| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase 4|This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 6416) |
| External Link | https://ncbi.nlm.nih.gov/gene/6416 |
| Similar Terms | |
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499 genes differentially expressed following the MAP2K4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0281289 |
| PCNA | proliferating cell nuclear antigen | 0.0170116 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.016204 |
| STK10 | serine/threonine kinase 10 | 0.0149662 |
| FCGBP | Fc fragment of IgG binding protein | 0.0147523 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0144486 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.0133604 |
| ADD3 | adducin 3 (gamma) | 0.0132147 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.013166 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.0120046 |
| KRT5 | keratin 5, type II | 0.0119902 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.0115167 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.0113782 |
| LTF | lactotransferrin | 0.0111194 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0109419 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0109019 |
| KRT15 | keratin 15, type I | 0.0107247 |
| FABP7 | fatty acid binding protein 7, brain | 0.0102726 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0102447 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0101656 |
| KRT14 | keratin 14, type I | 0.00989215 |
| CSTA | cystatin A (stefin A) | 0.00947749 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00922902 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00916953 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00890908 |
| MXRA7 | matrix-remodelling associated 7 | 0.00889975 |
| CRYAB | crystallin, alpha B | 0.00883858 |
| CCN2 | cellular communication network factor 2 | 0.00883302 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.00883224 |
| TCTA | T-cell leukemia translocation altered | 0.00876185 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00867557 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00863865 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00854943 |
| TUBA1A | tubulin, alpha 1a | 0.0084234 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00837707 |
| MMP7 | matrix metallopeptidase 7 | 0.00836878 |
| INSM1 | insulinoma-associated 1 | 0.00836038 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00831958 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.00829136 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.008223 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.00822034 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00817543 |
| GPX3 | glutathione peroxidase 3 | 0.00814252 |
| A2M | alpha-2-macroglobulin | 0.00809766 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00809622 |
| LAPTM5 | lysosomal protein transmembrane 5 | 0.00791005 |
| RCAN1 | regulator of calcineurin 1 | 0.00785969 |
| HLA-F | major histocompatibility complex, class I, F | 0.00784895 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00781307 |
| LY75 | lymphocyte antigen 75 | 0.0077961 |
| HLA-B | major histocompatibility complex, class I, B | 0.00778756 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.00775222 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 0.00774457 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 0.00772963 |
| CP | ceruloplasmin (ferroxidase) | 0.00772516 |
| RRBP1 | ribosome binding protein 1 | 0.00767991 |
| RGS10 | regulator of G-protein signaling 10 | 0.00762613 |
| RGS1 | regulator of G-protein signaling 1 | 0.00756349 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.00747757 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.0073649 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.00735648 |
| LASP1 | LIM and SH3 protein 1 | 0.00733514 |
| AQP9 | aquaporin 9 | 0.00724027 |
| TRIM29 | tripartite motif containing 29 | 0.00721058 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.00718974 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00711516 |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.0071027 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 0.0070555 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00705157 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.00699484 |
| PWP1 | PWP1 homolog (S. cerevisiae) | 0.00699371 |
| RGCC | regulator of cell cycle | 0.00698853 |
| VNN1 | vanin 1 | 0.00698059 |
| LXN | latexin | 0.0069562 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0069463 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.00693443 |
| MAL | mal, T-cell differentiation protein | 0.00687306 |
| LIG1 | ligase I, DNA, ATP-dependent | 0.00686924 |
| IRF6 | interferon regulatory factor 6 | 0.00686566 |
| KRT19 | keratin 19, type I | 0.00686227 |
| ATF4 | activating transcription factor 4 | 0.00686159 |
| GAL | galanin/GMAP prepropeptide | 0.00685877 |
| BATF3 | basic leucine zipper transcription factor, ATF-like 3 | 0.00685489 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00681152 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.00680482 |
| MCAM | melanoma cell adhesion molecule | 0.00676875 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00672767 |
| AEBP1 | AE binding protein 1 | 0.00672139 |
| XPO7 | exportin 7 | 0.00671073 |
| KRT13 | keratin 13, type I | 0.00670069 |
| CCNB2 | cyclin B2 | 0.00669364 |
| COL3A1 | collagen, type III, alpha 1 | 0.00664539 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 0.00664079 |
| PERP | PERP, TP53 apoptosis effector | 0.00661901 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.00661495 |
| OAT | ornithine aminotransferase | 0.00656215 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00655468 |
