| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase 6|This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5608) |
| External Link | https://ncbi.nlm.nih.gov/gene/5608 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the MAP2K6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HOPX | HOP homeobox | 0.0177438 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0172753 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0158273 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0143652 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.0137583 |
| FRZB | frizzled-related protein | 0.0133815 |
| GNAS | GNAS complex locus | 0.0132607 |
| MEF2C | myocyte enhancer factor 2C | 0.0126187 |
| MATN2 | matrilin 2 | 0.0123678 |
| HEATR1 | HEAT repeat containing 1 | 0.0123572 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.012346 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.0119276 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.0117026 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.011379 |
| ITM2A | integral membrane protein 2A | 0.011268 |
| TSPAN13 | tetraspanin 13 | 0.0109546 |
| CCNB1 | cyclin B1 | 0.0108472 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | 0.0104854 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.0104215 |
| C7 | complement component 7 | 0.0100927 |
| TSPAN7 | tetraspanin 7 | 0.0100295 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.00966711 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00960176 |
| DHFR | dihydrofolate reductase | 0.00943036 |
| CD99 | CD99 molecule | 0.00940719 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00923025 |
| MEN1 | multiple endocrine neoplasia I | 0.00918559 |
| F2R | coagulation factor II (thrombin) receptor | 0.00917918 |
| DES | desmin | 0.0090257 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.00901739 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.00901278 |
| FHL1 | four and a half LIM domains 1 | 0.00901165 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00894476 |
| HOXC6 | homeobox C6 | 0.00889996 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00887326 |
| NLGN4X | neuroligin 4, X-linked | 0.00884179 |
| ZW10 | zw10 kinetochore protein | 0.00883662 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.00883472 |
| KRT20 | keratin 20, type I | 0.00867381 |
| ACTC1 | actin, alpha, cardiac muscle 1 | 0.00862871 |
| PTCH1 | patched 1 | 0.00860937 |
| OLFM1 | olfactomedin 1 | 0.00855541 |
| PPP2R2B | protein phosphatase 2, regulatory subunit B, beta | 0.00850802 |
| MFAP4 | microfibrillar-associated protein 4 | 0.00836026 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.0083574 |
| MGP | matrix Gla protein | 0.00835563 |
| PEG3 | paternally expressed 3 | 0.00826805 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.00823951 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00823918 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.00821189 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.00813579 |
| GPM6A | glycoprotein M6A | 0.00810509 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.00803884 |
| FAM3C | family with sequence similarity 3, member C | 0.00801675 |
| FABP7 | fatty acid binding protein 7, brain | 0.00796674 |
| IL18 | interleukin 18 | 0.00795997 |
| DIO2 | deiodinase, iodothyronine, type II | 0.00787289 |
| TFF1 | trefoil factor 1 | 0.00779777 |
| CPE | carboxypeptidase E | 0.00779722 |
| HOMER1 | homer scaffolding protein 1 | 0.00778644 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | 0.00775905 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.00772706 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00771799 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00763065 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | 0.00761141 |
| PRELID3B | PRELI domain containing 3B | 0.00760659 |
| CLDND1 | claudin domain containing 1 | 0.00760515 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0075943 |
| CLCA1 | chloride channel accessory 1 | 0.00758674 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00758669 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00757958 |
| MYBPC1 | myosin binding protein C, slow type | 0.00755053 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.00752734 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.00749495 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00748113 |
| PDLIM3 | PDZ and LIM domain 3 | 0.00739772 |
| JAM2 | junctional adhesion molecule 2 | 0.00737902 |
| HELZ | helicase with zinc finger | 0.00736852 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.00735211 |
| SLN | sarcolipin | 0.00735203 |
| LMNB2 | lamin B2 | 0.00734201 |
| SYNM | synemin, intermediate filament protein | 0.00734019 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.00732414 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.00731069 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | 0.00729722 |
| CLIC5 | chloride intracellular channel 5 | 0.0072778 |
| GAS1 | growth arrest-specific 1 | 0.00723434 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 0.00722948 |
| KANK2 | KN motif and ankyrin repeat domains 2 | 0.0071775 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.00716844 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.00716378 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.00715279 |
| COL4A6 | collagen, type IV, alpha 6 | 0.00713569 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00712668 |
| EFNA5 | ephrin-A5 | 0.00707805 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00707551 |
| NRN1 | neuritin 1 | 0.00707542 |
| NDNF | neuron-derived neurotrophic factor | 0.00704476 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.00702993 |
