MAP3K14 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase kinase kinase 14|This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9020)
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Genes

310 genes differentially expressed following the MAP3K14 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 3.53632
ASCL5 achaete-scute family bHLH transcription factor 5 3.53632
TNS4 tensin 4 3.53632
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 3.53632
SPATA25 spermatogenesis associated 25 3.53632
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.53632
HSPA1L heat shock 70kDa protein 1-like 3.53632
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 3.53632
HYKK hydroxylysine kinase 3.53632
IL16 interleukin 16 3.53632
CTF1 cardiotrophin 1 3.53632
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.53632
NOS3 nitric oxide synthase 3 (endothelial cell) 3.53632
CLCA4 chloride channel accessory 4 3.53632
NCAN neurocan 3.53632
SUN3 Sad1 and UNC84 domain containing 3 3.53632
MST1 macrophage stimulating 1 3.53632
PNMA8B PNMA family member 8B 3.53632
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.53632
GBA1 glucosylceramidase beta 1 3.53632
CNR2 cannabinoid receptor 2 (macrophage) 3.53632
GBX1 gastrulation brain homeobox 1 3.53632
ADAM11 ADAM metallopeptidase domain 11 3.53632
OXT oxytocin/neurophysin I prepropeptide 3.53632
FAIM2 Fas apoptotic inhibitory molecule 2 3.53632
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 3.53632
ACP4 acid phosphatase 4 3.53632
VWA3A von Willebrand factor A domain containing 3A 3.53632
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.45406
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.45406
LRRC55 leucine rich repeat containing 55 3.45406
SLC25A41 solute carrier family 25, member 41 3.45406
MUC1 mucin 1, cell surface associated 3.45406
PON1 paraoxonase 1 3.45406
SP9 Sp9 transcription factor 3.45406
UMOD uromodulin 3.45406
IL2RB interleukin 2 receptor, beta 3.45406
TMC8 transmembrane channel-like 8 3.45406
SON SON DNA binding protein 3.45406
BMP8A bone morphogenetic protein 8a 3.45406
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.45406
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.45406
GPHB5 glycoprotein hormone beta 5 3.45406
CRIP1 cysteine-rich protein 1 (intestinal) 3.45406
C8ORF74 chromosome 8 open reading frame 74 3.45406
C3ORF22 chromosome 3 open reading frame 22 3.45406
CA7 carbonic anhydrase VII 3.45406
FOXJ1 forkhead box J1 3.45406
LRRC63 leucine rich repeat containing 63 3.45406
HBZ hemoglobin, zeta 3.45406
MUC22 mucin 22 3.45406
GPR22 G protein-coupled receptor 22 3.45406
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.45406
FAM86B2 family with sequence similarity 86, member B2 3.45406
GCKR glucokinase (hexokinase 4) regulator 3.45406
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.45406
NEU4 sialidase 4 3.45406
GRXCR2 glutaredoxin, cysteine rich 2 3.45406
LIPH lipase, member H 3.45406
SPATA31F3 SPATA31 subfamily F member 3 3.45406
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.45406
SPI1 Spi-1 proto-oncogene 3.45406
PDF peptide deformylase (mitochondrial) 3.45406
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 3.45406
ZMYM3 zinc finger, MYM-type 3 3.45406
TMEM190 transmembrane protein 190 3.45406
F5 coagulation factor V (proaccelerin, labile factor) 3.45406
CLEC6A C-type lectin domain family 6, member A 3.45406
CAVIN2 caveolae associated protein 2 3.45406
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.45406
CFAP141 cilia and flagella associated protein 141 3.45406
EPCIP exosomal polycystin 1 interacting protein 3.45406
FAM240C family with sequence similarity 240 member C 3.45406
IRF2-DT IRF2 divergent transcript 3.45406
LOC124903233 uncharacterized LOC124903233 3.45406
H4C14 H4 clustered histone 14 3.45406
SMIM43 small integral membrane protein 43 3.45406
ACP7 acid phosphatase 7, tartrate resistant (putative) 3.45406
ARMH2 armadillo like helical domain containing 2 3.45406
CNTN6 contactin 6 3.45406
LTF lactotransferrin 3.45406
DMP1 dentin matrix acidic phosphoprotein 1 3.45406
FOXD1 forkhead box D1 3.45406
ACTL10 actin-like 10 3.45406
CPED1 cadherin-like and PC-esterase domain containing 1 3.45406
HBA2 hemoglobin, alpha 2 3.45406
LAPTM5 lysosomal protein transmembrane 5 3.45406
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.45406
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.45406
STAR steroidogenic acute regulatory protein 3.45406
PEX12 peroxisomal biogenesis factor 12 3.45406
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.45406
ZNF350 zinc finger protein 350 3.45406
C7ORF57 chromosome 7 open reading frame 57 3.45406
PRR18 proline rich 18 3.45406
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.45406
GZMM granzyme M (lymphocyte met-ase 1) 3.45406
TLR1 toll-like receptor 1 3.45406
IL5 interleukin 5 3.45406
TMEM235 transmembrane protein 235 3.45406
LRRD1 leucine-rich repeats and death domain containing 1 3.45406
C2CD4B C2 calcium-dependent domain containing 4B 3.45406
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.45406
EGR2 early growth response 2 3.45406
IER5L immediate early response 5-like 3.45406
MAPK11 mitogen-activated protein kinase 11 3.45406
NUTM2B NUT family member 2B 3.45406
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.45406
LY96 lymphocyte antigen 96 3.45406
AMER3 APC membrane recruitment protein 3 3.45406
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.45406
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.45406
POTEJ POTE ankyrin domain family, member J 3.45406
POTEI POTE ankyrin domain family, member I 3.45406
ARL13A ADP-ribosylation factor-like 13A 3.45406
APOL1 apolipoprotein L, 1 3.45406
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.45406
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.45406
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.45406
COMP cartilage oligomeric matrix protein 3.45406
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.45406
CBX8 chromobox homolog 8 3.45406
APOC2 apolipoprotein C-II 3.45406
CREG2 cellular repressor of E1A-stimulated genes 2 3.45406
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.45406
AKNAD1 AKNA domain containing 1 3.45406
CDHR5 cadherin-related family member 5 3.45406
CTAGE9 CTAGE family, member 9 3.45406
ARR3 arrestin 3, retinal (X-arrestin) 3.45406
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.45406
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.45406
SOWAHA sosondowah ankyrin repeat domain family member A 3.45406
ISL1 ISL LIM homeobox 1 3.45406
PCDHGB4 protocadherin gamma subfamily B, 4 3.45406
STAB2 stabilin 2 3.45406
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 3.45406
DES desmin 3.45406
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.45406
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.45406
CLNK cytokine-dependent hematopoietic cell linker 3.45406
TMEM88 transmembrane protein 88 3.45406
ASCL1 achaete-scute family bHLH transcription factor 1 3.45406
IRX1 iroquois homeobox 1 3.45406
EVI2A ecotropic viral integration site 2A 3.45406
RDH16 retinol dehydrogenase 16 (all-trans) 3.45406
R3HDML R3H domain containing-like 3.45406
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.45406
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.45406
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.45406
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.45406
BTBD16 BTB (POZ) domain containing 16 3.45406
CLEC18B C-type lectin domain family 18, member B 3.45406
PMCH pro-melanin-concentrating hormone 3.45406
SORBS1 sorbin and SH3 domain containing 1 3.45406
C22ORF39 chromosome 22 open reading frame 39 3.45406
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.45406
IFITM10 interferon induced transmembrane protein 10 3.45406
ANXA1 annexin A1 3.45406
SYTL4 synaptotagmin-like 4 3.45406
CD28 CD28 molecule 3.45406
DCT dopachrome tautomerase 3.45406
ERVV-2 endogenous retrovirus group V, member 2 3.45406
DAPL1 death associated protein-like 1 3.45406
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.45406
AMDHD1 amidohydrolase domain containing 1 3.45406
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.45406
LHB luteinizing hormone beta polypeptide 3.45406
TGM7 transglutaminase 7 3.45406
FNDC7 fibronectin type III domain containing 7 3.36208
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.27747
EBF4 early B-cell factor 4 3.26062
EML2 echinoderm microtubule associated protein like 2 3.22197
E2F8 E2F transcription factor 8 3.00275
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 2.99659
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 2.92834
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.88524
THSD4 thrombospondin, type I, domain containing 4 2.86353
PDCL3 phosducin-like 3 2.75128
DYNLRB1 dynein, light chain, roadblock-type 1 2.64478
MED10 mediator complex subunit 10 2.64473
HIKESHI heat shock protein nuclear import factor hikeshi 2.58843
PTRH2 peptidyl-tRNA hydrolase 2 2.57099
MRPS35 mitochondrial ribosomal protein S35 2.56925
CENPX centromere protein X 2.54508
GTSF1 gametocyte specific factor 1 2.50101
ZNF675 zinc finger protein 675 2.49508
DRC3 dynein regulatory complex subunit 3 2.46558
INSL3 insulin-like 3 (Leydig cell) 2.46558
MICALL2 MICAL-like 2 2.46558
ZNF471 zinc finger protein 471 2.46558
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.46558
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.43148
UBP1 upstream binding protein 1 (LBP-1a) 2.3464
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.34587
GOLT1B golgi transport 1B 2.34478
GARIN1B golgi associated RAB2 interactor 1B 2.34266
DLG4 discs, large homolog 4 (Drosophila) 2.34266
CRYBG2 crystallin beta-gamma domain containing 2 2.30971
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 2.27653
PROCA1 protein interacting with cyclin A1 2.24004
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 2.22969
PRTG protogenin 2.21139
FAM120AOS family with sequence similarity 120A opposite strand 2.21038
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.1846
EPS8L2 EPS8-like 2 2.16327
EXOC3 exocyst complex component 3 2.1489
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino 2.14178
ASTN1 astrotactin 1 2.13335
H1-4 H1.4 linker histone, cluster member 2.13133
GPR180 G protein-coupled receptor 180 2.08226
TICRR TOPBP1-interacting checkpoint and replication regulator 2.07256
FNTB farnesyltransferase, CAAX box, beta 2.07
PTCHD1 patched domain containing 1 2.06438
NSD2 nuclear receptor binding SET domain protein 2 2.05638
HLA-DMA major histocompatibility complex, class II, DM alpha 2.04836
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.04252
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.04085
HAVCR2 hepatitis A virus cellular receptor 2 2.03311
CEP164 centrosomal protein 164kDa 2.02588
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 2.01628
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.01628
WDR73 WD repeat domain 73 2.00258

decreased expression

Symbol Name Standardized Value
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -3.53632
IL17RB interleukin 17 receptor B -3.53632
MYLK4 myosin light chain kinase family, member 4 -3.53632
CILP2 cartilage intermediate layer protein 2 -3.45406
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -3.45406
LOX lysyl oxidase -3.45406
EPHA5 EPH receptor A5 -3.45406
TENT5C terminal nucleotidyltransferase 5C -3.45406
GRIP2 glutamate receptor interacting protein 2 -3.36124
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.18968
ATG4A autophagy related 4A, cysteine peptidase -3.18968
ACVR1C activin A receptor, type IC -3.18968
SFN stratifin -3.18968
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -3.18968
NPSR1 neuropeptide S receptor 1 -3.18968
CC2D2B coiled-coil and C2 domain containing 2B -3.18968
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -3.18968
FRMPD2 FERM and PDZ domain containing 2 -3.18968
PF4V1 platelet factor 4 variant 1 -3.18968
TDRD1 tudor domain containing 1 -3.18968
CXCL2 chemokine (C-X-C motif) ligand 2 -3.18968
CA4 carbonic anhydrase IV -3.18968
POU5F2 POU domain class 5, transcription factor 2 -3.18968
CPNE5 copine V -3.18968
NICN1 nicolin 1 -3.18968
PTCH2 patched 2 -3.18968
SDS serine dehydratase -3.18968
TAS1R1 taste receptor, type 1, member 1 -3.18968
ZNF843 zinc finger protein 843 -3.18968
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -3.18968
CATSPERQ catsper channel auxiliary subunit theta -3.18968
KISS1 KiSS-1 metastasis-suppressor -3.18968
CHI3L2 chitinase 3-like 2 -3.18968
GLIPR1L2 GLI pathogenesis-related 1 like 2 -3.18968
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -3.18968
CXCR4 chemokine (C-X-C motif) receptor 4 -3.18968
TREH trehalase (brush-border membrane glycoprotein) -3.18968
PCDHGA7 protocadherin gamma subfamily A, 7 -3.18968
CFAP45 cilia and flagella associated protein 45 -3.18968
CFAP46 cilia and flagella associated protein 46 -3.03901
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -3.01077
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -3.00984
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 -2.98517
ZNF707 zinc finger protein 707 -2.91255
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -2.90544
MAPRE2 microtubule-associated protein, RP/EB family, member 2 -2.7373
MTRF1L mitochondrial translational release factor 1-like -2.68241
RANGAP1 Ran GTPase activating protein 1 -2.60701
MROH7 maestro heat-like repeat family member 7 -2.53588
SENP6 SUMO1/sentrin specific peptidase 6 -2.53281
TENT2 terminal nucleotidyltransferase 2 -2.49508
OPHN1 oligophrenin 1 -2.46558
TMEM53 transmembrane protein 53 -2.45911
THRB thyroid hormone receptor, beta -2.45601
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 -2.42069
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.3958
ZNF175 zinc finger protein 175 -2.37198
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.32902
OTUD1 OTU deubiquitinase 1 -2.32902
H2BC18 H2B clustered histone 18 -2.31593
DAPK3 death-associated protein kinase 3 -2.31155
IFRD2 interferon-related developmental regulator 2 -2.31087
NUP153 nucleoporin 153kDa -2.30078
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27653
PCYT1B phosphate cytidylyltransferase 1, choline, beta -2.25955
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.25752
INVS inversin -2.25416
WFS1 Wolfram syndrome 1 (wolframin) -2.24004
CCNL1 cyclin L1 -2.20366
PLXNA4 plexin A4 -2.16327
HAP1 huntingtin-associated protein 1 -2.16327
SF3B3 splicing factor 3b, subunit 3, 130kDa -2.16327
KLHL28 kelch-like family member 28 -2.16155
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -2.14178
PCDH10 protocadherin 10 -2.14178
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 -2.11278
TP73 tumor protein p73 -2.11114
MYCBPAP MYCBP associated protein -2.11114
SF1 splicing factor 1 -2.11114
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.11114
FBXL6 F-box and leucine-rich repeat protein 6 -2.10941
PSPH phosphoserine phosphatase -2.07514
KLF16 Kruppel-like factor 16 -2.06596
ANGPT2 angiopoietin 2 -2.06023
POC5 POC5 centriolar protein -2.03754
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.03754
PFN1 profilin 1 -2.03263
MAPK3 mitogen-activated protein kinase 3 -2.00033