| MUC16 | mucin 16, cell surface associated | 0.00652041 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00651932 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00648836 |
| PRR5 | proline rich 5 (renal) | 0.0064727 |
| BGN | biglycan | 0.00646392 |
| KRT23 | keratin 23, type I | 0.00646287 |
| HLA-C | major histocompatibility complex, class I, C | 0.00643684 |
| LCN2 | lipocalin 2 | 0.00643195 |
| CLCA1 | chloride channel accessory 1 | 0.00642576 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00640861 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00640118 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00636541 |
| FERMT1 | fermitin family member 1 | 0.00634378 |
| MT1X | metallothionein 1X | 0.00621649 |
| MT1F | metallothionein 1F | 0.00620244 |
| FOXG1 | forkhead box G1 | 0.00620083 |
| KIAA0226L | KIAA0226-like | 0.00618432 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.00611784 |
| ITM2C | integral membrane protein 2C | 0.00608598 |
| UNG | uracil-DNA glycosylase | 0.00607937 |
| KRT6A | keratin 6A, type II | 0.006078 |
| MME | membrane metallo-endopeptidase | 0.00607578 |
| MT1G | metallothionein 1G | 0.00607528 |
| PYGB | phosphorylase, glycogen; brain | 0.00607048 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.00606586 |
| NES | nestin | 0.00605706 |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | 0.00603566 |
| IER3 | immediate early response 3 | 0.00602922 |
| MREG | melanoregulin | 0.00599325 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | 0.0059901 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00598763 |
| HES1 | hes family bHLH transcription factor 1 | 0.00598232 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00596995 |
| KAT7 | K(lysine) acetyltransferase 7 | 0.0059637 |
| HAMP | hepcidin antimicrobial peptide | 0.00595368 |
| APOC2 | apolipoprotein C-II | 0.00594645 |
| CYB561 | cytochrome b561 | 0.00593409 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0059295 |
| TXNIP | thioredoxin interacting protein | 0.00592781 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00591824 |
| LGALS9 | lectin, galactoside-binding, soluble, 9 | 0.00591507 |
| ARPC3 | actin related protein 2/3 complex, subunit 3, 21kDa | 0.00588934 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.00588906 |
| GCAT | glycine C-acetyltransferase | 0.00588036 |
| ASRGL1 | asparaginase like 1 | 0.00586476 |
| TCTN2 | tectonic family member 2 | 0.00586205 |
| KLK11 | kallikrein-related peptidase 11 | 0.00585611 |
| HEBP2 | heme binding protein 2 | 0.0058404 |
| IL17RB | interleukin 17 receptor B | 0.00583369 |
| BSPRY | B-box and SPRY domain containing | 0.00583281 |
| OCRL | oculocerebrorenal syndrome of Lowe | 0.00581424 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.00581178 |
| MIA | melanoma inhibitory activity | 0.00581168 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00580945 |
| F12 | coagulation factor XII (Hageman factor) | 0.00576943 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00575644 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.00574782 |
| CLIC3 | chloride intracellular channel 3 | 0.00574481 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | 0.00574428 |
| COL1A2 | collagen, type I, alpha 2 | 0.00573053 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | 0.00572595 |
| GPX2 | glutathione peroxidase 2 | 0.00572119 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00570546 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00569135 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0056866 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00568474 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00566758 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00566489 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.00564724 |
| CALML3 | calmodulin-like 3 | 0.00564566 |
| NSG1 | neuron specific gene family member 1 | 0.00563732 |
| TADA2A | transcriptional adaptor 2A | 0.00563471 |
| KLF6 | Kruppel-like factor 6 | 0.00562062 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 0.00560806 |
| MCM4 | minichromosome maintenance complex component 4 | 0.00560648 |
| RXYLT1 | ribitol xylosyltransferase 1 | 0.0055974 |
| CD300A | CD300a molecule | 0.00559198 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00559063 |
| WDR61 | WD repeat domain 61 | 0.00558855 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.00558712 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.00557435 |
| KAZN | kazrin, periplakin interacting protein | 0.00557237 |
| LAMB1 | laminin, beta 1 | 0.00557077 |
| GSDMB | gasdermin B | 0.00556952 |
| AHCY | adenosylhomocysteinase | 0.00556834 |
| TRIM14 | tripartite motif containing 14 | 0.00556061 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | 0.00555439 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | 0.0055483 |
| PRR7 | proline rich 7 (synaptic) | 0.00554366 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.00552612 |
| FBL | fibrillarin | 0.00551599 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | 0.00551539 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00550194 |
| TTTY15 | testis-specific transcript, Y-linked 15 (non-protein coding) | 0.00549649 |
| TASP1 | taspase, threonine aspartase, 1 | 0.00549407 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.00548642 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00546803 |
| ROPN1B | rhophilin associated tail protein 1B | 0.00546085 |
| NCALD | neurocalcin delta | 0.0054424 |
| KRT6B | keratin 6B, type II | 0.00542091 |
| GLTP | glycolipid transfer protein | 0.00541306 |
| PSAP | prosaposin | 0.00539741 |
