MAP3K3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase kinase kinase 3|This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4215)
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Genes

307 genes differentially expressed following the MAP3K3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IGFL3 IGF-like family member 3 2.22324
CLEC19A C-type lectin domain family 19, member A 2.22324
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.22324
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.22324
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.22324
PLXNB3 plexin B3 2.22324
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.22324
SLC9C2 solute carrier family 9, member C2 (putative) 2.22324
ADGB androglobin 2.22324
NLRP10 NLR family, pyrin domain containing 10 2.22324
UNC13C unc-13 homolog C (C. elegans) 2.22324
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.22324
DEDD death effector domain containing 2.22324
CELF6 CUGBP, Elav-like family member 6 2.22324
ZEB2 zinc finger E-box binding homeobox 2 2.22324
TSGA13 testis specific, 13 2.22324
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.22324
SLC35G6 solute carrier family 35, member G6 2.22324
TMEM151A transmembrane protein 151A 2.22324
GPR151 G protein-coupled receptor 151 2.22324
SOX18 SRY (sex determining region Y)-box 18 2.22324
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.22324
TRDN triadin 2.22324
CRYAA crystallin, alpha A 2.22324
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.22324
HIC1 hypermethylated in cancer 1 2.22324
IL18R1 interleukin 18 receptor 1 2.22324
TDO2 tryptophan 2,3-dioxygenase 2.22324
STEAP4 STEAP family member 4 2.22324
NWD1 NACHT and WD repeat domain containing 1 2.22324
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 2.22324
PMCH pro-melanin-concentrating hormone 2.22324
GALR3 galanin receptor 3 2.22324
MYO1G myosin IG 2.22324
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.22324
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.22324
KYNU kynureninase 2.22324
YY2 YY2 transcription factor 2.22324
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.22324
NPIPA8 nuclear pore complex interacting protein family, member A8 2.22324
LRRC61 leucine rich repeat containing 61 2.22324
TREML1 triggering receptor expressed on myeloid cells-like 1 2.22324
KRT77 keratin 77, type II 2.22324
TLDC2 TBC/LysM-associated domain containing 2 2.22324
SCN2B sodium channel, voltage gated, type II beta subunit 2.22324
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.22324
PNLIPRP1 pancreatic lipase-related protein 1 2.22324
STMN4 stathmin-like 4 2.22324
BDKRB1 bradykinin receptor B1 2.22324
MYPN myopalladin 2.22324
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.22324
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.22324
LY6K lymphocyte antigen 6 complex, locus K 2.22324
SYT15 synaptotagmin XV 2.22324
ROPN1 rhophilin associated tail protein 1 2.22324
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.22324
SPATS1 spermatogenesis associated, serine-rich 1 2.22324
SPMIP11 sperm microtubule inner protein 11 2.22324
TMEM278 transmembrane protein 278 2.22324
RPS21-DT RPS21 divergent transcript 2.22324
H3C14 H3 clustered histone 14 2.22324
GARIN5B golgi associated RAB2 interactor family member 5B 2.22324
GARIN1A golgi associated RAB2 interactor 1A 2.22324
TAFA3 TAFA chemokine like family member 3 2.22324
KASH5 KASH domain containing 5 2.22324
SQOR sulfide quinone oxidoreductase 2.22324
STARD6 StAR-related lipid transfer (START) domain containing 6 2.22324
TSPO2 translocator protein 2 2.22324
AKR1D1 aldo-keto reductase family 1, member D1 2.22324
CCDC17 coiled-coil domain containing 17 2.22324
PRB4 proline-rich protein BstNI subfamily 4 2.22324
DTHD1 death domain containing 1 2.22324
ACTL10 actin-like 10 2.22324
ACTL8 actin-like 8 2.22324
ZNF18 zinc finger protein 18 2.22324
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.22324
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.22324
THPO thrombopoietin 2.22324
PEX12 peroxisomal biogenesis factor 12 2.22324
SBSN suprabasin 2.22324
S100B S100 calcium binding protein B 2.22324
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.22324
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.22324
GZMM granzyme M (lymphocyte met-ase 1) 2.22324
HAPLN2 hyaluronan and proteoglycan link protein 2 2.22324
TMCO2 transmembrane and coiled-coil domains 2 2.22324
PA2G4 proliferation-associated 2G4, 38kDa 2.22324
ANXA10 annexin A10 2.22324
GPR52 G protein-coupled receptor 52 2.22324
GAL3ST3 galactose-3-O-sulfotransferase 3 2.22324
KLHL41 kelch-like family member 41 2.22324
PRM1 protamine 1 2.22324
C11ORF16 chromosome 11 open reading frame 16 2.22324
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.22324
SPATA4 spermatogenesis associated 4 2.22324
TREH trehalase (brush-border membrane glycoprotein) 2.22324
APOC4 apolipoprotein C-IV 2.22324
CLEC4D C-type lectin domain family 4, member D 2.22324
WNT7B wingless-type MMTV integration site family, member 7B 2.22324
