| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase kinase 3|This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4215) |
| External Link | https://ncbi.nlm.nih.gov/gene/4215 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the MAP3K3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HOPX | HOP homeobox | 0.023639 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.0166547 |
| FABP7 | fatty acid binding protein 7, brain | 0.0165737 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.015702 |
| S100A7 | S100 calcium binding protein A7 | 0.0144615 |
| EMX2 | empty spiracles homeobox 2 | 0.0136846 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.0133357 |
| NEBL | nebulette | 0.0129113 |
| COPS7A | COP9 signalosome subunit 7A | 0.0128878 |
| KLK6 | kallikrein-related peptidase 6 | 0.0128473 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.0126428 |
| S100A8 | S100 calcium binding protein A8 | 0.012347 |
| MEF2C | myocyte enhancer factor 2C | 0.0122632 |
| DOK5 | docking protein 5 | 0.0122418 |
| NPR3 | natriuretic peptide receptor 3 | 0.0118766 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0118273 |
| FOXG1 | forkhead box G1 | 0.0116225 |
| AQP4 | aquaporin 4 | 0.01142 |
| MSLN | mesothelin | 0.0113743 |
| MOXD1 | monooxygenase, DBH-like 1 | 0.0113031 |
| BAALC | brain and acute leukemia, cytoplasmic | 0.0112963 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.0111267 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.0108932 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.0108682 |
| KRT7 | keratin 7, type II | 0.0105949 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.0105873 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | 0.0105763 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.0105042 |
| ANOS1 | anosmin 1 | 0.010465 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.0102447 |
| S100A2 | S100 calcium binding protein A2 | 0.0101671 |
| PRMT1 | protein arginine methyltransferase 1 | 0.0100983 |
| MLF1 | myeloid leukemia factor 1 | 0.0100149 |
| EFNB2 | ephrin-B2 | 0.0100126 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0100065 |
| PLK1 | polo-like kinase 1 | 0.00995461 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00994978 |
| FASN | fatty acid synthase | 0.00994289 |
| CDC42 | cell division cycle 42 | 0.00990005 |
| KLK10 | kallikrein-related peptidase 10 | 0.00976388 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00967042 |
| FAM107A | family with sequence similarity 107, member A | 0.00959096 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00955675 |
| S100A9 | S100 calcium binding protein A9 | 0.00947232 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.00944442 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.00940998 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00939305 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | 0.00934993 |
| ITM2C | integral membrane protein 2C | 0.00928623 |
| NRN1 | neuritin 1 | 0.0092853 |
| KRT10 | keratin 10, type I | 0.00918756 |
| KRT13 | keratin 13, type I | 0.0091498 |
| PITX3 | paired-like homeodomain 3 | 0.00912389 |
| SPRR1B | small proline-rich protein 1B | 0.00909295 |
| KLK5 | kallikrein-related peptidase 5 | 0.00907817 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 0.00899618 |
| RGS4 | regulator of G-protein signaling 4 | 0.00899104 |
| TMEM100 | transmembrane protein 100 | 0.00899072 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00898625 |
| PODXL | podocalyxin-like | 0.00895903 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00882683 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00881283 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 0.00876559 |
| HPF1 | histone PARylation factor 1 | 0.00875868 |
| MEIS2 | Meis homeobox 2 | 0.00870925 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00870578 |
| KLK8 | kallikrein-related peptidase 8 | 0.00866392 |
| AK4 | adenylate kinase 4 | 0.00862999 |
| FOLR1 | folate receptor 1 (adult) | 0.00861816 |
| GLO1 | glyoxalase I | 0.00857445 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00855874 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00855116 |
| TIPRL | TOR signaling pathway regulator | 0.00854851 |
| DHFR | dihydrofolate reductase | 0.00854833 |
| CLDN10 | claudin 10 | 0.00852455 |
| GFAP | glial fibrillary acidic protein | 0.00851391 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 0.00851299 |
| SIRT5 | sirtuin 5 | 0.0085025 |
| LTF | lactotransferrin | 0.00841753 |
| PRDX4 | peroxiredoxin 4 | 0.00841024 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00840022 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00838867 |