| RAI14 | retinoic acid induced 14 | 0.00539696 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.00537687 |
| HSP90B2P | heat shock protein 90kDa beta (Grp94), member 2, pseudogene | 0.0053767 |
| JAG1 | jagged 1 | 0.00534483 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00533685 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.00533655 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.00532182 |
| ARG2 | arginase 2 | 0.00531275 |
| CD81 | CD81 molecule | 0.00531053 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00530443 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | 0.00529541 |
| GSAP | gamma-secretase activating protein | 0.00528805 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00527869 |
| ANGPT2 | angiopoietin 2 | 0.00524775 |
| PKP1 | plakophilin 1 | 0.00524646 |
| NID2 | nidogen 2 (osteonidogen) | 0.00523548 |
| NCKAP1L | NCK-associated protein 1-like | 0.00522215 |
| PGD | phosphogluconate dehydrogenase | 0.0052161 |
| GNLY | granulysin | 0.00521555 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00521332 |
| GIMAP5 | GTPase, IMAP family member 5 | 0.00519257 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.00518985 |
| OLFM4 | olfactomedin 4 | 0.00517572 |
| CTSB | cathepsin B | 0.0051701 |
| ITGA6 | integrin, alpha 6 | 0.00515481 |
| MFNG | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.00513931 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00512587 |
| TMEM230 | transmembrane protein 230 | 0.00512402 |
| FABP1 | fatty acid binding protein 1, liver | 0.00511351 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | 0.00511244 |
| GLUL | glutamate-ammonia ligase | 0.00511187 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 0.00510337 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0050881 |
| MUC4 | mucin 4, cell surface associated | 0.00507992 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.00507849 |
| PANK2 | pantothenate kinase 2 | 0.00507498 |
| ACYP1 | acylphosphatase 1, erythrocyte (common) type | 0.00507395 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.00505148 |
| SV2A | synaptic vesicle glycoprotein 2A | 0.00505063 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.00504771 |
| NMRK1 | nicotinamide riboside kinase 1 | 0.00504688 |
| CAPNS1 | calpain, small subunit 1 | 0.00503692 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 0.00503168 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00502876 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.00501901 |
| GLYAT | glycine-N-acyltransferase | 0.00501521 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | 0.00500627 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.00499715 |
| CDCA4 | cell division cycle associated 4 | 0.00499056 |
| CCND2 | cyclin D2 | 0.00497788 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | 0.00496455 |
| Symbol | Name | Standardized Value |
|---|---|---|
| XIC | X chromosome inactivation center | -0.0230189 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0143368 |
| TPBG | trophoblast glycoprotein | -0.0116347 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0116283 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0112356 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0105834 |
| SPEN | spen family transcriptional repressor | -0.0100017 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00985937 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.00981587 |
| TPSAB1 | tryptase alpha/beta 1 | -0.0096294 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.00939379 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00936213 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0093281 |
| GOLM1 | golgi membrane protein 1 | -0.00888317 |
| HOXC6 | homeobox C6 | -0.00875768 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00872383 |
| BST2 | bone marrow stromal cell antigen 2 | -0.00868633 |
| SC5D | sterol-C5-desaturase | -0.00861672 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00861075 |
| GOLGA8A | golgin A8 family, member A | -0.0085953 |
| CLGN | calmegin | -0.00855794 |
| BAG2 | BCL2-associated athanogene 2 | -0.00837806 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.008267 |
| MFSD10 | major facilitator superfamily domain containing 10 | -0.00826216 |
| NELL1 | NEL-like 1 (chicken) | -0.00826067 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -0.00819276 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00816252 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00815727 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00813426 |
| EGR3 | early growth response 3 | -0.00805178 |
| GATA6 | GATA binding protein 6 | -0.00793388 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.00791105 |
| CD9 | CD9 molecule | -0.00783125 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00781348 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00769966 |
| EREG | epiregulin | -0.0076274 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00755979 |
| TSC22D2 | TSC22 domain family, member 2 | -0.00752721 |
| SYT1 | synaptotagmin I | -0.00751775 |
| FOXD1 | forkhead box D1 | -0.00749965 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -0.00748053 |
| QKI | QKI, KH domain containing, RNA binding | -0.00743508 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00742808 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | -0.00742609 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00737207 |
| SMC1A | structural maintenance of chromosomes 1A | -0.00733864 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0073176 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00731146 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00730139 |
