MAP3K1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase|The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 4214)
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Genes

315 genes differentially expressed following the MAP3K1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRDM1 PR domain containing 1, with ZNF domain 3.04707
DPEP2 dipeptidase 2 3.04707
PNMA5 paraneoplastic Ma antigen family member 5 3.04707
TM4SF20 transmembrane 4 L six family member 20 3.04707
TBX15 T-box 15 3.04707
SIRPB1 signal-regulatory protein beta 1 3.04707
CSTL1 cystatin-like 1 3.04707
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.04707
LRG1 leucine-rich alpha-2-glycoprotein 1 3.04707
HES5 hes family bHLH transcription factor 5 3.04707
TEX13B testis expressed 13B 3.04707
CFHR1 complement factor H-related 1 3.04707
IL11RA interleukin 11 receptor, alpha 3.04707
LRRD1 leucine-rich repeats and death domain containing 1 3.04707
ASB15 ankyrin repeat and SOCS box containing 15 3.04707
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.04707
ACTG2 actin, gamma 2, smooth muscle, enteric 3.04707
CELF6 CUGBP, Elav-like family member 6 3.04707
BTK Bruton agammaglobulinemia tyrosine kinase 3.04707
RSPO1 R-spondin 1 3.04707
CIITA class II, major histocompatibility complex, transactivator 3.04707
MMP20 matrix metallopeptidase 20 3.04707
ATOH1 atonal homolog 1 (Drosophila) 3.04707
ATOH7 atonal homolog 7 (Drosophila) 3.04707
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.04707
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.04707
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.04707
RTP2 receptor (chemosensory) transporter protein 2 3.04707
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.04707
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.04707
TREML1 triggering receptor expressed on myeloid cells-like 1 3.04707
UFC1 ubiquitin-fold modifier conjugating enzyme 1 3.04707
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 3.04707
CXCL2 chemokine (C-X-C motif) ligand 2 3.04707
ADAMTSL5 ADAMTS-like 5 3.04707
GSG1 germ cell associated 1 3.04707
TDRD9 tudor domain containing 9 3.04707
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.04707
TNS4 tensin 4 3.04707
SRSF7 serine/arginine-rich splicing factor 7 3.04707
SYCP2 synaptonemal complex protein 2 3.04707
GRXCR1 glutaredoxin, cysteine rich 1 3.04707
ROPN1B rhophilin associated tail protein 1B 3.04707
PROP1 PROP paired-like homeobox 1 3.04707
TAS2R60 taste receptor, type 2, member 60 3.04707
VN1R1 vomeronasal 1 receptor 1 3.04707
ACER1 alkaline ceramidase 1 3.04707
FRG2C FSHD region gene 2 family, member C 3.04707
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.04707
ZNF705A zinc finger protein 705A 3.04707
KY kyphoscoliosis peptidase 3.04707
OTOF otoferlin 3.04707
LINC02268 long intergenic non-protein coding RNA 2268 3.04707
CLEC20A C-type lectin domain containing 20A 3.04707
CPHXL cytoplasmic polyadenylated homeobox like 3.04707
MEIOSIN meiosis initiator 3.04707
SPATA46 spermatogenesis associated 46 3.04707
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.04707
H1-6 H1.6 linker histone, cluster member 3.04707
ARX aristaless related homeobox 3.04707
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.04707
LTF lactotransferrin 3.04707
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.04707
C4ORF17 chromosome 4 open reading frame 17 3.04707
CIMIP1 ciliary microtubule inner protein 1 3.04707
C5ORF52 chromosome 5 open reading frame 52 3.04707
PCDHB10 protocadherin beta 10 3.04707
RAB41 RAB41, member RAS oncogene family 3.04707
IZUMO4 IZUMO family member 4 3.04707
DNAI2 dynein, axonemal, intermediate chain 2 3.04707
ULBP1 UL16 binding protein 1 3.04707
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.04707
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.04707
TACR2 tachykinin receptor 2 3.04707
S100G S100 calcium binding protein G 3.04707
PRR4 proline rich 4 (lacrimal) 3.04707
