MAP3K12 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase kinase kinase 12|This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 7786)
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Genes

273 genes differentially expressed following the MAP3K12 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.62414
OR51D1 olfactory receptor, family 51, subfamily D, member 1 2.62414
ALPK2 alpha-kinase 2 2.62414
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.62414
RSPO3 R-spondin 3 2.62414
PAX2 paired box 2 2.62414
FOXR1 forkhead box R1 2.62414
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.62414
LRRC53 leucine rich repeat containing 53 2.62414
HORMAD2 HORMA domain containing 2 2.62414
GPR151 G protein-coupled receptor 151 2.62414
TM4SF5 transmembrane 4 L six family member 5 2.62414
MILR1 mast cell immunoglobulin-like receptor 1 2.62414
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.62414
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.62414
SLC46A3 solute carrier family 46, member 3 2.62414
PI16 peptidase inhibitor 16 2.62414
RXFP2 relaxin/insulin-like family peptide receptor 2 2.62414
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.62414
ADAMTSL5 ADAMTS-like 5 2.62414
NLRP5 NLR family, pyrin domain containing 5 2.62414
NEUROD2 neuronal differentiation 2 2.62414
IRX5 iroquois homeobox 5 2.62414
NPC1L1 NPC1-like 1 2.62414
METTL21C methyltransferase like 21C 2.62414
FGF7 fibroblast growth factor 7 2.62414
THEMIS thymocyte selection associated 2.62414
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.62414
MPO myeloperoxidase 2.62414
CRYGC crystallin, gamma C 2.62414
HBZ hemoglobin, zeta 2.62414
NPIPA3 nuclear pore complex interacting protein family, member A3 2.62414
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.62414
TRIM42 tripartite motif containing 42 2.62414
SPP2 secreted phosphoprotein 2, 24kDa 2.62414
ZPBP2 zona pellucida binding protein 2 2.62414
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.62414
FBXL8 F-box and leucine-rich repeat protein 8 2.62414
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.62414
HNF4A hepatocyte nuclear factor 4, alpha 2.62414
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.62414
SPEM1 spermatid maturation 1 2.62414
HTRA4 HtrA serine peptidase 4 2.62414
LOC124903317 uncharacterized LOC124903317 2.62414
BEND2 BEN domain containing 2 2.62414
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.62414
GMCL2 germ cell-less 2, spermatogenesis associated 2.62414
CCDC198 coiled-coil domain containing 198 2.62414
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.62414
CCDC187 coiled-coil domain containing 187 2.62414
H4C13 H4 clustered histone 13 2.62414
GARIN6 golgi associated RAB2 interactor family member 6 2.62414
GSG1L2 GSG1 like 2 2.62414
LOC124903372 uncharacterized LOC124903372 2.62414
CIMIP4 ciliary microtubule inner protein 4 2.62414
SPATA31F1 SPATA31 subfamily F member 1 2.62414
SPMIP7 sperm microtubule inner protein 7 2.62414
MIOX myo-inositol oxygenase 2.62414
FOXC2 forkhead box C2 2.62414
AKAP4 A kinase (PRKA) anchor protein 4 2.62414
NRN1 neuritin 1 2.62414
RGS9BP regulator of G protein signaling 9 binding protein 2.62414
NKX2-2 NK2 homeobox 2 2.62414
CLDN9 claudin 9 2.62414
TPTE transmembrane phosphatase with tensin homology 2.62414
GDF10 growth differentiation factor 10 2.62414
BARHL1 BarH-like homeobox 1 2.62414
IFNL1 interferon, lambda 1 2.62414
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.62414
PRR4 proline rich 4 (lacrimal) 2.62414
GJD2 gap junction protein, delta 2, 36kDa 2.62414
VCX3A variable charge, X-linked 3A 2.62414
OPN5 opsin 5 2.62414
NPIPB8 nuclear pore complex interacting protein family, member B8 2.62414
CSAG1 chondrosarcoma associated gene 1 2.62414
GRAP GRB2-related adaptor protein 2.62414
SPMAP1 sperm microtubule associated protein 1 2.62414
TGM6 transglutaminase 6 2.62414
FAM135B family with sequence similarity 135, member B 2.62414
CLRN1 clarin 1 2.62414
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.62414
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.62414
TNR tenascin R 2.62414
EFCAB3 EF-hand calcium binding domain 3 2.62414
POF1B premature ovarian failure, 1B 2.62414
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.62414
ZBP1 Z-DNA binding protein 1 2.62414
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.62414
MAB21L3 mab-21-like 3 (C. elegans) 2.62414
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.62414
CXCR3 chemokine (C-X-C motif) receptor 3 2.62414