| NAV3 | neuron navigator 3 | -0.00727791 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00726549 |
| DST | dystonin | -0.00719856 |
| PTER | phosphotriesterase related | -0.00718168 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.00714998 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00711139 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00710653 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00708268 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | -0.0070803 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0070225 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00698122 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00697553 |
| TMED5 | transmembrane emp24 protein transport domain containing 5 | -0.00693322 |
| IRS1 | insulin receptor substrate 1 | -0.00691832 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.00688579 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00679234 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.00678584 |
| ABAT | 4-aminobutyrate aminotransferase | -0.00678066 |
| TOX3 | TOX high mobility group box family member 3 | -0.00675604 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.00674755 |
| RHOB | ras homolog family member B | -0.00671755 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | -0.00670645 |
| FRY | furry homolog (Drosophila) | -0.00669899 |
| SMAD3 | SMAD family member 3 | -0.00667266 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00665053 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00661403 |
| REEP5 | receptor accessory protein 5 | -0.00659357 |
| CST6 | cystatin E/M | -0.00657931 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.00657769 |
| TMEM106B | transmembrane protein 106B | -0.00654814 |
| STC2 | stanniocalcin 2 | -0.0065436 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.00652075 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.00651384 |
| MIR22HG | MIR22 host gene | -0.0065103 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00649799 |
| SLC35F2 | solute carrier family 35, member F2 | -0.00649331 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00649195 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.00644488 |
| PRDX2 | peroxiredoxin 2 | -0.00644192 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00636988 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.0063671 |
| ZNF281 | zinc finger protein 281 | -0.00636678 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.00635904 |
| STK39 | serine threonine kinase 39 | -0.00633982 |
| TASOR2 | transcription activation suppressor family member 2 | -0.00632636 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0062963 |
| IFI44L | interferon-induced protein 44-like | -0.00628633 |
| CEP350 | centrosomal protein 350kDa | -0.00626645 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.00626355 |
| HSPA4L | heat shock 70kDa protein 4-like | -0.00625492 |
| SCG5 | secretogranin V | -0.00625203 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | -0.00622173 |
| LOXL2 | lysyl oxidase-like 2 | -0.00620198 |
| COLEC12 | collectin sub-family member 12 | -0.00620161 |
| TSPO | translocator protein (18kDa) | -0.00619096 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00618473 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00617354 |
| ANKRD12 | ankyrin repeat domain 12 | -0.00616818 |
| VEGFC | vascular endothelial growth factor C | -0.00613477 |
| CUX1 | cut-like homeobox 1 | -0.00613044 |
| DCLK1 | doublecortin-like kinase 1 | -0.00612905 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00611519 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.0061057 |
| NIT1 | nitrilase 1 | -0.00610072 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0060796 |
| CERS2 | ceramide synthase 2 | -0.0060758 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | -0.00606492 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00605872 |
| MEIS2 | Meis homeobox 2 | -0.00605782 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.00605662 |
| ESR1 | estrogen receptor 1 | -0.00605157 |
| LONP2 | lon peptidase 2, peroxisomal | -0.00604794 |
| CTSH | cathepsin H | -0.00604489 |
| AFF1 | AF4/FMR2 family, member 1 | -0.00603458 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | -0.00601568 |
| RNF4 | ring finger protein 4 | -0.00598985 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00596637 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.00595467 |
| SPATA5L1 | spermatogenesis associated 5-like 1 | -0.00595269 |
| IRF9 | interferon regulatory factor 9 | -0.0059523 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | -0.00593698 |
| MAPK8IP3 | mitogen-activated protein kinase 8 interacting protein 3 | -0.00592927 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0059124 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00590468 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00590048 |
| RHOD | ras homolog family member D | -0.00589475 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00587804 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | -0.00586717 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.00586702 |
| FBLN1 | fibulin 1 | -0.00584721 |
| SAP30 | Sin3A-associated protein, 30kDa | -0.00583449 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00578991 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00578765 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0057818 |
| SLC25A46 | solute carrier family 25, member 46 | -0.00575864 |
| EVI2A | ecotropic viral integration site 2A | -0.00575401 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -0.00572902 |
| FZD2 | frizzled class receptor 2 | -0.00570732 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.00569923 |