TLR6 toll-like receptor 6 3.04707
OVOL3 ovo-like zinc finger 3 3.04707
IL6 interleukin 6 3.04707
NPNT nephronectin 3.04707
SPEGNB SPEG neighbor 3.04707
PHOX2A paired-like homeobox 2a 3.04707
FAM209B family with sequence similarity 209, member B 3.04707
WNT7A wingless-type MMTV integration site family, member 7A 3.04707
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.04707
EMILIN3 elastin microfibril interfacer 3 3.04707
KLK11 kallikrein-related peptidase 11 3.04707
PRR35 proline rich 35 3.04707
OCM oncomodulin 3.04707
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.04707
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 3.04707
GLOD5 glyoxalase domain containing 5 3.04707
KCNK2 potassium channel, two pore domain subfamily K, member 2 3.04707
KRTAP5-11 keratin associated protein 5-11 3.04707
RSAD2 radical S-adenosyl methionine domain containing 2 3.04707
ARHGAP20 Rho GTPase activating protein 20 3.04707
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.04707
EDN2 endothelin 2 3.04707
POF1B premature ovarian failure, 1B 3.04707
EFCAB9 EF-hand calcium binding domain 9 3.04707
TPPP2 tubulin polymerization-promoting protein family member 2 3.04707
DMRT1 doublesex and mab-3 related transcription factor 1 3.04707
PCDHAC2 protocadherin alpha subfamily C, 2 3.04707
FKBP1C FK506 binding protein 1C 3.04707
DRC7 dynein regulatory complex subunit 7 3.04707
GJC2 gap junction protein, gamma 2, 47kDa 3.04707
GOLGA8N golgin A8 family, member N 3.04707
GOLGA8O golgin A8 family, member O 3.04707
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.04707
SIDT1 SID1 transmembrane family, member 1 3.04707
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 3.04707
OPTC opticin 3.04707
SIGLEC11 sialic acid binding Ig-like lectin 11 3.04707
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.04707
PGR progesterone receptor 3.04707
MYLK2 myosin light chain kinase 2 3.04707
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.04707
KLHL10 kelch-like family member 10 3.04707
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.04707
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.04707
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.04707
CABP5 calcium binding protein 5 3.04707
STAB1 stabilin 1 3.04707
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.04707
TSSK1B testis-specific serine kinase 1B 3.04707
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.04707
CLCF1 cardiotrophin-like cytokine factor 1 3.04707
NPR3 natriuretic peptide receptor 3 3.04707
KIF12 kinesin family member 12 3.04707
MEIG1 meiosis/spermiogenesis associated 1 3.04707
CIB4 calcium and integrin binding family member 4 3.04707
ZNF648 zinc finger protein 648 3.04707
VTCN1 V-set domain containing T cell activation inhibitor 1 3.04707
AOC1 amine oxidase, copper containing 1 3.04707
PMP2 peripheral myelin protein 2 3.04707
PF4V1 platelet factor 4 variant 1 3.04707
LRRC38 leucine rich repeat containing 38 3.04707
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.04707
PPY pancreatic polypeptide 3.04707
DAND5 DAN domain family member 5, BMP antagonist 3.04707
ITPKA inositol-trisphosphate 3-kinase A 3.04707
IL18R1 interleukin 18 receptor 1 3.04707
APOL1 apolipoprotein L, 1 3.04707
GSDMD gasdermin D 2.97734
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 2.95709
CDHR4 cadherin-related family member 4 2.943
NOS3 nitric oxide synthase 3 (endothelial cell) 2.943
IDI2 isopentenyl-diphosphate delta isomerase 2 2.943
VSTM2B V-set and transmembrane domain containing 2B 2.943
ERRFI1 ERBB receptor feedback inhibitor 1 2.92825
RAB30 RAB30, member RAS oncogene family 2.8777
RTCA RNA 3'-terminal phosphate cyclase 2.84693
BTN2A1 butyrophilin, subfamily 2, member A1 2.81367
CBFB core-binding factor, beta subunit 2.76009
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 2.74784
TRIM59 tripartite motif containing 59 2.73482
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.71259