OCM oncomodulin 2.62414
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.62414
LRRC15 leucine rich repeat containing 15 2.62414
DSC1 desmocollin 1 2.62414
CLEC18C C-type lectin domain family 18, member C 2.62414
PCDHGA2 protocadherin gamma subfamily A, 2 2.62414
TCP11X2 t-complex 11 family, X-linked 2 2.62414
SAMD9 sterile alpha motif domain containing 9 2.62414
FAM177B family with sequence similarity 177, member B 2.62414
RNASE13 ribonuclease, RNase A family, 13 (non-active) 2.62414
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.62414
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.62414
SYNGR4 synaptogyrin 4 2.62414
A3GALT2 alpha 1,3-galactosyltransferase 2 2.62414
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.62414
LGALS12 lectin, galactoside-binding, soluble, 12 2.62414
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.62414
FGF16 fibroblast growth factor 16 2.62414
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.62414
APOL3 apolipoprotein L, 3 2.62414
APOL1 apolipoprotein L, 1 2.62414
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.62414
CCDC166 coiled-coil domain containing 166 2.62414
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.62414
MAGEA2B melanoma antigen family A2B 2.62414
CHIT1 chitinase 1 (chitotriosidase) 2.62414
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.62414
DYTN dystrotelin 2.62414
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.62414
VAV1 vav 1 guanine nucleotide exchange factor 2.62414
PGR progesterone receptor 2.62414
RORC RAR-related orphan receptor C 2.62414
SLFN12L schlafen family member 12-like 2.62414
PSG8 pregnancy specific beta-1-glycoprotein 8 2.62414
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.62414
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2.62414
FBXL5 F-box and leucine-rich repeat protein 5 2.61883
PIMREG PICALM interacting mitotic regulator 2.61529
LPAR5 lysophosphatidic acid receptor 5 2.60389
TEKT5 tektin 5 2.60389
S100A11 S100 calcium binding protein A11 2.58186
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 2.58127
PANX1 pannexin 1 2.51153
ING2 inhibitor of growth family, member 2 2.51073
PANK3 pantothenate kinase 3 2.51073
ZNF514 zinc finger protein 514 2.50861
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.46304
GALK1 galactokinase 1 2.46216
RIOX2 ribosomal oxygenase 2 2.45276
ZNF75D zinc finger protein 75D 2.424
RPL35A ribosomal protein L35a 2.39583
ZNF441 zinc finger protein 441 2.39176
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.37512
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.36805
FAM50A family with sequence similarity 50, member A 2.34701
AHRR aryl-hydrocarbon receptor repressor 2.32309
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.3007
CSAD cysteine sulfinic acid decarboxylase 2.28236
CIPC CLOCK-interacting pacemaker 2.26668
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.26337
ENTHD1 ENTH domain containing 1 2.25026
ZNF225 zinc finger protein 225 2.24709
SERF2 small EDRK-rich factor 2 2.23627
ELP5 elongator acetyltransferase complex subunit 5 2.22742
SPINDOC spindlin interactor and repressor of chromatin binding 2.22692
EXTL2 exostosin-like glycosyltransferase 2 2.19789
PBRM1 polybromo 1 2.18831
NACA nascent polypeptide-associated complex alpha subunit 2.17305
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 2.14084
UFM1 ubiquitin-fold modifier 1 2.13655
ZIK1 zinc finger protein interacting with K protein 1 2.1085
RPL38 ribosomal protein L38 2.1085
PHF10 PHD finger protein 10 2.07452
FAM234B family with sequence similarity 234 member B 2.06874
RPL10A ribosomal protein L10a 2.06837
LENG1 leukocyte receptor cluster (LRC) member 1 2.05479
HMG20B high mobility group 20B 2.0541
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2.05234
NID2 nidogen 2 (osteonidogen) 2.05234
TULP3 tubby like protein 3 2.05044
ABHD12B abhydrolase domain containing 12B 2.04612
RTF2 replication termination factor 2 2.04151
JAKMIP1 janus kinase and microtubule interacting protein 1 2.03759
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.03008
RBMXL1 RNA binding motif protein, X-linked-like 1 2.01834
EPS8 epidermal growth factor receptor pathway substrate 8 2.01343
ATP5F1A ATP synthase F1 subunit alpha 2.00889
THOC2 THO complex 2 2.00773
CALCOCO1 calcium binding and coiled-coil domain 1 2.00045
ZNF333 zinc finger protein 333 2.00045
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.00045

decreased expression

Symbol Name Standardized Value
MCPH1 microcephalin 1 -2.62414