| ADRB2 | adrenoceptor beta 2, surface | -0.00569719 |
| TPP1 | tripeptidyl peptidase I | -0.0056969 |
| AKAP11 | A kinase (PRKA) anchor protein 11 | -0.00568205 |
| AGR2 | anterior gradient 2 | -0.00566407 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00565188 |
| STK26 | serine/threonine protein kinase 26 | -0.0056493 |
| CDA | cytidine deaminase | -0.00564777 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.00564156 |
| FA2H | fatty acid 2-hydroxylase | -0.00562843 |
| AHR | aryl hydrocarbon receptor | -0.00562249 |
| HOXA5 | homeobox A5 | -0.00560584 |
| SACS | sacsin molecular chaperone | -0.00560121 |
| S100A4 | S100 calcium binding protein A4 | -0.00559607 |
| RGS13 | regulator of G-protein signaling 13 | -0.00559416 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | -0.00557892 |
| S100A10 | S100 calcium binding protein A10 | -0.00555865 |
| TRMT13 | tRNA methyltransferase 13 homolog (S. cerevisiae) | -0.00553981 |
| PDGFC | platelet derived growth factor C | -0.00553006 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | -0.00552643 |
| KMT5B | lysine methyltransferase 5B | -0.00551757 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00549581 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | -0.00548141 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | -0.00547514 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00547407 |
| PIGK | phosphatidylinositol glycan anchor biosynthesis, class K | -0.00546881 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00545255 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | -0.00545008 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.00544651 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00544439 |
| MYO6 | myosin VI | -0.00543826 |
| JMJD1C | jumonji domain containing 1C | -0.00542711 |
| WASF1 | WAS protein family, member 1 | -0.00542176 |
| MTMR9 | myotubularin related protein 9 | -0.00541978 |
| ELANE | elastase, neutrophil expressed | -0.00541872 |
| SETBP1 | SET binding protein 1 | -0.00541748 |
| ANXA5 | annexin A5 | -0.00541745 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.00541662 |
| TLE4 | transducin-like enhancer of split 4 | -0.00540632 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.00540616 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.00540534 |
| INTS6 | integrator complex subunit 6 | -0.0053955 |
| AREG | amphiregulin | -0.00539118 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | -0.00538277 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.00537951 |
| PILRB | paired immunoglobin-like type 2 receptor beta | -0.00536636 |
| ADIRF | adipogenesis regulatory factor | -0.0053504 |
| CD1C | CD1c molecule | -0.00533099 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.00532781 |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 | -0.00532349 |
| REC8 | REC8 meiotic recombination protein | -0.00532254 |
| NPY | neuropeptide Y | -0.00531947 |
| TAC1 | tachykinin, precursor 1 | -0.00531414 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | -0.00531006 |
| TXNL1 | thioredoxin-like 1 | -0.00529721 |
| HOMER1 | homer scaffolding protein 1 | -0.00529508 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.00529448 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | -0.00529199 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | -0.00528989 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00528712 |
| MOCOS | molybdenum cofactor sulfurase | -0.00526606 |
| AGRN | agrin | -0.00524937 |
| BMERB1 | bMERB domain containing 1 | -0.00524511 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00523625 |
| RARA | retinoic acid receptor, alpha | -0.00523606 |
| USP6NL | USP6 N-terminal like | -0.00523443 |
| EMP2 | epithelial membrane protein 2 | -0.00521208 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00520317 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.00520269 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.00520127 |
| FNBP1L | formin binding protein 1-like | -0.00519408 |
| CTSG | cathepsin G | -0.00519205 |
| KIF5B | kinesin family member 5B | -0.00518289 |
| NOTCH2NL | notch 2 N-terminal like | -0.00517994 |
| MRFAP1L1 | Morf4 family associated protein 1-like 1 | -0.00517861 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.00516012 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.00515926 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00515593 |
| YAP1 | Yes-associated protein 1 | -0.0051512 |
| PANK3 | pantothenate kinase 3 | -0.00514777 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00514396 |
| SETD5 | SET domain containing 5 | -0.00514324 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00514052 |
| EPHA3 | EPH receptor A3 | -0.00512498 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00511536 |
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | -0.00511166 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.00510708 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00507846 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00507088 |
| ANK2 | ankyrin 2, neuronal | -0.00506754 |
| RGS4 | regulator of G-protein signaling 4 | -0.0050616 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00504749 |
| KYNU | kynureninase | -0.00504585 |
| NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit | -0.00504356 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0050305 |
| IDE | insulin-degrading enzyme | -0.00501479 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.00499962 |
| LMNA | lamin A/C | -0.00499471 |
| ZNF12 | zinc finger protein 12 | -0.0049876 |
| LPXN | leupaxin | -0.00498694 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00497751 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | -0.00497652 |