| SCEL | sciellin | 0.00838848 |
| MAL | mal, T-cell differentiation protein | 0.00838586 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.00835122 |
| KRT6A | keratin 6A, type II | 0.00833085 |
| TPM4 | tropomyosin 4 | 0.00829639 |
| PMP2 | peripheral myelin protein 2 | 0.00829578 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.00826942 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00825292 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00824843 |
| KLK7 | kallikrein-related peptidase 7 | 0.00816884 |
| RPS5 | ribosomal protein S5 | 0.00815549 |
| ANGPT1 | angiopoietin 1 | 0.00813728 |
| SFTPD | surfactant protein D | 0.00811866 |
| KIF20A | kinesin family member 20A | 0.00806339 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.00803723 |
| MAGT1 | magnesium transporter 1 | 0.008024 |
| CLIC5 | chloride intracellular channel 5 | 0.00800035 |
| CCDC85B | coiled-coil domain containing 85B | 0.00799287 |
| LDB2 | LIM domain binding 2 | 0.00798135 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00794687 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.00793733 |
| GSTA4 | glutathione S-transferase alpha 4 | 0.007933 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | 0.00792308 |
| BCHE | butyrylcholinesterase | 0.00792109 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00784911 |
| COG7 | component of oligomeric golgi complex 7 | 0.00781434 |
| TYRP1 | tyrosinase-related protein 1 | 0.00775616 |
| GTPBP8 | GTP-binding protein 8 (putative) | 0.00772739 |
| KRT5 | keratin 5, type II | 0.007697 |
| FOXC1 | forkhead box C1 | 0.00769116 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00768493 |
| PRKD3 | protein kinase D3 | 0.00765223 |
| SDC1 | syndecan 1 | 0.0076386 |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 | 0.00763614 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00762169 |
| TMEM45A | transmembrane protein 45A | 0.00758225 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00752593 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.00750329 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.00749441 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00748027 |
| KLK11 | kallikrein-related peptidase 11 | 0.00747336 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.00746673 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00745106 |
| CCNA2 | cyclin A2 | 0.00743077 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.00741047 |
| NDUFA9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | 0.00740252 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00740172 |
| LSM2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00736922 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | 0.00735572 |
| TMEM47 | transmembrane protein 47 | 0.00730873 |
| MUC16 | mucin 16, cell surface associated | 0.00730714 |
| FCN3 | ficolin (collagen/fibrinogen domain containing) 3 | 0.00730657 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.00725969 |
| SPA17 | sperm autoantigenic protein 17 | 0.00725426 |
| ISOC2 | isochorismatase domain containing 2 | 0.00722134 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.00722082 |
| SOSTDC1 | sclerostin domain containing 1 | 0.00718979 |
| LZTFL1 | leucine zipper transcription factor-like 1 | 0.00718674 |
| WDR61 | WD repeat domain 61 | 0.00716927 |
| TMEM168 | transmembrane protein 168 | 0.007165 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.00714268 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.00713717 |
| TRIM29 | tripartite motif containing 29 | 0.00712842 |
| NNMT | nicotinamide N-methyltransferase | 0.0071222 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00706456 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00704293 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.00701102 |
| NDRG2 | NDRG family member 2 | 0.00700224 |
| UNG | uracil-DNA glycosylase | 0.00697583 |
| PRKD1 | protein kinase D1 | 0.00697573 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00697273 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00697016 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00696093 |
| FAM162A | family with sequence similarity 162, member A | 0.00694397 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00694258 |
| TMEM14B | transmembrane protein 14B | 0.00693511 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00692075 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.00691498 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00691298 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | 0.00690712 |
| TMEM160 | transmembrane protein 160 | 0.00690313 |
| TSPAN12 | tetraspanin 12 | 0.00687738 |