ANKRD18A ankyrin repeat domain 18A 2.61623
AHCYL1 adenosylhomocysteinase-like 1 2.61558
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.53424
SLC25A42 solute carrier family 25, member 42 2.49492
TAGLN2 transgelin 2 2.48287
TEX11 testis expressed 11 2.42377
PLK5 polo-like kinase 5 2.42377
METTL26 methyltransferase like 26 2.37654
CLEC4D C-type lectin domain family 4, member D 2.3503
SHOX short stature homeobox 2.34532
MINAR2 membrane integral NOTCH2 associated receptor 2 2.34532
TAL2 T-cell acute lymphocytic leukemia 2 2.34532
EPHX2 epoxide hydrolase 2, cytoplasmic 2.34532
ANKRD18B ankyrin repeat domain 18B 2.34532
LCN12 lipocalin 12 2.34532
SLC35A4 solute carrier family 35, member A4 2.30448
DACH1 dachshund family transcription factor 1 2.30448
TBC1D7-LOC100130357 TBC1D7-LOC100130357 readthrough 2.26312
RASL10A RAS-like, family 10, member A 2.25042
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.23665
COL4A4 collagen, type IV, alpha 4 2.23609
NINJ2 ninjurin 2 2.18907
KMT2C lysine (K)-specific methyltransferase 2C 2.17186
ACTL6B actin-like 6B 2.16807
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 2.14862
C1ORF87 chromosome 1 open reading frame 87 2.13741
CFAP46 cilia and flagella associated protein 46 2.13204
SYT13 synaptotagmin XIII 2.13204
C1ORF198 chromosome 1 open reading frame 198 2.12983
RRBP1 ribosome binding protein 1 2.12651
MT1H metallothionein 1H 2.10582
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 2.09201
SRRT serrate, RNA effector molecule 2.09201
EXTL3 exostosin-like glycosyltransferase 3 2.08204
SSR1 signal sequence receptor, alpha 2.0666
ZBED4 zinc finger, BED-type containing 4 2.0666
AGER advanced glycosylation end product-specific receptor 2.0666
PCLO piccolo presynaptic cytomatrix protein 2.04299
SRSF5 serine/arginine-rich splicing factor 5 2.03648
UBXN8 UBX domain protein 8 2.00971
LRP2 low density lipoprotein receptor-related protein 2 2.00971
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.00971
NET1 neuroepithelial cell transforming 1 2.00505

decreased expression

Symbol Name Standardized Value
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -3.04707
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -3.04707
THEM6 thioesterase superfamily member 6 -3.04707
ANKRD7 ankyrin repeat domain 7 -3.04707
CAPN14 calpain 14 -3.04707
KLHL31 kelch-like family member 31 -3.04707
NUTM2G NUT family member 2G -3.04707
DUSP7 dual specificity phosphatase 7 -3.04707
FAM178B family with sequence similarity 178, member B -3.04707
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -3.04707
S1PR1 sphingosine-1-phosphate receptor 1 -3.04707
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -3.04707
SAE1 SUMO1 activating enzyme subunit 1 -3.04707
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -3.04707
CRYGB crystallin, gamma B -3.04707
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -3.04707
KDM6B lysine (K)-specific demethylase 6B -3.04707
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -3.04707
DHRS2 dehydrogenase/reductase (SDR family) member 2 -3.04707
CORT cortistatin -3.04707
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.04707
VEZT vezatin, adherens junctions transmembrane protein -3.04707
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -3.04707
RBM44 RNA binding motif protein 44 -3.04707
VCX3A variable charge, X-linked 3A -3.04707
SPMIP8 sperm microtubule inner protein 8 -3.04707
DRD2 dopamine receptor D2 -3.04707
USP2 ubiquitin specific peptidase 2 -3.04707
SH2D4B SH2 domain containing 4B -3.04707
RELN reelin -3.04707
AMH anti-Mullerian hormone -3.04707
LCN15 lipocalin 15 -3.04707
CCDC9B coiled-coil domain containing 9B -3.04707
PLAAT4 phospholipase A and acyltransferase 4 -3.04707
CSDC2 cold shock domain containing C2, RNA binding -3.04707
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -3.04707
MPIG6B megakaryocyte and platelet inhibitory receptor G6b -3.04707
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -3.04707