| THOC7 | THO complex 7 | 0.00702406 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.00700558 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 0.00700447 |
| HSPA13 | heat shock protein 70kDa family, member 13 | 0.00696361 |
| CFD | complement factor D (adipsin) | 0.00692719 |
| TCF4 | transcription factor 4 | 0.00692538 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00691188 |
| UNG | uracil-DNA glycosylase | 0.00690498 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.00690428 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.00690184 |
| ITGA6 | integrin, alpha 6 | 0.00689269 |
| FABP1 | fatty acid binding protein 1, liver | 0.0068855 |
| RAB25 | RAB25, member RAS oncogene family | 0.0068507 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00684807 |
| MDFIC | MyoD family inhibitor domain containing | 0.00683862 |
| CLTB | clathrin, light chain B | 0.00682663 |
| TPD52 | tumor protein D52 | 0.00682425 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.00682415 |
| PCP4 | Purkinje cell protein 4 | 0.00676529 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00673065 |
| COLEC12 | collectin sub-family member 12 | 0.00672045 |
| CDC7 | cell division cycle 7 | 0.00669245 |
| PDGFD | platelet derived growth factor D | 0.00667611 |
| CHGB | chromogranin B | 0.00663434 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.00661488 |
| CCND2 | cyclin D2 | 0.0065677 |
| TSPAN12 | tetraspanin 12 | 0.00656294 |
| LAMB1 | laminin, beta 1 | 0.00654549 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.00652057 |
| NFIB | nuclear factor I/B | 0.00651559 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 0.00651356 |
| WDR61 | WD repeat domain 61 | 0.00651254 |
| ACTB | actin, beta | 0.00650064 |
| TNNC1 | troponin C type 1 (slow) | 0.00649981 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00649968 |
| SDHD | succinate dehydrogenase complex, subunit D, integral membrane protein | 0.00649412 |
| CKM | creatine kinase, muscle | 0.00648028 |
| TRIP13 | thyroid hormone receptor interactor 13 | 0.00647295 |
| SLC38A1 | solute carrier family 38, member 1 | 0.00645263 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00644984 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00643179 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00642759 |
| THBS4 | thrombospondin 4 | 0.00642366 |
| REEP1 | receptor accessory protein 1 | 0.00642129 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.00642087 |
| DMBT1 | deleted in malignant brain tumors 1 | 0.00642023 |
| PTN | pleiotrophin | 0.00641975 |
| MYOT | myotilin | 0.00639974 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.00638596 |
| STON1 | stonin 1 | 0.0063834 |
| DMD | dystrophin | 0.00637619 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.00635254 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00634619 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | 0.00632916 |
| RUFY3 | RUN and FYVE domain containing 3 | 0.00632129 |
| CCDC47 | coiled-coil domain containing 47 | 0.00631837 |
| SASH1 | SAM and SH3 domain containing 1 | 0.00631715 |
| SMTN | smoothelin | 0.00630875 |
| PRKD3 | protein kinase D3 | 0.0062722 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00626112 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00625997 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.00619867 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.00619485 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | 0.00619396 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 0.00619085 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.00616401 |
| FCGBP | Fc fragment of IgG binding protein | 0.00616057 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00615482 |
| TMEM255A | transmembrane protein 255A | 0.00614671 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 0.00614665 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 0.00613814 |
| MTMR11 | myotubularin related protein 11 | 0.00613587 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00612369 |
| RADX | RPA1 related single stranded DNA binding protein, X-linked | 0.00611277 |
| TCEAL2 | transcription elongation factor A (SII)-like 2 | 0.00609869 |
| ZNF177 | zinc finger protein 177 | 0.00609307 |
| CD200 | CD200 molecule | 0.00609217 |
| ATP10B | ATPase, class V, type 10B | 0.00609211 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 0.00607958 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00607634 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.00606077 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.00604068 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00603797 |
| NPR3 | natriuretic peptide receptor 3 | 0.00598274 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00595974 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.00595216 |
| CNR1 | cannabinoid receptor 1 (brain) | 0.00594322 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00593934 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.00593888 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.00593537 |
| GTF2H2B | general transcription factor IIH, polypeptide 2B (pseudogene) | 0.00592825 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.00589009 |
| MELK | maternal embryonic leucine zipper kinase | 0.00588357 |
| FNBP1 | formin binding protein 1 | 0.00587099 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | 0.00586649 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00583168 |
| CHRDL1 | chordin-like 1 | 0.00581742 |
| PLSCR4 | phospholipid scramblase 4 | 0.00579163 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00575996 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00574487 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.00574369 |
