MAP3K3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description mitogen-activated protein kinase kinase kinase 3|This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4215)
External Link http://www.ncbi.nlm.nih.gov/gene/4215
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Genes

366 interacting proteins for MAP3K3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACTB actin, beta
ACTG1 actin gamma 1
ACTN4 actinin, alpha 4
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR2B activin A receptor, type IIB
ADAM28 ADAM metallopeptidase domain 28
ADCK1 aarF domain containing kinase 1
ADCK3 aarF domain containing kinase 3
ADK adenosine kinase
AFF4 AF4/FMR2 family, member 4
AHRR aryl-hydrocarbon receptor repressor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOA aldolase A, fructose-bisphosphate
ALK anaplastic lymphoma receptor tyrosine kinase
ALPK3 alpha-kinase 3
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA2 annexin A2
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARAF A-Raf proto-oncogene, serine/threonine kinase
ATAD3B ATPase family, AAA domain containing 3B
ATF2 activating transcription factor 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
AURKB aurora kinase B
AZI2 5-azacytidine induced 2
BAG2 BCL2-associated athanogene 2
BAG5 BCL2-associated athanogene 5
BCR breakpoint cluster region
BIRC2 baculoviral IAP repeat containing 2
BMP2K BMP2 inducible kinase
BMPR1A bone morphogenetic protein receptor, type IA
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRD3 bromodomain containing 3
BRD4 bromodomain containing 4
BTK Bruton agammaglobulinemia tyrosine kinase
C1QBP complement component 1, q subcomponent binding protein
C2CD5 C2 calcium-dependent domain containing 5
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CCNH cyclin H
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDC37 cell division cycle 37
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CFL2 cofilin 2 (muscle)
CHUK conserved helix-loop-helix ubiquitous kinase
CLK1 CDC-like kinase 1
CLTC clathrin, heavy chain (Hc)
COPS5 COP9 signalosome subunit 5
CORO1C coronin, actin binding protein, 1C
CPVL carboxypeptidase, vitellogenic-like
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DBN1 drebrin 1
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDR1 discoidin domain receptor tyrosine kinase 1
DLG1 discs, large homolog 1 (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF3J eukaryotic translation initiation factor 3, subunit J
EPHA7 EPH receptor A7
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
EPPK1 epiplakin 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
FASN fatty acid synthase
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FLNA filamin A, alpha
FRYL FRY-like
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAB1 GRB2-associated binding protein 1
GAK cyclin G associated kinase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAPVD1 GTPase activating protein and VPS9 domains 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GRAMD1A GRAM domain containing 1A
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GTF2I general transcription factor IIi
HAX1 HCLS1 associated protein X-1
HCK HCK proto-oncogene, Src family tyrosine kinase
HIPK1 homeodomain interacting protein kinase 1
HIST1H4F histone cluster 1, H4f
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
IARS isoleucyl-tRNA synthetase
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1B interleukin 1, beta
INPPL1 inositol polyphosphate phosphatase-like 1
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IRAK1 interleukin-1 receptor-associated kinase 1
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KIAA0195 KIAA0195
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LGALS7B lectin, galactoside-binding, soluble, 7B
LIMA1 LIM domain and actin binding 1
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LONP1 lon peptidase 1, mitochondrial
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MARS methionyl-tRNA synthetase
MATR3 matrin 3
MBP myelin basic protein
MCC mutated in colorectal cancers
MELK maternal embryonic leucine zipper kinase
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPRIP myosin phosphatase Rho interacting protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYLK2 myosin light chain kinase 2
MYO1A myosin IA
MYO1B myosin IB
MYO1C myosin IC
MYO1D myosin ID
MYO6 myosin VI
NCK2 NCK adaptor protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK11 NIMA-related kinase 11
NEK9 NIMA-related kinase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLK nemo-like kinase
NQO2 NAD(P)H dehydrogenase, quinone 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUDC nudC nuclear distribution protein
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDE4A phosphodiesterase 4A, cAMP-specific
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PDRG1 p53 and DNA-damage regulated 1
PFDN1 prefoldin subunit 1
PFDN2 prefoldin subunit 2
PFDN4 prefoldin subunit 4
PFDN5 prefoldin subunit 5
PFDN6 prefoldin subunit 6
PFKL phosphofructokinase, liver
PHGDH phosphoglycerate dehydrogenase
PIH1D1 PIH1 domain containing 1
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PKM pyruvate kinase, muscle
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PKN1 protein kinase N1
PKN3 protein kinase N3
PLK4 polo-like kinase 4
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PYGM phosphorylase, glycogen, muscle
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAI14 retinoic acid induced 14
RCAN1 regulator of calcineurin 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF126 ring finger protein 126
RPAP3 RNA polymerase II associated protein 3
RPL23 ribosomal protein L23
RPS16 ribosomal protein S16
RPS27 ribosomal protein S27
RPS27L ribosomal protein S27-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SACK1A scaffolding CK1 anchoring protein A
SCIN scinderin
SCO2 SCO2 cytochrome c oxidase assembly protein
SCRIB scribbled planar cell polarity protein
SEC16A SEC16 homolog A (S. cerevisiae)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLK STE20-like kinase
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPAG9 sperm associated antigen 9
SPEG SPEG complex locus
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SSB Sjogren syndrome antigen B (autoantigen La)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST13P4 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 4
STK16 serine/threonine kinase 16
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TCP1 t-complex 1
TEC tec protein tyrosine kinase
TESK2 testis-specific kinase 2
TFG TRK-fused gene
TGFBR1 transforming growth factor, beta receptor 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMOD3 tropomodulin 3 (ubiquitous)
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TNK2 tyrosine kinase, non-receptor, 2
TOM1L1 target of myb1 (chicken)-like 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TTN titin
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA3C tubulin, alpha 3c
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB6 tubulin, beta 6 class V
TYK2 tyrosine kinase 2
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBL4A ubiquitin-like 4A
ULK3 unc-51 like kinase 3
URI1 URI1, prefoldin-like chaperone
UXT ubiquitously-expressed, prefoldin-like chaperone
VBP1 von Hippel-Lindau binding protein 1
VCP valosin containing protein
VIM vimentin
VWF von Willebrand factor
WEE1 WEE1 G2 checkpoint kinase
WNK1 WNK lysine deficient protein kinase 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPOT exportin, tRNA
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB16 zinc finger and BTB domain containing 16