HAL histidine ammonia-lyase -3.04707
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -3.04707
PIH1D2 PIH1 domain containing 2 -3.04707
BLNK B-cell linker -3.04707
POU2F3 POU class 2 homeobox 3 -3.04707
F11 coagulation factor XI -3.04707
MAP3K19 mitogen-activated protein kinase kinase kinase 19 -3.04707
FIMP1 fertilization-influencing membrane protein 1 -3.04707
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -3.04707
NEK7 NIMA-related kinase 7 -2.95655
PLD6 phospholipase D family, member 6 -2.94031
NXPH2 neurexophilin 2 -2.90093
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.83944
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.76937
CENPS centromere protein S -2.76034
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.69497
LARP4 La ribonucleoprotein domain family, member 4 -2.6707
RNF4 ring finger protein 4 -2.60608
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -2.60518
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -2.59697
KCTD19 potassium channel tetramerization domain containing 19 -2.59697
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.59697
SCGB2B2 secretoglobin, family 2B, member 2 -2.57266
SLC22A17 solute carrier family 22, member 17 -2.55475
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -2.55337
ZNF710 zinc finger protein 710 -2.54556
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -2.54335
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.50732
BCAS1 breast carcinoma amplified sequence 1 -2.50732
DNM3 dynamin 3 -2.4313
MTAP methylthioadenosine phosphorylase -2.42377
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -2.42342
PLBD2 phospholipase B domain containing 2 -2.41742
TMEM50A transmembrane protein 50A -2.39906
GCLC glutamate-cysteine ligase, catalytic subunit -2.39906
SLC39A11 solute carrier family 39, member 11 -2.37467
PDCD11 programmed cell death 11 -2.34622
LIN7B lin-7 homolog B (C. elegans) -2.3304
PLPP1 phospholipid phosphatase 1 -2.32139
RAB22A RAB22A, member RAS oncogene family -2.31298
SIN3B SIN3 transcription regulator family member B -2.30393
ADCK1 aarF domain containing kinase 1 -2.24683
ALS2 amyotrophic lateral sclerosis 2 (juvenile) -2.23689
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.23585
KIF21A kinesin family member 21A -2.22428
UQCC4 ubiquinol-cytochrome c reductase complex assembly factor 4 -2.22205
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.22001
IGFBP5 insulin-like growth factor binding protein 5 -2.21562
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.21562
TOR4A torsin family 4, member A -2.19643
HDAC8 histone deacetylase 8 -2.19609
BEND5 BEN domain containing 5 -2.17461
DYNLT1 dynein, light chain, Tctex-type 1 -2.17186
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.16636
CHP2 calcineurin-like EF-hand protein 2 -2.16636
TRIM11 tripartite motif containing 11 -2.15744
HACD4 3-hydroxyacyl-CoA dehydratase 4 -2.12569
POLM polymerase (DNA directed), mu -2.09201
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) -2.08446
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.07339
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -2.07339
GLIPR2 GLI pathogenesis-related 2 -2.06972
CHD4 chromodomain helicase DNA binding protein 4 -2.0666
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.0608
ARHGAP25 Rho GTPase activating protein 25 -2.05457
CHLSN cholesin -2.04974
RAB7A RAB7A, member RAS oncogene family -2.04666
HSPA13 heat shock protein 70kDa family, member 13 -2.03648
UNC5CL unc-5 homolog C (C. elegans)-like -2.03648
PRAM1 PML-RARA regulated adaptor molecule 1 -2.03648
APOM apolipoprotein M -2.03648
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 -2.03648
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -2.03034
ZNF814 zinc finger protein 814 -2.03034
DCAF10 DDB1 and CUL4 associated factor 10 -2.01245
MYBPC2 myosin binding protein C, fast type -2.00971
EIF4H eukaryotic translation initiation factor 4H -2.00854