MAP2K5 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description mitogen-activated protein kinase kinase 5|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] (NCBI Entrez Gene Database, 5607)
External Link http://www.ncbi.nlm.nih.gov/gene/5607
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Genes

45 interacting proteins for MAP2K5 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ASRGL1 asparaginase like 1
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BAD BCL2-associated agonist of cell death
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CMYA5 cardiomyopathy associated 5
ENO1 enolase 1, (alpha)
ESRRA estrogen-related receptor alpha
GCH1 GTP cyclohydrolase 1
GRB2 growth factor receptor-bound protein 2
GRN granulin
GSK3B glycogen synthase kinase 3 beta
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HNF4A hepatocyte nuclear factor 4, alpha
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
LNX2 ligand of numb-protein X 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK7 mitogen-activated protein kinase 7
MAX MYC associated factor X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPD2 non-SMC condensin I complex, subunit D2
ONECUT1 one cut homeobox 1
PARD6A par-6 family cell polarity regulator alpha
PGAP1 post-GPI attachment to proteins 1
PITPNA phosphatidylinositol transfer protein, alpha
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
RIF1 replication timing regulatory factor 1
RPL28 ribosomal protein L28
SBF1 SET binding factor 1
SIRT3 sirtuin 3
SQSTM1 sequestosome 1
STAMBP STAM binding protein
TTF2 transcription termination factor, RNA polymerase II
UGDH UDP-glucose 6-dehydrogenase
UQCRH ubiquinol-cytochrome c reductase hinge protein
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta