| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase kinase 12|This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 7786) |
| External Link | https://ncbi.nlm.nih.gov/gene/7786 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the MAP3K12 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ATF3 | activating transcription factor 3 | 0.0152665 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0145534 |
| TUBB2A | tubulin, beta 2A class IIa | 0.0142351 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0128566 |
| THBS1 | thrombospondin 1 | 0.0121434 |
| EGR1 | early growth response 1 | 0.011783 |
| AGR2 | anterior gradient 2 | 0.0117605 |
| CCN2 | cellular communication network factor 2 | 0.0114213 |
| CRYAB | crystallin, alpha B | 0.0111639 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0110214 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.0108847 |
| DACH1 | dachshund family transcription factor 1 | 0.0107012 |
| UPP1 | uridine phosphorylase 1 | 0.0105632 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.0103798 |
| WDR61 | WD repeat domain 61 | 0.0103532 |
| CCNA2 | cyclin A2 | 0.0102097 |
| TOX3 | TOX high mobility group box family member 3 | 0.0100006 |
| KLF6 | Kruppel-like factor 6 | 0.009912 |
| CNTN1 | contactin 1 | 0.00943216 |
| PALLD | palladin, cytoskeletal associated protein | 0.00940787 |
| SFRP4 | secreted frizzled-related protein 4 | 0.00923982 |
| CHMP4A | charged multivesicular body protein 4A | 0.00921267 |
| NPC2 | Niemann-Pick disease, type C2 | 0.00916351 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.00914173 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.00908753 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00889632 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.00888427 |
| LCN2 | lipocalin 2 | 0.00879787 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.00873021 |
| CD52 | CD52 molecule | 0.00868371 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.00866117 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00852045 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0084854 |
| RIOK3 | RIO kinase 3 | 0.00846936 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00838707 |
| MVP | major vault protein | 0.00834252 |
| EFNA1 | ephrin-A1 | 0.00824833 |
| JUNB | jun B proto-oncogene | 0.00820354 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.00819853 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.00819688 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.00819588 |
| CLEC3B | C-type lectin domain family 3, member B | 0.00818252 |
| S100A14 | S100 calcium binding protein A14 | 0.00813932 |
| IL18 | interleukin 18 | 0.00810874 |
| BTG2 | BTG family, member 2 | 0.00810021 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0080545 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 0.00803064 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00791691 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.00788161 |
| MCOLN1 | mucolipin 1 | 0.00785258 |
| OSR2 | odd-skipped related transciption factor 2 | 0.00781882 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0078109 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00779824 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00776192 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.00776129 |
| REG1A | regenerating islet-derived 1 alpha | 0.00773486 |
| EGR3 | early growth response 3 | 0.00773137 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.00772891 |
| TMC5 | transmembrane channel-like 5 | 0.0076756 |
| TFF1 | trefoil factor 1 | 0.00765661 |
| TXNDC9 | thioredoxin domain containing 9 | 0.0076072 |
| TMEM176B | transmembrane protein 176B | 0.0075876 |
| DNTT | DNA nucleotidylexotransferase | 0.00758294 |
| TUFT1 | tuftelin 1 | 0.00757631 |
| ECM1 | extracellular matrix protein 1 | 0.00756103 |
| GAB2 | GRB2-associated binding protein 2 | 0.00755901 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.00746148 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.007448 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.00743917 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.00739775 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00736895 |
| COMP | cartilage oligomeric matrix protein | 0.00735997 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00734414 |
| TSPAN8 | tetraspanin 8 | 0.00731405 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00725491 |
| H1-2 | H1.2 linker histone, cluster member | 0.00725081 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | 0.00723158 |
| RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) | 0.00722995 |
| HDAC9 | histone deacetylase 9 | 0.00722957 |
| REG3A | regenerating islet-derived 3 alpha | 0.00720665 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.00719784 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00717181 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00716009 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.00715155 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00715118 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | 0.00714959 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.00711411 |
| MIR22HG | MIR22 host gene | 0.00710043 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00706722 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00706679 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.00706165 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.0070134 |
| NRCAM | neuronal cell adhesion molecule | 0.00699175 |
| ESR1 | estrogen receptor 1 | 0.00697357 |
| MAL | mal, T-cell differentiation protein | 0.00692455 |
| CPM | carboxypeptidase M | 0.00691982 |