| GLTP | glycolipid transfer protein | 0.00574314 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.0057393 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.00573712 |
| MAGT1 | magnesium transporter 1 | 0.00573273 |
| CYRIA | CYFIP related Rac1 interactor A | 0.00573087 |
| ADORA2B | adenosine A2b receptor | 0.00572161 |
| TCAF1 | TRPM8 channel-associated factor 1 | 0.00571566 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.00571447 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.00570497 |
| PITX1 | paired-like homeodomain 1 | 0.0057039 |
| TLE2 | transducin-like enhancer of split 2 | 0.0056938 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.00568291 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.00568234 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | 0.00566482 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0056591 |
| NCK1 | NCK adaptor protein 1 | 0.00565581 |
| MOXD1 | monooxygenase, DBH-like 1 | 0.00565288 |
| PDE10A | phosphodiesterase 10A | 0.0056388 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0056372 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.00563256 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00562542 |
| MACROH2A1 | macroH2A.1 histone | 0.00561659 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00558906 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.00558021 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00557346 |
| SLC35A5 | solute carrier family 35, member A5 | 0.0055663 |
| C1R | complement component 1, r subcomponent | 0.00556157 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.00556052 |
| ACAT1 | acetyl-CoA acetyltransferase 1 | 0.00554751 |
| RGS17 | regulator of G-protein signaling 17 | 0.00554467 |
| NKX2-2 | NK2 homeobox 2 | 0.00553726 |
| SCNN1B | sodium channel, non voltage gated 1 beta subunit | 0.00553354 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00552948 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00552665 |
| TPM4 | tropomyosin 4 | 0.0055244 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.00552301 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.00552175 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00551928 |
| EPHB3 | EPH receptor B3 | 0.00551754 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.00551346 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.00550314 |
| NELL2 | NEL-like 2 (chicken) | 0.00548314 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | 0.00546724 |
| CANT1 | calcium activated nucleotidase 1 | 0.00546473 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00546152 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00545144 |
| WASF1 | WAS protein family, member 1 | 0.00544615 |
| PLN | phospholamban | 0.00544142 |
| TRIM14 | tripartite motif containing 14 | 0.00541755 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | 0.00541645 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LTF | lactotransferrin | -0.0251972 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0239566 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.0155307 |
| CFB | complement factor B | -0.0142877 |
| S100A8 | S100 calcium binding protein A8 | -0.0142271 |
| S100A9 | S100 calcium binding protein A9 | -0.0139706 |
| S100A12 | S100 calcium binding protein A12 | -0.0137038 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.0132649 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0128794 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.012486 |
| LCN2 | lipocalin 2 | -0.0124693 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.0123211 |
| G0S2 | G0/G1 switch 2 | -0.0120338 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.0119053 |
| RGCC | regulator of cell cycle | -0.0118489 |
| SH3BP4 | SH3-domain binding protein 4 | -0.0117897 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.0117109 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0117027 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.0114801 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.0113706 |
| INHBA | inhibin, beta A | -0.0112635 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0107657 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0104648 |
| CSTA | cystatin A (stefin A) | -0.0102604 |
| MAGEA3 | melanoma antigen family A3 | -0.010167 |
| AQP9 | aquaporin 9 | -0.0101584 |
| IL1R1 | interleukin 1 receptor, type I | -0.0100773 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -0.0100458 |
| ATF3 | activating transcription factor 3 | -0.0100047 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00995382 |
| TRIB2 | tribbles pseudokinase 2 | -0.00980539 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00975874 |
| APOC1 | apolipoprotein C-I | -0.00968881 |
| MLPH | melanophilin | -0.00967604 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.00960506 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00942386 |
| VGLL4 | vestigial-like family member 4 | -0.0091754 |
| RIN2 | Ras and Rab interactor 2 | -0.00911744 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.00905294 |
| MSMB | microseminoprotein, beta- | -0.00902285 |
| RHOBTB1 | Rho-related BTB domain containing 1 | -0.00893798 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00886654 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00886485 |
| ZIC1 | Zic family member 1 | -0.00881667 |
| COG2 | component of oligomeric golgi complex 2 | -0.00879481 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.00868255 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00867163 |
| MNDA | myeloid cell nuclear differentiation antigen | -0.00863909 |
| IER5 | immediate early response 5 | -0.00859545 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00859381 |