| TSPAN13 | tetraspanin 13 | 0.00687178 |
| FJX1 | four jointed box 1 (Drosophila) | 0.00686414 |
| COMMD8 | COMM domain containing 8 | 0.00686283 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00684396 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.00684009 |
| TSPAN6 | tetraspanin 6 | 0.0068327 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.00681096 |
| LSM4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00680273 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.00680081 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.00679719 |
| ZNF204P | zinc finger protein 204, pseudogene | 0.00677893 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00677687 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.00674012 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.00670915 |
| ANXA10 | annexin A10 | 0.00670141 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.00668611 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | 0.00667393 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00666785 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | 0.00666513 |
| CYCS | cytochrome c, somatic | 0.00664521 |
| RDX | radixin | 0.0066296 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00660116 |
| CRYM | crystallin, mu | 0.00659744 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | 0.00658591 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.00658458 |
| EPYC | epiphycan | 0.00658183 |
| ZNF226 | zinc finger protein 226 | 0.00657292 |
| EAF2 | ELL associated factor 2 | 0.00654044 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 0.00652866 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.00646367 |
| VBP1 | von Hippel-Lindau binding protein 1 | 0.00645682 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00645026 |
| BGN | biglycan | 0.00644118 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00643554 |
| SEC13 | SEC13 homolog (S. cerevisiae) | 0.00643328 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.00643146 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00642165 |
| CRIP2 | cysteine-rich protein 2 | 0.00641232 |
| DAPK1 | death-associated protein kinase 1 | 0.00640898 |
| SELENOT | selenoprotein T | 0.00640758 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00640395 |
| NXT2 | nuclear transport factor 2-like export factor 2 | 0.00639799 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.00638895 |
| PTN | pleiotrophin | 0.00638242 |
| RPS9 | ribosomal protein S9 | 0.00637963 |
| KRT6B | keratin 6B, type II | 0.00637909 |
| CBR3 | carbonyl reductase 3 | 0.00637379 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.00637092 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.00636417 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00635811 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 0.00634808 |
| SFTPC | surfactant protein C | 0.0063192 |
| CD320 | CD320 molecule | 0.0063103 |
| PTH2R | parathyroid hormone 2 receptor | 0.00629132 |
| LYPLA1 | lysophospholipase I | 0.00629125 |
| NSL1 | NSL1, MIS12 kinetochore complex component | 0.00628949 |
| PROM1 | prominin 1 | 0.00627563 |
| CCK | cholecystokinin | 0.00627451 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00626833 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.00625551 |
| SCNN1B | sodium channel, non voltage gated 1 beta subunit | 0.00625062 |
| HTRA1 | HtrA serine peptidase 1 | 0.00623465 |
| S100B | S100 calcium binding protein B | 0.00623172 |
| RPIA | ribose 5-phosphate isomerase A | 0.00622833 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.00622783 |
| TCF4 | transcription factor 4 | 0.00622356 |
| PEX2 | peroxisomal biogenesis factor 2 | 0.00621874 |
| AKR1A1 | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 0.00620142 |
| SAR1B | secretion associated, Ras related GTPase 1B | 0.00620116 |
| NPY | neuropeptide Y | 0.0061844 |
| CD58 | CD58 molecule | 0.00614606 |
| MMUT | methylmalonyl-CoA mutase | 0.00614093 |
| CRIPT | cysteine-rich PDZ-binding protein | 0.00611753 |
| FAR2 | fatty acyl CoA reductase 2 | 0.00610928 |
| VRK3 | vaccinia related kinase 3 | 0.00609214 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0060816 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.0060805 |
| CALML5 | calmodulin-like 5 | 0.00608043 |
| MREG | melanoregulin | 0.00607983 |
| VDAC1 | voltage-dependent anion channel 1 | 0.00607734 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00606994 |
| TBX2 | T-box 2 | 0.00606483 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00605439 |
| LIG1 | ligase I, DNA, ATP-dependent | 0.00605011 |
