MAP2K3 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description mitogen-activated protein kinase kinase 3|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5606)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_MAP2K3
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Genes

75 co-expressed genes for MAP2K3 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AHSP alpha hemoglobin stabilizing protein
ALAD aminolevulinate dehydratase
ALAS2 5'-aminolevulinate synthase 2
ANK1 ankyrin 1, erythrocytic
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAT catalase
CDC27 cell division cycle 27
CLIC2 chloride intracellular channel 2
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTSE cathepsin E
DCAF11 DDB1 and CUL4 associated factor 11
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EPB42 erythrocyte membrane protein band 4.2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO7 F-box protein 7
FBXO9 F-box protein 9
FECH ferrochelatase
FOXO3 forkhead box O3
GLRX5 glutaredoxin 5
GYPA glycophorin A (MNS blood group)
GYPB glycophorin B (MNS blood group)
GYPC glycophorin C (Gerbich blood group)
GYPE glycophorin E (MNS blood group)
H1F0 H1 histone family, member 0
HBQ1 hemoglobin, theta 1
HDGF hepatoma-derived growth factor
HIST1H4C histone cluster 1, H4c
HMBS hydroxymethylbilane synthase
KAT2B K(lysine) acetyltransferase 2B
KLF1 Kruppel-like factor 1 (erythroid)
MAP2K3 mitogen-activated protein kinase kinase 3
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MARK3 MAP/microtubule affinity-regulating kinase 3
MKRN1 makorin ring finger protein 1
MPP1 membrane protein, palmitoylated 1, 55kDa
NARF nuclear prelamin A recognition factor
NCOA4 nuclear receptor coactivator 4
NFE2 nuclear factor, erythroid 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
OSBP2 oxysterol binding protein 2
PNP purine nucleoside phosphorylase
PPOX protoporphyrinogen oxidase
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
RAD23A RAD23 homolog A (S. cerevisiae)
RANBP10 RAN binding protein 10
RBM38 RNA binding motif protein 38
RCL1 RNA terminal phosphate cyclase-like 1
RHAG Rh-associated glycoprotein
RHCE Rh blood group, CcEe antigens
RHD Rh blood group, D antigen
RPIA ribose 5-phosphate isomerase A
SELENBP1 selenium binding protein 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
TAL1 T-cell acute lymphocytic leukemia 1
TFDP1 transcription factor Dp-1
TMCC2 transmembrane and coiled-coil domain family 2
TOP1 topoisomerase (DNA) I
TRAK2 trafficking protein, kinesin binding 2
TRIM10 tripartite motif containing 10
TSPO2 translocator protein 2
UBAC1 UBA domain containing 1
UROD uroporphyrinogen decarboxylase
USP15 ubiquitin specific peptidase 15
XK X-linked Kx blood group
XPO7 exportin 7