| SHTN1 | shootin 1 | -0.00853129 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00847288 |
| AK1 | adenylate kinase 1 | -0.0084428 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.00841436 |
| LY96 | lymphocyte antigen 96 | -0.00840239 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00833973 |
| PDLIM4 | PDZ and LIM domain 4 | -0.00831309 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00829728 |
| GLUL | glutamate-ammonia ligase | -0.00827032 |
| UROD | uroporphyrinogen decarboxylase | -0.00824504 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.00820448 |
| BCL2A1 | BCL2-related protein A1 | -0.00818915 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00816578 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00815569 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.00815192 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.00813827 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | -0.00813543 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.00813356 |
| RHOB | ras homolog family member B | -0.00812786 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.00812534 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00812167 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.00806591 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.00803924 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.00801401 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00797236 |
| GPI | glucose-6-phosphate isomerase | -0.00790794 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.007888 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.00787545 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00786618 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00779239 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00775523 |
| PRAME | preferentially expressed antigen in melanoma | -0.00770794 |
| IL1RN | interleukin 1 receptor antagonist | -0.00769028 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.00768365 |
| C5AR1 | complement component 5a receptor 1 | -0.00767881 |
| TFRC | transferrin receptor | -0.00765723 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.00763043 |
| CAPN3 | calpain 3, (p94) | -0.00761436 |
| RUNX3 | runt-related transcription factor 3 | -0.00761224 |
| GMPR | guanosine monophosphate reductase | -0.00759131 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.00758751 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00757237 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.0075332 |
| PPIF | peptidylprolyl isomerase F | -0.0075123 |
| KLHL24 | kelch-like family member 24 | -0.0074887 |
| RRAGD | Ras-related GTP binding D | -0.00748641 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00748234 |
| HIST1H2BD | histone cluster 1, H2bd | -0.0074617 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | -0.00744764 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00743169 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.00742686 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | -0.00741002 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.00738554 |
| BID | BH3 interacting domain death agonist | -0.00735876 |
| AGTR1 | angiotensin II receptor, type 1 | -0.00734968 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00732341 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | -0.0072958 |
| PIR | pirin (iron-binding nuclear protein) | -0.00728682 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | -0.00726706 |
| SORT1 | sortilin 1 | -0.00725099 |
| FOSL2 | FOS-like antigen 2 | -0.0072489 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00724299 |
| NAXD | NAD(P)HX dehydratase | -0.00723479 |
| TYMP | thymidine phosphorylase | -0.00722971 |
| SAMM50 | SAMM50 sorting and assembly machinery component | -0.00720944 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00718255 |
| GJB1 | gap junction protein, beta 1, 32kDa | -0.0071824 |
| ORM1 | orosomucoid 1 | -0.00717848 |
| NTS | neurotensin | -0.00716176 |
| SCO2 | SCO2 cytochrome c oxidase assembly protein | -0.00715648 |
| GPR137B | G protein-coupled receptor 137B | -0.00714606 |
| NADSYN1 | NAD synthetase 1 | -0.00713885 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00713552 |
| CYB5R1 | cytochrome b5 reductase 1 | -0.00713362 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00712718 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00712636 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -0.00712556 |
| TSPYL5 | TSPY-like 5 | -0.00711927 |
| ARG1 | arginase 1 | -0.00710797 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00708937 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00703155 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0069956 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00692115 |
| NCF1C | neutrophil cytosolic factor 1C pseudogene | -0.00691764 |
| FPR1 | formyl peptide receptor 1 | -0.00691401 |
| STC2 | stanniocalcin 2 | -0.00691237 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00686561 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.00684654 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00683061 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.00682682 |
| TPST2 | tyrosylprotein sulfotransferase 2 | -0.00680958 |
| GPX1 | glutathione peroxidase 1 | -0.00680183 |
| BUD31 | BUD31 homolog (S. cerevisiae) | -0.00677681 |
| PSMB5 | proteasome (prosome, macropain) subunit, beta type, 5 | -0.00677441 |
| QDPR | quinoid dihydropteridine reductase | -0.00675331 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00674838 |
| HGD | homogentisate 1,2-dioxygenase | -0.00674701 |
| MLF1 | myeloid leukemia factor 1 | -0.00674288 |