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.22324
DEFB107B defensin, beta 107B 2.22324
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.22324
NIM1K NIM1 serine/threonine protein kinase 2.22324
SOWAHA sosondowah ankyrin repeat domain family member A 2.22324
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.22324
EXTL1 exostosin-like glycosyltransferase 1 2.22324
AKNAD1 AKNA domain containing 1 2.22324
TUBB tubulin, beta class I 2.22324
CERKL ceramide kinase-like 2.22324
ACTC1 actin, alpha, cardiac muscle 1 2.22324
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.22324
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 2.22324
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.22324
DEFB135 defensin, beta 135 2.22324
C1ORF105 chromosome 1 open reading frame 105 2.22324
TYR tyrosinase 2.22324
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.22324
CDC34 cell division cycle 34 2.22324
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.22324
CXORF58 chromosome X open reading frame 58 2.22324
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.22324
CCDC170 coiled-coil domain containing 170 2.22324
LRRC25 leucine rich repeat containing 25 2.22324
CLEC1A C-type lectin domain family 1, member A 2.22324
TBX1 T-box 1 2.22324
UTS2R urotensin 2 receptor 2.22324
CFAP61 cilia and flagella associated protein 61 2.22324
SCUBE1 signal peptide, CUB domain, EGF-like 1 2.22324
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.22324
LRRC3 leucine rich repeat containing 3 2.22324
FCRL6 Fc receptor-like 6 2.22324
GSTA1 glutathione S-transferase alpha 1 2.22324
NUP62 nucleoporin 62kDa 2.22324
MYF6 myogenic factor 6 (herculin) 2.22324
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 2.22324
ERAP2 endoplasmic reticulum aminopeptidase 2 2.22324
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.22324
CD8A CD8a molecule 2.22324
GPBAR1 G protein-coupled bile acid receptor 1 2.22324
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2.22324
TBCEL tubulin folding cofactor E-like 2.22324
MT1H metallothionein 1H 2.22324
GH1 growth hormone 1 2.22324
LST1 leukocyte specific transcript 1 2.22324
PAGE2B P antigen family, member 2B 2.22324
SYTL4 synaptotagmin-like 4 2.22324
TGM2 transglutaminase 2 2.22324
NPR3 natriuretic peptide receptor 3 2.22324
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.22324
ZC2HC1B zinc finger, C2HC-type containing 1B 2.22324
NLRP1 NLR family, pyrin domain containing 1 2.22324
GGN gametogenetin 2.22324
C17ORF78 chromosome 17 open reading frame 78 2.22324
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.22324
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.22324
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.22324
EPX eosinophil peroxidase 2.22324
RORC RAR-related orphan receptor C 2.22324
HSF4 heat shock transcription factor 4 2.22324
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.22324
CALML6 calmodulin-like 6 2.22324
CABP7 calcium binding protein 7 2.22324
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.22324
FAM25G family with sequence similarity 25, member G 2.22324
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.22324
ZGRF1 zinc finger, GRF-type containing 1 2.20498
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.20498
ZNF185 zinc finger protein 185 (LIM domain) 2.20134
TNIP2 TNFAIP3 interacting protein 2 2.20134
ECPAS Ecm29 proteasome adaptor and scaffold 2.14687
DPF1 D4, zinc and double PHD fingers family 1 2.14342
H2AC4 H2A clustered histone 4 2.13931
CARD14 caspase recruitment domain family, member 14 2.11293
CCDC62 coiled-coil domain containing 62 2.11293
DIPK2A divergent protein kinase domain 2A 2.10533
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 2.10533
EPB41 erythrocyte membrane protein band 4.1 2.10533
TAPBP TAP binding protein (tapasin) 2.10533
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.10533
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.10533
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.10533
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.10533
SNRPC small nuclear ribonucleoprotein polypeptide C 2.10533
EIF6 eukaryotic translation initiation factor 6 2.10533
IGDCC3 immunoglobulin superfamily, DCC subclass, member 3 2.10533
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.10533
SAYSD1 SAYSVFN motif domain containing 1 2.08018
LRRC47 leucine rich repeat containing 47 2.07206
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.06594
GREB1 growth regulation by estrogen in breast cancer 1 2.05084
TSPAN3 tetraspanin 3 2.04984
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 2.04486
YEATS4 YEATS domain containing 4 2.04379
RPP38 ribonuclease P/MRP 38kDa subunit 2.03364
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2.01233
TBK1 TANK-binding kinase 1 2.00767
S100PBP S100P binding protein 2.00767
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.00767
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.00121

decreased expression

Symbol Name Standardized Value
MTRF1L mitochondrial translational release factor 1-like -2.22324
INTS7 integrator complex subunit 7 -2.22324
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.22324
GPSM3 G-protein signaling modulator 3 -2.22324
SMTNL1 smoothelin-like 1 -2.22324
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -2.22324
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -2.22324
TRIM34 tripartite motif containing 34 -2.22324
CCNH cyclin H -2.22324
AKAP8L A kinase (PRKA) anchor protein 8-like -2.22324
ZBTB1 zinc finger and BTB domain containing 1 -2.22324
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.22324
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.22324
PGBD5 piggyBac transposable element derived 5 -2.22324
DCDC1 doublecortin domain containing 1 -2.22324
SLC22A14 solute carrier family 22, member 14 -2.22324
ZCWPW1 zinc finger, CW type with PWWP domain 1 -2.22324
CRAT carnitine O-acetyltransferase -2.22324
SFXN3 sideroflexin 3 -2.22324
ASCC2 activating signal cointegrator 1 complex subunit 2 -2.22324
A2ML1 alpha-2-macroglobulin-like 1 -2.22324
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.22324
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -2.22324
MMP21 matrix metallopeptidase 21 -2.22324
CDK15 cyclin-dependent kinase 15 -2.22324
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.22324
NANOGP8 Nanog homeobox pseudogene 8 -2.22324
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.22324
KLK14 kallikrein-related peptidase 14 -2.22324
POLN polymerase (DNA directed) nu -2.22324
TMEM163 transmembrane protein 163 -2.22324
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.22324
DHFR2 dihydrofolate reductase 2 -2.22324
PYGO1 pygopus family PHD finger 1 -2.22324
PFN2 profilin 2 -2.22324
ZNF414 zinc finger protein 414 -2.22324
CKS2 CDC28 protein kinase regulatory subunit 2 -2.22324
EFCAB5 EF-hand calcium binding domain 5 -2.22324
MATN3 matrilin 3 -2.22324
BRIX1 BRX1, biogenesis of ribosomes -2.22324
CDH18 cadherin 18, type 2 -2.22324
POU2F2 POU class 2 homeobox 2 -2.19943
PEX16 peroxisomal biogenesis factor 16 -2.19943
GPATCH2 G patch domain containing 2 -2.19943
TMEM138 transmembrane protein 138 -2.15539
MYO5B myosin VB -2.14541
APTX aprataxin -2.11293
RMP64 ribonuclease MRP subunit p64 -2.11293
CATSPER3 cation channel, sperm associated 3 -2.10533
FOXN4 forkhead box N4 -2.10533
MRPL58 mitochondrial ribosomal protein L58 -2.10533
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.10533
VN1R1 vomeronasal 1 receptor 1 -2.10533
MYO9A myosin IXA -2.10533
TACSTD2 tumor-associated calcium signal transducer 2 -2.10533
ADGRG1 adhesion G protein-coupled receptor G1 -2.10533
MGAM maltase-glucoamylase -2.10533
TMEM40 transmembrane protein 40 -2.10533
HDGFL2 HDGF like 2 -2.10533
NECTIN3 nectin cell adhesion molecule 3 -2.10533
ASIC3 acid sensing (proton gated) ion channel 3 -2.10533
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.10533
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H -2.10533
SMIM47 small integral membrane protein 47 -2.10533
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.10533
DNAAF19 dynein axonemal assembly factor 19 -2.10533
CNTFR ciliary neurotrophic factor receptor -2.10533
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.10533
TTC36 tetratricopeptide repeat domain 36 -2.10533
FGF8 fibroblast growth factor 8 (androgen-induced) -2.10533
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.10533
NELL1 NEL-like 1 (chicken) -2.10533
PAQR6 progestin and adipoQ receptor family member VI -2.10533
BCO1 beta-carotene oxygenase 1 -2.10533
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.10533
CCDC159 coiled-coil domain containing 159 -2.10533
DYDC1 DPY30 domain containing 1 -2.10533
UBQLNL ubiquilin-like -2.10533
F11 coagulation factor XI -2.10533
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.10533
APIP APAF1 interacting protein -2.10533
ITGA10 integrin, alpha 10 -2.10533
PAX5 paired box 5 -2.10533
THRSP thyroid hormone responsive -2.10533
DSG3 desmoglein 3 -2.10533
C1ORF146 chromosome 1 open reading frame 146 -2.10533
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -2.10533
TCAP titin-cap -2.10533
PRTN3 proteinase 3 -2.10533
BTG4 B-cell translocation gene 4 -2.10533
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.08688
GDAP1 ganglioside induced differentiation associated protein 1 -2.08688
H2AC8 H2A clustered histone 8 -2.07521
EMG1 EMG1 N1-specific pseudouridine methyltransferase -2.07521
SPATA45 spermatogenesis associated 45 -2.06994
PCDHGB7 protocadherin gamma subfamily B, 7 -2.06994
MGARP mitochondria-localized glutamic acid-rich protein -2.05859
ODR4 odr-4 GPCR localization factor homolog -2.05799
XDH xanthine dehydrogenase -2.05603
OTUD4 OTU deubiquitinase 4 -2.05084
FKTN fukutin -2.04984
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 -2.03884
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -2.02433
CCDC180 coiled-coil domain containing 180 -2.02265
THOC3 THO complex 3 -2.00767
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.00202
LRRC37A leucine rich repeat containing 37A -2.00202
CA14 carbonic anhydrase XIV -2.00089