| GLTP | glycolipid transfer protein | 0.00604934 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00604853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL15A1 | collagen, type XV, alpha 1 | -0.0169865 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0166411 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.0151297 |
| CFB | complement factor B | -0.0141723 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0132577 |
| TMEM176B | transmembrane protein 176B | -0.0132529 |
| G0S2 | G0/G1 switch 2 | -0.0128632 |
| TFF1 | trefoil factor 1 | -0.0127515 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0127503 |
| STC2 | stanniocalcin 2 | -0.0127183 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.0126541 |
| APOB | apolipoprotein B | -0.0123899 |
| CFD | complement factor D (adipsin) | -0.0123027 |
| TRIB3 | tribbles pseudokinase 3 | -0.0122192 |
| BAG3 | BCL2-associated athanogene 3 | -0.012106 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0119517 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0116102 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.0115291 |
| MAGEA3 | melanoma antigen family A3 | -0.0114876 |
| FGG | fibrinogen gamma chain | -0.0113214 |
| STC1 | stanniocalcin 1 | -0.0109303 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.010563 |
| TYMP | thymidine phosphorylase | -0.0103004 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.0101846 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.0101749 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0101364 |
| RASA4 | RAS p21 protein activator 4 | -0.0100034 |
| HMOX1 | heme oxygenase 1 | -0.00999754 |
| IL32 | interleukin 32 | -0.00992571 |
| KRT18 | keratin 18, type I | -0.00989215 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00981353 |
| RTN2 | reticulon 2 | -0.00980927 |
| EGR1 | early growth response 1 | -0.00971644 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00965154 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00962885 |
| FADS3 | fatty acid desaturase 3 | -0.00956997 |
| ACKR3 | atypical chemokine receptor 3 | -0.00955246 |
| ABHD3 | abhydrolase domain containing 3 | -0.00953014 |
| CTSA | cathepsin A | -0.00952701 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00942866 |
| FGB | fibrinogen beta chain | -0.00938603 |
| DMXL2 | Dmx-like 2 | -0.00932393 |
| BTG2 | BTG family, member 2 | -0.0093081 |
| IRS1 | insulin receptor substrate 1 | -0.00930242 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0091965 |
| MGLL | monoglyceride lipase | -0.00916951 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00916444 |
| FGA | fibrinogen alpha chain | -0.00906133 |
| REG1A | regenerating islet-derived 1 alpha | -0.00902007 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00901614 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00894909 |
| TRIM22 | tripartite motif containing 22 | -0.00893403 |
| ATF3 | activating transcription factor 3 | -0.00888808 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0088643 |
| GAB2 | GRB2-associated binding protein 2 | -0.00885311 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00884976 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0088493 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.00884087 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00880923 |
| COL5A2 | collagen, type V, alpha 2 | -0.00871923 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00868631 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.00864727 |
| NID1 | nidogen 1 | -0.00859364 |
| ORM1 | orosomucoid 1 | -0.00858227 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -0.00853432 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.00852849 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00850326 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00850237 |
| GOLM1 | golgi membrane protein 1 | -0.00848609 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.00847945 |
| TPBG | trophoblast glycoprotein | -0.00847125 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | -0.00846741 |
| IRF9 | interferon regulatory factor 9 | -0.0084207 |
| TTR | transthyretin | -0.00842013 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | -0.00836086 |
| IRS2 | insulin receptor substrate 2 | -0.00831658 |
| CARD10 | caspase recruitment domain family, member 10 | -0.00831244 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00830987 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.00829108 |
| XIC | X chromosome inactivation center | -0.00824896 |
| NIT1 | nitrilase 1 | -0.00824401 |
| CTSL | cathepsin L | -0.00821705 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.00814189 |