| ODC1 | ornithine decarboxylase 1 | -0.00673531 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00668844 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | -0.0066873 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00668389 |
| ASRGL1 | asparaginase like 1 | -0.0066476 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00663565 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00663456 |
| PON2 | paraoxonase 2 | -0.00662984 |
| DCT | dopachrome tautomerase | -0.00662234 |
| TNFRSF14 | tumor necrosis factor receptor superfamily, member 14 | -0.00661937 |
| S100A11 | S100 calcium binding protein A11 | -0.00660194 |
| MYLIP | myosin regulatory light chain interacting protein | -0.00657228 |
| MCM2 | minichromosome maintenance complex component 2 | -0.00656811 |
| CST7 | cystatin F (leukocystatin) | -0.00656717 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00656517 |
| DNAAF1 | dynein, axonemal, assembly factor 1 | -0.00654017 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00653931 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.00653328 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00652003 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00652002 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | -0.00651819 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00648694 |
| HHAT | hedgehog acyltransferase | -0.00647198 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00645722 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00644423 |
| MVP | major vault protein | -0.00641149 |
| TRIM8 | tripartite motif containing 8 | -0.00640735 |
| TRIP6 | thyroid hormone receptor interactor 6 | -0.00638842 |
| GLRX | glutaredoxin (thioltransferase) | -0.0063818 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.00636111 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00634254 |
| ZNF331 | zinc finger protein 331 | -0.00630698 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.00628793 |
| MYO1B | myosin IB | -0.006287 |
| RGS1 | regulator of G-protein signaling 1 | -0.00628409 |
| PLA1A | phospholipase A1 member A | -0.00627668 |
| UFD1 | ubiquitin recognition factor in ER associated degradation 1 | -0.00627523 |
| GPX4 | glutathione peroxidase 4 | -0.00626996 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00626795 |
| TRIM13 | tripartite motif containing 13 | -0.00626321 |
| ZNF394 | zinc finger protein 394 | -0.00625849 |
| HP | haptoglobin | -0.00625674 |
| IQCG | IQ motif containing G | -0.00624561 |
| PGD | phosphogluconate dehydrogenase | -0.00623959 |
| POR | P450 (cytochrome) oxidoreductase | -0.00621915 |
| NUP58 | nucleoporin 58 | -0.00620368 |
| ANXA3 | annexin A3 | -0.00620236 |
| GAS6 | growth arrest-specific 6 | -0.00619299 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | -0.00618318 |
| PLK2 | polo-like kinase 2 | -0.00618171 |
| XCL1 | chemokine (C motif) ligand 1 | -0.00617724 |
| BAAT | bile acid CoA:amino acid N-acyltransferase | -0.00616678 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00616295 |
| PYCARD | PYD and CARD domain containing | -0.00615903 |
| MMP10 | matrix metallopeptidase 10 | -0.00614197 |
| CHMP4A | charged multivesicular body protein 4A | -0.00613749 |
| CFAP45 | cilia and flagella associated protein 45 | -0.00613184 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.00612585 |
| DIPK1A | divergent protein kinase domain 1A | -0.00611113 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | -0.00609846 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.00608981 |
| CES1 | carboxylesterase 1 | -0.00608707 |
| TBC1D4 | TBC1 domain family, member 4 | -0.00608197 |
| H1-0 | H1.0 linker histone | -0.00607959 |
| AAMDC | adipogenesis associated, Mth938 domain containing | -0.0060763 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | -0.00606437 |
| ZNF423 | zinc finger protein 423 | -0.00605836 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | -0.00604302 |
| TSPAN14 | tetraspanin 14 | -0.0060382 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.00603192 |
| PMEL | premelanosome protein | -0.0060184 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.00601606 |
| ATG101 | autophagy related 101 | -0.00599669 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00599282 |
| GSR | glutathione reductase | -0.00597701 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00597372 |
| MEF2A | myocyte enhancer factor 2A | -0.00597246 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -0.00596143 |
| GALC | galactosylceramidase | -0.00595965 |
| TADA2A | transcriptional adaptor 2A | -0.005954 |
| SLC25A46 | solute carrier family 25, member 46 | -0.00594834 |
| USP3 | ubiquitin specific peptidase 3 | -0.005938 |
| NRIP3 | nuclear receptor interacting protein 3 | -0.00592664 |
| FOXJ1 | forkhead box J1 | -0.00590758 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -0.0059058 |
| OGFRL1 | opioid growth factor receptor-like 1 | -0.00588343 |
| LGMN | legumain | -0.00588305 |
| MGMT | O-6-methylguanine-DNA methyltransferase | -0.00588195 |
| TFIP11 | tuftelin interacting protein 11 | -0.00588161 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00587565 |
| PPP1R7 | protein phosphatase 1, regulatory subunit 7 | -0.00585914 |
| PLAUR | plasminogen activator, urokinase receptor | -0.00584129 |
| SMYD2 | SET and MYND domain containing 2 | -0.00583384 |
| KAZN | kazrin, periplakin interacting protein | -0.00582738 |
| STYXL1 | serine/threonine/tyrosine interacting-like 1 | -0.00580972 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | -0.00579767 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00579194 |
| VAMP3 | vesicle-associated membrane protein 3 | -0.00578414 |
| CPM | carboxypeptidase M | -0.00578365 |
| LRRC47 | leucine rich repeat containing 47 | -0.00578347 |
| MSRB1 | methionine sulfoxide reductase B1 | -0.00578024 |