| PROM1 | prominin 1 | 0.00688677 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.00686541 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | 0.00680958 |
| IFT20 | intraflagellar transport 20 | 0.00680501 |
| HMOX1 | heme oxygenase 1 | 0.00679492 |
| C6ORF48 | chromosome 6 open reading frame 48 | 0.00673922 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00673356 |
| LAMA3 | laminin, alpha 3 | 0.00671842 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00671489 |
| SH2D1A | SH2 domain containing 1A | 0.00669109 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00667903 |
| CAB39 | calcium binding protein 39 | 0.00667634 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.00667414 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00666748 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.00665526 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00665273 |
| GATA6 | GATA binding protein 6 | 0.00658955 |
| RBPMS | RNA binding protein with multiple splicing | 0.00658768 |
| FGF13 | fibroblast growth factor 13 | 0.00658726 |
| OAT | ornithine aminotransferase | 0.00657451 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00651922 |
| SLC44A4 | solute carrier family 44, member 4 | 0.00648728 |
| RNF167 | ring finger protein 167 | 0.00648672 |
| REG1B | regenerating islet-derived 1 beta | 0.00648038 |
| KLF10 | Kruppel-like factor 10 | 0.00647668 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | 0.00647534 |
| MAP7 | microtubule-associated protein 7 | 0.00646851 |
| PSAP | prosaposin | 0.00645964 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.00645944 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.00645775 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.00645047 |
| AREG | amphiregulin | 0.00644459 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0064383 |
| DUSP5 | dual specificity phosphatase 5 | 0.00643322 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.00641026 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00638818 |
| CLU | clusterin | 0.00636726 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00635706 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.00635192 |
| ZNF277 | zinc finger protein 277 | 0.0063451 |
| EFHD1 | EF-hand domain family, member D1 | 0.00631714 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.00630066 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00629935 |
| THBS4 | thrombospondin 4 | 0.00625826 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.00625185 |
| MYO6 | myosin VI | 0.00621659 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00618262 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.00617024 |
| MICB | MHC class I polypeptide-related sequence B | 0.00616957 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | 0.00615881 |
| AOX1 | aldehyde oxidase 1 | 0.00615873 |
| AKIRIN1 | akirin 1 | 0.00615597 |
| ICAM2 | intercellular adhesion molecule 2 | 0.0061411 |
| MED6 | mediator complex subunit 6 | 0.00612081 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 0.00611916 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00611498 |
| HIST3H2A | histone cluster 3, H2a | 0.00610568 |
| FAM102A | family with sequence similarity 102, member A | 0.00610191 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | 0.00607896 |
| RPL36 | ribosomal protein L36 | 0.00603334 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00602206 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00601741 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.00601292 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00600869 |
| HCP5 | HLA complex P5 (non-protein coding) | 0.00599005 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00597616 |
| MFAP5 | microfibrillar associated protein 5 | 0.00596917 |
| SELENOW | selenoprotein W | 0.00596485 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00592683 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | 0.00592082 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.00591561 |
| MEN1 | multiple endocrine neoplasia I | 0.00591446 |
| AOC1 | amine oxidase, copper containing 1 | 0.00590895 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00590125 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.00589988 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.00589563 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.00589146 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00587974 |
| KLK12 | kallikrein-related peptidase 12 | 0.00586995 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.0058688 |
| AMOTL2 | angiomotin like 2 | 0.00584932 |
| IL32 | interleukin 32 | 0.00584289 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.00582635 |
| ZNHIT3 | zinc finger, HIT-type containing 3 | 0.00582595 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.00581616 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.00580176 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | 0.00579407 |
| ACP1 | acid phosphatase 1, soluble | 0.00576607 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00575769 |
| GPX1 | glutathione peroxidase 1 | 0.00575082 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 0.00573359 |
| FBLN5 | fibulin 5 | 0.00573005 |
| CLCA1 | chloride channel accessory 1 | 0.00572603 |
| LST1 | leukocyte specific transcript 1 | 0.00572331 |
| CD34 | CD34 molecule | 0.00572054 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00570999 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00570918 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.00570815 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00570686 |
| LIAS | lipoic acid synthetase | 0.00570063 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00569447 |
| JAM3 | junctional adhesion molecule 3 | 0.00569363 |