| ALB | albumin | -0.00808656 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00808106 |
| HECA | headcase homolog (Drosophila) | -0.0080107 |
| CPD | carboxypeptidase D | -0.00798918 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00797237 |
| LYZ | lysozyme | -0.00796831 |
| H1-0 | H1.0 linker histone | -0.00796516 |
| MX1 | MX dynamin-like GTPase 1 | -0.00796085 |
| FGL2 | fibrinogen-like 2 | -0.0079506 |
| SLC35D1 | solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 | -0.00793266 |
| NOTCH2 | notch 2 | -0.00793112 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | -0.00787003 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | -0.0078589 |
| VEGFC | vascular endothelial growth factor C | -0.00785426 |
| FNDC3A | fibronectin type III domain containing 3A | -0.00784689 |
| FYB1 | FYN binding protein 1 | -0.0078404 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00778699 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.00778669 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -0.00777351 |
| KHNYN | KH and NYN domain containing | -0.00776727 |
| GSN | gelsolin | -0.00775564 |
| PNMA1 | paraneoplastic Ma antigen 1 | -0.00773747 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00773295 |
| ENAH | enabled homolog (Drosophila) | -0.00772604 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00772229 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00772202 |
| ABAT | 4-aminobutyrate aminotransferase | -0.00769068 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00766392 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.00765728 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.007655 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00765027 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.00759861 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.00757796 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00757583 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00756554 |
| RTN4 | reticulon 4 | -0.00754702 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.00753328 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0075229 |
| VTN | vitronectin | -0.0075194 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.00751391 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00748424 |
| MFSD1 | major facilitator superfamily domain containing 1 | -0.00748021 |
| S100A10 | S100 calcium binding protein A10 | -0.00747281 |
| CUX1 | cut-like homeobox 1 | -0.00741969 |
| HGD | homogentisate 1,2-dioxygenase | -0.00741344 |
| APOC3 | apolipoprotein C-III | -0.00740793 |
| SLC16A6 | solute carrier family 16, member 6 | -0.00740741 |
| TOB2 | transducer of ERBB2, 2 | -0.00738895 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.00735484 |
| DUSP5 | dual specificity phosphatase 5 | -0.00734927 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00734463 |
| AHSG | alpha-2-HS-glycoprotein | -0.0073265 |
| TBX3 | T-box 3 | -0.00730462 |
| IER5 | immediate early response 5 | -0.00729934 |
| RGS5 | regulator of G-protein signaling 5 | -0.00729579 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00726552 |
| DUSP1 | dual specificity phosphatase 1 | -0.00725923 |
| MAGEA12 | melanoma antigen family A12 | -0.0072546 |
| MMP2 | matrix metallopeptidase 2 | -0.00724992 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00723382 |
| ADCY9 | adenylate cyclase 9 | -0.00723337 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | -0.00722809 |
| IL6 | interleukin 6 | -0.00722717 |
| DSG2 | desmoglein 2 | -0.00721434 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.00721358 |
| CHN2 | chimerin 2 | -0.00720305 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.00720238 |
| NCOA3 | nuclear receptor coactivator 3 | -0.00719975 |
| LYST | lysosomal trafficking regulator | -0.00718192 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00716726 |
| RHOB | ras homolog family member B | -0.00716623 |
| AREG | amphiregulin | -0.0071489 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.00712515 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.007109 |
| C1S | complement component 1, s subcomponent | -0.0071048 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00708744 |
| HIC2 | hypermethylated in cancer 2 | -0.00705266 |
| USP6NL | USP6 N-terminal like | -0.00704679 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | -0.00704062 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.00703861 |
| LRRC8D | leucine rich repeat containing 8 family, member D | -0.00703347 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00702911 |
| TPP1 | tripeptidyl peptidase I | -0.00701246 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.00700522 |
