241 |
| HSPA13 | heat shock protein 70kDa family, member 13 | -0.00543761 |
| GATA6 | GATA binding protein 6 | -0.00539392 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.00534605 |
| MIR22HG | MIR22 host gene | -0.00531563 |
| KRT20 | keratin 20, type I | -0.00530817 |
| CXORF40A | chromosome X open reading frame 40A | -0.00530804 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.00529771 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00523363 |
| KIF1A | kinesin family member 1A | -0.00520377 |
| VPS4B | vacuolar protein sorting 4 homolog B (S. cerevisiae) | -0.00519699 |
| MFAP5 | microfibrillar associated protein 5 | -0.00517064 |
| NUP58 | nucleoporin 58 | -0.00514646 |
| COMP | cartilage oligomeric matrix protein | -0.00513004 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.00508604 |
| GCH1 | GTP cyclohydrolase 1 | -0.00507646 |
| PCDH9 | protocadherin 9 | -0.00504846 |
| RAB21 | RAB21, member RAS oncogene family | -0.00503134 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.0049925 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.00498056 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00496977 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.0049496 |
| FRZB | frizzled-related protein | -0.00494295 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00493856 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.00493771 |
| LEFTY1 | left-right determination factor 1 | -0.00492041 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00491814 |
| CCL21 | chemokine (C-C motif) ligand 21 | -0.00491625 |
| CCDC59 | coiled-coil domain containing 59 | -0.00490014 |
| CD2AP | CD2-associated protein | -0.00489292 |
| DUSP2 | dual specificity phosphatase 2 | -0.00487947 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.00487569 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00487402 |
| ELN | elastin | -0.00485587 |
| IL33R | interleukin 33 receptor | -0.00484873 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00484624 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00483096 |
| ESR1 | estrogen receptor 1 | -0.0048267 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00479233 |
| IRF4 | interferon regulatory factor 4 | -0.00479095 |
| SV2C | synaptic vesicle glycoprotein 2C | -0.00478942 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.00477547 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00477085 |
| SCAF8 | SR-related CTD-associated factor 8 | -0.00475268 |
| KIAA0125 | KIAA0125 | -0.00474902 |
| CALCA | calcitonin-related polypeptide alpha | -0.00474478 |
| MAB21L2 | mab-21-like 2 (C. elegans) | -0.00474386 |
| TPBG | trophoblast glycoprotein | -0.0047424 |
| JAM2 | junctional adhesion molecule 2 | -0.00473435 |
| WTAP | Wilms tumor 1 associated protein | -0.00472159 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00471935 |
| BDKRB1 | bradykinin receptor B1 | -0.00470392 |
| DCN | decorin | -0.0046976 |
| NEFM | neurofilament, medium polypeptide | -0.00469591 |
| CHGB | chromogranin B | -0.00469501 |
| ANO3 | anoctamin 3 | -0.00467069 |
| CDC20 | cell division cycle 20 | -0.00466571 |
| SUCO | SUN domain containing ossification factor | -0.00466536 |
| MINK1 | misshapen-like kinase 1 | -0.00466036 |
| CD320 | CD320 molecule | -0.00465578 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.00463627 |
| CLIC3 | chloride intracellular channel 3 | -0.00461146 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | -0.00459304 |
| RGS2 | regulator of G-protein signaling 2 | -0.00457953 |
| SLC35G2 | solute carrier family 35, member G2 | -0.0045724 |
| CFD | complement factor D (adipsin) | -0.00453914 |
| ACKR3 | atypical chemokine receptor 3 | -0.0045389 |
| TSPAN13 | tetraspanin 13 | -0.00453048 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | -0.00452707 |
| ITM2A | integral membrane protein 2A | -0.00451726 |
| STAT5A | signal transducer and activator of transcription 5A | -0.00451238 |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | -0.00450751 |
| TNPO1 | transportin 1 | -0.00449342 |
| FZD10 | frizzled class receptor 10 | -0.00448926 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | -0.00442345 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.00440479 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -0.00439649 |
| TUBB4B | tubulin, beta 4B class IVb | -0.00439218 |
| MMP3 | matrix metallopeptidase 3 | -0.00438961 |
| GPX2 | glutathione peroxidase 2 | -0.00437785 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.00437387 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00436661 |
| HAS1 | hyaluronan synthase 1 | -0.00436609 |
| ACAA2 | acetyl-CoA acyltransferase 2 | -0.00434138 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | -0.00432808 |
| STK26 | serine/threonine protein kinase 26 | -0.00432555 |
| TOR1AIP1 | torsin A interacting protein 1 | -0.00432358 |
| CXORF40B | chromosome X open reading frame 40B | -0.0043124 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00429656 |
| CCNC | cyclin C | -0.00428262 |
| RGS3 | regulator of G-protein signaling 3 | -0.0042756 |
| VBP1 | von Hippel-Lindau binding protein 1 | -0.00425743 |
| TMF1 | TATA element modulatory factor 1 | -0.00425338 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00425244 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -0.00424992 |
| SMAD7 | SMAD family member 7 | -0.00424347 |
| CYB561 | cytochrome b561 | -0.00423996 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.00422376 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | -0.00420121 |
| IL24 | interleukin 24 | -0.00419191 |
| LUM | lumican | -0.00419016 |
| TUBB3 | tubulin, beta 3 class III | -0.00418749 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | -0.00417468 |
| PTHLH | parathyroid hormone-like hormone | -0.00416973 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.00416035 |
| SPRR2B | small proline-rich protein 2B | -0.00415684 |
| CTH | cystathionine gamma-lyase | -0.0041405 |
| TIPRL | TOR signaling pathway regulator | -0.00412656 |
| ZBTB11 | zinc finger and BTB domain containing 11 | -0.0041245 |
| TXNL4B | thioredoxin-like 4B | -0.00412395 |
| KLF10 | Kruppel-like factor 10 | -0.00412083 |
| SPRR1B | small proline-rich protein 1B | -0.00412056 |
| IER3 | immediate early response 3 | -0.00411793 |