| LAMA2 | laminin, alpha 2 | 0.00568174 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0056782 |
| PXDC1 | PX domain containing 1 | 0.00567567 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 0.00564145 |
| TMEM100 | transmembrane protein 100 | 0.00563363 |
| GOLT1B | golgi transport 1B | 0.00562918 |
| MICA | MHC class I polypeptide-related sequence A | 0.00561991 |
| TSLIG2 | tRNA splicing ligase complex subunit 2 | 0.00561967 |
| RHOB | ras homolog family member B | 0.00561858 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | 0.00561427 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.00561297 |
| HLA-F | major histocompatibility complex, class I, F | 0.00561281 |
| JUN | jun proto-oncogene | 0.00560931 |
| C9ORF16 | chromosome 9 open reading frame 16 | 0.00560549 |
| KIAA0753 | KIAA0753 | 0.00559979 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.00559241 |
| HIST1H2BH | histone cluster 1, H2bh | 0.00558675 |
| SASH1 | SAM and SH3 domain containing 1 | 0.00558042 |
| HPSE | heparanase | 0.00557337 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.00556574 |
| PLIN3 | perilipin 3 | 0.0055637 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00556199 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00556101 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 0.00555152 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00548794 |
| TPD52L1 | tumor protein D52-like 1 | 0.00548775 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.00547823 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.00547281 |
| ATP10B | ATPase, class V, type 10B | 0.00546332 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 0.00544345 |
| INHBA | inhibin, beta A | 0.00544229 |
| IL1A | interleukin 1, alpha | 0.00543409 |
| HLA-F-AS1 | HLA-F antisense RNA 1 | 0.00542545 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 0.00540541 |
| SIRAL2 | SIR2 antiphage like 2 | 0.00540274 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0053965 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.0053889 |
| H1-0 | H1.0 linker histone | 0.00538509 |
| GLRX3 | glutaredoxin 3 | 0.00538385 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.00537627 |
| RETREG1 | reticulophagy regulator 1 | 0.00536565 |
| TNXB | tenascin XB | 0.00535563 |
| CLTB | clathrin, light chain B | 0.00535256 |
| SPATA7 | spermatogenesis associated 7 | 0.00533324 |
| ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent | 0.00532568 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00532498 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00532019 |
| FRMD4B | FERM domain containing 4B | 0.00531664 |
| TANK | TRAF family member-associated NFKB activator | 0.00530638 |
| CALCA | calcitonin-related polypeptide alpha | 0.00530449 |
| LPIN1 | lipin 1 | 0.00529404 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | -0.0150601 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -0.0134372 |
| PCNA | proliferating cell nuclear antigen | -0.01246 |
| TMSB15A | thymosin beta 15a | -0.0112649 |
| FASN | fatty acid synthase | -0.0109453 |
| APMAP | adipocyte plasma membrane associated protein | -0.0107575 |
| MAGEA3 | melanoma antigen family A3 | -0.0105757 |
| SRGN | serglycin | -0.0101423 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -0.0101033 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00985056 |
| TCF4 | transcription factor 4 | -0.00968743 |
| PIGB | phosphatidylinositol glycan anchor biosynthesis, class B | -0.00965927 |
| NELL2 | NEL-like 2 (chicken) | -0.0096271 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00955998 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.00954149 |
| CCNB1 | cyclin B1 | -0.00935976 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00925965 |
| TGM2 | transglutaminase 2 | -0.00925692 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00909966 |
| CBS | cystathionine-beta-synthase | -0.00903309 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00895722 |
| HCRT | hypocretin (orexin) neuropeptide precursor | -0.00890211 |
| PTN | pleiotrophin | -0.00871681 |
| PWP1 | PWP1 homolog (S. cerevisiae) | -0.00868444 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.00863068 |
| COL6A1 | collagen, type VI, alpha 1 | -0.00858582 |
| ZNF395 | zinc finger protein 395 | -0.00857527 |
| CLC | Charcot-Leyden crystal galectin | -0.00829881 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00824771 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00822537 |
| LMNB1 | lamin B1 | -0.00819473 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00819074 |
| COL3A1 | collagen, type III, alpha 1 | -0.00813684 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.00810733 |
| KIF20A | kinesin family member 20A | -0.0080866 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00807077 |
| HLTF | helicase-like transcription factor | -0.00805367 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00802426 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00799828 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.00799308 |
| COL1A2 | collagen, type I, alpha 2 | -0.0078276 |
| MCCC2 | methylcrotonoyl-CoA carboxylase 2 (beta) | -0.00781461 |
| NTS | neurotensin | -0.00780606 |
| LOXL2 | lysyl oxidase-like 2 | -0.00771418 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.00769436 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00769374 |
| FOXM1 | forkhead box M1 | -0.0076889 |
| LOX | lysyl oxidase | -0.00765299 |
| SLC35E2B | solute carrier family 35, member E2B | -0.00763897 |
| SLC2A4RG | SLC2A4 regulator | -0.00755371 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00754554 |
| PRAME | preferentially expressed antigen in melanoma | -0.00751889 |