| NAV2 | neuron navigator 2 | -0.00700022 |
| GLUL | glutamate-ammonia ligase | -0.00699457 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00698059 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -0.00697804 |
| GOLGA8A | golgin A8 family, member A | -0.00697759 |
| FKBP4 | FK506 binding protein 4, 59kDa | -0.00696328 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.0069526 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 | -0.00695041 |
| ATXN7 | ataxin 7 | -0.00693598 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -0.00692631 |
| ZNF281 | zinc finger protein 281 | -0.0069244 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00692132 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00692024 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00691957 |
| PLIN2 | perilipin 2 | -0.00690863 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00690576 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | -0.00690352 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00689649 |
| ITK | IL2-inducible T-cell kinase | -0.00688953 |
| CTSZ | cathepsin Z | -0.00688232 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.00686328 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00685768 |
| USP47 | ubiquitin specific peptidase 47 | -0.00685249 |
| CDV3 | CDV3 homolog (mouse) | -0.00685171 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00683806 |
| MTF2 | metal response element binding transcription factor 2 | -0.00683068 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | -0.00681641 |
| CEP170 | centrosomal protein 170kDa | -0.0068128 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00681115 |
| USP3 | ubiquitin specific peptidase 3 | -0.00678985 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.00677256 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00675209 |
| AKAP17A | A kinase (PRKA) anchor protein 17A | -0.00674803 |
| CPE | carboxypeptidase E | -0.00674054 |
| STK26 | serine/threonine protein kinase 26 | -0.00673645 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00673591 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.00672875 |
| PLA1A | phospholipase A1 member A | -0.00671859 |
| MKRN1 | makorin ring finger protein 1 | -0.00671725 |
| SMAD3 | SMAD family member 3 | -0.00667795 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.00667463 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00665207 |
| REC8 | REC8 meiotic recombination protein | -0.00665052 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.00663721 |
| MCL1 | myeloid cell leukemia 1 | -0.00662529 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.0066217 |
| LSM8 | LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00660353 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00659911 |
| WDR45 | WD repeat domain 45 | -0.0065914 |
| RBM26 | RNA binding motif protein 26 | -0.00655819 |
| NCOA2 | nuclear receptor coactivator 2 | -0.00655452 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -0.00654712 |
| REG3A | regenerating islet-derived 3 alpha | -0.00654356 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0065431 |
| ERBIN | erbb2 interacting protein | -0.00653851 |
| FBLN1 | fibulin 1 | -0.00653662 |
| TLR4 | toll-like receptor 4 | -0.00652636 |
| PRRC2C | proline-rich coiled-coil 2C | -0.00651552 |
| SPAG9 | sperm associated antigen 9 | -0.00651233 |
| TMEM176A | transmembrane protein 176A | -0.00650572 |
| MID1IP1 | MID1 interacting protein 1 | -0.00650156 |
| FAM117A | family with sequence similarity 117, member A | -0.00649524 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.00649075 |
| CLU | clusterin | -0.00648652 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0064712 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.00646501 |
| TOB1 | transducer of ERBB2, 1 | -0.00646498 |
| MMD | monocyte to macrophage differentiation-associated | -0.00646321 |
| VWF | von Willebrand factor | -0.00645621 |
| SERINC1 | serine incorporator 1 | -0.00644148 |
| AGTR1 | angiotensin II receptor, type 1 | -0.00644117 |
| SOCS1 | suppressor of cytokine signaling 1 | -0.00643525 |
| SPATA20 | spermatogenesis associated 20 | -0.00643119 |
| CDK17 | cyclin-dependent kinase 17 | -0.00642818 |
| RAB7A | RAB7A, member RAS oncogene family | -0.00640162 |
| ADNP | activity-dependent neuroprotector homeobox | -0.00639738 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00639618 |
| CCL8 | chemokine (C-C motif) ligand 8 | -0.00639106 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00634996 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.00634672 |
| CHGB | chromogranin B | -0.00633833 |
| CCNG2 | cyclin G2 | -0.00632631 |