DEPP1 DEPP autophagy regulator 1 -2.62414
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.62414
APP-DT APP divergent transcript -2.62414
ZNF251 zinc finger protein 251 -2.62414
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.62414
TMEM18 transmembrane protein 18 -2.62414
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.62414
PARD3B par-3 family cell polarity regulator beta -2.62414
CLEC4A C-type lectin domain family 4, member A -2.62414
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.62414
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -2.61883
STUM stum, mechanosensory transduction mediator homolog -2.61529
C2ORF69 chromosome 2 open reading frame 69 -2.60337
TMEM222 transmembrane protein 222 -2.59682
IFT57 intraflagellar transport 57 -2.59303
FAM153A family with sequence similarity 153, member A -2.51073
DMBX1 diencephalon/mesencephalon homeobox 1 -2.51073
DMRTC1B DMRT-like family C1B -2.51073
C8ORF48 chromosome 8 open reading frame 48 -2.51073
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.51073
UNC45B unc-45 homolog B (C. elegans) -2.51073
BTBD19 BTB (POZ) domain containing 19 -2.51073
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.51073
NOTUM notum pectinacetylesterase homolog (Drosophila) -2.51073
CDH5 cadherin 5, type 2 (vascular endothelium) -2.51073
STRBP spermatid perinuclear RNA binding protein -2.51073
STEAP4 STEAP family member 4 -2.51073
SIX6 SIX homeobox 6 -2.51073
ACOT12 acyl-CoA thioesterase 12 -2.51073
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -2.51073
KLHL1 kelch-like family member 1 -2.51073
ARR3 arrestin 3, retinal (X-arrestin) -2.51073
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.51073
PLCZ1 phospholipase C, zeta 1 -2.51073
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.51073
TF transferrin -2.51073
TPPP3 tubulin polymerization-promoting protein family member 3 -2.51073
SMIM17 small integral membrane protein 17 -2.51073
EXTL1 exostosin-like glycosyltransferase 1 -2.51073
CLDN14 claudin 14 -2.51073
TBX1 T-box 1 -2.51073
ALOX15B arachidonate 15-lipoxygenase, type B -2.51073
ACE2 angiotensin I converting enzyme 2 -2.51073
OR51M1 olfactory receptor, family 51, subfamily M, member 1 -2.51073
SMIM22 small integral membrane protein 22 -2.51073
MBOAT4 membrane bound O-acyltransferase domain containing 4 -2.51073
MAP3K4-AS1 MAP3K4 antisense RNA 1 -2.51073
SYT15B synaptotagmin 15B -2.50594
DEDD death effector domain containing -2.50274
TRAM1L1 translocation associated membrane protein 1-like 1 -2.4567
ATAD3B ATPase family, AAA domain containing 3B -2.42149
RAG2 recombination activating gene 2 -2.42109
RUFY4 RUN and FYVE domain containing 4 -2.42109
TMIE transmembrane inner ear -2.39845
SPATA9 spermatogenesis associated 9 -2.39845
CSDC2 cold shock domain containing C2, RNA binding -2.39845
OSBPL11 oxysterol binding protein-like 11 -2.3984
NCBP2 nuclear cap binding protein subunit 2, 20kDa -2.38216
DOT1L DOT1-like histone H3K79 methyltransferase -2.36805
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -2.33395
PCDHGA11 protocadherin gamma subfamily A, 11 -2.32569
CD109 CD109 molecule -2.3251
ARHGAP12 Rho GTPase activating protein 12 -2.29464
GMFB glia maturation factor, beta -2.25026
ZNF18 zinc finger protein 18 -2.2502
AMOTL1 angiomotin like 1 -2.2502
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 -2.23627
ARSJ arylsulfatase family, member J -2.23465
LCOR ligand dependent nuclear receptor corepressor -2.21206
TPMT thiopurine S-methyltransferase -2.20691
CA11 carbonic anhydrase XI -2.20691
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -2.17285
FRS2 fibroblast growth factor receptor substrate 2 -2.17074
RBPJ recombination signal binding protein for immunoglobulin kappa J region -2.16425
GDAP1 ganglioside induced differentiation associated protein 1 -2.14084
SLC22A23 solute carrier family 22, member 23 -2.11366
SCN3B sodium channel, voltage gated, type III beta subunit -2.10324
SEPTIN2 septin 2 -2.10287
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -2.05479
CHMP1A charged multivesicular body protein 1A -2.05479
SH2B3 SH2B adaptor protein 3 -2.05479
PRKD3 protein kinase D3 -2.0541
IFT74 intraflagellar transport 74 -2.03609
NCLN nicalin -2.02412
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.02067
STK31 serine/threonine kinase 31 -2.02067
ZNF502 zinc finger protein 502 -2.02067
C2ORF80 chromosome 2 open reading frame 80 -2.02067
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.00889
FBXO36 F-box protein 36 -2.00154