| SNX5 | sorting nexin 5 | -0.00749185 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00748776 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | -0.00747148 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.00740656 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00737453 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00736985 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | -0.00732949 |
| KIF14 | kinesin family member 14 | -0.00731886 |
| EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 | -0.00730159 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0072918 |
| NDRG3 | NDRG family member 3 | -0.00724439 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.00724064 |
| KIF18B | kinesin family member 18B | -0.0072184 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00715459 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -0.0071522 |
| SPRR3 | small proline-rich protein 3 | -0.00715026 |
| LRRC17 | leucine rich repeat containing 17 | -0.00713938 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -0.00712709 |
| METTL7A | methyltransferase like 7A | -0.00701512 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | -0.00694713 |
| RAD51AP1 | RAD51 associated protein 1 | -0.00694666 |
| COPS7A | COP9 signalosome subunit 7A | -0.00692079 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.00691947 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00690819 |
| LYZ | lysozyme | -0.00689765 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -0.00686894 |
| CDC7 | cell division cycle 7 | -0.00686356 |
| RAPSN | receptor-associated protein of the synapse | -0.00685743 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00684346 |
| NELFCD | negative elongation factor complex member C/D | -0.00681474 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.00681299 |
| HK2 | hexokinase 2 | -0.00679846 |
| S100A8 | S100 calcium binding protein A8 | -0.00678257 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.00676889 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | -0.00673316 |
| KRT13 | keratin 13, type I | -0.00672519 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.00670772 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | -0.00666483 |
| MARCKSL1 | MARCKS-like 1 | -0.00663982 |
| RAB21 | RAB21, member RAS oncogene family | -0.0066345 |
| TPI1 | triosephosphate isomerase 1 | -0.00663135 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | -0.00662938 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00662077 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | -0.00659466 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.00657814 |
| PLXNA1 | plexin A1 | -0.00657006 |
| TFR2 | transferrin receptor 2 | -0.00655904 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00655723 |
| ZWINT | ZW10 interacting kinetochore protein | -0.00651152 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00647293 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | -0.00643237 |
| SMAD3 | SMAD family member 3 | -0.0064201 |
| MFSD10 | major facilitator superfamily domain containing 10 | -0.00641731 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -0.0064167 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.006384 |
| PRC1 | protein regulator of cytokinesis 1 | -0.00634027 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -0.0063268 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.00631898 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | -0.00631547 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00630052 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00629852 |
| MCM2 | minichromosome maintenance complex component 2 | -0.00629376 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00625448 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00624178 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.00623992 |
| GUSB | glucuronidase, beta | -0.00622333 |
| FLOT1 | flotillin 1 | -0.00622017 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.00621526 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00621235 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.00620104 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.0061967 |
| ZNF512B | zinc finger protein 512B | -0.00618317 |
| BID | BH3 interacting domain death agonist | -0.00616948 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.00616001 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00615746 |
| USP21 | ubiquitin specific peptidase 21 | -0.00613204 |
| RRM2 | ribonucleotide reductase M2 | -0.00611502 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.00609333 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.00606437 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00605909 |
| VEGFA | vascular endothelial growth factor A | -0.00603897 |
| VEGFB | vascular endothelial growth factor B | -0.00603083 |
| KRT23 | keratin 23, type I | -0.00600491 |
| UNG | uracil-DNA glycosylase | -0.00599784 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | -0.00599251 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.00599062 |
| EXTL2 | exostosin-like glycosyltransferase 2 | -0.00597845 |
| DUT | deoxyuridine triphosphatase | -0.00597018 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00596861 |
| CTBP1 | C-terminal binding protein 1 | -0.00595312 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.00592543 |
| CDK14 | cyclin-dependent kinase 14 | -0.00590284 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.00589886 |
| S100A9 | S100 calcium binding protein A9 | -0.00589319 |
| RPIA | ribose 5-phosphate isomerase A | -0.00588611 |
| SACM1L | SAC1 suppressor of actin mutations 1-like (yeast) | -0.00587579 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.00587134 |