| SPRR1A | small proline-rich protein 1A | -0.00411579 |
| PLSCR4 | phospholipid scramblase 4 | -0.00411522 |
| CFH | complement factor H | -0.0041104 |
| SMAD2 | SMAD family member 2 | -0.00410772 |
| DOK5 | docking protein 5 | -0.00409243 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.00409208 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.00408895 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.00407587 |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 | -0.00406878 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -0.00404863 |
| TDO2 | tryptophan 2,3-dioxygenase | -0.00404823 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | -0.00404511 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.00404449 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) | -0.00404374 |
| NEFH | neurofilament, heavy polypeptide | -0.00404286 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00404011 |
| TRIM36 | tripartite motif containing 36 | -0.00403701 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00403552 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00402063 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00401797 |
| DCX | doublecortin | -0.00401336 |
| CPEB1 | cytoplasmic polyadenylation element binding protein 1 | -0.00400795 |
| HDAC9 | histone deacetylase 9 | -0.0039991 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | -0.00399868 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | -0.00399796 |
| CALR | calreticulin | -0.00399594 |
| MT1M | metallothionein 1M | -0.00399183 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.00397588 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.00396313 |
| FAM162A | family with sequence similarity 162, member A | -0.00394317 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00394132 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.00393816 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | -0.00393569 |
| CDX1 | caudal type homeobox 1 | -0.00393515 |
| ZNF587 | zinc finger protein 587 | -0.00393458 |
| MRM3 | mitochondrial rRNA methyltransferase 3 | -0.00392435 |
| BMP6 | bone morphogenetic protein 6 | -0.00392202 |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | -0.00389387 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.00388951 |
| CAPN6 | calpain 6 | -0.00388494 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.00387947 |
| KRT16 | keratin 16, type I | -0.00387868 |
| ZBTB1 | zinc finger and BTB domain containing 1 | -0.00387069 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00386874 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.00385857 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | -0.00384797 |
| KRT14 | keratin 14, type I | -0.00384699 |
| RAD21 | RAD21 homolog (S. pombe) | -0.00384482 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.0038319 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | -0.00381991 |
| COL2A1 | collagen, type II, alpha 1 | -0.00381445 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.00379974 |
| TXNL1 | thioredoxin-like 1 | -0.00379881 |
| BMP4 | bone morphogenetic protein 4 | -0.0037986 |
| PRRC2C | proline-rich coiled-coil 2C | -0.00379841 |
| MPZ | myelin protein zero | -0.00379484 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.00378315 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.00377563 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.00376277 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.00375839 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.00375345 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0037511 |
| CLIC2 | chloride intracellular channel 2 | -0.00374576 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.00374267 |
| RGS5 | regulator of G-protein signaling 5 | -0.00373956 |
| COPS3 | COP9 signalosome subunit 3 | -0.00373369 |
| PRPH | peripherin | -0.00372262 |
| PFDN4 | prefoldin subunit 4 | -0.0037218 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00371678 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00370357 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0036966 |
| AQP8 | aquaporin 8 | -0.00369344 |
| CD177 | CD177 molecule | -0.00367422 |
| CCND3 | cyclin D3 | -0.00366138 |
| POPDC3 | popeye domain containing 3 | -0.00365608 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00365516 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.00365318 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.00364405 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.00364336 |
| CHUK | conserved helix-loop-helix ubiquitous kinase | -0.00364154 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00363824 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00363614 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00362858 |
| FCN3 | ficolin (collagen/fibrinogen domain containing) 3 | -0.00362836 |
| IL4R | interleukin 4 receptor | -0.00362164 |
| INA | internexin neuronal intermediate filament protein, alpha | -0.00361929 |
| LETM1 | leucine zipper-EF-hand containing transmembrane protein 1 | -0.00361508 |
| WIF1 | WNT inhibitory factor 1 | -0.00361427 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.00360969 |
| ATG14 | autophagy related 14 | -0.00360691 |
| PELO | pelota homolog (Drosophila) | -0.00360189 |
| EIF1B | eukaryotic translation initiation factor 1B | -0.00359932 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | -0.0035928 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -0.00358212 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | -0.00357794 |
| ASPN | asporin | -0.0035759 |
| LRRC49 | leucine rich repeat containing 49 | -0.00357171 |
| TLCD3A | TLC domain containing 3A | -0.0035709 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.00356529 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.00356474 |
| PLS3 | plastin 3 | -0.00355928 |
| SLC35D1 | solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 | -0.00355796 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.00355655 |
| TCL1A | T-cell leukemia/lymphoma 1A | -0.00355339 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00355328 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.00354886 |
| PDGFD | platelet derived growth factor D | -0.00354739 |
| PIMREG | PICALM interacting mitotic regulator | -0.00354601 |