| LBR | lamin B receptor | -0.00587092 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | -0.00586061 |
| GSDME | gasdermin E | -0.00585139 |
| PTMS | parathymosin | -0.00582817 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00581577 |
| PCLAF | PCNA clamp associated factor | -0.00576972 |
| MLF2 | myeloid leukemia factor 2 | -0.00576358 |
| H2AFV | H2A histone family, member V | -0.00574984 |
| HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 | -0.0057478 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.00574723 |
| HHEX | hematopoietically expressed homeobox | -0.00574648 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0057464 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.0057386 |
| APBA2 | amyloid beta (A4) precursor protein-binding, family A, member 2 | -0.00573528 |
| FLOT2 | flotillin 2 | -0.00572679 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.00571488 |
| ANKMY2 | ankyrin repeat and MYND domain containing 2 | -0.00570664 |
| INHBB | inhibin, beta B | -0.00569567 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00569517 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | -0.00568294 |
| LDB2 | LIM domain binding 2 | -0.00567232 |
| TMEM109 | transmembrane protein 109 | -0.00565886 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | -0.00565709 |
| TARDBP | TAR DNA binding protein | -0.00562435 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -0.00561283 |
| TMPO | thymopoietin | -0.00559661 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00558236 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.00557986 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00557312 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | -0.00556801 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.0055423 |
| TENM1 | teneurin transmembrane protein 1 | -0.00554226 |
| COLEC12 | collectin sub-family member 12 | -0.00553644 |
| TGFB1 | transforming growth factor, beta 1 | -0.00552474 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.00552365 |
| CST7 | cystatin F (leukocystatin) | -0.00551736 |
| CDK16 | cyclin-dependent kinase 16 | -0.00551327 |
| PLEK | pleckstrin | -0.00551105 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.00550033 |
| ATN1 | atrophin 1 | -0.00549797 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00549032 |
| TFRC | transferrin receptor | -0.00548974 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00548503 |
| ZNF532 | zinc finger protein 532 | -0.00548302 |
| FGG | fibrinogen gamma chain | -0.00547575 |
| CALML5 | calmodulin-like 5 | -0.00546534 |
| USP48 | ubiquitin specific peptidase 48 | -0.00545406 |
| HMG20B | high mobility group 20B | -0.00544809 |
| PCBP2 | poly(rC) binding protein 2 | -0.00544192 |
| PHKA2 | phosphorylase kinase, alpha 2 (liver) | -0.00539784 |
| DPAGT1 | dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) | -0.00539379 |
| TBC1D4 | TBC1 domain family, member 4 | -0.00538645 |
| KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | -0.00537754 |
| LOXL1 | lysyl oxidase-like 1 | -0.00537023 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.00535389 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00533616 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00533376 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00532875 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | -0.00532769 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | -0.00531669 |
| TP63 | tumor protein p63 | -0.00530042 |
| TMEM41B | transmembrane protein 41B | -0.00528378 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.0052826 |
| KRT6A | keratin 6A, type II | -0.00527043 |
| TMEM45A | transmembrane protein 45A | -0.00526584 |
| DHFR | dihydrofolate reductase | -0.00526131 |
| RO60 | Ro60, Y RNA binding protein | -0.00525505 |
| CCDC86 | coiled-coil domain containing 86 | -0.00525409 |
| MLEC | malectin | -0.00524764 |
| JADE1 | jade family PHD finger 1 | -0.00524328 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.00523381 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | -0.00523157 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | -0.00520997 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | -0.00520134 |
| ZNF580 | zinc finger protein 580 | -0.00519984 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.00519253 |
| KRT5 | keratin 5, type II | -0.00518571 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.00518336 |
| UPK1B | uroplakin 1B | -0.00516558 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | -0.00515625 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | -0.00515556 |
| DEFA4 | defensin, alpha 4, corticostatin | -0.00514559 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.00514412 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00514189 |
| CBX5 | chromobox homolog 5 | -0.00514172 |
| TAPBP | TAP binding protein (tapasin) | -0.00513309 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | -0.0051281 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | -0.0051255 |
| CD200 | CD200 molecule | -0.00511134 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.00509442 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00509026 |
| MPZL2 | myelin protein zero-like 2 | -0.00508629 |
| SQLE | squalene epoxidase | -0.0050812 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00507523 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.00507096 |
| ANXA10 | annexin A10 | -0.00506443 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00505404 |
| FKBP4 | FK506 binding protein 4, 59kDa | -0.00505334 |
| KIF11 | kinesin family member 11 | -0.00505113 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | -0.00504294 |
